Structure information

H1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

3RZE

SPECIES

Homo sapiens

RESOLUTION

3.100

PREFERRED CHAIN

A

REFERENCE

10.1038/NATURE10236

PUBLICATION DATE

June 15, 2011

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Ligand Interaction Browser

Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
doxepin D107 3.32x32 TM3 polar (charge-assisted hydrogen bond)
doxepin Y108 3.33x33 TM3 aromatic (edge-to-face)
doxepin Y108 3.33x33 TM3 Van der Waals
doxepin S111 3.36x36 TM3 Van der Waals
doxepin T112 3.37x37 TM3 polar (hydrogen bond)
doxepin T112 3.37x37 TM3 Van der Waals
doxepin I115 3.40x40 TM3 hydrophobic
doxepin I115 3.40x40 TM3 Van der Waals
doxepin W158 4.56x57 TM4 Van der Waals
doxepin W158 4.56x57 TM4 aromatic (face-to-edge)
doxepin T194 5.42x43 TM5 Van der Waals
doxepin N198 5.46x461 TM5 Van der Waals
doxepin F424 6.44x44 TM6 hydrophobic
doxepin F424 6.44x44 TM6 Van der Waals
doxepin W428 6.48x48 TM6 Van der Waals
doxepin W428 6.48x48 TM6 aromatic (face-to-edge)
doxepin Y431 6.51x51 TM6 Van der Waals
doxepin Y431 6.51x51 TM6 hydrophobic
doxepin F432 6.52x52 TM6 aromatic (edge-to-face)
doxepin F432 6.52x52 TM6 Van der Waals
doxepin F435 6.55x55 TM6 Van der Waals
doxepin F435 6.55x55 TM6 aromatic (face-to-edge)
doxepin I454 7.39x38 TM7 hydrophobic
doxepin Y458 7.43x42 TM7 Van der Waals

Ligands

doxepin

3D interaction viewer Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.


Residue Diagrams

L N L G V T V L C I T S L V V V L P 1 V S L S V A D L I V G V A V M P M N I L Y 2 I F V S F I S A T S A V Y D M S L W F L 3 A S A T I L G A W F L S F L W V I P I 4 Y F W L M L L T P L Y F N I I A T M V K F 5 G F I M A A F I L C W I P Y F I F F M V 6 L P N L T S N I Y G L W I T F M H L H 7
Download: PNG | SVG
ICL1 R K L H ICL1ECL1 S K W S L ECL1ICL2 P L R Y L K Y R ICL2ECL2 W N H F M Q Q T S V R R E D K C E T D F Y D ECL2ICL3 R S L P S F S E I K L R P E N P K G D A K K P G K E S P W E V L K R K P K D A G G G S V L K S P S Q T P K E M K S P V V F S Q E D D R E V D K L Y C F P L D I V H M Q A A A E G S S R D Y V A V N R S H G Q L K T D E Q G L N T H G A S E I S E D Q M L G D S Q S F S R T D S D T T T E T A P G K G K L R S G S N T G L D Y I K F T W K R L R S H S R Q Y V S ICL3ECL3 K N C C ECL3N-term M S L P N S S C L L E D K M C E G N K T T M A S P Q L M N-termC-term I R S C-term P L V V V L S T I C L V T V G L N L L V L Y A V R S E T V G N L Y I V S L S V A D L I V G A V V M P M N I L Y L L M G R P L C L F W L S M D Y V A S T A S I F S V F I L C I D R Y R S V Q Q T K T R A S A T I L G A W F L S F L W V I P I L G V T W F K V M T A I I N F Y L P T L L M L W F Y A K I Y K A V R Q H C Q H R E L I N G L H M N R E R K A A K Q L G F I M A A F I L C W I P Y F I F F M V I A F C N E H L H M F T I W L G Y I N S T L N P L I Y P L C N E N F K R F K K T I L H
Download: PNG | SVG

Residue Table


GPCRdb(A)
GPCRdb(A)
H1 receptor
TM3
3x32 3.32x32 D107
3x33 3.33x33 Y108
3x36 3.36x36 S111
3x37 3.37x37 T112
3x40 3.40x40 I115
TM4
4x57 4.56x57 W158
TM5
5x43 5.42x43 T194
5x461 5.46x461 N198
TM6
6x44 6.44x44 F424
6x48 6.48x48 W428
6x51 6.51x51 Y431
6x52 6.52x52 F432
6x55 6.55x55 F435
TM7
7x38 7.39x38 I454
7x42 7.43x42 Y458