Structure information

M2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

4MQS

SPECIES

Homo sapiens

RESOLUTION

3.500

PREFERRED CHAIN

A

REFERENCE

10.1038/NATURE12735

PUBLICATION DATE

Nov. 27, 2013

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
iperoxo Y104 3.33x33 TM3 hydrophobic
iperoxo V111 3.40x40 TM3 hydrophobic
iperoxo W155 4.57x57 TM4 hydrophobic
iperoxo A194 5.46x461 TM5 hydrophobic
iperoxo F195 5.47x47 TM5 hydrophobic
iperoxo W400 6.48x48 TM6 hydrophobic
iperoxo Y403 6.51x51 TM6 hydrophobic
iperoxo N404 6.52x52 TM6 polar (hydrogen bond)
iperoxo N404 6.52x52 TM6 Van der Waals
iperoxo Y426 7.39x38 TM7 hydrophobic
iperoxo Y426 7.39x38 TM7 Van der Waals
iperoxo C429 7.42x41 TM7 Van der Waals
iperoxo Y430 7.43x42 TM7 Van der Waals
iperoxo Y430 7.43x42 TM7 hydrophobic

Ligands

iperoxo

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Residue Diagrams

I N G I I T V L S L S G A V L V I F V V 1 F S L A C A D L I I G F V S M N L Y T L Y 2 I L L N M V S A N S V V Y D L A L W L D 3 A G M M I A A A W V L S F I L W A P A I 4 Y L V T M I I V P L Y F A A I A T G F T V 5 L A I L L A F I I T W A P Y N V M V L I 6 A P N I T S N I Y C L W Y G I T W V T 7
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ICL1 R H L Q ICL1ECL1 Y W P L ECL1ICL2 P L T Y P V K R ICL2ECL2 V R T V E D G E C Y I Q F F S ECL2ICL3 P V A N Q D P V S P S L V Q G R I V K P N N N N M P S S D D G L E H N K I Q N G K A P R D P V T E N C V Q G E E K E S S N D S T S V S A V A S N M R D D E I T Q D E N T V S T S L G H S K D E N S K Q T C I R I G T K T P K S D S C T P T N T T V E V V G S S G Q N G D E K Q N I V A R K I V K M T K Q P A K K ICL3ECL3 A P C I ECL3N-term M N N S T N S S N N S L A L T S P Y N-termC-term C H Y K N I G A T R C-term K T F E V V F I V L V A G S L S L V T I I G N I L V M V S I K V N T V N N Y F L F S L A C A D L I I G V F S M N L Y T L Y T V I G G P V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K T T K M A G M M I A A A W V L S F I L W A P A I L F W Q F I V G N A A V T F G T A I A A F Y L P V I I M T V L Y W H I S R A S K S R I K K D K K E K P P P S R E K K V T R T I L A I L L A F I I T W A P Y N V M V L I N T F C P N T V W T I G Y W L C Y I N S T I N P A C Y A L C N A T F K H F K K T L L M
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Residue Table


GPCRdb(A)
GPCRdb(A)
M2 receptor
TM3
3x33 3.33x33 Y104
3x40 3.40x40 V111
TM4
4x57 4.57x57 W155
TM5
5x461 5.46x461 A194
5x47 5.47x47 F195
TM6
6x48 6.48x48 W400
6x51 6.51x51 Y403
6x52 6.52x52 N404
TM7
7x38 7.39x38 Y426
7x41 7.42x41 C429
7x42 7.43x42 Y430