Stabilising Mutation Analyser

Group by: Mutant Subsets: Only show mutations present in minimum 2 GPCRs
STATE TARGETS MUTATIONS FREQUENCY SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS
No. Receptor Families
No. Structures
PDBs Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43
V
A
1 1 4
4XEE, 4GRV, 4XES, 5T04
Inactive
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54
A
L
1 1 8
4BWB, 4GRV, 3ZEV, 5T04, 4BV0, 4BUO, 4XES, 4XEE
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38
M
A
1 1 1
5LWE
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32
M
C
1 1 2
5VEW, 5VEX
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48
E
F
1 1 1
5EE7
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39
F
A
1 1 1
5EE7
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2
G
M
1 1 5
5CGD, 5CGC, 6FFH, 4OO9, 6FFI
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43
K
A
1 1 23
5MZP, 3UZA, 5OLZ, 5IUB, 5OLG, 5NM2, 3RFM, 5OM1, 5N2R, 5IU7, 5OLO, 5OLH, 5NLX, 5OLV, 3PWH, 3UZC, 3REY, 5IUA, 5OM4, 5MZJ, 5NM4, 5IU8, 5IU4
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42
P
A
1 1 1
5NX2
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60
L
A
1 1 2
4K5Y, 4Z9G
Intermediate
A (Rhodopsin)
Lipid
Peptide
Free fatty acid
Proteinase-activated
PAR2
FFAR1
FFA1
PAR2
TM3 3x34
G
F
A
2 2 5
5NJ6, 5TZR, 4PHU, 5NDD, 5NDZ
1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38
I
A
1 1 3
5NJ6, 5NDD, 5NDZ
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40
V
F
1 1 2
5L7D, 5L7I
1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51
Y
A
1 1 3
5NJ6, 5NDD, 5NDZ
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28
E
Q
2 1 5
5DGY, 2X72, 6CMO, 5W0P, 4ZWJ
10
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40
L
A
1 1 4
5TZY, 5TZR, 4PHU, 5KW2
2 1 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53
S
A
1 1 5
5CGD, 5CGC, 6FFH, 4OO9, 6FFI
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43
M
L
1 1 3
5NJ6, 5NDD, 5NDZ
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
CRFR1
GLR
CRF1
glucagon
TM2 2x48
S
A
L
A
2 2 3
4K5Y, 5EE7, 4Z9G
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59
V
C
1 1 1
4Z36
4
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50
D
N
1 1 1
5WF5
Pos Match 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42
T
A
1 1 5
5CGD, 5CGC, 6FFH, 4OO9, 6FFI
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44
W
A
1 1 2
4K5Y, 4Z9G
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
TM2 2x56
S
C
A
2 1 3
5VEW, 5EE7, 5VEX
Inactive
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM2 2x52
A
L
2 1 28
2YDV, 5MZP, 3UZA, 5OLZ, 5IUB, 5N2S, 4UG2, 5OLG, 5NM2, 3RFM, 5OM1, 5N2R, 5IU7, 5OLO, 5OLH, 5NLX, 5OLV, 3PWH, 3UZC, 4UHR, 3REY, 5IUA, 2YDO, 5OM4, 5MZJ, 5NM4, 5IU8, 5IU4
1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62
T
A
1 1 4
4UHR, 2YDV, 2YDO, 4UG2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54
M
A
1 1 1
5EE7
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60
T
I
1 1 2
5EN0, 5DYS
17
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50
I
A
1 1 5
5CGD, 5CGC, 6FFH, 4OO9, 6FFI
Pos Match
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48
T
A
1 1 1
5LWE
4
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39
R
A
1 1 2
5EE7, 5YQZ
2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39
T
A
1 1 1
5LWE
6
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31
D
K
1 1 1
4BVN
8
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54
I
A
1 1 4
4BWB, 4BV0, 3ZEV, 4BUO
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40
M
Y
2 1 5
5DGY, 4A4M, 6CMO, 5W0P, 4ZWJ
1 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36
V
A
1 1 2
4K5Y, 4Z9G
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51
F
A
1 1 2
4K5Y, 4Z9G
1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48
N
Y
1 1 5
5CGD, 5CGC, 6FFH, 4OO9, 6FFI
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48
I
A
1 1 2
4K5Y, 4Z9G
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67
V
A
1 1 1
5X33
1
Inactive
Active
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46
T
A
1 1 4
5XRA, 5TGZ, 5XR8, 5U09
1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46
G
A
1 1 3
5NJ6, 5NDD, 5NDZ
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46
L
A
1 1 4
4UHR, 2YDV, 2YDO, 4UG2
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63
C
A
1 1 1
5NX2
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM3 3x36
T
A
2 1 24
5MZP, 3UZA, 5OLZ, 5IUB, 5N2S, 5OLG, 5NM2, 3RFM, 5OM1, 5N2R, 5IU7, 5OLO, 5OLH, 5NLX, 5OLV, 3PWH, 3UZC, 3REY, 5IUA, 5OM4, 5MZJ, 5NM4, 5IU8, 5IU4
18
Inactive
Active
Intermediate
A (Rhodopsin)
Lipid
Sensory
Peptide
Opsins
Leukotriene
Neurotensin
OPSD
Q9WTK1
OPSD
NTR1
BLT1
NTS1
Rhodopsin
N-term
N
S
G
D
C
A
4 3 17
2X72, 4A4M, 2J4Y, 5DYS, 4ZWJ, 4GRV, 5W0P, 4XES, 4XEE, 3C9M, 5X33, 5DGY, 5T04, 5EN0, 6CMO, 4BEY, 4BEZ
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55
R
A
1 1 23
5MZP, 3UZA, 5OLZ, 5IUB, 5OLG, 5NM2, 3RFM, 5OM1, 5N2R, 5IU7, 5OLO, 5OLH, 5NLX, 5OLV, 3PWH, 3UZC, 3REY, 5IUA, 5OM4, 5MZJ, 5NM4, 5IU8, 5IU4
1 2
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36
F
A
1 1 24
2YCZ, 2Y01, 3ZPR, 4GPO, 2YCW, 2YCY, 6H7M, 2YCX, 5F8U, 2Y04, 6IBL, 6H7L, 2Y03, 6H7O, 2Y00, 4AMJ, 6H7J, 2Y02, 4BVN, 2VT4, 3ZPQ, 5A8E, 6H7N, 4AMI
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27
A
L
1 1 18
4AMJ, 2YCZ, 2Y01, 3ZPR, 2Y02, 4GPO, 4BVN, 2YCW, 2YCY, 2VT4, 3ZPQ, 5A8E, 2YCX, 5F8U, 2Y04, 2Y03, 4AMI, 2Y00
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31
L
F
1 1 1
5NX2
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56
D
A
1 1 1
5X93
Inactive
Active
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45
C
N
1 1 2
6BQG, 6BQH
Pos Match 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42
L
A
1 1 3
5NJ6, 5NDD, 5NDZ
Inactive
Intermediate
A (Rhodopsin)
Nucleotide
Peptide
Aminergic
Neurotensin
Adenosine
Dopamine
AA2AR
AA1R
DRD2
NTR1
D2
NTS1
A2A
A1
TM6 6x37
L
A
4 3 26
5MZP, 3UZA, 5OLZ, 5IUB, 5N2S, 5OLG, 5NM2, 3RFM, 5OM1, 5N2R, 5IU7, 5OLO, 5OLH, 5NLX, 5OLV, 3PWH, 6CM4, 4GRV, 3UZC, 3REY, 5IUA, 5OM4, 5MZJ, 5NM4, 5IU8, 5IU4
1 1 4
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53
V
E
1 1 3
5NJ6, 5NDD, 5NDZ
5
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56
V
A
1 1 1
5NX2
2 2
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM5 5x63
Y
L
A
2 1 24
5MZP, 3UZA, 5OLZ, 5IUB, 5N2S, 5OLG, 5NM2, 3RFM, 5OM1, 5N2R, 5IU7, 5OLO, 5OLH, 5NLX, 5OLV, 3PWH, 3UZC, 3REY, 5IUA, 5OM4, 5MZJ, 5NM4, 5IU8, 5IU4
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37
Q
A
1 1 4
4UHR, 2YDV, 2YDO, 4UG2
9
Intermediate
A (Rhodopsin)
Lipid
Peptide
Neurotensin
Free fatty acid
NTR1
FFAR1
FFA1
NTS1
TM3 3x49
G
E
A
2 2 6
4PHU, 5TZY, 5TZR, 4GRV, 4XES, 5KW2
Pos Match 2
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53
Y
A
1 1 2
4K5Y, 4Z9G
Pos Match 1
Inactive
Active
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32
R
E
1 1 3
5TGZ, 5XRA, 5XR8
1 5
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51
D
C
1 1 1
4RWS
14
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2RY1
P2Y12
P2Y1
P2Y12
TM7 7x49
D
N
2 1 5
4XNV, 4XNW, 4NTJ, 4PXZ, 4PY0
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61
G
N
1 1 4
6AKX, 6AKY, 5UIW, 4MBS
6
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47
S
C
1 1 1
5LWE
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21
K
G
1 1 1
5X33
1
Inactive
Intermediate
A (Rhodopsin)
Lipid
Aminergic
Adrenoceptors
Free fatty acid
ADRB1
FFAR1
β1
FFA1
TM5 5x58
Y
F
A
2 2 22
2YCZ, 2Y01, 3ZPR, 5TZY, 4GPO, 2YCW, 2YCY, 2YCX, 5KW2, 4PHU, 5F8U, 2Y04, 5TZR, 2Y03, 2Y00, 4AMJ, 2Y02, 4BVN, 2VT4, 3ZPQ, 5A8E, 4AMI
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49
K
E
1 1 4
6AKX, 6AKY, 5UIW, 4MBS
3 1 2
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Adenosine
Dopamine
AA2AR
AA1R
DRD2
D2
A2A
A1
TM6 6x41
V
L
A
3 2 25
5MZP, 3UZA, 5OLZ, 5IUB, 5N2S, 5OLG, 5NM2, 3RFM, 5OM1, 5N2R, 5IU7, 5OLO, 5OLH, 5NLX, 5OLV, 3PWH, 6CM4, 3UZC, 3REY, 5IUA, 5OM4, 5MZJ, 5NM4, 5IU8, 5IU4
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52
G
I
1 1 2
5VEW, 5VEX
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39
S
A
1 1 1
5WF6
Pos Match 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
TM2 2x59
V
I
F
2 1 3
5VEW, 5EE7, 5VEX
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41
T
A
1 1 1
5LWE
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35
E
A
1 1 5
5CGD, 5CGC, 6FFH, 4OO9, 6FFI
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59
R
S
1 1 24
2YCZ, 2Y01, 3ZPR, 4GPO, 2YCW, 2YCY, 6H7M, 2YCX, 5F8U, 2Y04, 6IBL, 6H7L, 2Y03, 6H7O, 2Y00, 4AMJ, 6H7J, 2Y02, 4BVN, 2VT4, 3ZPQ, 5A8E, 6H7N, 4AMI
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64
M
A
1 1 3
5NJ6, 5NDD, 5NDZ
1 3
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53
Y
L
1 1 2
5A8E, 4BVN
Pos Match Pos Match 3
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67
H
G
1 1 1
5X33
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48
S
A
1 1 2
5VEW, 5VEX
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CXCR4
CXCR4
CCR9
TM6 6x36
V
T
P
A
2 1 4
3OE9, 4RWS, 5LWE, 3OE0
2 1 5
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
ECL1
T
G
Q
L
D
R
F
A
E
2 1 2
5EE7, 5NX2
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
CRFR1
GLP1R
GLR
CRF1
GLP-1
glucagon
TM6 6x30
Y
K
A
3 2 5
5VEW, 4K5Y, 5EE7, 4Z9G, 5VEX
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43
K
A
1 1 2
4K5Y, 4Z9G
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55
R
Y
1 1 2
5XPR, 5X93
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
TM3 3x24
G
S
A
2 1 3
5VEW, 5EE7, 5VEX
Inactive
A (Rhodopsin)
Peptide
Aminergic
Apelin
Adrenoceptors
Dopamine
DRD2
ADRB1
APJ
apelin
D2
β1
TM3 3x40
V
I
V
A
3 3 4
5A8E, 6CM4, 4BVN, 5VBL
2
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48
W
K
1 1 1
5VBL
Pos Match 22
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31
C
F
1 1 2
5VEW, 5VEX
1
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
C
A
1 1 3
5VEW, 5NX2, 5VEX
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48
G
A
1 1 1
5EE7
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51
I
C
1 1 2
5VEW, 5VEX
1
Inactive
Intermediate
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
CRFR1
GLP1R
CRF1
GLP-1
ECL2 45x52
F
T
A
2 2 3
4K5Y, 4Z9G, 5NX2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29
N
A
1 1 1
5LWE
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63
H
C
1 1 2
4QKX, 3PDS
10
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37
H
A
1 1 3
5NJ6, 5NDD, 5NDZ
1 1 1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM7 7x41
S
T
A
2 1 24
5MZP, 3UZA, 5OLZ, 5IUB, 5N2S, 5OLG, 5NM2, 3RFM, 5OM1, 5N2R, 5IU7, 5OLO, 5OLH, 5NLX, 5OLV, 3PWH, 3UZC, 3REY, 5IUA, 5OM4, 5MZJ, 5NM4, 5IU8, 5IU4
6
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36
K
A
1 1 2
5XPR, 5X93
2
Inactive
Active
A (Rhodopsin)
Peptide
Aminergic
Adrenoceptors
Endothelin
EDNRB
ADRB1
β1
ETB
TM7 7x48
I
F
M
A
2 2 26
2YCZ, 2Y01, 3ZPR, 4GPO, 2YCW, 2YCY, 6H7M, 2YCX, 5F8U, 2Y04, 6IBL, 6H7L, 2Y03, 6H7O, 2Y00, 4AMJ, 6H7J, 2Y02, 4BVN, 2VT4, 3ZPQ, 5A8E, 5XPR, 5X93, 6H7N, 4AMI
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53
M
V
1 1 24
2YCZ, 2Y01, 3ZPR, 4GPO, 2YCW, 2YCY, 6H7M, 2YCX, 5F8U, 2Y04, 6IBL, 6H7L, 2Y03, 6H7O, 2Y00, 4AMJ, 6H7J, 2Y02, 4BVN, 2VT4, 3ZPQ, 5A8E, 6H7N, 4AMI
2
Inactive
Active
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
Cannabinoid
LPAR1
CNR1
LPA1
CB1
TM5 5x37
E
D
K
C
2 2 4
5TGZ, 5XRA, 5XR8, 4Z36
1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60
C
Y
1 1 4
6AKX, 6AKY, 5UIW, 4MBS
2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50
V
A
1 1 1
5LWE
1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54
S
A
1 1 2
5XPR, 5X93
3
Inactive
Active
Intermediate
A (Rhodopsin)
Protein
Aminergic
Adrenoceptors
Chemokine
5-Hydroxytryptamine
Dopamine
ADRB2
DRD3
ADRB1
CXCR4
5HT1B
5HT2B
D3
5-HT1B
5-HT2B
β2
CXCR4
β1
TM3 3x41
M
L
E
W
6 4 24
5V54, 6DRY, 3OE0, 3PBL, 5TUD, 3ODU, 3OE9, 3NY9, 6G79, 4NC3, 3NYA, 4IAR, 5TVN, 3NY8, 6DRZ, 3OE6, 3OE8, 4IAQ, 6DRX, 4RWS, 5A8E, 4IB4, 6DS0, 3D4S
1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33
A
D
1 1 4
6AKX, 6AKY, 5UIW, 4MBS
2 1 6
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38
S
A
1 1 2
4K5Y, 4Z9G
1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47
H
V
1 1 1
5NX2
1
STATE TARGETS MUTATIONS FREQUENCY DATA (MUTANT) SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51
D
C 1 1 1
4RWS
0.68 -0.02 14
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39
R
A 1 1 2
5EE7, 5YQZ
0 0.50 2
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x48
S
A 1 1 2
4K5Y, 4Z9G
0.2 0 0.50
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53
M
V 1 1 24
2YCZ, 2Y01, 3ZPR, 4GPO, 2YCW, 2YCY, 6H7M, 2YCX, 5F8U, 2Y04, 6IBL, 6H7L, 2Y03, 6H7O, 2Y00, 4AMJ, 6H7J, 2Y02, 4BVN, 2VT4, 3ZPQ, 5A8E, 6H7N, 4AMI
0.23 0.33 0.61 -0.46 2
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54
S
A 1 1 2
5XPR, 5X93
0.1 0 0.50 3
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
CRFR1
GLP1R
GLR
CRF1
GLP-1
glucagon
TM6 6x30
Y
K
A 3 2 5
5VEW, 4K5Y, 5EE7, 4Z9G, 5VEX
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39
F
A 1 1 1
5EE7
0.07 0 0.50
Inactive
Active
Intermediate
A (Rhodopsin)
Protein
Aminergic
Adrenoceptors
Chemokine
5-Hydroxytryptamine
Dopamine
ADRB2
DRD3
ADRB1
CXCR4
5HT1B
5HT2B
D3
5-HT1B
5-HT2B
β2
CXCR4
β1
TM3 3x41
M
L
E
W 6 4 24
5V54, 6DRY, 3OE0, 3PBL, 5TUD, 3ODU, 3OE9, 3NY9, 6G79, 4NC3, 3NYA, 4IAR, 5TVN, 3NY8, 6DRZ, 3OE6, 3OE8, 4IAQ, 6DRX, 4RWS, 5A8E, 4IB4, 6DS0, 3D4S
0.03 0.49 -2.09 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51
Y
A 1 1 3
5NJ6, 5NDD, 5NDZ
0.0 0 0.50
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
ECL1
G
T
E 2 1 2
5EE7, 5NX2
0.40 0.11
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60
L
A 1 1 2
4K5Y, 4Z9G
0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM3 3x40
I
V 1 1 2
5A8E, 4BVN
0.24 0.61 -0.46 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48
T
A 1 1 1
5LWE
0.03 0 0.50 4
Inactive
A (Rhodopsin)
Peptide
Aminergic
Apelin
Dopamine
DRD2
APJ
apelin
D2
TM3 3x40
V
I
A 2 2 2
6CM4, 5VBL
0.06 0 0.50 2
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x48
F
M 1 1 24
2YCZ, 2Y01, 3ZPR, 4GPO, 2YCW, 2YCY, 6H7M, 2YCX, 5F8U, 2Y04, 6IBL, 6H7L, 2Y03, 6H7O, 2Y00, 4AMJ, 6H7J, 2Y02, 4BVN, 2VT4, 3ZPQ, 5A8E, 6H7N, 4AMI
0.05 0.24 -0.67
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48
S
A 1 1 2
5VEW, 5VEX
0.07 0 0.50
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56
D
A 1 1 1
5X93
0.08 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48
E
F 1 1 1
5EE7
0.13 0.54 -1.71
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31
L
F 1 1 1
5NX2
0.4 0.54 -1.71
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56
V
A 1 1 1
5NX2
0.07 0 0.50 2 2
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36
K
A 1 1 2
5XPR, 5X93
0.07 0 0.50 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51
I
C 1 1 2
5VEW, 5VEX
0.68 -0.02 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62
T
A 1 1 4
4UHR, 2YDV, 2YDO, 4UG2
0.13 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33
A
D 1 1 4
6AKX, 6AKY, 5UIW, 4MBS
0.69 0.43 2 1 6
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61
G
N 1 1 4
6AKX, 6AKY, 5UIW, 4MBS
0.03 0.65 0.85 6
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59
V
C 1 1 1
4Z36
0.01 0.68 -0.02 4
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37
Q
A 1 1 4
4UHR, 2YDV, 2YDO, 4UG2
0.03 0 0.50 9
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1
G
Q
A 1 1 1
5NX2
0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38
S
A 1 1 2
4K5Y, 4Z9G
0 0.50 1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM5 5x63
Y
L
A 2 1 24
5MZP, 3UZA, 5OLZ, 5IUB, 5N2S, 5OLG, 5NM2, 3RFM, 5OM1, 5N2R, 5IU7, 5OLO, 5OLH, 5NLX, 5OLV, 3PWH, 3UZC, 3REY, 5IUA, 5OM4, 5MZJ, 5NM4, 5IU8, 5IU4
0.06 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31
C
F 1 1 2
5VEW, 5VEX
0.07 0.54 -1.71 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39
T
A 1 1 1
5LWE
0.08 0 0.50 6
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM5 5x58
Y
A 1 1 18
4AMJ, 2YCZ, 2Y01, 3ZPR, 2Y02, 4GPO, 4BVN, 2YCW, 2YCY, 2VT4, 3ZPQ, 5A8E, 2YCX, 5F8U, 2Y04, 2Y03, 4AMI, 2Y00
0.03 0 0.50
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63
H
C 1 1 2
4QKX, 3PDS
0.0 0.68 -0.02 10
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59
R
S 1 1 24
2YCZ, 2Y01, 3ZPR, 4GPO, 2YCW, 2YCY, 6H7M, 2YCX, 5F8U, 2Y04, 6IBL, 6H7L, 2Y03, 6H7O, 2Y00, 4AMJ, 6H7J, 2Y02, 4BVN, 2VT4, 3ZPQ, 5A8E, 6H7N, 4AMI
0.04 0.50 0.46
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Adenosine
Dopamine
AA2AR
AA1R
DRD2
D2
A2A
A1
TM6 6x41
V
L
A 3 2 25
5MZP, 3UZA, 5OLZ, 5IUB, 5N2S, 5OLG, 5NM2, 3RFM, 5OM1, 5N2R, 5IU7, 5OLO, 5OLH, 5NLX, 5OLV, 3PWH, 6CM4, 3UZC, 3REY, 5IUA, 5OM4, 5MZJ, 5NM4, 5IU8, 5IU4
0.05 0 0.50
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55
R
Y 1 1 2
5XPR, 5X93
0.09 0.53 -0.71
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46
L
A 1 1 4
4UHR, 2YDV, 2YDO, 4UG2
0 0.50
Intermediate
A (Rhodopsin)
Lipid
Peptide
Neurotensin
Free fatty acid
NTR1
FFAR1
FFA1
NTS1
TM3 3x49
G
E
A 2 2 6
4PHU, 5TZY, 5TZR, 4GRV, 4XES, 5KW2
0.01 0 0.50 Pos & Mutant AA Match 2
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47
H
V 1 1 1
5NX2
0.61 -0.46 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
C 1 1 2
5VEW, 5VEX
0.68 -0.02
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51
F
A 1 1 2
4K5Y, 4Z9G
0 0.50 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48
I
A 1 1 2
4K5Y, 4Z9G
0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44
W
A 1 1 2
4K5Y, 4Z9G
0.07 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47
S
C 1 1 1
5LWE
0.02 0.68 -0.02
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43
K
A 1 1 2
4K5Y, 4Z9G
0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48
N
Y 1 1 5
5CGD, 5CGC, 6FFH, 4OO9, 6FFI
0.05 0.53 -0.71
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43
M
L 1 1 3
5NJ6, 5NDD, 5NDZ
0.73 0.21 -1.25
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53
S
A 1 1 5
5CGD, 5CGC, 6FFH, 4OO9, 6FFI
0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43
K
A 1 1 23
5MZP, 3UZA, 5OLZ, 5IUB, 5OLG, 5NM2, 3RFM, 5OM1, 5N2R, 5IU7, 5OLO, 5OLH, 5NLX, 5OLV, 3PWH, 3UZC, 3REY, 5IUA, 5OM4, 5MZJ, 5NM4, 5IU8, 5IU4
0.13 0 0.50
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36
F
A 1 1 24
2YCZ, 2Y01, 3ZPR, 4GPO, 2YCW, 2YCY, 6H7M, 2YCX, 5F8U, 2Y04, 6IBL, 6H7L, 2Y03, 6H7O, 2Y00, 4AMJ, 6H7J, 2Y02, 4BVN, 2VT4, 3ZPQ, 5A8E, 6H7N, 4AMI
0.1 0.11 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52
G
I 1 1 2
5VEW, 5VEX
0.07 0.41 -1.12
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38
M
A 1 1 1
5LWE
0.12 0 0.50 1
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40
M
Y 2 1 5
5DGY, 4A4M, 6CMO, 5W0P, 4ZWJ
0.01 0.53 -0.71 1 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x56
S
A 1 1 1
5EE7
0.27 0 0.50
Inactive
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
N-term
N
D
C 2 1 12
2X72, 4A4M, 2J4Y, 5DYS, 4ZWJ, 5W0P, 3C9M, 5DGY, 5EN0, 6CMO, 4BEY, 4BEZ
0.68 -0.02
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37
H
A 1 1 3
5NJ6, 5NDD, 5NDZ
0.05 0 0.50 1 1 1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21
K
G 1 1 1
5X33
0.67 1.00 1.15 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46
G
A 1 1 3
5NJ6, 5NDD, 5NDZ
0.11 0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53
V
E 1 1 3
5NJ6, 5NDD, 5NDZ
0.01 0.40 0.11 5
Inactive
Intermediate
A (Rhodopsin)
Nucleotide
Peptide
Aminergic
Neurotensin
Adenosine
Dopamine
AA2AR
AA1R
DRD2
NTR1
D2
NTS1
A2A
A1
TM6 6x37
L
A 4 3 26
5MZP, 3UZA, 5OLZ, 5IUB, 5N2S, 5OLG, 5NM2, 3RFM, 5OM1, 5N2R, 5IU7, 5OLO, 5OLH, 5NLX, 5OLV, 3PWH, 6CM4, 4GRV, 3UZC, 3REY, 5IUA, 5OM4, 5MZJ, 5NM4, 5IU8, 5IU4
0.04 0 0.50 1 1 4
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28
E
Q 2 1 5
5DGY, 2X72, 6CMO, 5W0P, 4ZWJ
0.01 0.39 0.77 10
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53
Y
A 1 1 2
4K5Y, 4Z9G
0 0.50 Pos & Mutant AA Match 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
TM2 2x59
V
I
F 2 1 3
5VEW, 5EE7, 5VEX
0.54 -1.71
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43
V
A 1 1 4
4XEE, 4GRV, 4XES, 5T04
0.19 0 0.50
Inactive
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54
A
L 1 1 8
4BWB, 4GRV, 3ZEV, 5T04, 4BV0, 4BUO, 4XES, 4XEE
0.37 0.21 -1.25
Inactive
Active
Intermediate
A (Rhodopsin)
Lipid
Peptide
Neurotensin
Leukotriene
Q9WTK1
NTR1
BLT1
NTS1
C-term
G
S
A 2 2 5
5T04, 4XEE, 4GRV, 4XES, 5X33
0 0.50
Inactive
Active
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32
R
E 1 1 3
5TGZ, 5XRA, 5XR8
0.04 0.40 0.11 1 5
Inactive
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM2 2x52
A
L 2 1 28
2YDV, 5MZP, 3UZA, 5OLZ, 5IUB, 5N2S, 4UG2, 5OLG, 5NM2, 3RFM, 5OM1, 5N2R, 5IU7, 5OLO, 5OLH, 5NLX, 5OLV, 3PWH, 3UZC, 4UHR, 3REY, 5IUA, 2YDO, 5OM4, 5MZJ, 5NM4, 5IU8, 5IU4
0.63 0.21 -1.25 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49
K
E 1 1 4
6AKX, 6AKY, 5UIW, 4MBS
0.12 0.40 0.11 3 1 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
TM3 3x24
G
S
A 2 1 3
5VEW, 5EE7, 5VEX
0.07 0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50
D
N 1 1 1
5WF5
0.03 0.65 0.85 Pos & AA Mutant Match 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36
V
A 1 1 2
4K5Y, 4Z9G
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54
M
A 1 1 1
5EE7
0.27 0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27
A
L 1 1 18
4AMJ, 2YCZ, 2Y01, 3ZPR, 2Y02, 4GPO, 4BVN, 2YCW, 2YCY, 2VT4, 3ZPQ, 5A8E, 2YCX, 5F8U, 2Y04, 2Y03, 4AMI, 2Y00
0.11 0.11 0.21 -1.25
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM5 5x58
Y
F 1 1 4
5TZY, 5TZR, 4PHU, 5KW2
0.01 0.54 -1.71
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67
V
A 1 1 1
5X33
0.08 0 0.50 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1
D
R 1 1 1
5NX2
0.21 1.81
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
A 1 1 1
5NX2
0 0.50
Inactive
Active
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM5 5x37
E
K 1 1 3
5TGZ, 5XRA, 5XR8
0.11 0.26 2.80 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41
T
A 1 1 1
5LWE
0.07 0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38
I
A 1 1 3
5NJ6, 5NDD, 5NDZ
0.14 0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53
Y
L 1 1 2
5A8E, 4BVN
0.03 0.21 -1.25 Pos Match (But Not Mutant AA) Pos & Mutant AA Match 3
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35
E
A 1 1 5
5CGD, 5CGC, 6FFH, 4OO9, 6FFI
0.05 0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64
M
A 1 1 3
5NJ6, 5NDD, 5NDZ
0.13 0 0.50 1 3
Intermediate
A (Rhodopsin)
Lipid
Peptide
Free fatty acid
Proteinase-activated
PAR2
FFAR1
FFA1
PAR2
TM3 3x34
G
F
A 2 2 5
5NJ6, 5TZR, 4PHU, 5NDD, 5NDZ
0.07 0 0.50 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
TM6 6x36
T
P 1 1 3
3OE9, 4RWS, 3OE0
0.0 3.16 0.14 2 1 5
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60
C
Y 1 1 4
6AKX, 6AKY, 5UIW, 4MBS
0.07 0.53 -0.71 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29
N
A 1 1 1
5LWE
0.13 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x48
A
L 1 1 1
5EE7
0.2 0.21 -1.25
Inactive
Active
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45
C
N 1 1 2
6BQG, 6BQH
0.67 0.65 0.85 Pos & AA Mutant Match 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32
M
C 1 1 2
5VEW, 5VEX
0.68 -0.02
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48
W
K 1 1 1
5VBL
0.26 2.80 Pos Match (But Not Mutant AA) 22
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60
T
I 1 1 2
5EN0, 5DYS
0.04 0.29 0.41 -1.12 17
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50
V
A 1 1 1
5LWE
0.06 0 0.50 1
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54
I
A 1 1 4
4BWB, 4BV0, 3ZEV, 4BUO
0.02 0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50
I
A 1 1 5
5CGD, 5CGC, 6FFH, 4OO9, 6FFI
0 0.50 Pos & Mutant AA Match
Inactive
Active
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46
T
A 1 1 4
5XRA, 5TGZ, 5XR8, 5U09
0.01 0 0.50 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48
G
A 1 1 1
5EE7
0.33 0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31
D
K 1 1 1
4BVN
0.04 0.11 0.26 2.80 8
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM7 7x41
S
T
A 2 1 24
5MZP, 3UZA, 5OLZ, 5IUB, 5N2S, 5OLG, 5NM2, 3RFM, 5OM1, 5N2R, 5IU7, 5OLO, 5OLH, 5NLX, 5OLV, 3PWH, 3UZC, 3REY, 5IUA, 5OM4, 5MZJ, 5NM4, 5IU8, 5IU4
0.38 0 0.50 6
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42
T
A 1 1 5
5CGD, 5CGC, 6FFH, 4OO9, 6FFI
0.05 0 0.50
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40
L
A 1 1 4
5TZY, 5TZR, 4PHU, 5KW2
0.06 0 0.50 2 1 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42
L
A 1 1 3
5NJ6, 5NDD, 5NDZ
0.13 0 0.50
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM7 7x48
I
A 1 1 2
5XPR, 5X93
0.13 0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39
S
A 1 1 1
5WF6
0.03 0 0.50 Pos & AA Mutant Match 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2
G
M 1 1 5
5CGD, 5CGC, 6FFH, 4OO9, 6FFI
0.24 -0.67
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2RY1
P2Y12
P2Y1
P2Y12
TM7 7x49
D
N 2 1 5
4XNV, 4XNW, 4NTJ, 4PXZ, 4PY0
0.72 0.65 0.85
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM2 2x56
S
C 1 1 2
5VEW, 5VEX
0.68 -0.02
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55
R
A 1 1 23
5MZP, 3UZA, 5OLZ, 5IUB, 5OLG, 5NM2, 3RFM, 5OM1, 5N2R, 5IU7, 5OLO, 5OLH, 5NLX, 5OLV, 3PWH, 3UZC, 3REY, 5IUA, 5OM4, 5MZJ, 5NM4, 5IU8, 5IU4
0.08 0 0.50 1 2
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63
C
A 1 1 1
5NX2
0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM6 6x36
V
A 1 1 1
5LWE
0.02 0 0.50 2 1 5
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM3 3x36
T
A 2 1 24
5MZP, 3UZA, 5OLZ, 5IUB, 5N2S, 5OLG, 5NM2, 3RFM, 5OM1, 5N2R, 5IU7, 5OLO, 5OLH, 5NLX, 5OLV, 3PWH, 3UZC, 3REY, 5IUA, 5OM4, 5MZJ, 5NM4, 5IU8, 5IU4
0.02 0 0.50 18
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM5 5x37
D
C 1 1 1
4Z36
0.68 -0.02 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ICL2
L
F 1 1 1
5NX2
0.54 -1.71
Inactive
Intermediate
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
CRFR1
GLP1R
CRF1
GLP-1
ECL2 45x52
F
T
A 2 2 3
4K5Y, 4Z9G, 5NX2
0 0.50
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40
V
F 1 1 2
5L7D, 5L7I
0.54 -1.71 1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67
H
G 1 1 1
5X33
0.24 1.00 1.15
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42
P
A 1 1 1
5NX2
0 0.50
STATE TARGETS MUTATIONS FREQUENCY DATA (WILD TYPE) SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32 M
C
1 1 2
5VEW, 5VEX
0.13 0.24 -0.67
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x48 A
L
1 1 1
5EE7
0.2 0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ICL2 L
F
1 1 1
5NX2
0.21 -1.25
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39 S
A
1 1 1
5WF6
0.72 0.50 0.46 Pos & Wild Type AA Match 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35 E
A
1 1 5
5CGD, 5CGC, 6FFH, 4OO9, 6FFI
0.09 0.40 0.11
Inactive
Intermediate
A (Rhodopsin)
Lipid
Aminergic
Adrenoceptors
Free fatty acid
ADRB1
FFAR1
β1
FFA1
TM5 5x58 Y
F
A
2 2 22
2YCZ, 2Y01, 3ZPR, 5TZY, 4GPO, 2YCW, 2YCY, 2YCX, 5KW2, 4PHU, 5F8U, 2Y04, 5TZR, 2Y03, 2Y00, 4AMJ, 2Y02, 4BVN, 2VT4, 3ZPQ, 5A8E, 4AMI
0.72 0.53 -0.71
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50 I
A
1 1 5
5CGD, 5CGC, 6FFH, 4OO9, 6FFI
0.5 0.41 -1.12 Pos & Wild Type AA Match
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46 L
A
1 1 4
4UHR, 2YDV, 2YDO, 4UG2
0.9 0.21 -1.25
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37 H
A
1 1 3
5NJ6, 5NDD, 5NDZ
0.03 0.61 0.11 1 1 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43 M
L
1 1 3
5NJ6, 5NDD, 5NDZ
0.05 0.24 -0.67
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59 V
C
1 1 1
4Z36
0.12 0.61 -0.46 4
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM7 7x41 S
A
1 1 23
5MZP, 3UZA, 5OLZ, 5IUB, 5OLG, 5NM2, 3RFM, 5OM1, 5N2R, 5IU7, 5OLO, 5OLH, 5NLX, 5OLV, 3PWH, 3UZC, 3REY, 5IUA, 5OM4, 5MZJ, 5NM4, 5IU8, 5IU4
0.16 0.50 0.46 6
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM3 3x40 V
A
1 1 1
5VBL
0.24 0.61 -0.46 2
Inactive
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54 A
L
1 1 8
4BWB, 4GRV, 3ZEV, 5T04, 4BV0, 4BUO, 4XES, 4XEE
0.04 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38 S
A
1 1 2
4K5Y, 4Z9G
0.13 0.50 0.46 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x48 S
A
1 1 2
4K5Y, 4Z9G
0.07 0.50 0.46
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM3 3x49 E
A
1 1 2
4GRV, 4XES
0.21 0.40 0.11 Pos & Wild Type AA Match 2
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67 V
A
1 1 1
5X33
0.02 0.61 -0.46 1
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48 W
K
1 1 1
5VBL
0.68 0.49 -2.09 Pos & Wild Type AA Match 22
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55 R
A
1 1 23
5MZP, 3UZA, 5OLZ, 5IUB, 5OLG, 5NM2, 3RFM, 5OM1, 5N2R, 5IU7, 5OLO, 5OLH, 5NLX, 5OLV, 3PWH, 3UZC, 3REY, 5IUA, 5OM4, 5MZJ, 5NM4, 5IU8, 5IU4
0.05 0.21 1.81 1 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61 G
N
1 1 4
6AKX, 6AKY, 5UIW, 4MBS
0.02 1.00 1.15 6
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43 V
A
1 1 4
4XEE, 4GRV, 4XES, 5T04
0.1 0.61 -0.46
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28 E
Q
2 1 5
5DGY, 2X72, 6CMO, 5W0P, 4ZWJ
0.02 0.57 0.40 0.11 10
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48 G
A
1 1 1
5EE7
0.13 1.00 1.15
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31 D
K
1 1 1
4BVN
0.1 0.22 0.69 0.43 8
Inactive
Active
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM5 5x37 E
K
1 1 3
5TGZ, 5XRA, 5XR8
0.03 0.40 0.11 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49 K
E
1 1 4
6AKX, 6AKY, 5UIW, 4MBS
0.13 0.26 2.80 3 1 2
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM3 3x36 T
A
2 1 24
5MZP, 3UZA, 5OLZ, 5IUB, 5N2S, 5OLG, 5NM2, 3RFM, 5OM1, 5N2R, 5IU7, 5OLO, 5OLH, 5NLX, 5OLV, 3PWH, 3UZC, 3REY, 5IUA, 5OM4, 5MZJ, 5NM4, 5IU8, 5IU4
0.05 0.66 0.25 18
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
TM2 2x56 S
C
A
2 1 3
5VEW, 5EE7, 5VEX
0.47 0.50 0.46
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 T
E
1 1 1
5NX2
0.66 0.25
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM6 6x36 V
A
1 1 1
5LWE
0.15 0.61 -0.46 2 1 5
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48 N
Y
1 1 5
5CGD, 5CGC, 6FFH, 4OO9, 6FFI
0.41 0.65 0.85
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM3 3x24 G
A
1 1 1
5EE7
0.4 1.00 1.15
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46 G
A
1 1 3
5NJ6, 5NDD, 5NDZ
0.54 1.00 1.15
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54 M
A
1 1 1
5EE7
0.07 0.24 -0.67
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM5 5x37 D
C
1 1 1
4Z36
0.01 0.69 0.43 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60 L
A
1 1 2
4K5Y, 4Z9G
0.33 0.21 -1.25
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33 A
D
1 1 4
6AKX, 6AKY, 5UIW, 4MBS
0.29 0 0.50 2 1 6
Inactive
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
ECL3 D
C
1 1 8
3C9M, 2X72, 4A4M, 2J4Y, 5DYS, 5EN0, 4BEY, 4BEZ
0.69 0.43
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
ECL2 45x52 F
A
1 1 2
4K5Y, 4Z9G
0.13 0.54 -1.71
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62 T
A
1 1 4
4UHR, 2YDV, 2YDO, 4UG2
0.1 0.66 0.25
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39 T
A
1 1 1
5LWE
0.03 0.66 0.25 6
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
A1
TM5 5x63 Y
A
1 1 1
5N2S
0.03 0.53 -0.71
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2RY1
P2Y12
P2Y1
P2Y12
TM7 7x49 D
N
2 1 5
4XNV, 4XNW, 4NTJ, 4PXZ, 4PY0
0.2 0.69 0.43
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38 I
A
1 1 3
5NJ6, 5NDD, 5NDZ
0.08 0.41 -1.12
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54 I
A
1 1 4
4BWB, 4BV0, 3ZEV, 4BUO
0.33 0.41 -1.12
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43 K
A
1 1 2
4K5Y, 4Z9G
0.13 0.26 2.80
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42 L
A
1 1 3
5NJ6, 5NDD, 5NDZ
0.24 0.21 -1.25
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53 S
A
1 1 5
5CGD, 5CGC, 6FFH, 4OO9, 6FFI
0.14 0.50 0.46
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x48 F
M
1 1 24
2YCZ, 2Y01, 3ZPR, 4GPO, 2YCW, 2YCY, 6H7M, 2YCX, 5F8U, 2Y04, 6IBL, 6H7L, 2Y03, 6H7O, 2Y00, 4AMJ, 6H7J, 2Y02, 4BVN, 2VT4, 3ZPQ, 5A8E, 6H7N, 4AMI
0.06 0.33 0.54 -1.71
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM3 3x49 G
A
1 1 4
5TZY, 5TZR, 4PHU, 5KW2
0.01 1.00 1.15 Pos & Wild Type AA Match 2
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48 I
A
1 1 2
4K5Y, 4Z9G
0.2 0.41 -1.12
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44 W
A
1 1 2
4K5Y, 4Z9G
0.13 0.49 -2.09
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31 C
F
1 1 2
5VEW, 5VEX
0.07 0.68 -0.02 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
TM6 6x36 T
P
1 1 3
3OE9, 4RWS, 3OE0
0.25 0.66 0.25 2 1 5
Active
Intermediate
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2B
5-HT2B
TM3 3x41 M
W
1 1 8
5TVN, 6DRX, 6DRY, 4NC3, 6DRZ, 5TUD, 4IB4, 6DS0
0.04 0.24 -0.67 1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27 A
L
1 1 18
4AMJ, 2YCZ, 2Y01, 3ZPR, 2Y02, 4GPO, 4BVN, 2YCW, 2YCY, 2VT4, 3ZPQ, 5A8E, 2YCX, 5F8U, 2Y04, 2Y03, 4AMI, 2Y00
0.08 0.11 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48 E
F
1 1 1
5EE7
0.27 0.40 0.11
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50 D
N
1 1 1
5WF5
0.92 0.69 0.43 Pos & Wild Type AA Match 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39 F
A
1 1 1
5EE7
0.33 0.54 -1.71
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM6 6x41 V
A
1 1 23
5MZP, 3UZA, 5OLZ, 5IUB, 5OLG, 5NM2, 3RFM, 5OM1, 5N2R, 5IU7, 5OLO, 5OLH, 5NLX, 5OLV, 3PWH, 3UZC, 3REY, 5IUA, 5OM4, 5MZJ, 5NM4, 5IU8, 5IU4
0.41 0.61 -0.46
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60 T
I
1 1 2
5EN0, 5DYS
0.08 0.43 0.66 0.25 17
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x24 S
A
1 1 2
5VEW, 5VEX
0.27 0.50 0.46
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51 Y
A
1 1 3
5NJ6, 5NDD, 5NDZ
0.66 0.53 -0.71
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42 T
A
1 1 5
5CGD, 5CGC, 6FFH, 4OO9, 6FFI
0.09 0.66 0.25
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
ECL2 G
A
E
2 1 2
5EE7, 5NX2
1.00 1.15
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x30 Y
A
1 1 2
4K5Y, 4Z9G
0.73 0.53 -0.71
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53 V
E
1 1 3
5NJ6, 5NDD, 5NDZ
0.07 0.61 -0.46 5
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Adenosine
Dopamine
AA1R
DRD2
D2
A1
TM6 6x41 L
A
2 2 2
6CM4, 5N2S
0.19 0.21 -1.25
Inactive
Active
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46 T
A
1 1 4
5XRA, 5TGZ, 5XR8, 5U09
0.01 0.66 0.25 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63 C
A
1 1 1
5NX2
0.07 0.68 -0.02
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47 H
V
1 1 1
5NX2
0.73 0.61 0.11 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48 T
A
1 1 1
5LWE
0.05 0.66 0.25 4
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x59 V
F
1 1 1
5EE7
0.4 0.61 -0.46
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50 V
A
1 1 1
5LWE
0.02 0.61 -0.46 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLR
GLP-1
glucagon
TM6 6x30 K
A
2 1 3
5VEW, 5EE7, 5VEX
0.2 0.26 2.80
Inactive
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45 G
C
A
1 1 3
5VEW, 5NX2, 5VEX
1.0 1.00 1.15
Inactive
Active
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59 R
S
1 1 24
2YCZ, 2Y01, 3ZPR, 4GPO, 2YCW, 2YCY, 6H7M, 2YCX, 5F8U, 2Y04, 6IBL, 6H7L, 2Y03, 6H7O, 2Y00, 4AMJ, 6H7J, 2Y02, 4BVN, 2VT4, 3ZPQ, 5A8E, 6H7N, 4AMI
0.23 0.21 1.81
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47 S
C
1 1 1
5LWE
0.56 0.50 0.46
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 D
R
1 1 1
5NX2
0.69 0.43
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43 K
A
1 1 23
5MZP, 3UZA, 5OLZ, 5IUB, 5OLG, 5NM2, 3RFM, 5OM1, 5N2R, 5IU7, 5OLO, 5OLH, 5NLX, 5OLV, 3PWH, 3UZC, 3REY, 5IUA, 5OM4, 5MZJ, 5NM4, 5IU8, 5IU4
0.16 0.26 2.80
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29 N
A
1 1 1
5LWE
0.04 0.65 0.85
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31 L
F
1 1 1
5NX2
0.2 0.21 -1.25
Inactive
Active
Intermediate
A (Rhodopsin)
Protein
Aminergic
Chemokine
5-Hydroxytryptamine
Dopamine
5HT1B
DRD3
CXCR4
CXCR4
D3
5-HT1B
TM3 3x41 L
W
3 3 11
5V54, 3OE0, 3OE6, 3PBL, 3OE8, 4IAQ, 3ODU, 4RWS, 3OE9, 6G79, 4IAR
0.31 0.21 -1.25 1
Inactive
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
N-term N
C
2 1 12
2X72, 4A4M, 2J4Y, 5DYS, 4ZWJ, 5W0P, 3C9M, 5DGY, 5EN0, 6CMO, 4BEY, 4BEZ
0.65 0.85
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64 M
A
1 1 3
5NJ6, 5NDD, 5NDZ
0.01 0.24 -0.67 1 3
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53 Y
A
1 1 2
4K5Y, 4Z9G
0.93 0.53 -0.71 Pos & Wild Type AA Match 1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
C-term S
A
1 1 1
5X33
0.50 0.46
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40 L
A
1 1 4
5TZY, 5TZR, 4PHU, 5KW2
0.03 0.21 -1.25 2 1 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2 G
M
1 1 5
5CGD, 5CGC, 6FFH, 4OO9, 6FFI
1.00 1.15
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
ADRB1
β2
β1
TM3 3x41 E
W
2 1 5
5A8E, 3NY8, 3NY9, 3NYA, 3D4S
0.01 0.33 0.40 0.11 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52 G
I
1 1 2
5VEW, 5VEX
0.2 1.00 1.15
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60 C
Y
1 1 4
6AKX, 6AKY, 5UIW, 4MBS
0.02 0.68 -0.02 2
Inactive
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
AA1R
A2A
A1
TM2 2x52 A