Structure information

β1-adrenoceptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

2YCW

SPECIES

Meleagris gallopavo

RESOLUTION

3.000

PREFERRED CHAIN

A

REFERENCE

10.1073/PNAS.1100185108

PUBLICATION DATE

June 1, 2011

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Carazolol W117 3.28x28 TM3 hydrophobic
Carazolol D121 3.32x32 TM3 polar (charge-assisted hydrogen bond)
Carazolol V122 3.33x33 TM3 hydrophobic
Carazolol V122 3.33x33 TM3 Van der Waals
Carazolol V125 3.36x36 TM3 hydrophobic
Carazolol V125 3.36x36 TM3 Van der Waals
Carazolol F201 45.52x52 ECL2 Van der Waals
Carazolol F201 45.52x52 ECL2 aromatic (edge-to-face)
Carazolol Y207 5.38x39 TM5 hydrophobic
Carazolol Y207 5.38x39 TM5 Van der Waals
Carazolol S211 5.42x43 TM5 polar (hydrogen bond)
Carazolol S211 5.42x43 TM5 Van der Waals
Carazolol S215 5.46x461 TM5 Van der Waals
Carazolol W303 6.48x48 TM6 Van der Waals
Carazolol W303 6.48x48 TM6 hydrophobic
Carazolol F306 6.51x51 TM6 hydrophobic
Carazolol F306 6.51x51 TM6 Van der Waals
Carazolol F307 6.52x52 TM6 aromatic (edge-to-face)
Carazolol F307 6.52x52 TM6 Van der Waals
Carazolol N310 6.55x55 TM6 Van der Waals
Carazolol N329 7.39x38 TM7 Van der Waals
Carazolol N329 7.39x38 TM7 polar (hydrogen bond)
Carazolol N329 7.39x38 TM7 polar (hydrogen bond)
Carazolol Y333 7.43x42 TM7 polar (hydrogen bond)
Carazolol Y333 7.43x42 TM7 polar (hydrogen bond)

Ligands

Carazolol

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Residue Diagrams

V N G A V I L L V V L A M L L S M G A E 1 T S L A C A D L V M G L L V V P F G A T L 2 V C L T E I S A T V C L V D L S T W C E 3 A K V I I C T V W A I S A L V S F L P I 4 Y V F I M I L L P I Y F S I I S S A I A Y 5 G I I M G V F T L C W L P F F L V N I V 6 I P N F A S N A Y G L W N F F V F L W 7
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ICL1 Q R L Q ICL1ECL1 T W L W ECL1ICL2 P F R Y Q S L M ICL2ECL2 W W R D E D P Q A L K C Y Q D P G C C D F V T ECL2ICL3 G R F Y G S Q E Q P Q P P P L P Q H Q P I L G N G R A S K ICL3ECL3 R D L V ECL3N-term M G D G W L P P D C G P H N R S G G G G A T A A P T G S R Q V S N-termC-term F P R K A D R R L H A G G Q P A P L P G G F I S T L G S P E H S P G G T W S D C N G G T R G G S E S S L E E R H S K T S R S E S K M E R E K N I L A T T R F Y C T F L G N G D K A V F C T V L R I V K L F E D A T C T C P H T H K L K M K W R F K Q H Q A C-term A E L L S Q Q W E A G M S L L M A L V V L L I V A G N V L V I A A I G R T T L T N L F I T S L A C A D L V M G L L V V P F G A T L V V R G G S F L C E C W T S L D V L C V T A S I E T L C V I A I D R Y L A I T S T R A R A K V I I C T V W A I S A L V S F L P I M M H N R A Y A I A S S I I S F Y I P L L I M I F V Y L R V Y R E A K E Q I R K I D R C E R K T S R V M A M R E H K A L K T L G I I M G V F T L C W L P F F L V N I V N V F N P D W L F V F F N W L G Y A N S A F N P I I Y C R S P D F K R F R K A L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
β1-adrenoceptor
TM3
3x28 3.28x28 W117
3x32 3.32x32 D121
3x33 3.33x33 V122
3x36 3.36x36 V125
ECL2
45x52 45.52x52 F201
TM5
5x39 5.38x39 Y207
5x43 5.42x43 S211
5x461 5.46x461 S215
TM6
6x48 6.48x48 W303
6x51 6.51x51 F306
6x52 6.52x52 F307
6x55 6.55x55 N310
TM7
7x38 7.39x38 N329
7x42 7.43x42 Y333