Structure information

A2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

4UHR

SPECIES

Homo sapiens

RESOLUTION

2.600

PREFERRED CHAIN

A

REFERENCE

10.1124/mol.114.097360

PUBLICATION DATE

April 8, 2015

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CGS 21680 V84 3.32x32 TM3 hydrophobic
CGS 21680 L85 3.33x33 TM3 hydrophobic
CGS 21680 T88 3.36x36 TM3 polar (hydrogen bond)
CGS 21680 A89 3.37x37 TM3 Van der Waals
CGS 21680 F168 45.52x52 ECL2 aromatic (face-to-face)
CGS 21680 F168 45.52x52 ECL2 Van der Waals
CGS 21680 E169 ECL2 polar (charge-assisted hydrogen bond)
CGS 21680 M177 5.38x40 TM5 Van der Waals
CGS 21680 N181 5.42x43 TM5 Van der Waals
CGS 21680 W246 6.48x48 TM6 hydrophobic
CGS 21680 W246 6.48x48 TM6 Van der Waals
CGS 21680 L249 6.51x51 TM6 Van der Waals
CGS 21680 L249 6.51x51 TM6 hydrophobic
CGS 21680 H250 6.52x52 TM6 Van der Waals
CGS 21680 H250 6.52x52 TM6 polar (hydrogen bond)
CGS 21680 N253 6.55x55 TM6 polar (hydrogen bond)
CGS 21680 N253 6.55x55 TM6 polar (hydrogen bond)
CGS 21680 M270 7.35x34 TM7 Van der Waals
CGS 21680 I274 7.39x38 TM7 Van der Waals
CGS 21680 I274 7.39x38 TM7 hydrophobic
CGS 21680 S277 7.42x41 TM7 polar (hydrogen bond)
CGS 21680 S277 7.42x41 TM7 Van der Waals
CGS 21680 H278 7.43x42 TM7 polar (hydrogen bond)
CGS 21680 H278 7.43x42 TM7 Van der Waals

Ligands

CGS 21680

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Residue Diagrams

V N G L I A L V A I A L E V T I Y V S S 1 V S L A A A D I A V G L V A I P F A I T I 2 A L L S F I S S Q T L V L V F C A I F L 3 A K G I I A I C W V L S F A I G L T P M 4 Y V G L M L L L P V L V C A F F N F Y V M Y 5 A I I V G L F A L C W L P L H I I N C F 6 F P N V V S N T H S L V I A L Y M L W 7
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ICL1 S N L Q ICL1ECL1 F C A ECL1ICL2 P L R Y N G L V ICL2ECL2 W N N C G Q P K E G K N H S Q G C G E G Q V A C L F E D V V ECL2ICL3 Q P L P G ICL3ECL3 P D C S H A ECL3C-term K A A G T S A R V L A A H G S D G E Q V S L R L N G H P P G V W A N G S A P H P E R R P N G Y A L G L V S G G S A Q E S Q G N T G L P D V E L L S H E L K G V C P E P P G L D D P L A Q D G A G V S C-term M P I M G S S V Y I T V E L A I A V L A I L G N V L V C W A V W L N N V T N Y F V V S L A A A D I A V G V L A I P F A I T I S T G A C H G C L F I A C F V L V L T Q S S I F S L L A I A I D R Y I A I R I T G T R A K G I I A I C W V L S F A I G L T P M L G P M N Y M V Y F N F F A C V L V P L L L M L G V Y L R I F L A A R R Q L K Q M E S E R A R S T L Q K E V H A A K S L A I I V G L F A L C W L P L H I I N C F T F F C P L W L M Y L A I V L S H T N S V V N P F I Y A Y R I R E F R K H V L P F F R Q T I I R S R Q Q E
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Residue Table


GPCRdb(A)
GPCRdb(A)
A2A receptor
TM3
3x32 3.32x32 V84
3x33 3.33x33 L85
3x36 3.36x36 T88
3x37 3.37x37 Q89
ECL2
45x52 45.52x52 F168
TM5
5x40 5.38x40 M177
5x43 5.42x43 N181
TM6
6x48 6.48x48 W246
6x51 6.51x51 L249
6x52 6.52x52 H250
6x55 6.55x55 N253
TM7
7x34 7.35x34 M270
7x38 7.39x38 I274
7x41 7.42x41 S277
7x42 7.43x42 H278