Ligand source activities (1 row/activity)
Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Potency) |
# tested GPCRs (Potency) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
138107701 | 186881 | 39 | None | 1 | 7 | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 360 | 8 | 3 | 3 | 3.5 | CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O | 10.1016/j.ejmech.2022.114154 | ||
5311181 | 186881 | 39 | None | 1 | 7 | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 360 | 8 | 3 | 3 | 3.5 | CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O | 10.1016/j.ejmech.2022.114154 | ||
CHEMBL494 | 186881 | 39 | None | 1 | 7 | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 360 | 8 | 3 | 3 | 3.5 | CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O | 10.1016/j.ejmech.2022.114154 | ||
127052613 | 139676 | 0 | None | -1 | 6 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 431 | 7 | 3 | 7 | 3.1 | O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/[C@@H](O)COc3ccccc3)O2)n1 | 10.1021/acsmedchemlett.5b00455 | ||
CHEMBL3804978 | 139676 | 0 | None | -1 | 6 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 431 | 7 | 3 | 7 | 3.1 | O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/[C@@H](O)COc3ccccc3)O2)n1 | 10.1021/acsmedchemlett.5b00455 | ||
127052614 | 139696 | 0 | None | -40 | 6 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 415 | 7 | 2 | 6 | 4.1 | O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/CCOc3ccccc3)O2)n1 | 10.1021/acsmedchemlett.5b00455 | ||
CHEMBL3805176 | 139696 | 0 | None | -40 | 6 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 415 | 7 | 2 | 6 | 4.1 | O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/CCOc3ccccc3)O2)n1 | 10.1021/acsmedchemlett.5b00455 | ||
58681361 | 144148 | 0 | None | -19 | 3 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 318 | 8 | 2 | 3 | 3.5 | Cc1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)cc1 | nan | ||
CHEMBL3908432 | 144148 | 0 | None | -19 | 3 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 318 | 8 | 2 | 3 | 3.5 | Cc1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)cc1 | nan | ||
1955 | 16 | 1 | None | -2089 | 5 | Human | 4.7 | pEC50 | = | 4.7 | Functional | ChEMBL | 428 | 13 | 4 | 5 | 3.6 | O[C@@H](COc1cccc(c1)Cl)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1CCCCCCC(=O)O)O | 10.1016/s0960-894x(00)00273-0 | ||
5311240 | 16 | 1 | None | -2089 | 5 | Human | 4.7 | pEC50 | = | 4.7 | Functional | ChEMBL | 428 | 13 | 4 | 5 | 3.6 | O[C@@H](COc1cccc(c1)Cl)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1CCCCCCC(=O)O)O | 10.1016/s0960-894x(00)00273-0 | ||
CHEMBL36041 | 16 | 1 | None | -2089 | 5 | Human | 4.7 | pEC50 | = | 4.7 | Functional | ChEMBL | 428 | 13 | 4 | 5 | 3.6 | O[C@@H](COc1cccc(c1)Cl)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1CCCCCCC(=O)O)O | 10.1016/s0960-894x(00)00273-0 | ||
56839536 | 142637 | 0 | None | -1 | 7 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 604 | 15 | 2 | 7 | 5.1 | CCCCCCCCNC(=O)c1coc([C@@H]2CCCN2Cc2cc(F)ccc2CCC(=O)NS(=O)(=O)C(F)(F)F)n1 | nan | ||
CHEMBL3896035 | 142637 | 0 | None | -1 | 7 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 604 | 15 | 2 | 7 | 5.1 | CCCCCCCCNC(=O)c1coc([C@@H]2CCCN2Cc2cc(F)ccc2CCC(=O)NS(=O)(=O)C(F)(F)F)n1 | nan | ||
56839342 | 148475 | 0 | None | -1 | 7 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 646 | 13 | 2 | 7 | 6.0 | O=C(CCc1ccc(Cl)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F | nan | ||
CHEMBL3942394 | 148475 | 0 | None | -1 | 7 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 646 | 13 | 2 | 7 | 6.0 | O=C(CCc1ccc(Cl)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F | nan | ||
145977227 | 163455 | 0 | None | -1995 | 4 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 437 | 10 | 2 | 6 | 5.2 | C[C@@](O)(C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1)CC1CCCC1 | 10.1016/j.bmc.2017.11.035 | ||
CHEMBL4208379 | 163455 | 0 | None | -1995 | 4 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 437 | 10 | 2 | 6 | 5.2 | C[C@@](O)(C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1)CC1CCCC1 | 10.1016/j.bmc.2017.11.035 | ||
11955358 | 152548 | 0 | None | -1 | 3 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 364 | 8 | 2 | 2 | 4.7 | O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc3c(c2)CCC3)[C@H](O)C[C@H]1Cl | nan | ||
CHEMBL3976116 | 152548 | 0 | None | -1 | 3 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 364 | 8 | 2 | 2 | 4.7 | O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc3c(c2)CCC3)[C@H](O)C[C@H]1Cl | nan | ||
156022045 | 177626 | 0 | None | -4 | 3 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 351 | 14 | 2 | 4 | 3.8 | CCCCCC(O)CCc1cccc(=O)n1CCCCCCC(=O)O | 10.1016/j.bmcl.2020.127104 | ||
CHEMBL4649582 | 177626 | 0 | None | -4 | 3 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 351 | 14 | 2 | 4 | 3.8 | CCCCCC(O)CCc1cccc(=O)n1CCCCCCC(=O)O | 10.1016/j.bmcl.2020.127104 | ||
2720 | 3793 | 55 | None | -478 | 5 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 390 | 10 | 3 | 4 | 3.6 | CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O | 10.1016/j.ejmech.2022.114154 | ||
5820 | 3793 | 55 | None | -478 | 5 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 390 | 10 | 3 | 4 | 3.6 | CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O | 10.1016/j.ejmech.2022.114154 | ||
6918140 | 3793 | 55 | None | -478 | 5 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 390 | 10 | 3 | 4 | 3.6 | CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O | 10.1016/j.ejmech.2022.114154 | ||
CHEMBL1237119 | 3793 | 55 | None | -478 | 5 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 390 | 10 | 3 | 4 | 3.6 | CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O | 10.1016/j.ejmech.2022.114154 | ||
DB00374 | 3793 | 55 | None | -478 | 5 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 390 | 10 | 3 | 4 | 3.6 | CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O | 10.1016/j.ejmech.2022.114154 | ||
1883 | 3033 | 71 | None | -1 | 10 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1021/acsmedchemlett.5b00455 | ||
1916 | 3033 | 71 | None | -1 | 10 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1021/acsmedchemlett.5b00455 | ||
5280360 | 3033 | 71 | None | -1 | 10 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1021/acsmedchemlett.5b00455 | ||
913 | 3033 | 71 | None | -1 | 10 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1021/acsmedchemlett.5b00455 | ||
CHEMBL548 | 3033 | 71 | None | -1 | 10 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1021/acsmedchemlett.5b00455 | ||
DB00917 | 3033 | 71 | None | -1 | 10 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1021/acsmedchemlett.5b00455 | ||
6441607 | 154540 | 21 | None | -12 | 4 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 382 | 12 | 4 | 4 | 3.7 | CCCCC(C)(C)[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCC(=O)O | 10.1016/s0960-894x(00)00273-0 | ||
CHEMBL40183 | 154540 | 21 | None | -12 | 4 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 382 | 12 | 4 | 4 | 3.7 | CCCCC(C)(C)[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCC(=O)O | 10.1016/s0960-894x(00)00273-0 | ||
10389527 | 152811 | 15 | None | -1122 | 2 | Human | 4.5 | pEC50 | = | 4.5 | Functional | ChEMBL | 460 | 13 | 4 | 4 | 4.6 | O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1cccc(C(F)(F)F)c1 | 10.1016/s0960-894x(00)00273-0 | ||
CHEMBL39784 | 152811 | 15 | None | -1122 | 2 | Human | 4.5 | pEC50 | = | 4.5 | Functional | ChEMBL | 460 | 13 | 4 | 4 | 4.6 | O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1cccc(C(F)(F)F)c1 | 10.1016/s0960-894x(00)00273-0 | ||
126495398 | 139681 | 0 | None | -416 | 3 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 403 | 7 | 2 | 6 | 3.9 | O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3CCCOc3ccccc3)O2)n1 | 10.1021/acsmedchemlett.5b00455 | ||
CHEMBL3805044 | 139681 | 0 | None | -416 | 3 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 403 | 7 | 2 | 6 | 3.9 | O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3CCCOc3ccccc3)O2)n1 | 10.1021/acsmedchemlett.5b00455 | ||
56649302 | 152134 | 0 | None | -1 | 6 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 630 | 13 | 2 | 7 | 5.5 | O=C(CCc1ccc(F)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F | nan | ||
CHEMBL3972583 | 152134 | 0 | None | -1 | 6 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 630 | 13 | 2 | 7 | 5.5 | O=C(CCc1ccc(F)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F | nan | ||
1884 | 3034 | 46 | None | -22 | 9 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 10.1016/s0960-894x(00)00273-0 | ||
5280363 | 3034 | 46 | None | -22 | 9 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 10.1016/s0960-894x(00)00273-0 | ||
912 | 3034 | 46 | None | -22 | 9 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 10.1016/s0960-894x(00)00273-0 | ||
CHEMBL815 | 3034 | 46 | None | -22 | 9 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 10.1016/s0960-894x(00)00273-0 | ||
DB12789 | 3034 | 46 | None | -22 | 9 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 10.1016/s0960-894x(00)00273-0 | ||
56839344 | 151519 | 0 | None | -208 | 8 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 656 | 13 | 2 | 9 | 5.1 | O=C(CCc1cc2c(cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC3CCCCC3)co1)OCO2)NS(=O)(=O)C(F)(F)F | nan | ||
CHEMBL3967284 | 151519 | 0 | None | -208 | 8 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 656 | 13 | 2 | 9 | 5.1 | O=C(CCc1cc2c(cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC3CCCCC3)co1)OCO2)NS(=O)(=O)C(F)(F)F | nan | ||
16725337 | 149069 | 0 | None | -3981 | 4 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 443 | 12 | 2 | 4 | 6.0 | CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1 | nan | ||
CHEMBL3947001 | 149069 | 0 | None | -3981 | 4 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 443 | 12 | 2 | 4 | 6.0 | CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1 | nan | ||
16725337 | 149069 | 0 | None | -3981 | 4 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 443 | 12 | 2 | 4 | 6.0 | CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1 | nan | ||
CHEMBL3947001 | 149069 | 0 | None | -3981 | 4 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 443 | 12 | 2 | 4 | 6.0 | CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1 | nan | ||
56839343 | 143747 | 0 | None | -1 | 6 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 642 | 14 | 2 | 8 | 5.4 | COc1ccc(CCC(=O)NS(=O)(=O)C(F)(F)F)c(CN2CCC[C@H]2c2nc(C(=O)NCCCCC3CCCCC3)co2)c1 | nan | ||
CHEMBL3904989 | 143747 | 0 | None | -1 | 6 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 642 | 14 | 2 | 8 | 5.4 | COc1ccc(CCC(=O)NS(=O)(=O)C(F)(F)F)c(CN2CCC[C@H]2c2nc(C(=O)NCCCCC3CCCCC3)co2)c1 | nan | ||
127052615 | 139740 | 0 | None | -181 | 3 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 401 | 6 | 2 | 6 | 3.7 | O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/COc3ccccc3)O2)n1 | 10.1021/acsmedchemlett.5b00455 | ||
CHEMBL3805693 | 139740 | 0 | None | -181 | 3 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 401 | 6 | 2 | 6 | 3.7 | O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/COc3ccccc3)O2)n1 | 10.1021/acsmedchemlett.5b00455 | ||
1894 | 943 | 35 | None | -229 | 5 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 424 | 11 | 4 | 5 | 3.2 | OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O | 10.1016/s0960-894x(00)00273-0 | ||
5311053 | 943 | 35 | None | -229 | 5 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 424 | 11 | 4 | 5 | 3.2 | OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O | 10.1016/s0960-894x(00)00273-0 | ||
CHEMBL37853 | 943 | 35 | None | -229 | 5 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 424 | 11 | 4 | 5 | 3.2 | OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O | 10.1016/s0960-894x(00)00273-0 | ||
DB11507 | 943 | 35 | None | -229 | 5 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 424 | 11 | 4 | 5 | 3.2 | OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O | 10.1016/s0960-894x(00)00273-0 | ||
126495463 | 139777 | 0 | None | -69 | 3 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 389 | 6 | 2 | 6 | 3.5 | O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3CCOc3ccccc3)O2)n1 | 10.1021/acsmedchemlett.5b00455 | ||
CHEMBL3806130 | 139777 | 0 | None | -69 | 3 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 389 | 6 | 2 | 6 | 3.5 | O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3CCOc3ccccc3)O2)n1 | 10.1021/acsmedchemlett.5b00455 | ||
126495491 | 139695 | 0 | None | -75 | 4 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 429 | 8 | 2 | 6 | 4.5 | O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/CCCOc3ccccc3)O2)n1 | 10.1021/acsmedchemlett.5b00455 | ||
CHEMBL3805169 | 139695 | 0 | None | -75 | 4 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 429 | 8 | 2 | 6 | 4.5 | O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/CCCOc3ccccc3)O2)n1 | 10.1021/acsmedchemlett.5b00455 | ||
59179917 | 161060 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 390 | 3 | 1 | 6 | 4.3 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3ccc(C(F)(F)F)nc32)n1 | 10.1016/j.bmcl.2018.06.022 | ||
CHEMBL4129609 | 161060 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 390 | 3 | 1 | 6 | 4.3 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3ccc(C(F)(F)F)nc32)n1 | 10.1016/j.bmcl.2018.06.022 | ||
59179887 | 105355 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 389 | 3 | 1 | 5 | 4.9 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3ccc(C(F)(F)F)cc32)n1 | 10.1016/j.bmcl.2018.06.022 | ||
CHEMBL3127163 | 105355 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 389 | 3 | 1 | 5 | 4.9 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3ccc(C(F)(F)F)cc32)n1 | 10.1016/j.bmcl.2018.06.022 | ||
59179944 | 160835 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 395 | 3 | 1 | 6 | 4.4 | O=C(O)c1csc(-n2nc(C3=CCCCO3)c3ccc(C(F)(F)F)cc32)n1 | 10.1016/j.bmcl.2018.06.022 | ||
CHEMBL4126319 | 160835 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 395 | 3 | 1 | 6 | 4.4 | O=C(O)c1csc(-n2nc(C3=CCCCO3)c3ccc(C(F)(F)F)cc32)n1 | 10.1016/j.bmcl.2018.06.022 | ||
72725270 | 157504 | 0 | None | - | 1 | Rat | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 388 | 4 | 1 | 6 | 4.0 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2sc(N3CC=CCC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4085914 | 157504 | 0 | None | - | 1 | Rat | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 388 | 4 | 1 | 6 | 4.0 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2sc(N3CC=CCC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
73052407 | 156252 | 0 | None | - | 1 | Rat | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 350 | 4 | 1 | 6 | 3.3 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2sc(N(C)C)nc12 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4070938 | 156252 | 0 | None | - | 1 | Rat | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 350 | 4 | 1 | 6 | 3.3 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2sc(N(C)C)nc12 | 10.1016/j.bmc.2017.04.028 | ||
137640239 | 156270 | 0 | None | - | 1 | Rat | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 357 | 4 | 1 | 6 | 3.1 | Cc1cc(C(=O)O)nn1Cc1cc(C#N)cc2cc(-c3ccccc3)nn12 | 10.1016/j.bmc.2017.03.003 | ||
CHEMBL4071137 | 156270 | 0 | None | - | 1 | Rat | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 357 | 4 | 1 | 6 | 3.1 | Cc1cc(C(=O)O)nn1Cc1cc(C#N)cc2cc(-c3ccccc3)nn12 | 10.1016/j.bmc.2017.03.003 | ||
60151285 | 157318 | 0 | None | - | 1 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 407 | 4 | 1 | 4 | 4.4 | O=C(O)c1cccc(Cc2c(-c3ccccc3)nn3cc(Br)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4083796 | 157318 | 0 | None | - | 1 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 407 | 4 | 1 | 4 | 4.4 | O=C(O)c1cccc(Cc2c(-c3ccccc3)nn3cc(Br)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
50907865 | 127689 | 0 | None | - | 1 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 347 | 5 | 1 | 4 | 4.7 | COc1ccc2c(c1)cc(-c1ccoc1)n2Cc1cccc(C(=O)O)c1 | nan | ||
CHEMBL3665552 | 127689 | 0 | None | - | 1 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 347 | 5 | 1 | 4 | 4.7 | COc1ccc2c(c1)cc(-c1ccoc1)n2Cc1cccc(C(=O)O)c1 | nan | ||
72950767 | 158723 | 0 | None | - | 1 | Rat | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 396 | 5 | 1 | 6 | 3.9 | COc1cccc(-c2cc3cc(Cl)cc(Cn4nc(C(=O)O)cc4C)n3n2)c1 | 10.1016/j.bmc.2017.03.003 | ||
CHEMBL4099299 | 158723 | 0 | None | - | 1 | Rat | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 396 | 5 | 1 | 6 | 3.9 | COc1cccc(-c2cc3cc(Cl)cc(Cn4nc(C(=O)O)cc4C)n3n2)c1 | 10.1016/j.bmc.2017.03.003 | ||
137643997 | 157881 | 0 | None | - | 1 | Rat | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 387 | 4 | 1 | 5 | 5.2 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2sc(C3=CCCCC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4090320 | 157881 | 0 | None | - | 1 | Rat | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 387 | 4 | 1 | 5 | 5.2 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2sc(C3=CCCCC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
137656506 | 159186 | 0 | None | - | 1 | Rat | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 374 | 4 | 1 | 6 | 3.6 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2sc(N3CC=CC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4104745 | 159186 | 0 | None | - | 1 | Rat | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 374 | 4 | 1 | 6 | 3.6 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2sc(N3CC=CC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
123776027 | 156836 | 0 | None | - | 1 | Rat | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 369 | 4 | 1 | 5 | 4.4 | O=C(O)c1cccc(Cc2c(-c3ccsc3)nn3cc(Cl)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4078135 | 156836 | 0 | None | - | 1 | Rat | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 369 | 4 | 1 | 5 | 4.4 | O=C(O)c1cccc(Cc2c(-c3ccsc3)nn3cc(Cl)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
60151418 | 158126 | 0 | None | - | 1 | Rat | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 369 | 4 | 1 | 5 | 4.4 | O=C(O)c1csc(Cc2c(-c3ccccc3)nn3cc(Cl)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4092926 | 158126 | 0 | None | - | 1 | Rat | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 369 | 4 | 1 | 5 | 4.4 | O=C(O)c1csc(Cc2c(-c3ccccc3)nn3cc(Cl)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
137649602 | 156871 | 0 | None | - | 1 | Rat | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 362 | 5 | 1 | 6 | 3.3 | COc1ccc(Cn2nc(C(=O)O)cc2C)n2nc(-c3ccccc3)cc12 | 10.1016/j.bmc.2017.03.003 | ||
CHEMBL4078569 | 156871 | 0 | None | - | 1 | Rat | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 362 | 5 | 1 | 6 | 3.3 | COc1ccc(Cn2nc(C(=O)O)cc2C)n2nc(-c3ccccc3)cc12 | 10.1016/j.bmc.2017.03.003 | ||
123243963 | 155246 | 0 | None | - | 1 | Rat | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 369 | 4 | 1 | 5 | 4.4 | O=C(O)c1cccc(Cc2c(-c3cccs3)nn3cc(Cl)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4059518 | 155246 | 0 | None | - | 1 | Rat | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 369 | 4 | 1 | 5 | 4.4 | O=C(O)c1cccc(Cc2c(-c3cccs3)nn3cc(Cl)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
86704843 | 156866 | 0 | None | - | 1 | Rat | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 371 | 5 | 1 | 5 | 3.9 | CC(=O)c1ccc2c(Cc3cccc(C(=O)O)n3)c(-c3ccccc3)nn2c1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4078505 | 156866 | 0 | None | - | 1 | Rat | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 371 | 5 | 1 | 5 | 3.9 | CC(=O)c1ccc2c(Cc3cccc(C(=O)O)n3)c(-c3ccccc3)nn2c1 | 10.1016/j.bmcl.2017.07.055 | ||
68184171 | 157875 | 0 | None | - | 1 | Rat | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 397 | 4 | 1 | 4 | 5.0 | O=C(O)c1cccc(Cc2c(-c3ccc(Cl)cc3)nn3cc(Cl)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4090286 | 157875 | 0 | None | - | 1 | Rat | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 397 | 4 | 1 | 4 | 5.0 | O=C(O)c1cccc(Cc2c(-c3ccc(Cl)cc3)nn3cc(Cl)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
145963362 | 160826 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 395 | 3 | 1 | 5 | 4.4 | O=C(O)c1csc(N2N=C(c3ccccc3)C3CCC(C(F)(F)F)CC32)n1 | 10.1016/j.bmcl.2018.06.022 | ||
CHEMBL4126167 | 160826 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 395 | 3 | 1 | 5 | 4.4 | O=C(O)c1csc(N2N=C(c3ccccc3)C3CCC(C(F)(F)F)CC32)n1 | 10.1016/j.bmcl.2018.06.022 | ||
68259039 | 160963 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 390 | 3 | 1 | 6 | 4.3 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3ncc(C(F)(F)F)cc32)n1 | 10.1016/j.bmcl.2018.06.022 | ||
CHEMBL4128163 | 160963 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 390 | 3 | 1 | 6 | 4.3 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3ncc(C(F)(F)F)cc32)n1 | 10.1016/j.bmcl.2018.06.022 | ||
145961578 | 161045 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 379 | 5 | 1 | 7 | 3.4 | CN(C)c1ccc2c(-c3ccccc3)nn(Cc3nc(C(=O)O)cs3)c2n1 | 10.1016/j.bmcl.2018.06.022 | ||
CHEMBL4129401 | 161045 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 379 | 5 | 1 | 7 | 3.4 | CN(C)c1ccc2c(-c3ccccc3)nn(Cc3nc(C(=O)O)cs3)c2n1 | 10.1016/j.bmcl.2018.06.022 | ||
59179974 | 161053 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 403 | 4 | 1 | 5 | 4.9 | O=C(O)c1csc(Cn2nc(-c3ccccc3)c3ccc(C(F)(F)F)cc32)n1 | 10.1016/j.bmcl.2018.06.022 | ||
CHEMBL4129545 | 161053 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 403 | 4 | 1 | 5 | 4.9 | O=C(O)c1csc(Cn2nc(-c3ccccc3)c3ccc(C(F)(F)F)cc32)n1 | 10.1016/j.bmcl.2018.06.022 | ||
72950439 | 158241 | 0 | None | - | 1 | Rat | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 332 | 4 | 1 | 5 | 3.3 | Cc1cc(C(=O)O)nn1Cc1cccc2cc(-c3ccccc3)nn12 | 10.1016/j.bmc.2017.03.003 | ||
CHEMBL4094186 | 158241 | 0 | None | - | 1 | Rat | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 332 | 4 | 1 | 5 | 3.3 | Cc1cc(C(=O)O)nn1Cc1cccc2cc(-c3ccccc3)nn12 | 10.1016/j.bmc.2017.03.003 | ||
137636144 | 155398 | 0 | None | - | 1 | Rat | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 394 | 5 | 1 | 5 | 4.7 | CC(C)c1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)nn12 | 10.1016/j.bmc.2017.03.003 | ||
CHEMBL4061088 | 155398 | 0 | None | - | 1 | Rat | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 394 | 5 | 1 | 5 | 4.7 | CC(C)c1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)nn12 | 10.1016/j.bmc.2017.03.003 | ||
123616733 | 156633 | 0 | None | - | 1 | Rat | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 369 | 4 | 1 | 4 | 4.7 | O=C(O)c1cccc(Cc2c(C3CCCCC3)nn3cc(Cl)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4075546 | 156633 | 0 | None | - | 1 | Rat | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 369 | 4 | 1 | 4 | 4.7 | O=C(O)c1cccc(Cc2c(C3CCCCC3)nn3cc(Cl)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
123896585 | 158596 | 0 | None | - | 1 | Rat | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 353 | 4 | 1 | 5 | 3.9 | O=C(O)c1cccc(Cc2c(-c3ccco3)nn3cc(Cl)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4098000 | 158596 | 0 | None | - | 1 | Rat | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 353 | 4 | 1 | 5 | 3.9 | O=C(O)c1cccc(Cc2c(-c3ccco3)nn3cc(Cl)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
137634687 | 155249 | 0 | None | - | 1 | Rat | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 364 | 5 | 1 | 6 | 3.7 | CCN(C)c1nc2c(Cn3nc(C(=O)O)cc3C)cc(Cl)cc2s1 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4059569 | 155249 | 0 | None | - | 1 | Rat | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 364 | 5 | 1 | 6 | 3.7 | CCN(C)c1nc2c(Cn3nc(C(=O)O)cc3C)cc(Cl)cc2s1 | 10.1016/j.bmc.2017.04.028 | ||
50907648 | 127687 | 0 | None | - | 1 | Rat | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 358 | 5 | 1 | 4 | 4.5 | COc1ccc2c(c1)cc(-c1ccccc1)n2Cc1cccc(C(=O)O)n1 | nan | ||
CHEMBL3665550 | 127687 | 0 | None | - | 1 | Rat | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 358 | 5 | 1 | 4 | 4.5 | COc1ccc2c(c1)cc(-c1ccccc1)n2Cc1cccc(C(=O)O)n1 | nan | ||
69670884 | 127691 | 0 | None | - | 1 | Rat | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 375 | 5 | 1 | 3 | 5.2 | COc1cc2cc(-c3ccccc3)n(Cc3cccc(C(=O)O)c3)c2cc1F | nan | ||
CHEMBL3665554 | 127691 | 0 | None | - | 1 | Rat | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 375 | 5 | 1 | 3 | 5.2 | COc1cc2cc(-c3ccccc3)n(Cc3cccc(C(=O)O)c3)c2cc1F | nan | ||
123494981 | 158024 | 0 | None | - | 1 | Rat | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 353 | 4 | 1 | 5 | 3.9 | O=C(O)c1cccc(Cc2c(-c3ccoc3)nn3cc(Cl)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4091761 | 158024 | 0 | None | - | 1 | Rat | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 353 | 4 | 1 | 5 | 3.9 | O=C(O)c1cccc(Cc2c(-c3ccoc3)nn3cc(Cl)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
59179887 | 105355 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 389 | 3 | 1 | 5 | 4.9 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3ccc(C(F)(F)F)cc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
CHEMBL3127163 | 105355 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 389 | 3 | 1 | 5 | 4.9 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3ccc(C(F)(F)F)cc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
137654396 | 158003 | 0 | None | - | 1 | Rat | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 346 | 5 | 1 | 5 | 3.4 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(CC(C)C)nn12 | 10.1016/j.bmc.2017.03.003 | ||
CHEMBL4091562 | 158003 | 0 | None | - | 1 | Rat | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 346 | 5 | 1 | 5 | 3.4 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(CC(C)C)nn12 | 10.1016/j.bmc.2017.03.003 | ||
123939480 | 156584 | 0 | None | - | 1 | Rat | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 384 | 4 | 1 | 5 | 4.1 | O=C(O)c1cccc(Cc2c(N3CCCCCC3)nn3cc(Cl)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4074958 | 156584 | 0 | None | - | 1 | Rat | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 384 | 4 | 1 | 5 | 4.1 | O=C(O)c1cccc(Cc2c(N3CCCCCC3)nn3cc(Cl)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
137634540 | 155425 | 0 | None | - | 1 | Rat | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 400 | 4 | 1 | 5 | 4.6 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(-c3cccc(Cl)c3)nn12 | 10.1016/j.bmc.2017.03.003 | ||
CHEMBL4061415 | 155425 | 0 | None | - | 1 | Rat | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 400 | 4 | 1 | 5 | 4.6 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(-c3cccc(Cl)c3)nn12 | 10.1016/j.bmc.2017.03.003 | ||
73052564 | 157629 | 0 | None | - | 1 | Rat | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 376 | 4 | 1 | 6 | 4.8 | O=C(O)c1ccc(Oc2cc(Cl)cc3sc(N4CC=CCC4)nc23)o1 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4087549 | 157629 | 0 | None | - | 1 | Rat | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 376 | 4 | 1 | 6 | 4.8 | O=C(O)c1ccc(Oc2cc(Cl)cc3sc(N4CC=CCC4)nc23)o1 | 10.1016/j.bmc.2017.04.028 | ||
137634190 | 155957 | 0 | None | - | 1 | Rat | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 362 | 5 | 1 | 6 | 3.3 | COc1ccc2cc(-c3ccccc3)nn2c1Cn1nc(C(=O)O)cc1C | 10.1016/j.bmc.2017.03.003 | ||
CHEMBL4067673 | 155957 | 0 | None | - | 1 | Rat | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 362 | 5 | 1 | 6 | 3.3 | COc1ccc2cc(-c3ccccc3)nn2c1Cn1nc(C(=O)O)cc1C | 10.1016/j.bmc.2017.03.003 | ||
137662245 | 158530 | 0 | None | - | 1 | Rat | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 414 | 8 | 1 | 5 | 5.5 | CCCC/C=C/c1cc(Cn2nc(C(=O)O)cc2C)n2nc(-c3ccccc3)cc2c1 | 10.1016/j.bmc.2017.03.003 | ||
CHEMBL4097281 | 158530 | 0 | None | - | 1 | Rat | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 414 | 8 | 1 | 5 | 5.5 | CCCC/C=C/c1cc(Cn2nc(C(=O)O)cc2C)n2nc(-c3ccccc3)cc2c1 | 10.1016/j.bmc.2017.03.003 | ||
123660109 | 156748 | 0 | None | - | 1 | Rat | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 327 | 4 | 1 | 4 | 3.5 | O=C(O)c1cccc(Cc2c(C3CC3)nn3cc(Cl)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4076910 | 156748 | 0 | None | - | 1 | Rat | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 327 | 4 | 1 | 4 | 3.5 | O=C(O)c1cccc(Cc2c(C3CC3)nn3cc(Cl)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
60151152 | 158005 | 0 | None | - | 1 | Rat | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 397 | 4 | 1 | 4 | 4.7 | O=C(O)c1cccc(Cc2c(-c3ccccc3)nn3cc(C(F)(F)F)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4091580 | 158005 | 0 | None | - | 1 | Rat | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 397 | 4 | 1 | 4 | 4.7 | O=C(O)c1cccc(Cc2c(-c3ccccc3)nn3cc(C(F)(F)F)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
137650133 | 156993 | 0 | None | - | 1 | Rat | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 394 | 5 | 1 | 6 | 4.3 | C=C(C)c1cc(Cn2nc(C(=O)O)cc2C)c2nc(N3CC=CCC3)sc2c1 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4080094 | 156993 | 0 | None | - | 1 | Rat | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 394 | 5 | 1 | 6 | 4.3 | C=C(C)c1cc(Cn2nc(C(=O)O)cc2C)c2nc(N3CC=CCC3)sc2c1 | 10.1016/j.bmc.2017.04.028 | ||
73052249 | 155362 | 0 | None | - | 1 | Rat | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 372 | 4 | 1 | 6 | 3.5 | Cc1cc(C(=O)O)nn1Cc1cc(F)cc2sc(N3CC=CCC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4060696 | 155362 | 0 | None | - | 1 | Rat | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 372 | 4 | 1 | 6 | 3.5 | Cc1cc(C(=O)O)nn1Cc1cc(F)cc2sc(N3CC=CCC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
69671009 | 127699 | 0 | None | - | 1 | Rat | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 375 | 5 | 1 | 3 | 5.2 | COc1ccc2c(c1)cc(-c1cccc(F)c1)n2Cc1cccc(C(=O)O)c1 | nan | ||
CHEMBL3665562 | 127699 | 0 | None | - | 1 | Rat | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 375 | 5 | 1 | 3 | 5.2 | COc1ccc2c(c1)cc(-c1cccc(F)c1)n2Cc1cccc(C(=O)O)c1 | nan | ||
69670809 | 127702 | 0 | None | - | 1 | Rat | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 381 | 5 | 1 | 4 | 5.3 | COc1cc2cc(-c3ccccc3)n(Cc3ccc(C(=O)O)o3)c2cc1Cl | nan | ||
CHEMBL3665565 | 127702 | 0 | None | - | 1 | Rat | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 381 | 5 | 1 | 4 | 5.3 | COc1cc2cc(-c3ccccc3)n(Cc3ccc(C(=O)O)o3)c2cc1Cl | nan | ||
137647738 | 157316 | 0 | None | - | 1 | Rat | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 330 | 4 | 1 | 5 | 3.1 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(C3CC3)nn12 | 10.1016/j.bmc.2017.03.003 | ||
CHEMBL4083777 | 157316 | 0 | None | - | 1 | Rat | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 330 | 4 | 1 | 5 | 3.1 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(C3CC3)nn12 | 10.1016/j.bmc.2017.03.003 | ||
123567605 | 158624 | 0 | None | - | 1 | Rat | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 356 | 4 | 1 | 5 | 3.3 | O=C(O)c1cccc(Cc2c(N3CCCC3)nn3cc(Cl)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4098345 | 158624 | 0 | None | - | 1 | Rat | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 356 | 4 | 1 | 5 | 3.3 | O=C(O)c1cccc(Cc2c(N3CCCC3)nn3cc(Cl)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
60151153 | 155471 | 0 | None | - | 1 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 343 | 4 | 1 | 4 | 4.0 | Cc1ccc2c(Cc3cccc(C(=O)O)n3)c(-c3ccccc3)nn2c1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4062060 | 155471 | 0 | None | - | 1 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 343 | 4 | 1 | 4 | 4.0 | Cc1ccc2c(Cc3cccc(C(=O)O)n3)c(-c3ccccc3)nn2c1 | 10.1016/j.bmcl.2017.07.055 | ||
69670904 | 127692 | 0 | None | - | 1 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 375 | 5 | 1 | 3 | 5.2 | COc1ccc2c(c1)cc(-c1ccccc1)n2Cc1cccc(C(=O)O)c1F | nan | ||
CHEMBL3665555 | 127692 | 0 | None | - | 1 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 375 | 5 | 1 | 3 | 5.2 | COc1ccc2c(c1)cc(-c1ccccc1)n2Cc1cccc(C(=O)O)c1F | nan | ||
137643436 | 157679 | 0 | None | - | 1 | Rat | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 351 | 4 | 1 | 4 | 4.2 | O=C(O)c1ccn(Cc2cc(Cl)cc3cc(-c4ccccc4)nn23)c1 | 10.1016/j.bmc.2017.03.003 | ||
CHEMBL4088199 | 157679 | 0 | None | - | 1 | Rat | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 351 | 4 | 1 | 4 | 4.2 | O=C(O)c1ccn(Cc2cc(Cl)cc3cc(-c4ccccc4)nn23)c1 | 10.1016/j.bmc.2017.03.003 | ||
86704858 | 156223 | 0 | None | - | 1 | Rat | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 369 | 5 | 1 | 4 | 4.6 | O=C(O)c1cccc(Cc2c(-c3ccccc3)nn3cc(C4CC4)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4070685 | 156223 | 0 | None | - | 1 | Rat | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 369 | 5 | 1 | 4 | 4.6 | O=C(O)c1cccc(Cc2c(-c3ccccc3)nn3cc(C4CC4)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
137634566 | 155469 | 0 | None | - | 1 | Rat | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 346 | 6 | 1 | 5 | 3.6 | CCCCc1cc2cc(Cl)cc(Cn3nc(C(=O)O)cc3C)n2n1 | 10.1016/j.bmc.2017.03.003 | ||
CHEMBL4062041 | 155469 | 0 | None | - | 1 | Rat | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 346 | 6 | 1 | 5 | 3.6 | CCCCc1cc2cc(Cl)cc(Cn3nc(C(=O)O)cc3C)n2n1 | 10.1016/j.bmc.2017.03.003 | ||
59179268 | 103410 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 373 | 3 | 1 | 5 | 4.5 | O=C(O)c1csc(-n2nc3c(c2-c2ccccc2)CCc2ccccc2-3)n1 | 10.1016/j.bmcl.2013.10.065 | ||
CHEMBL3092133 | 103410 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 373 | 3 | 1 | 5 | 4.5 | O=C(O)c1csc(-n2nc3c(c2-c2ccccc2)CCc2ccccc2-3)n1 | 10.1016/j.bmcl.2013.10.065 | ||
137636914 | 155637 | 0 | None | - | 1 | Rat | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 396 | 5 | 1 | 7 | 3.5 | CC(=O)c1cc(Cn2nc(C(=O)O)cc2C)c2nc(N3CC=CCC3)sc2c1 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4063975 | 155637 | 0 | None | - | 1 | Rat | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 396 | 5 | 1 | 7 | 3.5 | CC(=O)c1cc(Cn2nc(C(=O)O)cc2C)c2nc(N3CC=CCC3)sc2c1 | 10.1016/j.bmc.2017.04.028 | ||
123463167 | 156767 | 0 | None | - | 1 | Rat | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 343 | 5 | 1 | 4 | 3.9 | CC(C)Cc1nn2cc(Cl)ccc2c1Cc1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4077168 | 156767 | 0 | None | - | 1 | Rat | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 343 | 5 | 1 | 4 | 3.9 | CC(C)Cc1nn2cc(Cl)ccc2c1Cc1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2017.07.055 | ||
137641401 | 157778 | 0 | None | - | 1 | Rat | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 408 | 6 | 1 | 5 | 4.8 | CC(C)Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)nn12 | 10.1016/j.bmc.2017.03.003 | ||
CHEMBL4089248 | 157778 | 0 | None | - | 1 | Rat | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 408 | 6 | 1 | 5 | 4.8 | CC(C)Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)nn12 | 10.1016/j.bmc.2017.03.003 | ||
60151150 | 157731 | 0 | None | - | 1 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 355 | 5 | 1 | 4 | 4.3 | C=Cc1ccc2c(Cc3cccc(C(=O)O)n3)c(-c3ccccc3)nn2c1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4088835 | 157731 | 0 | None | - | 1 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 355 | 5 | 1 | 4 | 4.3 | C=Cc1ccc2c(Cc3cccc(C(=O)O)n3)c(-c3ccccc3)nn2c1 | 10.1016/j.bmcl.2017.07.055 | ||
50907649 | 127685 | 0 | None | - | 1 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 357 | 5 | 1 | 3 | 5.1 | COc1ccc2c(c1)cc(-c1ccccc1)n2Cc1cccc(C(=O)O)c1 | nan | ||
CHEMBL3665548 | 127685 | 0 | None | - | 1 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 357 | 5 | 1 | 3 | 5.1 | COc1ccc2c(c1)cc(-c1ccccc1)n2Cc1cccc(C(=O)O)c1 | nan | ||
73052563 | 157699 | 0 | None | - | 1 | Rat | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 397 | 5 | 1 | 7 | 3.4 | Cc1cc(C(=O)O)nn1Cc1cc(N(C)C)cc2sc(N3CC=CCC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4088446 | 157699 | 0 | None | - | 1 | Rat | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 397 | 5 | 1 | 7 | 3.4 | Cc1cc(C(=O)O)nn1Cc1cc(N(C)C)cc2sc(N3CC=CCC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
137639565 | 156221 | 0 | None | - | 1 | Rat | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 346 | 3 | 1 | 5 | 3.5 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(C(C)(C)C)nn12 | 10.1016/j.bmc.2017.03.003 | ||
CHEMBL4070667 | 156221 | 0 | None | - | 1 | Rat | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 346 | 3 | 1 | 5 | 3.5 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(C(C)(C)C)nn12 | 10.1016/j.bmc.2017.03.003 | ||
57399080 | 67854 | 0 | None | -10 | 2 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 366 | 4 | 1 | 4 | 5.0 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)oc12 | 10.1016/j.bmc.2017.03.003 | ||
CHEMBL1915252 | 67854 | 0 | None | -10 | 2 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 366 | 4 | 1 | 4 | 5.0 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)oc12 | 10.1016/j.bmc.2017.03.003 | ||
73052092 | 157071 | 0 | None | - | 1 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 432 | 4 | 1 | 6 | 4.1 | Cc1cc(C(=O)O)nn1Cc1cc(Br)cc2sc(N3CC=CCC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4081022 | 157071 | 0 | None | - | 1 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 432 | 4 | 1 | 6 | 4.1 | Cc1cc(C(=O)O)nn1Cc1cc(Br)cc2sc(N3CC=CCC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
50908090 | 127710 | 0 | None | - | 1 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 371 | 5 | 1 | 5 | 4.9 | COc1cc2cc(-c3ccoc3)n(Cc3ccc(C(=O)O)o3)c2cc1Cl | nan | ||
CHEMBL3665573 | 127710 | 0 | None | - | 1 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 371 | 5 | 1 | 5 | 4.9 | COc1cc2cc(-c3ccoc3)n(Cc3ccc(C(=O)O)o3)c2cc1Cl | nan | ||
69671115 | 127686 | 0 | None | - | 1 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 323 | 5 | 1 | 3 | 4.5 | COc1ccc2c(c1)cc(C(C)C)n2Cc1cccc(C(=O)O)c1 | nan | ||
CHEMBL3665549 | 127686 | 0 | None | - | 1 | Rat | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 323 | 5 | 1 | 3 | 4.5 | COc1ccc2c(c1)cc(C(C)C)n2Cc1cccc(C(=O)O)c1 | nan | ||
137642144 | 157805 | 0 | None | - | 1 | Rat | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 400 | 4 | 1 | 5 | 4.6 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(-c3ccccc3Cl)nn12 | 10.1016/j.bmc.2017.03.003 | ||
CHEMBL4089560 | 157805 | 0 | None | - | 1 | Rat | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 400 | 4 | 1 | 5 | 4.6 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(-c3ccccc3Cl)nn12 | 10.1016/j.bmc.2017.03.003 | ||
50907864 | 127690 | 0 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 364 | 5 | 1 | 5 | 4.5 | COc1ccc2c(c1)cc(-c1ccsc1)n2Cc1cccc(C(=O)O)n1 | nan | ||
CHEMBL3665553 | 127690 | 0 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 364 | 5 | 1 | 5 | 4.5 | COc1ccc2c(c1)cc(-c1ccsc1)n2Cc1cccc(C(=O)O)n1 | nan | ||
137633834 | 156066 | 0 | None | - | 1 | Rat | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 379 | 4 | 1 | 7 | 3.2 | Cc1cc(C(=O)O)nn1Cc1cc(C#N)cc2sc(N3CC=CCC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4068881 | 156066 | 0 | None | - | 1 | Rat | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 379 | 4 | 1 | 7 | 3.2 | Cc1cc(C(=O)O)nn1Cc1cc(C#N)cc2sc(N3CC=CCC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
86704827 | 158100 | 0 | None | - | 1 | Rat | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 329 | 4 | 1 | 4 | 3.7 | O=C(O)c1cccc(Cc2c(-c3ccccc3)nn3ccccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4092517 | 158100 | 0 | None | - | 1 | Rat | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 329 | 4 | 1 | 4 | 3.7 | O=C(O)c1cccc(Cc2c(-c3ccccc3)nn3ccccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
137657628 | 159121 | 0 | None | - | 1 | Rat | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 373 | 4 | 1 | 5 | 4.3 | O=C(O)c1ccn(Cc2cc(Cl)cc3sc(N4CC=CCC4)nc23)c1 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4103920 | 159121 | 0 | None | - | 1 | Rat | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 373 | 4 | 1 | 5 | 4.3 | O=C(O)c1ccn(Cc2cc(Cl)cc3sc(N4CC=CCC4)nc23)c1 | 10.1016/j.bmc.2017.04.028 | ||
50908089 | 127712 | 0 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 394 | 5 | 1 | 4 | 4.7 | COc1ccc2c(c1)cc(-c1cc(F)ccc1F)n2Cc1cccc(C(=O)O)n1 | nan | ||
CHEMBL3665575 | 127712 | 0 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 394 | 5 | 1 | 4 | 4.7 | COc1ccc2c(c1)cc(-c1cc(F)ccc1F)n2Cc1cccc(C(=O)O)n1 | nan | ||
137661624 | 158700 | 0 | None | - | 1 | Rat | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 368 | 4 | 1 | 6 | 3.6 | Cc1cc(Cn2nc(C(=O)O)cc2C)c2nc(N3CC=CCC3)sc2c1 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4099055 | 158700 | 0 | None | - | 1 | Rat | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 368 | 4 | 1 | 6 | 3.6 | Cc1cc(Cn2nc(C(=O)O)cc2C)c2nc(N3CC=CCC3)sc2c1 | 10.1016/j.bmc.2017.04.028 | ||
69670796 | 127704 | 0 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 394 | 5 | 1 | 4 | 4.7 | COc1cc2cc(-c3cccc(F)c3)n(Cc3cccc(C(=O)O)n3)c2cc1F | nan | ||
CHEMBL3665567 | 127704 | 0 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 394 | 5 | 1 | 4 | 4.7 | COc1cc2cc(-c3cccc(F)c3)n(Cc3cccc(C(=O)O)n3)c2cc1F | nan | ||
123950503 | 156615 | 0 | None | - | 1 | Rat | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 388 | 4 | 1 | 6 | 3.2 | O=C(O)c1cccc(Cc2c(N3CCSCC3)nn3cc(Cl)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4075282 | 156615 | 0 | None | - | 1 | Rat | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 388 | 4 | 1 | 6 | 3.2 | O=C(O)c1cccc(Cc2c(N3CCSCC3)nn3cc(Cl)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
137641270 | 156486 | 0 | None | - | 1 | Rat | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 366 | 4 | 1 | 5 | 3.9 | Cc1cc(C(=O)O)nn1Cc1ccc(Cl)c2cc(-c3ccccc3)nn12 | 10.1016/j.bmc.2017.03.003 | ||
CHEMBL4073554 | 156486 | 0 | None | - | 1 | Rat | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 366 | 4 | 1 | 5 | 3.9 | Cc1cc(C(=O)O)nn1Cc1ccc(Cl)c2cc(-c3ccccc3)nn12 | 10.1016/j.bmc.2017.03.003 | ||
69670842 | 127709 | 0 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 382 | 5 | 1 | 5 | 4.7 | COc1cc2cc(-c3ccoc3)n(Cc3cccc(C(=O)O)n3)c2cc1Cl | nan | ||
CHEMBL3665572 | 127709 | 0 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 382 | 5 | 1 | 5 | 4.7 | COc1cc2cc(-c3ccoc3)n(Cc3cccc(C(=O)O)n3)c2cc1Cl | nan | ||
137634992 | 155404 | 0 | None | - | 1 | Rat | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 404 | 4 | 1 | 6 | 4.6 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2sc(N3CCCCCC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4061154 | 155404 | 0 | None | - | 1 | Rat | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 404 | 4 | 1 | 6 | 4.6 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2sc(N3CCCCCC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
137641333 | 156498 | 0 | None | - | 1 | Rat | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 392 | 7 | 1 | 6 | 4.4 | CCCN(CC)c1nc2c(Cn3nc(C(=O)O)cc3C)cc(Cl)cc2s1 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4073810 | 156498 | 0 | None | - | 1 | Rat | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 392 | 7 | 1 | 6 | 4.4 | CCCN(CC)c1nc2c(Cn3nc(C(=O)O)cc3C)cc(Cl)cc2s1 | 10.1016/j.bmc.2017.04.028 | ||
50908088 | 127703 | 0 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 394 | 5 | 1 | 4 | 4.7 | COc1cc2cc(-c3ccccc3F)n(Cc3cccc(C(=O)O)n3)c2cc1F | nan | ||
CHEMBL3665566 | 127703 | 0 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 394 | 5 | 1 | 4 | 4.7 | COc1cc2cc(-c3ccccc3F)n(Cc3cccc(C(=O)O)n3)c2cc1F | nan | ||
50907869 | 127713 | 0 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 393 | 5 | 1 | 5 | 4.5 | COc1cc2cc(-c3cccnc3)n(Cc3cccc(C(=O)O)n3)c2cc1Cl | nan | ||
CHEMBL3665576 | 127713 | 0 | None | - | 1 | Rat | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 393 | 5 | 1 | 5 | 4.5 | COc1cc2cc(-c3cccnc3)n(Cc3cccc(C(=O)O)n3)c2cc1Cl | nan | ||
60151013 | 157804 | 0 | None | - | 1 | Rat | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 362 | 4 | 1 | 3 | 4.9 | O=C(O)c1cccc(Cc2c(-c3ccccc3)nn3cc(Cl)ccc23)c1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4089536 | 157804 | 0 | None | - | 1 | Rat | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 362 | 4 | 1 | 3 | 4.9 | O=C(O)c1cccc(Cc2c(-c3ccccc3)nn3cc(Cl)ccc23)c1 | 10.1016/j.bmcl.2017.07.055 | ||
137632486 | 155927 | 0 | None | - | 1 | Rat | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 400 | 4 | 1 | 5 | 4.6 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(-c3ccc(Cl)cc3)nn12 | 10.1016/j.bmc.2017.03.003 | ||
CHEMBL4067374 | 155927 | 0 | None | - | 1 | Rat | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 400 | 4 | 1 | 5 | 4.6 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(-c3ccc(Cl)cc3)nn12 | 10.1016/j.bmc.2017.03.003 | ||
86704838 | 155952 | 0 | None | - | 1 | Rat | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 369 | 5 | 1 | 4 | 4.7 | C=C(C)c1ccc2c(Cc3cccc(C(=O)O)n3)c(-c3ccccc3)nn2c1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4067608 | 155952 | 0 | None | - | 1 | Rat | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 369 | 5 | 1 | 4 | 4.7 | C=C(C)c1ccc2c(Cc3cccc(C(=O)O)n3)c(-c3ccccc3)nn2c1 | 10.1016/j.bmcl.2017.07.055 | ||
73052094 | 156694 | 0 | None | - | 1 | Rat | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 402 | 4 | 1 | 6 | 4.4 | CC1=CCCN(c2nc3c(Cn4nc(C(=O)O)cc4C)cc(Cl)cc3s2)C1 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4076413 | 156694 | 0 | None | - | 1 | Rat | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 402 | 4 | 1 | 6 | 4.4 | CC1=CCCN(c2nc3c(Cn4nc(C(=O)O)cc4C)cc(Cl)cc3s2)C1 | 10.1016/j.bmc.2017.04.028 | ||
73052406 | 156909 | 0 | None | - | 1 | Rat | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 376 | 4 | 1 | 6 | 3.8 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2sc(N3CCCC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4079088 | 156909 | 0 | None | - | 1 | Rat | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 376 | 4 | 1 | 6 | 3.8 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2sc(N3CCCC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
137638600 | 156142 | 0 | None | - | 1 | Rat | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 380 | 5 | 1 | 5 | 4.2 | CCc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)nn12 | 10.1016/j.bmc.2017.03.003 | ||
CHEMBL4069759 | 156142 | 0 | None | - | 1 | Rat | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 380 | 5 | 1 | 5 | 4.2 | CCc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)nn12 | 10.1016/j.bmc.2017.03.003 | ||
137647406 | 157137 | 0 | None | - | 1 | Rat | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 400 | 4 | 1 | 5 | 4.3 | Cc1cc(C(=O)O)nn1Cc1cc(C(F)(F)F)cc2cc(-c3ccccc3)nn12 | 10.1016/j.bmc.2017.03.003 | ||
CHEMBL4081686 | 157137 | 0 | None | - | 1 | Rat | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 400 | 4 | 1 | 5 | 4.3 | Cc1cc(C(=O)O)nn1Cc1cc(C(F)(F)F)cc2cc(-c3ccccc3)nn12 | 10.1016/j.bmc.2017.03.003 | ||
73052247 | 159232 | 0 | None | - | 1 | Rat | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 383 | 4 | 1 | 5 | 4.9 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2sc(-c3ccccc3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4105272 | 159232 | 0 | None | - | 1 | Rat | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 383 | 4 | 1 | 5 | 4.9 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2sc(-c3ccccc3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
73052403 | 157737 | 0 | None | - | 1 | Rat | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 354 | 4 | 1 | 6 | 3.3 | Cc1cc(C(=O)O)nn1Cc1cccc2sc(N3CC=CCC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4088913 | 157737 | 0 | None | - | 1 | Rat | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 354 | 4 | 1 | 6 | 3.3 | Cc1cc(C(=O)O)nn1Cc1cccc2sc(N3CC=CCC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
69670810 | 127698 | 0 | None | - | 1 | Rat | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 375 | 5 | 1 | 3 | 5.2 | COc1ccc2c(c1)cc(-c1ccccc1F)n2Cc1cccc(C(=O)O)c1 | nan | ||
CHEMBL3665561 | 127698 | 0 | None | - | 1 | Rat | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 375 | 5 | 1 | 3 | 5.2 | COc1ccc2c(c1)cc(-c1ccccc1F)n2Cc1cccc(C(=O)O)c1 | nan | ||
69670851 | 127701 | 0 | None | - | 1 | Rat | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 410 | 5 | 1 | 4 | 5.3 | COc1cc2cc(-c3cccc(F)c3)n(Cc3cccc(C(=O)O)n3)c2cc1Cl | nan | ||
CHEMBL3665564 | 127701 | 0 | None | - | 1 | Rat | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 410 | 5 | 1 | 4 | 5.3 | COc1cc2cc(-c3cccc(F)c3)n(Cc3cccc(C(=O)O)n3)c2cc1Cl | nan | ||
137642337 | 157791 | 0 | None | - | 1 | Rat | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 362 | 4 | 1 | 6 | 3.4 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2sc(N3CCC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4089396 | 157791 | 0 | None | - | 1 | Rat | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 362 | 4 | 1 | 6 | 3.4 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2sc(N3CCC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
73052095 | 155488 | 0 | None | - | 1 | Rat | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 347 | 4 | 1 | 5 | 4.2 | C=C(C)c1nc2c(Cn3nc(C(=O)O)cc3C)cc(Cl)cc2s1 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4062313 | 155488 | 0 | None | - | 1 | Rat | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 347 | 4 | 1 | 5 | 4.2 | C=C(C)c1nc2c(Cn3nc(C(=O)O)cc3C)cc(Cl)cc2s1 | 10.1016/j.bmc.2017.04.028 | ||
69670895 | 127705 | 0 | None | - | 1 | Rat | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 394 | 5 | 1 | 4 | 4.7 | COc1cc2cc(-c3ccc(F)cc3)n(Cc3cccc(C(=O)O)n3)c2cc1F | nan | ||
CHEMBL3665568 | 127705 | 0 | None | - | 1 | Rat | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 394 | 5 | 1 | 4 | 4.7 | COc1cc2cc(-c3ccc(F)cc3)n(Cc3cccc(C(=O)O)n3)c2cc1F | nan | ||
50907866 | 127694 | 0 | None | - | 1 | Rat | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 365 | 5 | 1 | 4 | 4.8 | COc1ccc2c(c1)cc(-c1cccc(F)c1)n2Cc1ccc(C(=O)O)o1 | nan | ||
CHEMBL3665557 | 127694 | 0 | None | - | 1 | Rat | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 365 | 5 | 1 | 4 | 4.8 | COc1ccc2c(c1)cc(-c1cccc(F)c1)n2Cc1ccc(C(=O)O)o1 | nan | ||
69670960 | 127708 | 0 | None | - | 1 | Rat | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 361 | 5 | 1 | 4 | 5.0 | COc1cc2cc(-c3ccccc3)n(Cc3ccc(C(=O)O)o3)c2cc1C | nan | ||
CHEMBL3665571 | 127708 | 0 | None | - | 1 | Rat | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 361 | 5 | 1 | 4 | 5.0 | COc1cc2cc(-c3ccccc3)n(Cc3ccc(C(=O)O)o3)c2cc1C | nan | ||
69670950 | 127688 | 0 | None | - | 1 | Rat | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 363 | 5 | 1 | 4 | 5.1 | COc1ccc2c(c1)cc(-c1ccsc1)n2Cc1cccc(C(=O)O)c1 | nan | ||
CHEMBL3665551 | 127688 | 0 | None | - | 1 | Rat | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 363 | 5 | 1 | 4 | 5.1 | COc1ccc2c(c1)cc(-c1ccsc1)n2Cc1cccc(C(=O)O)c1 | nan | ||
69670882 | 127700 | 0 | None | - | 1 | Rat | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 375 | 5 | 1 | 3 | 5.2 | COc1ccc2c(c1)cc(-c1ccc(F)cc1)n2Cc1cccc(C(=O)O)c1 | nan | ||
CHEMBL3665563 | 127700 | 0 | None | - | 1 | Rat | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 375 | 5 | 1 | 3 | 5.2 | COc1ccc2c(c1)cc(-c1ccc(F)cc1)n2Cc1cccc(C(=O)O)c1 | nan | ||
137652966 | 158038 | 0 | None | - | 1 | Rat | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 358 | 5 | 1 | 5 | 3.9 | C=Cc1cc(Cn2nc(C(=O)O)cc2C)n2nc(-c3ccccc3)cc2c1 | 10.1016/j.bmc.2017.03.003 | ||
CHEMBL4091957 | 158038 | 0 | None | - | 1 | Rat | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 358 | 5 | 1 | 5 | 3.9 | C=Cc1cc(Cn2nc(C(=O)O)cc2C)n2nc(-c3ccccc3)cc2c1 | 10.1016/j.bmc.2017.03.003 | ||
73052560 | 158472 | 0 | None | - | 1 | Rat | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 384 | 5 | 1 | 7 | 3.3 | COc1cc(Cn2nc(C(=O)O)cc2C)c2nc(N3CC=CCC3)sc2c1 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4096603 | 158472 | 0 | None | - | 1 | Rat | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 384 | 5 | 1 | 7 | 3.3 | COc1cc(Cn2nc(C(=O)O)cc2C)c2nc(N3CC=CCC3)sc2c1 | 10.1016/j.bmc.2017.04.028 | ||
50907868 | 127711 | 0 | None | - | 1 | Rat | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 378 | 5 | 1 | 5 | 4.8 | COc1cc2cc(-c3ccsc3)n(Cc3cccc(C(=O)O)n3)c2cc1C | nan | ||
CHEMBL3665574 | 127711 | 0 | None | - | 1 | Rat | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 378 | 5 | 1 | 5 | 4.8 | COc1cc2cc(-c3ccsc3)n(Cc3cccc(C(=O)O)n3)c2cc1C | nan | ||
69671242 | 127696 | 0 | None | - | 1 | Rat | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 358 | 5 | 1 | 4 | 4.5 | COc1ccc2c(c1)cc(-c1cccnc1)n2Cc1cccc(C(=O)O)c1 | nan | ||
CHEMBL3665559 | 127696 | 0 | None | - | 1 | Rat | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 358 | 5 | 1 | 4 | 4.5 | COc1ccc2c(c1)cc(-c1cccnc1)n2Cc1cccc(C(=O)O)c1 | nan | ||
5311234 | 114641 | 19 | None | -19 | 4 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 390 | 11 | 4 | 5 | 2.5 | O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)COc1ccccc1 | 10.1021/jm010264b | ||
CHEMBL334398 | 114641 | 19 | None | -19 | 4 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 390 | 11 | 4 | 5 | 2.5 | O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)COc1ccccc1 | 10.1021/jm010264b | ||
86704854 | 156474 | 0 | None | - | 1 | Rat | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 347 | 4 | 1 | 4 | 3.8 | O=C(O)c1cccc(Cc2c(-c3ccccc3)nn3cc(F)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4073415 | 156474 | 0 | None | - | 1 | Rat | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 347 | 4 | 1 | 4 | 3.8 | O=C(O)c1cccc(Cc2c(-c3ccccc3)nn3cc(F)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
69670955 | 127697 | 0 | None | - | 1 | Rat | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 372 | 5 | 1 | 4 | 4.8 | COc1cc2cc(-c3ccccc3)n(Cc3cccc(C(=O)O)n3)c2cc1C | nan | ||
CHEMBL3665560 | 127697 | 0 | None | - | 1 | Rat | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 372 | 5 | 1 | 4 | 4.8 | COc1cc2cc(-c3ccccc3)n(Cc3cccc(C(=O)O)n3)c2cc1C | nan | ||
68259032 | 160816 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 377 | 4 | 1 | 7 | 3.5 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3ccc(N4CCC4)nc32)n1 | 10.1016/j.bmcl.2018.06.022 | ||
CHEMBL4126096 | 160816 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 377 | 4 | 1 | 7 | 3.5 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3ccc(N4CCC4)nc32)n1 | 10.1016/j.bmcl.2018.06.022 | ||
59179305 | 103408 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 359 | 3 | 1 | 5 | 4.3 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3c2-c2ccccc2C3)n1 | 10.1016/j.bmcl.2013.10.065 | ||
CHEMBL3092131 | 103408 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 359 | 3 | 1 | 5 | 4.3 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3c2-c2ccccc2C3)n1 | 10.1016/j.bmcl.2013.10.065 | ||
137645257 | 157091 | 0 | None | - | 1 | Rat | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 396 | 5 | 1 | 6 | 3.9 | COc1ccc(-c2cc3cc(Cl)cc(Cn4nc(C(=O)O)cc4C)n3n2)cc1 | 10.1016/j.bmc.2017.03.003 | ||
CHEMBL4081279 | 157091 | 0 | None | - | 1 | Rat | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 396 | 5 | 1 | 6 | 3.9 | COc1ccc(-c2cc3cc(Cl)cc(Cn4nc(C(=O)O)cc4C)n3n2)cc1 | 10.1016/j.bmc.2017.03.003 | ||
137644454 | 157767 | 0 | None | - | 1 | Rat | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 358 | 4 | 1 | 5 | 3.9 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(C3CCCC3)nn12 | 10.1016/j.bmc.2017.03.003 | ||
CHEMBL4089147 | 157767 | 0 | None | - | 1 | Rat | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 358 | 4 | 1 | 5 | 3.9 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(C3CCCC3)nn12 | 10.1016/j.bmc.2017.03.003 | ||
137658953 | 158509 | 0 | None | - | 1 | Rat | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 440 | 4 | 1 | 8 | 2.4 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2sc(N3CCS(=O)(=O)CC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4097022 | 158509 | 0 | None | - | 1 | Rat | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 440 | 4 | 1 | 8 | 2.4 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2sc(N3CCS(=O)(=O)CC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
73052404 | 158512 | 0 | None | - | 1 | Rat | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 390 | 4 | 1 | 6 | 4.2 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2sc(N3CCCCC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4097108 | 158512 | 0 | None | - | 1 | Rat | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 390 | 4 | 1 | 6 | 4.2 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2sc(N3CCCCC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
137660170 | 158561 | 0 | None | - | 1 | Rat | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 389 | 4 | 1 | 5 | 5.2 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2sc(C3CCCCC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4097566 | 158561 | 0 | None | - | 1 | Rat | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 389 | 4 | 1 | 5 | 5.2 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2sc(C3CCCCC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
86704841 | 159148 | 0 | None | - | 1 | Rat | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 354 | 4 | 1 | 5 | 3.6 | N#Cc1ccc2c(Cc3cccc(C(=O)O)n3)c(-c3ccccc3)nn2c1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4104259 | 159148 | 0 | None | - | 1 | Rat | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 354 | 4 | 1 | 5 | 3.6 | N#Cc1ccc2c(Cc3cccc(C(=O)O)n3)c(-c3ccccc3)nn2c1 | 10.1016/j.bmcl.2017.07.055 | ||
137653807 | 158328 | 0 | None | - | 1 | Rat | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 346 | 4 | 1 | 5 | 3.6 | Cc1cc(Cn2nc(C(=O)O)cc2C)n2nc(-c3ccccc3)cc2c1 | 10.1016/j.bmc.2017.03.003 | ||
CHEMBL4095087 | 158328 | 0 | None | - | 1 | Rat | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 346 | 4 | 1 | 5 | 3.6 | Cc1cc(Cn2nc(C(=O)O)cc2C)n2nc(-c3ccccc3)cc2c1 | 10.1016/j.bmc.2017.03.003 | ||
68184174 | 156019 | 0 | None | - | 1 | Rat | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 360 | 5 | 1 | 6 | 3.1 | COc1ccc2c(Cc3cncc(C(=O)O)n3)c(-c3ccccc3)nn2c1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4068383 | 156019 | 0 | None | - | 1 | Rat | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 360 | 5 | 1 | 6 | 3.1 | COc1ccc2c(Cc3cncc(C(=O)O)n3)c(-c3ccccc3)nn2c1 | 10.1016/j.bmcl.2017.07.055 | ||
137661287 | 158952 | 0 | None | - | 1 | Rat | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 336 | 4 | 2 | 6 | 3.2 | CNc1nc2c(Cn3nc(C(=O)O)cc3C)cc(Cl)cc2s1 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4101880 | 158952 | 0 | None | - | 1 | Rat | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 336 | 4 | 2 | 6 | 3.2 | CNc1nc2c(Cn3nc(C(=O)O)cc3C)cc(Cl)cc2s1 | 10.1016/j.bmc.2017.04.028 | ||
60151420 | 156134 | 0 | None | - | 1 | Rat | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 343 | 3 | 1 | 4 | 4.0 | CC(C)(C)c1nn2cc(Cl)ccc2c1Cc1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4069600 | 156134 | 0 | None | - | 1 | Rat | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 343 | 3 | 1 | 4 | 4.0 | CC(C)(C)c1nn2cc(Cl)ccc2c1Cc1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2017.07.055 | ||
68184172 | 156097 | 0 | None | - | 1 | Rat | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 397 | 4 | 1 | 4 | 5.0 | O=C(O)c1cccc(Cc2c(-c3cccc(Cl)c3)nn3cc(Cl)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4069239 | 156097 | 0 | None | - | 1 | Rat | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 397 | 4 | 1 | 4 | 5.0 | O=C(O)c1cccc(Cc2c(-c3cccc(Cl)c3)nn3cc(Cl)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
137646866 | 157030 | 0 | None | - | 1 | Rat | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 405 | 4 | 1 | 7 | 3.0 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2sc(N3CCN(C)CC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4080521 | 157030 | 0 | None | - | 1 | Rat | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 405 | 4 | 1 | 7 | 3.0 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2sc(N3CCN(C)CC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
46220498 | 92642 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 361 | 4 | 1 | 5 | 4.7 | Cc1c(-c2ccccc2)nn(-c2nc(C(=O)O)cs2)c1-c1ccccc1 | 10.1016/j.bmcl.2013.09.032 | ||
CHEMBL2442495 | 92642 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 361 | 4 | 1 | 5 | 4.7 | Cc1c(-c2ccccc2)nn(-c2nc(C(=O)O)cs2)c1-c1ccccc1 | 10.1016/j.bmcl.2013.09.032 | ||
46220498 | 92642 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 361 | 4 | 1 | 5 | 4.7 | Cc1c(-c2ccccc2)nn(-c2nc(C(=O)O)cs2)c1-c1ccccc1 | 10.1016/j.bmcl.2013.10.065 | ||
CHEMBL2442495 | 92642 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 361 | 4 | 1 | 5 | 4.7 | Cc1c(-c2ccccc2)nn(-c2nc(C(=O)O)cs2)c1-c1ccccc1 | 10.1016/j.bmcl.2013.10.065 | ||
137650623 | 156961 | 0 | None | - | 1 | Rat | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 374 | 4 | 1 | 6 | 3.7 | O=C(O)c1ccn(Cc2cc(Cl)cc3sc(N4CC=CCC4)nc23)n1 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4079668 | 156961 | 0 | None | - | 1 | Rat | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 374 | 4 | 1 | 6 | 3.7 | O=C(O)c1ccn(Cc2cc(Cl)cc3sc(N4CC=CCC4)nc23)n1 | 10.1016/j.bmc.2017.04.028 | ||
50907870 | 127714 | 0 | None | - | 1 | Rat | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 372 | 6 | 1 | 4 | 5.0 | CCC(C)c1cc2cc(OC)c(Cl)cc2n1Cc1cccc(C(=O)O)n1 | nan | ||
CHEMBL3665577 | 127714 | 0 | None | - | 1 | Rat | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 372 | 6 | 1 | 4 | 5.0 | CCC(C)c1cc2cc(OC)c(Cl)cc2n1Cc1cccc(C(=O)O)n1 | nan | ||
137643527 | 157874 | 0 | None | - | 1 | Rat | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 416 | 4 | 1 | 6 | 4.7 | CC1=C(C)CN(c2nc3c(Cn4nc(C(=O)O)cc4C)cc(Cl)cc3s2)CC1 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4090279 | 157874 | 0 | None | - | 1 | Rat | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 416 | 4 | 1 | 6 | 4.7 | CC1=C(C)CN(c2nc3c(Cn4nc(C(=O)O)cc4C)cc(Cl)cc3s2)CC1 | 10.1016/j.bmc.2017.04.028 | ||
69670943 | 127707 | 0 | None | - | 1 | Rat | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 398 | 5 | 1 | 5 | 5.2 | COc1cc2cc(-c3ccsc3)n(Cc3cccc(C(=O)O)n3)c2cc1Cl | nan | ||
CHEMBL3665570 | 127707 | 0 | None | - | 1 | Rat | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 398 | 5 | 1 | 5 | 5.2 | COc1cc2cc(-c3ccsc3)n(Cc3cccc(C(=O)O)n3)c2cc1Cl | nan | ||
137637918 | 155716 | 0 | None | - | 1 | Rat | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 366 | 4 | 1 | 5 | 3.9 | Cc1cc(C(=O)O)nn1Cc1c(Cl)ccc2cc(-c3ccccc3)nn12 | 10.1016/j.bmc.2017.03.003 | ||
CHEMBL4064961 | 155716 | 0 | None | - | 1 | Rat | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 366 | 4 | 1 | 5 | 3.9 | Cc1cc(C(=O)O)nn1Cc1c(Cl)ccc2cc(-c3ccccc3)nn12 | 10.1016/j.bmc.2017.03.003 | ||
137642895 | 157536 | 0 | None | - | 1 | Rat | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 407 | 5 | 1 | 6 | 3.1 | CS(=O)(=O)c1ccc2c(Cc3cccc(C(=O)O)n3)c(-c3ccccc3)nn2c1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4086353 | 157536 | 0 | None | - | 1 | Rat | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 407 | 5 | 1 | 6 | 3.1 | CS(=O)(=O)c1ccc2c(Cc3cccc(C(=O)O)n3)c(-c3ccccc3)nn2c1 | 10.1016/j.bmcl.2017.07.055 | ||
123163794 | 157650 | 0 | None | - | 1 | Rat | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 393 | 5 | 1 | 5 | 4.3 | COc1ccc(-c2nn3cc(Cl)ccc3c2Cc2cccc(C(=O)O)n2)cc1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4087854 | 157650 | 0 | None | - | 1 | Rat | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 393 | 5 | 1 | 5 | 4.3 | COc1ccc(-c2nn3cc(Cl)ccc3c2Cc2cccc(C(=O)O)n2)cc1 | 10.1016/j.bmcl.2017.07.055 | ||
50907867 | 127695 | 0 | None | - | 1 | Rat | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 364 | 5 | 1 | 5 | 4.5 | COc1ccc2c(c1)cc(-c1ccccc1)n2Cc1csc(C(=O)O)n1 | nan | ||
CHEMBL3665558 | 127695 | 0 | None | - | 1 | Rat | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 364 | 5 | 1 | 5 | 4.5 | COc1ccc2c(c1)cc(-c1ccccc1)n2Cc1csc(C(=O)O)n1 | nan | ||
69670812 | 127706 | 0 | None | - | 1 | Rat | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 377 | 5 | 1 | 5 | 4.0 | COc1cc2cc(-c3cccnc3)n(Cc3cccc(C(=O)O)n3)c2cc1F | nan | ||
CHEMBL3665569 | 127706 | 0 | None | - | 1 | Rat | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 377 | 5 | 1 | 5 | 4.0 | COc1cc2cc(-c3cccnc3)n(Cc3cccc(C(=O)O)n3)c2cc1F | nan | ||
1498200 | 92635 | 8 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 369 | 4 | 1 | 6 | 3.7 | COc1ccc(-c2cc(C(F)(F)F)nn2-c2nc(C(=O)O)cs2)cc1 | 10.1016/j.bmcl.2013.09.032 | ||
CHEMBL2442485 | 92635 | 8 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 369 | 4 | 1 | 6 | 3.7 | COc1ccc(-c2cc(C(F)(F)F)nn2-c2nc(C(=O)O)cs2)cc1 | 10.1016/j.bmcl.2013.09.032 | ||
60151149 | 159223 | 0 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 359 | 5 | 1 | 5 | 3.7 | COc1ccc2c(Cc3cccc(C(=O)O)n3)c(-c3ccccc3)nn2c1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4105205 | 159223 | 0 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 359 | 5 | 1 | 5 | 3.7 | COc1ccc2c(Cc3cccc(C(=O)O)n3)c(-c3ccccc3)nn2c1 | 10.1016/j.bmcl.2017.07.055 | ||
73052093 | 157121 | 0 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 378 | 6 | 1 | 6 | 4.0 | CCN(CC)c1nc2c(Cn3nc(C(=O)O)cc3C)cc(Cl)cc2s1 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4081524 | 157121 | 0 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 378 | 6 | 1 | 6 | 4.0 | CCN(CC)c1nc2c(Cn3nc(C(=O)O)cc3C)cc(Cl)cc2s1 | 10.1016/j.bmc.2017.04.028 | ||
73052565 | 156572 | 0 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 392 | 4 | 1 | 6 | 5.2 | O=C(O)c1ccc(Sc2cc(Cl)cc3sc(N4CC=CCC4)nc23)o1 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4074797 | 156572 | 0 | None | - | 1 | Rat | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 392 | 4 | 1 | 6 | 5.2 | O=C(O)c1ccc(Sc2cc(Cl)cc3sc(N4CC=CCC4)nc23)o1 | 10.1016/j.bmc.2017.04.028 | ||
137632435 | 155832 | 0 | None | - | 1 | Rat | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 374 | 4 | 1 | 5 | 4.6 | O=C(O)c1ccc(Cc2cc(Cl)cc3sc(N4CC=CCC4)nc23)o1 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4066183 | 155832 | 0 | None | - | 1 | Rat | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 374 | 4 | 1 | 5 | 4.6 | O=C(O)c1ccc(Cc2cc(Cl)cc3sc(N4CC=CCC4)nc23)o1 | 10.1016/j.bmc.2017.04.028 | ||
60151284 | 156356 | 0 | None | - | 1 | Rat | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 348 | 5 | 1 | 5 | 3.9 | COc1ccc2c(Cc3ccc(C(=O)O)o3)c(-c3ccccc3)nn2c1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4072169 | 156356 | 0 | None | - | 1 | Rat | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 348 | 5 | 1 | 5 | 3.9 | COc1ccc2c(Cc3ccc(C(=O)O)o3)c(-c3ccccc3)nn2c1 | 10.1016/j.bmcl.2017.07.055 | ||
59179260 | 103407 | 0 | None | 5 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 362 | 4 | 2 | 6 | 3.9 | Nc1c(-c2ccccc2)nn(-c2nc(C(=O)O)cs2)c1-c1ccccc1 | 10.1016/j.bmcl.2013.10.065 | ||
CHEMBL3092130 | 103407 | 0 | None | 5 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 362 | 4 | 2 | 6 | 3.9 | Nc1c(-c2ccccc2)nn(-c2nc(C(=O)O)cs2)c1-c1ccccc1 | 10.1016/j.bmcl.2013.10.065 | ||
137658582 | 158756 | 0 | None | - | 1 | Rat | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 374 | 5 | 1 | 6 | 3.5 | CC(=O)c1cc(Cn2nc(C(=O)O)cc2C)n2nc(-c3ccccc3)cc2c1 | 10.1016/j.bmc.2017.03.003 | ||
CHEMBL4099699 | 158756 | 0 | None | - | 1 | Rat | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 374 | 5 | 1 | 6 | 3.5 | CC(=O)c1cc(Cn2nc(C(=O)O)cc2C)n2nc(-c3ccccc3)cc2c1 | 10.1016/j.bmc.2017.03.003 | ||
73052405 | 157786 | 0 | None | - | 1 | Rat | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 392 | 4 | 1 | 7 | 3.0 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2sc(N3CCOCC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4089322 | 157786 | 0 | None | - | 1 | Rat | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 392 | 4 | 1 | 7 | 3.0 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2sc(N3CCOCC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
73052559 | 155560 | 0 | None | - | 1 | Rat | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 402 | 4 | 1 | 6 | 4.4 | CC1=CCN(c2nc3c(Cn4nc(C(=O)O)cc4C)cc(Cl)cc3s2)CC1 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4063118 | 155560 | 0 | None | - | 1 | Rat | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 402 | 4 | 1 | 6 | 4.4 | CC1=CCN(c2nc3c(Cn4nc(C(=O)O)cc4C)cc(Cl)cc3s2)CC1 | 10.1016/j.bmc.2017.04.028 | ||
123578350 | 156607 | 0 | None | - | 1 | Rat | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 397 | 4 | 1 | 4 | 5.0 | O=C(O)c1cccc(Cc2c(-c3ccccc3Cl)nn3cc(Cl)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4075209 | 156607 | 0 | None | - | 1 | Rat | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 397 | 4 | 1 | 4 | 5.0 | O=C(O)c1cccc(Cc2c(-c3ccccc3Cl)nn3cc(Cl)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
73052408 | 156147 | 0 | None | - | 1 | Rat | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 408 | 4 | 1 | 7 | 3.8 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2sc(N3CCSCC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4069825 | 156147 | 0 | None | - | 1 | Rat | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 408 | 4 | 1 | 7 | 3.8 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2sc(N3CCSCC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
69671038 | 127693 | 0 | None | - | 1 | Rat | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 392 | 5 | 1 | 4 | 5.1 | COc1cc2cc(-c3ccccc3)n(Cc3cccc(C(=O)O)n3)c2cc1Cl | nan | ||
CHEMBL3665556 | 127693 | 0 | None | - | 1 | Rat | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 392 | 5 | 1 | 4 | 5.1 | COc1cc2cc(-c3ccccc3)n(Cc3cccc(C(=O)O)n3)c2cc1Cl | nan | ||
44568186 | 12477 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 488 | 10 | 2 | 5 | 5.8 | CCNCc1ccc(NC(=O)c2cc(C)n(Cc3cc(Cl)ccc3OCc3ccccc3)n2)cc1 | 10.1016/j.bmc.2022.116614 | ||
CHEMBL1186853 | 12477 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 488 | 10 | 2 | 5 | 5.8 | CCNCc1ccc(NC(=O)c2cc(C)n(Cc3cc(Cl)ccc3OCc3ccccc3)n2)cc1 | 10.1016/j.bmc.2022.116614 | ||
CHEMBL480790 | 12477 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 488 | 10 | 2 | 5 | 5.8 | CCNCc1ccc(NC(=O)c2cc(C)n(Cc3cc(Cl)ccc3OCc3ccccc3)n2)cc1 | 10.1016/j.bmc.2022.116614 | ||
72950602 | 155386 | 0 | None | - | 1 | Rat | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 372 | 4 | 1 | 5 | 4.3 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(C3CCCCC3)nn12 | 10.1016/j.bmc.2017.03.003 | ||
CHEMBL4060959 | 155386 | 0 | None | - | 1 | Rat | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 372 | 4 | 1 | 5 | 4.3 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(C3CCCCC3)nn12 | 10.1016/j.bmc.2017.03.003 | ||
86704880 | 156606 | 0 | None | - | 1 | Rat | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 372 | 4 | 1 | 6 | 2.5 | O=C(O)c1cccc(Cc2c(N3CCOCC3)nn3cc(Cl)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4075206 | 156606 | 0 | None | - | 1 | Rat | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 372 | 4 | 1 | 6 | 2.5 | O=C(O)c1cccc(Cc2c(N3CCOCC3)nn3cc(Cl)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
44448598 | 155096 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 431 | 7 | 1 | 4 | 5.7 | Cc1cc(C(=O)Nc2ccccc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmc.2022.116614 | ||
CHEMBL404698 | 155096 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 431 | 7 | 1 | 4 | 5.7 | Cc1cc(C(=O)Nc2ccccc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmc.2022.116614 | ||
137644912 | 157736 | 0 | None | - | 1 | Rat | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 367 | 4 | 1 | 5 | 4.4 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2nc(-c3ccccc3)oc12 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4088911 | 157736 | 0 | None | - | 1 | Rat | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 367 | 4 | 1 | 5 | 4.4 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2nc(-c3ccccc3)oc12 | 10.1016/j.bmc.2017.04.028 | ||
137652358 | 156798 | 0 | None | - | 1 | Rat | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 369 | 4 | 2 | 7 | 2.9 | Cc1cc(C(=O)O)nn1Cc1cc(N)cc2sc(N3CC=CCC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4077663 | 156798 | 0 | None | - | 1 | Rat | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 369 | 4 | 2 | 7 | 2.9 | Cc1cc(C(=O)O)nn1Cc1cc(N)cc2sc(N3CC=CCC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
60151421 | 155744 | 0 | None | - | 1 | Rat | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 370 | 4 | 1 | 5 | 3.7 | O=C(O)c1cccc(Cc2c(N3CCCCC3)nn3cc(Cl)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4065274 | 155744 | 0 | None | - | 1 | Rat | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 370 | 4 | 1 | 5 | 3.7 | O=C(O)c1cccc(Cc2c(N3CCCCC3)nn3cc(Cl)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
137655484 | 158428 | 0 | None | - | 1 | Rat | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 398 | 5 | 2 | 7 | 3.0 | Cc1cc(C(=O)O)nn1Cc1cc(C(=O)O)cc2sc(N3CC=CCC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4096167 | 158428 | 0 | None | - | 1 | Rat | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 398 | 5 | 2 | 7 | 3.0 | Cc1cc(C(=O)O)nn1Cc1cc(C(=O)O)cc2sc(N3CC=CCC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
137650219 | 156702 | 0 | None | - | 1 | Rat | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 383 | 4 | 1 | 5 | 4.9 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2nc(-c3ccccc3)sc12 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4076480 | 156702 | 0 | None | - | 1 | Rat | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 383 | 4 | 1 | 5 | 4.9 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2nc(-c3ccccc3)sc12 | 10.1016/j.bmc.2017.04.028 | ||
60151147 | 158804 | 0 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 363 | 4 | 1 | 4 | 4.3 | O=C(O)c1cccc(Cc2c(-c3ccccc3)nn3cc(Cl)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4100262 | 158804 | 0 | None | - | 1 | Rat | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 363 | 4 | 1 | 4 | 4.3 | O=C(O)c1cccc(Cc2c(-c3ccccc3)nn3cc(Cl)ccc23)n1 | 10.1016/j.bmcl.2017.07.055 | ||
1498314 | 92640 | 9 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 355 | 3 | 2 | 6 | 3.4 | O=C(O)c1csc(-n2nc(-c3ccccc3O)cc2C(F)(F)F)n1 | 10.1016/j.bmcl.2013.09.032 | ||
CHEMBL2442490 | 92640 | 9 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 355 | 3 | 2 | 6 | 3.4 | O=C(O)c1csc(-n2nc(-c3ccccc3O)cc2C(F)(F)F)n1 | 10.1016/j.bmcl.2013.09.032 | ||
123512315 | 156204 | 0 | None | - | 1 | Rat | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 393 | 5 | 1 | 5 | 4.3 | COc1cccc(-c2nn3cc(Cl)ccc3c2Cc2cccc(C(=O)O)n2)c1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4070541 | 156204 | 0 | None | - | 1 | Rat | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 393 | 5 | 1 | 5 | 4.3 | COc1cccc(-c2nn3cc(Cl)ccc3c2Cc2cccc(C(=O)O)n2)c1 | 10.1016/j.bmcl.2017.07.055 | ||
137643688 | 157712 | 0 | None | - | 1 | Rat | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 396 | 5 | 1 | 6 | 3.9 | COc1ccccc1-c1cc2cc(Cl)cc(Cn3nc(C(=O)O)cc3C)n2n1 | 10.1016/j.bmc.2017.03.003 | ||
CHEMBL4088628 | 157712 | 0 | None | - | 1 | Rat | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 396 | 5 | 1 | 6 | 3.9 | COc1ccccc1-c1cc2cc(Cl)cc(Cn3nc(C(=O)O)cc3C)n2n1 | 10.1016/j.bmc.2017.03.003 | ||
137646417 | 157070 | 0 | None | - | 1 | Rat | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 367 | 4 | 1 | 5 | 4.4 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2oc(-c3ccccc3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4081019 | 157070 | 0 | None | - | 1 | Rat | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 367 | 4 | 1 | 5 | 4.4 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2oc(-c3ccccc3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
60151419 | 157064 | 0 | None | - | 1 | Rat | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 375 | 5 | 1 | 5 | 4.4 | CSc1ccc2c(Cc3cccc(C(=O)O)n3)c(-c3ccccc3)nn2c1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4080957 | 157064 | 0 | None | - | 1 | Rat | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 375 | 5 | 1 | 5 | 4.4 | CSc1ccc2c(Cc3cccc(C(=O)O)n3)c(-c3ccccc3)nn2c1 | 10.1016/j.bmcl.2017.07.055 | ||
137652680 | 158384 | 0 | None | - | 1 | Rat | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 383 | 5 | 2 | 7 | 3.4 | CNc1cc(Cn2nc(C(=O)O)cc2C)c2nc(N3CC=CCC3)sc2c1 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4095679 | 158384 | 0 | None | - | 1 | Rat | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 383 | 5 | 2 | 7 | 3.4 | CNc1cc(Cn2nc(C(=O)O)cc2C)c2nc(N3CC=CCC3)sc2c1 | 10.1016/j.bmc.2017.04.028 | ||
72950604 | 155894 | 0 | None | - | 1 | Rat | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 352 | 4 | 1 | 5 | 3.6 | O=C(O)c1ccn(Cc2cc(Cl)cc3cc(-c4ccccc4)nn23)n1 | 10.1016/j.bmc.2017.03.003 | ||
CHEMBL4066926 | 155894 | 0 | None | - | 1 | Rat | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 352 | 4 | 1 | 5 | 3.6 | O=C(O)c1ccn(Cc2cc(Cl)cc3cc(-c4ccccc4)nn23)n1 | 10.1016/j.bmc.2017.03.003 | ||
69670901 | 123909 | 0 | None | - | 1 | Rat | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 341 | 4 | 1 | 2 | 5.4 | Cc1ccc2c(c1)cc(-c1ccccc1)n2Cc1cccc(C(=O)O)c1 | nan | ||
CHEMBL3639644 | 123909 | 0 | None | - | 1 | Rat | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 341 | 4 | 1 | 2 | 5.4 | Cc1ccc2c(c1)cc(-c1ccccc1)n2Cc1cccc(C(=O)O)c1 | nan | ||
72722417 | 155706 | 0 | None | - | 1 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 366 | 4 | 1 | 5 | 3.9 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)nn12 | 10.1016/j.bmc.2017.03.003 | ||
CHEMBL4064816 | 155706 | 0 | None | - | 1 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 366 | 4 | 1 | 5 | 3.9 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)nn12 | 10.1016/j.bmc.2017.03.003 | ||
72722417 | 155706 | 0 | None | - | 1 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 366 | 4 | 1 | 5 | 3.9 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)nn12 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4064816 | 155706 | 0 | None | - | 1 | Rat | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 366 | 4 | 1 | 5 | 3.9 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)nn12 | 10.1016/j.bmc.2017.04.028 | ||
73052244 | 159154 | 0 | None | - | 1 | Rat | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 380 | 5 | 1 | 6 | 4.0 | C=Cc1cc(Cn2nc(C(=O)O)cc2C)c2nc(N3CC=CCC3)sc2c1 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4104333 | 159154 | 0 | None | - | 1 | Rat | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 380 | 5 | 1 | 6 | 4.0 | C=Cc1cc(Cn2nc(C(=O)O)cc2C)c2nc(N3CC=CCC3)sc2c1 | 10.1016/j.bmc.2017.04.028 | ||
86704834 | 158464 | 0 | None | - | 1 | Rat | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 359 | 5 | 1 | 5 | 3.7 | COc1ccn2nc(-c3ccccc3)c(Cc3cccc(C(=O)O)n3)c2c1 | 10.1016/j.bmcl.2017.07.055 | ||
CHEMBL4096532 | 158464 | 0 | None | - | 1 | Rat | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 359 | 5 | 1 | 5 | 3.7 | COc1ccn2nc(-c3ccccc3)c(Cc3cccc(C(=O)O)n3)c2c1 | 10.1016/j.bmcl.2017.07.055 | ||
137658360 | 159032 | 0 | None | - | 1 | Rat | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 362 | 5 | 1 | 6 | 3.3 | COc1cc(Cn2nc(C(=O)O)cc2C)n2nc(-c3ccccc3)cc2c1 | 10.1016/j.bmc.2017.03.003 | ||
CHEMBL4102847 | 159032 | 0 | None | - | 1 | Rat | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 362 | 5 | 1 | 6 | 3.3 | COc1cc(Cn2nc(C(=O)O)cc2C)n2nc(-c3ccccc3)cc2c1 | 10.1016/j.bmc.2017.03.003 | ||
72950605 | 158506 | 0 | None | - | 1 | Rat | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 394 | 6 | 1 | 5 | 4.6 | CCCc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)nn12 | 10.1016/j.bmc.2017.03.003 | ||
CHEMBL4096952 | 158506 | 0 | None | - | 1 | Rat | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 394 | 6 | 1 | 5 | 4.6 | CCCc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)nn12 | 10.1016/j.bmc.2017.03.003 | ||
73052250 | 156112 | 0 | None | - | 1 | Rat | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 438 | 5 | 1 | 7 | 4.2 | Cc1cc(C(=O)O)nn1Cc1cc(OC(F)(F)F)cc2sc(N3CC=CCC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
CHEMBL4069371 | 156112 | 0 | None | - | 1 | Rat | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 438 | 5 | 1 | 7 | 4.2 | Cc1cc(C(=O)O)nn1Cc1cc(OC(F)(F)F)cc2sc(N3CC=CCC3)nc12 | 10.1016/j.bmc.2017.04.028 | ||
10238338 | 1870 | 23 | None | - | 1 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 441 | 6 | 1 | 3 | 6.4 | Clc1ccc(c(c1)C1=C(CCC1)c1cccc(n1)C(=O)O)OCc1ccc(cc1F)F | 10.1016/j.bmcl.2006.10.041 | ||
3360 | 1870 | 23 | None | - | 1 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 441 | 6 | 1 | 3 | 6.4 | Clc1ccc(c(c1)C1=C(CCC1)c1cccc(n1)C(=O)O)OCc1ccc(cc1F)F | 10.1016/j.bmcl.2006.10.041 | ||
CHEMBL234940 | 1870 | 23 | None | - | 1 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 441 | 6 | 1 | 3 | 6.4 | Clc1ccc(c(c1)C1=C(CCC1)c1cccc(n1)C(=O)O)OCc1ccc(cc1F)F | 10.1016/j.bmcl.2006.10.041 | ||
71519478 | 86081 | 0 | None | - | 0 | Mouse | 5.9 | pKd | = | 5.9 | Functional | ChEMBL | 460 | 8 | 1 | 3 | 6.2 | CCC(C)NC(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
CHEMBL2315050 | 86081 | 0 | None | - | 0 | Mouse | 5.9 | pKd | = | 5.9 | Functional | ChEMBL | 460 | 8 | 1 | 3 | 6.2 | CCC(C)NC(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
71519478 | 86081 | 0 | None | - | 0 | Mouse | 5.9 | pKd | = | 5.9 | Functional | ChEMBL | 460 | 8 | 1 | 3 | 6.2 | CCC(C)NC(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
CHEMBL2315050 | 86081 | 0 | None | - | 0 | Mouse | 5.9 | pKd | = | 5.9 | Functional | ChEMBL | 460 | 8 | 1 | 3 | 6.2 | CCC(C)NC(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
71519328 | 86078 | 0 | None | - | 0 | Mouse | 4.8 | pKd | = | 4.8 | Functional | ChEMBL | 458 | 6 | 0 | 3 | 5.9 | O=C(c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1)N1CCCC1 | 10.1016/j.bmcl.2012.11.046 | ||
CHEMBL2315047 | 86078 | 0 | None | - | 0 | Mouse | 4.8 | pKd | = | 4.8 | Functional | ChEMBL | 458 | 6 | 0 | 3 | 5.9 | O=C(c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1)N1CCCC1 | 10.1016/j.bmcl.2012.11.046 | ||
128069 | 48278 | 5 | None | - | 0 | Human | 5.8 | pKd | = | 5.8 | Functional | ChEMBL | 437 | 4 | 2 | 5 | 3.0 | CCS(=O)(=O)CCC(=O)NNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21 | 10.1021/jm950454k | ||
CHEMBL155667 | 48278 | 5 | None | - | 0 | Human | 5.8 | pKd | = | 5.8 | Functional | ChEMBL | 437 | 4 | 2 | 5 | 3.0 | CCS(=O)(=O)CCC(=O)NNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21 | 10.1021/jm950454k | ||
71519328 | 86078 | 0 | None | - | 0 | Mouse | 4.8 | pKd | = | 4.8 | Functional | ChEMBL | 458 | 6 | 0 | 3 | 5.9 | O=C(c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1)N1CCCC1 | 10.1016/j.bmcl.2012.11.046 | ||
CHEMBL2315047 | 86078 | 0 | None | - | 0 | Mouse | 4.8 | pKd | = | 4.8 | Functional | ChEMBL | 458 | 6 | 0 | 3 | 5.9 | O=C(c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1)N1CCCC1 | 10.1016/j.bmcl.2012.11.046 | ||
10669894 | 119201 | 0 | None | - | 0 | Human | 5.7 | pKd | = | 5.7 | Functional | ChEMBL | 421 | 5 | 1 | 4 | 4.1 | O=C(CCc1ccncc1)NCC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21 | 10.1021/jm950454k | ||
CHEMBL347397 | 119201 | 0 | None | - | 0 | Human | 5.7 | pKd | = | 5.7 | Functional | ChEMBL | 421 | 5 | 1 | 4 | 4.1 | O=C(CCc1ccncc1)NCC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21 | 10.1021/jm950454k | ||
9845906 | 119274 | 0 | None | - | 0 | Human | 5.7 | pKd | = | 5.7 | Functional | ChEMBL | 436 | 6 | 1 | 5 | 2.9 | CCS(=O)(=O)CCC(=O)NCC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21 | 10.1021/jm950454k | ||
CHEMBL348061 | 119274 | 0 | None | - | 0 | Human | 5.7 | pKd | = | 5.7 | Functional | ChEMBL | 436 | 6 | 1 | 5 | 2.9 | CCS(=O)(=O)CCC(=O)NCC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21 | 10.1021/jm950454k | ||
71517031 | 86088 | 0 | None | - | 0 | Mouse | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 558 | 8 | 1 | 5 | 6.1 | Cc1ccc(S(=O)(=O)NC(=O)c2cccc(Cc3cc(Cl)ccc3OCc3ccc(Cl)cc3F)n2)cc1 | 10.1016/j.bmcl.2012.11.046 | ||
CHEMBL2315057 | 86088 | 0 | None | - | 0 | Mouse | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 558 | 8 | 1 | 5 | 6.1 | Cc1ccc(S(=O)(=O)NC(=O)c2cccc(Cc3cc(Cl)ccc3OCc3ccc(Cl)cc3F)n2)cc1 | 10.1016/j.bmcl.2012.11.046 | ||
71517032 | 86089 | 0 | None | - | 0 | Mouse | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 612 | 8 | 1 | 5 | 7.1 | O=C(NS(=O)(=O)c1ccc(Cl)c(Cl)c1)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
CHEMBL2315059 | 86089 | 0 | None | - | 0 | Mouse | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 612 | 8 | 1 | 5 | 7.1 | O=C(NS(=O)(=O)c1ccc(Cl)c(Cl)c1)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
71517031 | 86088 | 0 | None | - | 0 | Mouse | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 558 | 8 | 1 | 5 | 6.1 | Cc1ccc(S(=O)(=O)NC(=O)c2cccc(Cc3cc(Cl)ccc3OCc3ccc(Cl)cc3F)n2)cc1 | 10.1016/j.bmcl.2012.11.046 | ||
CHEMBL2315057 | 86088 | 0 | None | - | 0 | Mouse | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 558 | 8 | 1 | 5 | 6.1 | Cc1ccc(S(=O)(=O)NC(=O)c2cccc(Cc3cc(Cl)ccc3OCc3ccc(Cl)cc3F)n2)cc1 | 10.1016/j.bmcl.2012.11.046 | ||
71517032 | 86089 | 0 | None | - | 0 | Mouse | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 612 | 8 | 1 | 5 | 7.1 | O=C(NS(=O)(=O)c1ccc(Cl)c(Cl)c1)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
CHEMBL2315059 | 86089 | 0 | None | - | 0 | Mouse | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 612 | 8 | 1 | 5 | 7.1 | O=C(NS(=O)(=O)c1ccc(Cl)c(Cl)c1)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
71717964 | 86084 | 0 | None | - | 0 | Mouse | 5.7 | pKd | = | 5.7 | Functional | ChEMBL | 498 | 7 | 1 | 3 | 6.6 | O=C(NC1CC2CCC1C2)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
CHEMBL2315053 | 86084 | 0 | None | - | 0 | Mouse | 5.7 | pKd | = | 5.7 | Functional | ChEMBL | 498 | 7 | 1 | 3 | 6.6 | O=C(NC1CC2CCC1C2)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
71717964 | 86084 | 0 | None | - | 0 | Mouse | 5.7 | pKd | = | 5.7 | Functional | ChEMBL | 498 | 7 | 1 | 3 | 6.6 | O=C(NC1CC2CCC1C2)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
CHEMBL2315053 | 86084 | 0 | None | - | 0 | Mouse | 5.7 | pKd | = | 5.7 | Functional | ChEMBL | 498 | 7 | 1 | 3 | 6.6 | O=C(NC1CC2CCC1C2)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
10599088 | 119088 | 0 | None | - | 0 | Human | 5.6 | pKd | = | 5.6 | Functional | ChEMBL | 436 | 6 | 1 | 5 | 3.6 | CCS(=O)(=O)CCC(=O)CNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21 | 10.1021/jm950454k | ||
CHEMBL346268 | 119088 | 0 | None | - | 0 | Human | 5.6 | pKd | = | 5.6 | Functional | ChEMBL | 436 | 6 | 1 | 5 | 3.6 | CCS(=O)(=O)CCC(=O)CNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21 | 10.1021/jm950454k | ||
24753314 | 86085 | 0 | None | - | 0 | Mouse | 5.6 | pKd | = | 5.6 | Functional | ChEMBL | 404 | 6 | 1 | 3 | 4.8 | NC(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
CHEMBL2315054 | 86085 | 0 | None | - | 0 | Mouse | 5.6 | pKd | = | 5.6 | Functional | ChEMBL | 404 | 6 | 1 | 3 | 4.8 | NC(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
24753314 | 86085 | 0 | None | - | 0 | Mouse | 5.6 | pKd | = | 5.6 | Functional | ChEMBL | 404 | 6 | 1 | 3 | 4.8 | NC(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
CHEMBL2315054 | 86085 | 0 | None | - | 0 | Mouse | 5.6 | pKd | = | 5.6 | Functional | ChEMBL | 404 | 6 | 1 | 3 | 4.8 | NC(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
71519330 | 86080 | 0 | None | - | 0 | Mouse | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 460 | 8 | 1 | 3 | 6.1 | CC(C)CNC(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
CHEMBL2315049 | 86080 | 0 | None | - | 0 | Mouse | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 460 | 8 | 1 | 3 | 6.1 | CC(C)CNC(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
14976003 | 119031 | 1 | None | - | 0 | Human | 7.5 | pKd | = | 7.5 | Functional | ChEMBL | 474 | 3 | 3 | 5 | 4.0 | O=C(NNC(=O)C(F)(F)C(O)c1ccccn1)N1Cc2ccccc2Oc2ccc(Cl)cc21 | 10.1021/jm950454k | ||
CHEMBL345797 | 119031 | 1 | None | - | 0 | Human | 7.5 | pKd | = | 7.5 | Functional | ChEMBL | 474 | 3 | 3 | 5 | 4.0 | O=C(NNC(=O)C(F)(F)C(O)c1ccccn1)N1Cc2ccccc2Oc2ccc(Cl)cc21 | 10.1021/jm950454k | ||
132749 | 3485 | 12 | None | - | 0 | Human | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 422 | 3 | 2 | 4 | 4.2 | O=C(NNC(=O)N1Cc2ccccc2Oc2c1cc(Cl)cc2)CCc1ccncc1 | 10.1021/jm950454k | ||
1923 | 3485 | 12 | None | - | 0 | Human | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 422 | 3 | 2 | 4 | 4.2 | O=C(NNC(=O)N1Cc2ccccc2Oc2c1cc(Cl)cc2)CCc1ccncc1 | 10.1021/jm950454k | ||
CHEMBL155358 | 3485 | 12 | None | - | 0 | Human | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 422 | 3 | 2 | 4 | 4.2 | O=C(NNC(=O)N1Cc2ccccc2Oc2c1cc(Cl)cc2)CCc1ccncc1 | 10.1021/jm950454k | ||
9933776 | 168070 | 0 | None | - | 0 | Human | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 456 | 7 | 1 | 5 | 5.0 | O=C(CCSCc1ccco1)NCC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21 | 10.1021/jm950454k | ||
CHEMBL436218 | 168070 | 0 | None | - | 0 | Human | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 456 | 7 | 1 | 5 | 5.0 | O=C(CCSCc1ccco1)NCC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21 | 10.1021/jm950454k | ||
71519482 | 86086 | 0 | None | - | 0 | Mouse | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 578 | 8 | 1 | 5 | 6.5 | O=C(NS(=O)(=O)c1ccc(Cl)cc1)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
CHEMBL2315055 | 86086 | 0 | None | - | 0 | Mouse | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 578 | 8 | 1 | 5 | 6.5 | O=C(NS(=O)(=O)c1ccc(Cl)cc1)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
71519482 | 86086 | 0 | None | - | 0 | Mouse | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 578 | 8 | 1 | 5 | 6.5 | O=C(NS(=O)(=O)c1ccc(Cl)cc1)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
CHEMBL2315055 | 86086 | 0 | None | - | 0 | Mouse | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 578 | 8 | 1 | 5 | 6.5 | O=C(NS(=O)(=O)c1ccc(Cl)cc1)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
71519479 | 86082 | 0 | None | - | 0 | Mouse | 5.4 | pKd | = | 5.4 | Functional | ChEMBL | 460 | 6 | 1 | 3 | 6.2 | CC(C)(C)NC(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
CHEMBL2315051 | 86082 | 0 | None | - | 0 | Mouse | 5.4 | pKd | = | 5.4 | Functional | ChEMBL | 460 | 6 | 1 | 3 | 6.2 | CC(C)(C)NC(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
71519479 | 86082 | 0 | None | - | 0 | Mouse | 5.4 | pKd | = | 5.4 | Functional | ChEMBL | 460 | 6 | 1 | 3 | 6.2 | CC(C)(C)NC(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
CHEMBL2315051 | 86082 | 0 | None | - | 0 | Mouse | 5.4 | pKd | = | 5.4 | Functional | ChEMBL | 460 | 6 | 1 | 3 | 6.2 | CC(C)(C)NC(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
71519480 | 86083 | 0 | None | - | 0 | Mouse | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 460 | 8 | 0 | 3 | 6.2 | CCN(CC)C(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
CHEMBL2315052 | 86083 | 0 | None | - | 0 | Mouse | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 460 | 8 | 0 | 3 | 6.2 | CCN(CC)C(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
71519480 | 86083 | 0 | None | - | 0 | Mouse | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 460 | 8 | 0 | 3 | 6.2 | CCN(CC)C(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
CHEMBL2315052 | 86083 | 0 | None | - | 0 | Mouse | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 460 | 8 | 0 | 3 | 6.2 | CCN(CC)C(=O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
11495634 | 14736 | 7 | None | - | 3 | Mouse | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | 405 | 6 | 1 | 3 | 5.4 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
CHEMBL1207972 | 14736 | 7 | None | - | 3 | Mouse | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | 405 | 6 | 1 | 3 | 5.4 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
CHEMBL467114 | 14736 | 7 | None | - | 3 | Mouse | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | 405 | 6 | 1 | 3 | 5.4 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
11495634 | 14736 | 7 | None | - | 3 | Mouse | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | 405 | 6 | 1 | 3 | 5.4 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
CHEMBL1207972 | 14736 | 7 | None | - | 3 | Mouse | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | 405 | 6 | 1 | 3 | 5.4 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
CHEMBL467114 | 14736 | 7 | None | - | 3 | Mouse | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | 405 | 6 | 1 | 3 | 5.4 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
2288900 | 87590 | 11 | None | - | 1 | Human | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 496 | 11 | 1 | 5 | 4.1 | CCc1ccccc1N(CC(=O)NCCc1ccc(OC)c(OC)c1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL234399 | 87590 | 11 | None | - | 1 | Human | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 496 | 11 | 1 | 5 | 4.1 | CCc1ccccc1N(CC(=O)NCCc1ccc(OC)c(OC)c1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
11963255 | 95252 | 12 | None | - | 1 | Human | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | 427 | 6 | 1 | 5 | 5.8 | Cc1cc(NC(=O)OC(C)(C)C)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL258199 | 95252 | 12 | None | - | 1 | Human | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | 427 | 6 | 1 | 5 | 5.8 | Cc1cc(NC(=O)OC(C)(C)C)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
71517030 | 86087 | 0 | None | - | 0 | Mouse | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | 612 | 8 | 1 | 5 | 7.1 | O=C(NS(=O)(=O)c1cc(Cl)ccc1Cl)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
CHEMBL2315056 | 86087 | 0 | None | - | 0 | Mouse | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | 612 | 8 | 1 | 5 | 7.1 | O=C(NS(=O)(=O)c1cc(Cl)ccc1Cl)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
71519327 | 86077 | 0 | None | - | 0 | Mouse | 6.3 | pKd | = | 6.3 | Functional | ChEMBL | 458 | 8 | 1 | 3 | 5.8 | O=C(NCC1CC1)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
CHEMBL2315046 | 86077 | 0 | None | - | 0 | Mouse | 6.3 | pKd | = | 6.3 | Functional | ChEMBL | 458 | 8 | 1 | 3 | 5.8 | O=C(NCC1CC1)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
71519327 | 86077 | 0 | None | - | 0 | Mouse | 6.3 | pKd | = | 6.3 | Functional | ChEMBL | 458 | 8 | 1 | 3 | 5.8 | O=C(NCC1CC1)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
CHEMBL2315046 | 86077 | 0 | None | - | 0 | Mouse | 6.3 | pKd | = | 6.3 | Functional | ChEMBL | 458 | 8 | 1 | 3 | 5.8 | O=C(NCC1CC1)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
71517030 | 86087 | 0 | None | - | 0 | Mouse | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | 612 | 8 | 1 | 5 | 7.1 | O=C(NS(=O)(=O)c1cc(Cl)ccc1Cl)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
CHEMBL2315056 | 86087 | 0 | None | - | 0 | Mouse | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | 612 | 8 | 1 | 5 | 7.1 | O=C(NS(=O)(=O)c1cc(Cl)ccc1Cl)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
10742479 | 119738 | 0 | None | - | 0 | Human | 7.2 | pKd | = | 7.2 | Functional | ChEMBL | 456 | 7 | 1 | 5 | 5.6 | O=C(CCSCc1ccco1)CNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21 | 10.1021/jm950454k | ||
CHEMBL352251 | 119738 | 0 | None | - | 0 | Human | 7.2 | pKd | = | 7.2 | Functional | ChEMBL | 456 | 7 | 1 | 5 | 5.6 | O=C(CCSCc1ccco1)CNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21 | 10.1021/jm950454k | ||
11962967 | 94788 | 0 | None | - | 1 | Human | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | 413 | 7 | 1 | 5 | 5.4 | Cc1cc(NC(=O)OC(C)C)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL256092 | 94788 | 0 | None | - | 1 | Human | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | 413 | 7 | 1 | 5 | 5.4 | Cc1cc(NC(=O)OC(C)C)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
11495634 | 14736 | 7 | None | 100 | 3 | Human | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | 405 | 6 | 1 | 3 | 5.4 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL1207972 | 14736 | 7 | None | 100 | 3 | Human | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | 405 | 6 | 1 | 3 | 5.4 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL467114 | 14736 | 7 | None | 100 | 3 | Human | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | 405 | 6 | 1 | 3 | 5.4 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2009.02.112 | ||
1924 | 3486 | 33 | None | - | 0 | Human | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | 457 | 5 | 2 | 5 | 5.1 | O=C(NNC(=O)N1Cc2ccccc2Oc2c1cc(Cl)cc2)CCSCc1ccco1 | 10.1021/jm950454k | ||
9933831 | 3486 | 33 | None | - | 0 | Human | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | 457 | 5 | 2 | 5 | 5.1 | O=C(NNC(=O)N1Cc2ccccc2Oc2c1cc(Cl)cc2)CCSCc1ccco1 | 10.1021/jm950454k | ||
CHEMBL358653 | 3486 | 33 | None | - | 0 | Human | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | 457 | 5 | 2 | 5 | 5.1 | O=C(NNC(=O)N1Cc2ccccc2Oc2c1cc(Cl)cc2)CCSCc1ccco1 | 10.1021/jm950454k | ||
71519329 | 86079 | 0 | None | - | 0 | Mouse | 6.0 | pKd | = | 6.0 | Functional | ChEMBL | 458 | 7 | 1 | 3 | 6.0 | O=C(NC1CCC1)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
CHEMBL2315048 | 86079 | 0 | None | - | 0 | Mouse | 6.0 | pKd | = | 6.0 | Functional | ChEMBL | 458 | 7 | 1 | 3 | 6.0 | O=C(NC1CCC1)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
71519329 | 86079 | 0 | None | - | 0 | Mouse | 6.0 | pKd | = | 6.0 | Functional | ChEMBL | 458 | 7 | 1 | 3 | 6.0 | O=C(NC1CCC1)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
CHEMBL2315048 | 86079 | 0 | None | - | 0 | Mouse | 6.0 | pKd | = | 6.0 | Functional | ChEMBL | 458 | 7 | 1 | 3 | 6.0 | O=C(NC1CCC1)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2012.11.046 | ||
24760466 | 14669 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Functional | ChEMBL | 368 | 4 | 1 | 4 | 5.0 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2cc(C(F)(F)F)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1207394 | 14669 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Functional | ChEMBL | 368 | 4 | 1 | 4 | 5.0 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2cc(C(F)(F)F)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL402392 | 14669 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Functional | ChEMBL | 368 | 4 | 1 | 4 | 5.0 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2cc(C(F)(F)F)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
10007859 | 165936 | 0 | None | 6 | 3 | Human | 10.0 | pKi | = | 10 | Functional | ChEMBL | 554 | 7 | 2 | 4 | 6.7 | CC(=O)Nc1cc(C(=O)O)cc(-n2c(C)ccc2-c2cc(Br)ccc2OCc2ccc(F)cc2F)c1 | 10.1016/j.bmcl.2006.10.078 | ||
CHEMBL427844 | 165936 | 0 | None | 6 | 3 | Human | 10.0 | pKi | = | 10 | Functional | ChEMBL | 554 | 7 | 2 | 4 | 6.7 | CC(=O)Nc1cc(C(=O)O)cc(-n2c(C)ccc2-c2cc(Br)ccc2OCc2ccc(F)cc2F)c1 | 10.1016/j.bmcl.2006.10.078 | ||
24760390 | 14564 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Functional | ChEMBL | 378 | 4 | 1 | 4 | 4.7 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2cc(Br)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1206284 | 14564 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Functional | ChEMBL | 378 | 4 | 1 | 4 | 4.7 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2cc(Br)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL257134 | 14564 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Functional | ChEMBL | 378 | 4 | 1 | 4 | 4.7 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2cc(Br)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
9868012 | 123331 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 420 | 6 | 1 | 3 | 7.0 | O=C(O)c1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
CHEMBL362543 | 123331 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 420 | 6 | 1 | 3 | 7.0 | O=C(O)c1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
9868012 | 123331 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 420 | 6 | 1 | 3 | 7.0 | O=C(O)c1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
CHEMBL362543 | 123331 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 420 | 6 | 1 | 3 | 7.0 | O=C(O)c1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
15604659 | 14674 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 308 | 6 | 1 | 3 | 4.3 | CC(C)COc1ccc(Cl)cc1Cc1ccc(C(=O)O)o1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL1207404 | 14674 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 308 | 6 | 1 | 3 | 4.3 | CC(C)COc1ccc(Cl)cc1Cc1ccc(C(=O)O)o1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL403330 | 14674 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 308 | 6 | 1 | 3 | 4.3 | CC(C)COc1ccc(Cl)cc1Cc1ccc(C(=O)O)o1 | 10.1016/j.bmcl.2008.01.071 | ||
24784836 | 67816 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Functional | ChEMBL | 332 | 4 | 1 | 4 | 4.5 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(C(C)C)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
CHEMBL1915012 | 67816 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Functional | ChEMBL | 332 | 4 | 1 | 4 | 4.5 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(C(C)C)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
11340370 | 80170 | 7 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 468 | 6 | 1 | 4 | 5.6 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL2110364 | 80170 | 7 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 468 | 6 | 1 | 4 | 5.6 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL214971 | 80170 | 7 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 468 | 6 | 1 | 4 | 5.6 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2006.06.086 | ||
24760470 | 14570 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 334 | 4 | 1 | 4 | 4.6 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1206294 | 14570 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 334 | 4 | 1 | 4 | 4.6 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL257997 | 14570 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 334 | 4 | 1 | 4 | 4.6 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
24760470 | 14570 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 334 | 4 | 1 | 4 | 4.6 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1206294 | 14570 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 334 | 4 | 1 | 4 | 4.6 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL257997 | 14570 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 334 | 4 | 1 | 4 | 4.6 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
11418874 | 81062 | 0 | None | - | 0 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 424 | 6 | 1 | 4 | 5.5 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)ccc1OCc1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL215992 | 81062 | 0 | None | - | 0 | Human | 9.3 | pKi | = | 9.3 | Functional | ChEMBL | 424 | 6 | 1 | 4 | 5.5 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)ccc1OCc1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2006.06.086 | ||
11211840 | 140727 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Functional | ChEMBL | 403 | 6 | 1 | 3 | 6.1 | O=C(O)c1cccc(-n2cccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
CHEMBL383090 | 140727 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Functional | ChEMBL | 403 | 6 | 1 | 3 | 6.1 | O=C(O)c1cccc(-n2cccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
11640317 | 138160 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Functional | ChEMBL | 417 | 6 | 1 | 3 | 6.4 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.02.014 | ||
CHEMBL377852 | 138160 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Functional | ChEMBL | 417 | 6 | 1 | 3 | 6.4 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.02.014 | ||
11393812 | 14580 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 322 | 6 | 1 | 4 | 3.6 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL1206405 | 14580 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 322 | 6 | 1 | 4 | 3.6 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL270208 | 14580 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 322 | 6 | 1 | 4 | 3.6 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.01.071 | ||
24760391 | 14668 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Functional | ChEMBL | 318 | 4 | 1 | 4 | 4.2 | CC(C)Cc1cn(-c2nc(C(=O)O)co2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1207393 | 14668 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Functional | ChEMBL | 318 | 4 | 1 | 4 | 4.2 | CC(C)Cc1cn(-c2nc(C(=O)O)co2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL402338 | 14668 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Functional | ChEMBL | 318 | 4 | 1 | 4 | 4.2 | CC(C)Cc1cn(-c2nc(C(=O)O)co2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
10095268 | 85729 | 0 | None | 7 | 3 | Human | 9.0 | pKi | = | 9 | Functional | ChEMBL | 449 | 6 | 1 | 3 | 6.8 | Cc1ccc(-n2c(C)ccc2-c2cc(Cl)ccc2OCc2ccc(F)cc2)cc1C(=O)O | 10.1016/j.bmcl.2006.11.059 | ||
CHEMBL231184 | 85729 | 0 | None | 7 | 3 | Human | 9.0 | pKi | = | 9 | Functional | ChEMBL | 449 | 6 | 1 | 3 | 6.8 | Cc1ccc(-n2c(C)ccc2-c2cc(Cl)ccc2OCc2ccc(F)cc2)cc1C(=O)O | 10.1016/j.bmcl.2006.11.059 | ||
11383800 | 140939 | 0 | None | - | 0 | Human | 9.0 | pKi | = | 9.0 | Functional | ChEMBL | 392 | 6 | 1 | 4 | 4.4 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)ccc1OCc1ccc(F)cc1F | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL384332 | 140939 | 0 | None | - | 0 | Human | 9.0 | pKi | = | 9.0 | Functional | ChEMBL | 392 | 6 | 1 | 4 | 4.4 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)ccc1OCc1ccc(F)cc1F | 10.1016/j.bmcl.2006.06.086 | ||
24760471 | 14675 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 317 | 4 | 1 | 3 | 4.8 | CC(C)Cc1cn(-c2ccc(C(=O)O)o2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1207406 | 14675 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 317 | 4 | 1 | 3 | 4.8 | CC(C)Cc1cn(-c2ccc(C(=O)O)o2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL403407 | 14675 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 317 | 4 | 1 | 3 | 4.8 | CC(C)Cc1cn(-c2ccc(C(=O)O)o2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
9868012 | 123331 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 420 | 6 | 1 | 3 | 7.0 | O=C(O)c1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL362543 | 123331 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 420 | 6 | 1 | 3 | 7.0 | O=C(O)c1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.06.086 | ||
11978148 | 14567 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 343 | 6 | 1 | 4 | 4.2 | O=C(O)c1coc(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL1206289 | 14567 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 343 | 6 | 1 | 4 | 4.2 | O=C(O)c1coc(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL257464 | 14567 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 343 | 6 | 1 | 4 | 4.2 | O=C(O)c1coc(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.01.071 | ||
15604737 | 14585 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 342 | 6 | 1 | 3 | 4.8 | O=C(O)c1ccc(Cc2cc(Cl)ccc2OCc2ccccc2)o1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL1206426 | 14585 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 342 | 6 | 1 | 3 | 4.8 | O=C(O)c1ccc(Cc2cc(Cl)ccc2OCc2ccccc2)o1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL272793 | 14585 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 342 | 6 | 1 | 3 | 4.8 | O=C(O)c1ccc(Cc2cc(Cl)ccc2OCc2ccccc2)o1 | 10.1016/j.bmcl.2008.01.071 | ||
15604741 | 14689 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 356 | 6 | 1 | 3 | 5.1 | Cc1cc(C(=O)O)oc1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL1207453 | 14689 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 356 | 6 | 1 | 3 | 5.1 | Cc1cc(C(=O)O)oc1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL407175 | 14689 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 356 | 6 | 1 | 3 | 5.1 | Cc1cc(C(=O)O)oc1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.01.071 | ||
44432912 | 144701 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7 | Functional | ChEMBL | 479 | 9 | 0 | 7 | 5.1 | CCc1ccccc1N(Cc1nnc(Oc2ccc(OC)cc2)o1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL391268 | 144701 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7 | Functional | ChEMBL | 479 | 9 | 0 | 7 | 5.1 | CCc1ccccc1N(Cc1nnc(Oc2ccc(OC)cc2)o1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
11697614 | 14772 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Functional | ChEMBL | 405 | 6 | 1 | 3 | 5.4 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(F)cc2Cl)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL1208255 | 14772 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Functional | ChEMBL | 405 | 6 | 1 | 3 | 5.4 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(F)cc2Cl)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL513491 | 14772 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Functional | ChEMBL | 405 | 6 | 1 | 3 | 5.4 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(F)cc2Cl)n1 | 10.1016/j.bmcl.2009.02.112 | ||
44568634 | 12553 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Functional | ChEMBL | 466 | 8 | 2 | 5 | 5.6 | Cc1cc(NC(=O)c2ccc(C3CCCN3)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1187235 | 12553 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Functional | ChEMBL | 466 | 8 | 2 | 5 | 5.6 | Cc1cc(NC(=O)c2ccc(C3CCCN3)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL494466 | 12553 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Functional | ChEMBL | 466 | 8 | 2 | 5 | 5.6 | Cc1cc(NC(=O)c2ccc(C3CCCN3)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
44568760 | 12557 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Functional | ChEMBL | 470 | 11 | 3 | 6 | 4.3 | Cc1cc(C(=O)Nc2ccc(CNCCO)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1187259 | 12557 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Functional | ChEMBL | 470 | 11 | 3 | 6 | 4.3 | Cc1cc(C(=O)Nc2ccc(CNCCO)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL495107 | 12557 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Functional | ChEMBL | 470 | 11 | 3 | 6 | 4.3 | Cc1cc(C(=O)Nc2ccc(CNCCO)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
44432908 | 86802 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 535 | 7 | 0 | 5 | 6.6 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3ccc(Cl)cc3Cl)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL232926 | 86802 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 535 | 7 | 0 | 5 | 6.6 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3ccc(Cl)cc3Cl)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
11407950 | 80685 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 436 | 6 | 1 | 4 | 4.6 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1c(F)cccc1F | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL215573 | 80685 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 436 | 6 | 1 | 4 | 4.6 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1c(F)cccc1F | 10.1016/j.bmcl.2006.06.086 | ||
44439617 | 147678 | 1 | None | - | 0 | Human | 6.0 | pKi | = | 6.0 | Functional | ChEMBL | 452 | 9 | 1 | 4 | 4.1 | CCc1ccccc1N(CC(=O)NCc1ccccc1OC)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL393595 | 147678 | 1 | None | - | 0 | Human | 6.0 | pKi | = | 6.0 | Functional | ChEMBL | 452 | 9 | 1 | 4 | 4.1 | CCc1ccccc1N(CC(=O)NCc1ccccc1OC)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
44416198 | 165383 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Functional | ChEMBL | 468 | 6 | 1 | 4 | 5.3 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL425076 | 165383 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Functional | ChEMBL | 468 | 6 | 1 | 4 | 5.3 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.086 | ||
1283333 | 91104 | 7 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 456 | 8 | 1 | 3 | 4.7 | CCc1ccccc1N(CC(=O)NCc1ccc(Cl)cc1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL240436 | 91104 | 7 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 456 | 8 | 1 | 3 | 4.7 | CCc1ccccc1N(CC(=O)NCc1ccc(Cl)cc1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
11384586 | 80658 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 418 | 6 | 1 | 4 | 4.4 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccc(F)cc1 | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL215453 | 80658 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 418 | 6 | 1 | 4 | 4.4 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccc(F)cc1 | 10.1016/j.bmcl.2006.06.086 | ||
44416199 | 141326 | 0 | None | - | 0 | Human | 6.0 | pKi | = | 6.0 | Functional | ChEMBL | 468 | 6 | 1 | 4 | 5.6 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1cc(Cl)cc(Cl)c1 | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL386543 | 141326 | 0 | None | - | 0 | Human | 6.0 | pKi | = | 6.0 | Functional | ChEMBL | 468 | 6 | 1 | 4 | 5.6 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1cc(Cl)cc(Cl)c1 | 10.1016/j.bmcl.2006.06.086 | ||
24760396 | 14664 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 300 | 4 | 1 | 4 | 4.0 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2ccccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1207383 | 14664 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 300 | 4 | 1 | 4 | 4.0 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2ccccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL401785 | 14664 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 300 | 4 | 1 | 4 | 4.0 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2ccccc12 | 10.1016/j.bmcl.2008.03.018 | ||
2176335 | 146644 | 10 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 496 | 10 | 1 | 5 | 4.2 | COc1ccc(CCNC(=O)CN(c2cccc(C)c2C)S(=O)(=O)c2ccc(C)cc2)cc1OC | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL392793 | 146644 | 10 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 496 | 10 | 1 | 5 | 4.2 | COc1ccc(CCNC(=O)CN(c2cccc(C)c2C)S(=O)(=O)c2ccc(C)cc2)cc1OC | 10.1016/j.bmcl.2006.12.060 | ||
119461 | 317 | 66 | None | - | 0 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 298 | 3 | 1 | 4 | 3.4 | CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C | 10.1021/jm401431x | ||
1896 | 317 | 66 | None | - | 0 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 298 | 3 | 1 | 4 | 3.4 | CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C | 10.1021/jm401431x | ||
CHEMBL1317823 | 317 | 66 | None | - | 0 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 298 | 3 | 1 | 4 | 3.4 | CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C | 10.1021/jm401431x | ||
44432923 | 86849 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 493 | 10 | 0 | 7 | 4.9 | CCc1ccccc1N(Cc1nnc(COc2ccc(OC)cc2)o1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL233155 | 86849 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 493 | 10 | 0 | 7 | 4.9 | CCc1ccccc1N(Cc1nnc(COc2ccc(OC)cc2)o1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
24894002 | 12476 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 474 | 9 | 2 | 5 | 5.4 | CNCc1ccc(NC(=O)c2cc(C)n(Cc3cc(Cl)ccc3OCc3ccccc3)n2)cc1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1186852 | 12476 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 474 | 9 | 2 | 5 | 5.4 | CNCc1ccc(NC(=O)c2cc(C)n(Cc3cc(Cl)ccc3OCc3ccccc3)n2)cc1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL480789 | 12476 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 474 | 9 | 2 | 5 | 5.4 | CNCc1ccc(NC(=O)c2cc(C)n(Cc3cc(Cl)ccc3OCc3ccccc3)n2)cc1 | 10.1016/j.bmcl.2008.05.118 | ||
44568636 | 12547 | 1 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 452 | 7 | 2 | 5 | 4.8 | Cc1cc(NC(=O)c2ccc3c(c2)CCNC3)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1187203 | 12547 | 1 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 452 | 7 | 2 | 5 | 4.8 | Cc1cc(NC(=O)c2ccc3c(c2)CCNC3)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL493254 | 12547 | 1 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 452 | 7 | 2 | 5 | 4.8 | Cc1cc(NC(=O)c2ccc3c(c2)CCNC3)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
11271578 | 141465 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 478 | 6 | 1 | 4 | 5.0 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1cccc(Br)c1 | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL387454 | 141465 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 478 | 6 | 1 | 4 | 5.0 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1cccc(Br)c1 | 10.1016/j.bmcl.2006.06.086 | ||
3688070 | 90204 | 7 | None | - | 0 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 502 | 10 | 1 | 5 | 4.2 | COc1ccc(CCNC(=O)CN(c2ccc(Cl)cc2)S(=O)(=O)c2ccc(C)cc2)cc1OC | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL238925 | 90204 | 7 | None | - | 0 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 502 | 10 | 1 | 5 | 4.2 | COc1ccc(CCNC(=O)CN(c2ccc(Cl)cc2)S(=O)(=O)c2ccc(C)cc2)cc1OC | 10.1016/j.bmcl.2006.12.060 | ||
2288900 | 87590 | 11 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 496 | 11 | 1 | 5 | 4.1 | CCc1ccccc1N(CC(=O)NCCc1ccc(OC)c(OC)c1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL234399 | 87590 | 11 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 496 | 11 | 1 | 5 | 4.1 | CCc1ccccc1N(CC(=O)NCCc1ccc(OC)c(OC)c1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
44439615 | 154396 | 0 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 440 | 8 | 1 | 3 | 4.2 | CCc1ccccc1N(CC(=O)NCc1ccccc1F)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL401042 | 154396 | 0 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 440 | 8 | 1 | 3 | 4.2 | CCc1ccccc1N(CC(=O)NCc1ccccc1F)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
44416127 | 139630 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 400 | 6 | 1 | 4 | 4.3 | Cc1cn(Cc2cc(Br)ccc2OCc2ccccc2)nc1C(=O)O | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL380297 | 139630 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 400 | 6 | 1 | 4 | 4.3 | Cc1cn(Cc2cc(Br)ccc2OCc2ccccc2)nc1C(=O)O | 10.1016/j.bmcl.2006.06.086 | ||
2467304 | 91571 | 12 | None | - | 0 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 422 | 8 | 1 | 3 | 3.9 | Cc1ccc(S(=O)(=O)N(CC(=O)NCCc2ccccc2)c2ccccc2C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL241672 | 91571 | 12 | None | - | 0 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 422 | 8 | 1 | 3 | 3.9 | Cc1ccc(S(=O)(=O)N(CC(=O)NCCc2ccccc2)c2ccccc2C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
11464169 | 77442 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 415 | 6 | 1 | 3 | 6.3 | O=C(O)c1cccc(-c2ccncc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
CHEMBL209244 | 77442 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 415 | 6 | 1 | 3 | 6.3 | O=C(O)c1cccc(-c2ccncc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
44439606 | 90930 | 0 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 452 | 9 | 1 | 4 | 4.1 | CCc1ccccc1N(CC(=O)NCc1cccc(OC)c1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL240247 | 90930 | 0 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 452 | 9 | 1 | 4 | 4.1 | CCc1ccccc1N(CC(=O)NCc1cccc(OC)c1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
44439609 | 147142 | 0 | None | - | 0 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 456 | 8 | 1 | 3 | 4.7 | CCc1ccccc1N(CC(=O)NCc1cccc(Cl)c1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL393178 | 147142 | 0 | None | - | 0 | Human | 5.9 | pKi | = | 5.9 | Functional | ChEMBL | 456 | 8 | 1 | 3 | 4.7 | CCc1ccccc1N(CC(=O)NCc1cccc(Cl)c1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
11235004 | 79703 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 400 | 6 | 1 | 4 | 4.3 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL213221 | 79703 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 400 | 6 | 1 | 4 | 4.3 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL258184 | 79703 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 400 | 6 | 1 | 4 | 4.3 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2006.06.086 | ||
11750434 | 76772 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 417 | 6 | 1 | 3 | 6.4 | Cc1ccc(-c2cccc(C(=O)O)c2)n1-c1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2006.02.014 | ||
CHEMBL207688 | 76772 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 417 | 6 | 1 | 3 | 6.4 | Cc1ccc(-c2cccc(C(=O)O)c2)n1-c1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2006.02.014 | ||
44455168 | 14691 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 358 | 6 | 1 | 3 | 5.3 | O=C(O)c1ccc(Cc2cc(Cl)ccc2OCc2ccccc2)s1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL1207466 | 14691 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 358 | 6 | 1 | 3 | 5.3 | O=C(O)c1ccc(Cc2cc(Cl)ccc2OCc2ccccc2)s1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL408367 | 14691 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 358 | 6 | 1 | 3 | 5.3 | O=C(O)c1ccc(Cc2cc(Cl)ccc2OCc2ccccc2)s1 | 10.1016/j.bmcl.2008.01.071 | ||
11963255 | 95252 | 12 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 427 | 6 | 1 | 5 | 5.8 | Cc1cc(NC(=O)OC(C)(C)C)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL258199 | 95252 | 12 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 427 | 6 | 1 | 5 | 5.8 | Cc1cc(NC(=O)OC(C)(C)C)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
11595316 | 154820 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 319 | 6 | 1 | 3 | 4.1 | CC(C)COc1ccc(Cl)cc1Cc1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL257998 | 154820 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 319 | 6 | 1 | 3 | 4.1 | CC(C)COc1ccc(Cl)cc1Cc1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL403329 | 154820 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 319 | 6 | 1 | 3 | 4.1 | CC(C)COc1ccc(Cl)cc1Cc1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2008.01.071 | ||
44432886 | 86570 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 535 | 7 | 0 | 5 | 6.3 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3ccc(C(F)(F)F)cc3)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL232389 | 86570 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 535 | 7 | 0 | 5 | 6.3 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3ccc(C(F)(F)F)cc3)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
24894001 | 12484 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 480 | 9 | 1 | 5 | 5.8 | Cc1cc(NC(=O)c2ccc(CN3CCCC3)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1186882 | 12484 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 480 | 9 | 1 | 5 | 5.8 | Cc1cc(NC(=O)c2ccc(CN3CCCC3)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL481689 | 12484 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 480 | 9 | 1 | 5 | 5.8 | Cc1cc(NC(=O)c2ccc(CN3CCCC3)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
24894000 | 12486 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 454 | 10 | 2 | 5 | 5.3 | CCNCc1ccc(C(=O)Nc2cc(C)n(Cc3cc(Cl)ccc3OCC(C)C)n2)cc1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1186890 | 12486 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 454 | 10 | 2 | 5 | 5.3 | CCNCc1ccc(C(=O)Nc2cc(C)n(Cc3cc(Cl)ccc3OCC(C)C)n2)cc1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL481870 | 12486 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 454 | 10 | 2 | 5 | 5.3 | CCNCc1ccc(C(=O)Nc2cc(C)n(Cc3cc(Cl)ccc3OCC(C)C)n2)cc1 | 10.1016/j.bmcl.2008.05.118 | ||
44439594 | 90207 | 0 | None | - | 0 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 496 | 11 | 1 | 5 | 4.1 | CCc1ccccc1N(CC(=O)NCCc1ccc(OC)c(OC)c1)S(=O)(=O)c1ccccc1C | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL238931 | 90207 | 0 | None | - | 0 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 496 | 11 | 1 | 5 | 4.1 | CCc1ccccc1N(CC(=O)NCCc1ccc(OC)c(OC)c1)S(=O)(=O)c1ccccc1C | 10.1016/j.bmcl.2006.12.060 | ||
44439599 | 90521 | 0 | None | - | 0 | Human | 5.8 | pKi | = | 5.8 | Functional | ChEMBL | 496 | 11 | 1 | 5 | 4.1 | CCc1ccccc1N(CC(=O)NCCc1ccc(OC)c(OC)c1)S(=O)(=O)c1cccc(C)c1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL239365 | 90521 | 0 | None | - | 0 | Human | 5.8 | pKi | = | 5.8 | Functional | ChEMBL | 496 | 11 | 1 | 5 | 4.1 | CCc1ccccc1N(CC(=O)NCCc1ccc(OC)c(OC)c1)S(=O)(=O)c1cccc(C)c1 | 10.1016/j.bmcl.2006.12.060 | ||
44439595 | 90255 | 0 | None | - | 0 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 512 | 12 | 1 | 6 | 3.8 | CCc1ccccc1N(CC(=O)NCCc1ccc(OC)c(OC)c1)S(=O)(=O)c1ccc(OC)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL239137 | 90255 | 0 | None | - | 0 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 512 | 12 | 1 | 6 | 3.8 | CCc1ccccc1N(CC(=O)NCCc1ccc(OC)c(OC)c1)S(=O)(=O)c1ccc(OC)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
2897583 | 154293 | 9 | None | - | 0 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 452 | 9 | 1 | 4 | 3.9 | COc1ccc(CCNC(=O)CN(c2ccccc2C)S(=O)(=O)c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL400422 | 154293 | 9 | None | - | 0 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 452 | 9 | 1 | 4 | 3.9 | COc1ccc(CCNC(=O)CN(c2ccccc2C)S(=O)(=O)c2ccc(C)cc2)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
44439590 | 90083 | 0 | None | - | 0 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 550 | 11 | 1 | 5 | 4.8 | CCc1ccccc1N(CC(=O)NCCc1ccc(OC)c(OC)c1)S(=O)(=O)c1ccc(C(F)(F)F)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL238727 | 90083 | 0 | None | - | 0 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 550 | 11 | 1 | 5 | 4.8 | CCc1ccccc1N(CC(=O)NCCc1ccc(OC)c(OC)c1)S(=O)(=O)c1ccc(C(F)(F)F)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
24760472 | 14548 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 328 | 4 | 1 | 3 | 4.6 | CC(C)Cc1cn(-c2cccc(C(=O)O)n2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1206254 | 14548 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 328 | 4 | 1 | 3 | 4.6 | CC(C)Cc1cn(-c2cccc(C(=O)O)n2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL254763 | 14548 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 328 | 4 | 1 | 3 | 4.6 | CC(C)Cc1cn(-c2cccc(C(=O)O)n2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
44432883 | 168477 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 510 | 8 | 0 | 6 | 5.4 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3ccc(N(C)C)cc3)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL439559 | 168477 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 510 | 8 | 0 | 6 | 5.4 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3ccc(N(C)C)cc3)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44439601 | 90139 | 0 | None | - | 0 | Human | 5.7 | pKi | = | 5.7 | Functional | ChEMBL | 516 | 11 | 1 | 5 | 4.5 | CCc1ccccc1N(CC(=O)NCCc1ccc(OC)c(OC)c1)S(=O)(=O)c1ccccc1Cl | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL238752 | 90139 | 0 | None | - | 0 | Human | 5.7 | pKi | = | 5.7 | Functional | ChEMBL | 516 | 11 | 1 | 5 | 4.5 | CCc1ccccc1N(CC(=O)NCCc1ccc(OC)c(OC)c1)S(=O)(=O)c1ccccc1Cl | 10.1016/j.bmcl.2006.12.060 | ||
44432905 | 86800 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Functional | ChEMBL | 501 | 7 | 0 | 5 | 6.0 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3cccc(Cl)c3)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL232924 | 86800 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Functional | ChEMBL | 501 | 7 | 0 | 5 | 6.0 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3cccc(Cl)c3)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
11189804 | 80168 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 436 | 6 | 1 | 4 | 4.6 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccc(F)cc1F | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL214967 | 80168 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 436 | 6 | 1 | 4 | 4.6 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccc(F)cc1F | 10.1016/j.bmcl.2006.06.086 | ||
11281276 | 141168 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 408 | 6 | 1 | 4 | 5.0 | Cc1cc(C(=O)O)nn1Cc1cc(F)ccc1OCc1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL385620 | 141168 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 408 | 6 | 1 | 4 | 5.0 | Cc1cc(C(=O)O)nn1Cc1cc(F)ccc1OCc1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2006.06.086 | ||
44439583 | 91541 | 0 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 438 | 8 | 2 | 4 | 3.6 | Cc1ccc(S(=O)(=O)N(CC(=O)NCCc2cccc(O)c2)c2ccccc2C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL241494 | 91541 | 0 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 438 | 8 | 2 | 4 | 3.6 | Cc1ccc(S(=O)(=O)N(CC(=O)NCCc2cccc(O)c2)c2ccccc2C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
44439614 | 91107 | 0 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 490 | 8 | 1 | 3 | 5.1 | CCc1ccccc1N(CC(=O)NCc1ccc(C(F)(F)F)cc1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL240457 | 91107 | 0 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 490 | 8 | 1 | 3 | 5.1 | CCc1ccccc1N(CC(=O)NCc1ccc(C(F)(F)F)cc1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
44439612 | 91244 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 500 | 8 | 1 | 3 | 4.8 | CCc1ccccc1N(CC(=O)NCc1ccc(Br)cc1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL240844 | 91244 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 500 | 8 | 1 | 3 | 4.8 | CCc1ccccc1N(CC(=O)NCc1ccc(Br)cc1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
1000070 | 159656 | 6 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 422 | 8 | 1 | 3 | 4.1 | CCc1ccccc1N(CC(=O)NCc1ccccc1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL410957 | 159656 | 6 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 422 | 8 | 1 | 3 | 4.1 | CCc1ccccc1N(CC(=O)NCc1ccccc1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
44439596 | 146649 | 0 | None | - | 0 | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 507 | 11 | 1 | 6 | 3.7 | CCc1ccccc1N(CC(=O)NCCc1ccc(OC)c(OC)c1)S(=O)(=O)c1cccc(C#N)c1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL392795 | 146649 | 0 | None | - | 0 | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 507 | 11 | 1 | 6 | 3.7 | CCc1ccccc1N(CC(=O)NCCc1ccc(OC)c(OC)c1)S(=O)(=O)c1cccc(C#N)c1 | 10.1016/j.bmcl.2006.12.060 | ||
11719237 | 14740 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 421 | 6 | 1 | 3 | 5.9 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL1207976 | 14740 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 421 | 6 | 1 | 3 | 5.9 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL467720 | 14740 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 421 | 6 | 1 | 3 | 5.9 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2009.02.112 | ||
11350546 | 77752 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 415 | 6 | 1 | 3 | 6.3 | O=C(O)c1cccc(-c2cnccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
CHEMBL210268 | 77752 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 415 | 6 | 1 | 3 | 6.3 | O=C(O)c1cccc(-c2cnccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
9866503 | 76681 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 414 | 6 | 1 | 2 | 7.0 | O=C(O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
CHEMBL207174 | 76681 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 414 | 6 | 1 | 2 | 7.0 | O=C(O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
11178059 | 154741 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 434 | 6 | 1 | 4 | 4.9 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccccc1Cl | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL402880 | 154741 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 434 | 6 | 1 | 4 | 4.9 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccccc1Cl | 10.1016/j.bmcl.2006.06.086 | ||
44439591 | 146647 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 560 | 11 | 1 | 5 | 4.6 | CCc1ccccc1N(CC(=O)NCCc1ccc(OC)c(OC)c1)S(=O)(=O)c1ccc(Br)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL392794 | 146647 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 560 | 11 | 1 | 5 | 4.6 | CCc1ccccc1N(CC(=O)NCCc1ccc(OC)c(OC)c1)S(=O)(=O)c1ccc(Br)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
28568627 | 90150 | 1 | None | - | 0 | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 482 | 10 | 1 | 5 | 4.1 | CCc1ccccc1N(CC(=O)NCc1ccc(OC)c(OC)c1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL238754 | 90150 | 1 | None | - | 0 | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 482 | 10 | 1 | 5 | 4.1 | CCc1ccccc1N(CC(=O)NCc1ccc(OC)c(OC)c1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
10046844 | 76707 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 404 | 6 | 1 | 4 | 5.5 | O=C(O)c1cccc(-n2cncc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
CHEMBL207293 | 76707 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 404 | 6 | 1 | 4 | 5.5 | O=C(O)c1cccc(-n2cncc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
44439586 | 91570 | 0 | None | - | 0 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 531 | 10 | 3 | 6 | 2.5 | CNS(=O)(=O)c1cc(CCNC(=O)CN(c2ccccc2C)S(=O)(=O)c2ccc(C)cc2)ccc1O | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL241671 | 91570 | 0 | None | - | 0 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 531 | 10 | 3 | 6 | 2.5 | CNS(=O)(=O)c1cc(CCNC(=O)CN(c2ccccc2C)S(=O)(=O)c2ccc(C)cc2)ccc1O | 10.1016/j.bmcl.2006.12.060 | ||
24760322 | 14553 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 362 | 4 | 1 | 4 | 5.4 | CC(C)(C)CCc1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1206265 | 14553 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 362 | 4 | 1 | 4 | 5.4 | CC(C)(C)CCc1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL255675 | 14553 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 362 | 4 | 1 | 4 | 5.4 | CC(C)(C)CCc1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
3813994 | 90065 | 2 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 536 | 10 | 1 | 5 | 4.6 | COc1ccc(CCNC(=O)CN(c2cccc(C(F)(F)F)c2)S(=O)(=O)c2ccc(C)cc2)cc1OC | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL238725 | 90065 | 2 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 536 | 10 | 1 | 5 | 4.6 | COc1ccc(CCNC(=O)CN(c2cccc(C(F)(F)F)c2)S(=O)(=O)c2ccc(C)cc2)cc1OC | 10.1016/j.bmcl.2006.12.060 | ||
9866503 | 76681 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 414 | 6 | 1 | 2 | 7.0 | O=C(O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL207174 | 76681 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 414 | 6 | 1 | 2 | 7.0 | O=C(O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2008.11.032 | ||
44439592 | 90205 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 507 | 11 | 1 | 6 | 3.7 | CCc1ccccc1N(CC(=O)NCCc1ccc(OC)c(OC)c1)S(=O)(=O)c1ccc(C#N)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL238929 | 90205 | 0 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 507 | 11 | 1 | 6 | 3.7 | CCc1ccccc1N(CC(=O)NCCc1ccc(OC)c(OC)c1)S(=O)(=O)c1ccc(C#N)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
44432879 | 168683 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 531 | 9 | 0 | 6 | 6.1 | CCOc1ccc(Cc2nnc(CN(c3cccc(Cl)c3Cl)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL441126 | 168683 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 531 | 9 | 0 | 6 | 6.1 | CCOc1ccc(Cc2nnc(CN(c3cccc(Cl)c3Cl)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44432868 | 154467 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 481 | 8 | 0 | 5 | 5.6 | CCc1ccccc1N(Cc1nnc(Cc2ccc(Cl)cc2)o1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL401432 | 154467 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 481 | 8 | 0 | 5 | 5.6 | CCc1ccccc1N(Cc1nnc(Cc2ccc(Cl)cc2)o1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
11339792 | 138758 | 0 | None | - | 0 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 445 | 7 | 1 | 6 | 4.2 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1cccc([N+](=O)[O-])c1 | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL379151 | 138758 | 0 | None | - | 0 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 445 | 7 | 1 | 6 | 4.2 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1cccc([N+](=O)[O-])c1 | 10.1016/j.bmcl.2006.06.086 | ||
3778726 | 89861 | 7 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 546 | 10 | 1 | 5 | 4.3 | COc1ccc(CCNC(=O)CN(c2cccc(Br)c2)S(=O)(=O)c2ccc(C)cc2)cc1OC | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL238514 | 89861 | 7 | None | - | 0 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 546 | 10 | 1 | 5 | 4.3 | COc1ccc(CCNC(=O)CN(c2cccc(Br)c2)S(=O)(=O)c2ccc(C)cc2)cc1OC | 10.1016/j.bmcl.2006.12.060 | ||
1009982 | 87589 | 16 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 452 | 9 | 1 | 4 | 4.1 | CCc1ccccc1N(CC(=O)NCc1ccc(OC)cc1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL234398 | 87589 | 16 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 452 | 9 | 1 | 4 | 4.1 | CCc1ccccc1N(CC(=O)NCc1ccc(OC)cc1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
3855927 | 91540 | 9 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 482 | 10 | 1 | 5 | 3.9 | COc1ccc(CCNC(=O)CN(c2ccccc2C)S(=O)(=O)c2ccc(C)cc2)cc1OC | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL241493 | 91540 | 9 | None | - | 0 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 482 | 10 | 1 | 5 | 3.9 | COc1ccc(CCNC(=O)CN(c2ccccc2C)S(=O)(=O)c2ccc(C)cc2)cc1OC | 10.1016/j.bmcl.2006.12.060 | ||
44432870 | 86361 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 491 | 10 | 0 | 6 | 5.3 | CCOc1ccc(Cc2nnc(CN(c3ccccc3CC)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL232159 | 86361 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 491 | 10 | 0 | 6 | 5.3 | CCOc1ccc(Cc2nnc(CN(c3ccccc3CC)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44432875 | 154128 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 497 | 8 | 0 | 6 | 5.3 | COc1ccc(Cc2nnc(CN(c3cccc(Cl)c3C)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL399613 | 154128 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 497 | 8 | 0 | 6 | 5.3 | COc1ccc(Cc2nnc(CN(c3cccc(Cl)c3C)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44432878 | 154129 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 517 | 8 | 0 | 6 | 5.7 | COc1ccc(Cc2nnc(CN(c3cccc(Cl)c3Cl)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL399614 | 154129 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 517 | 8 | 0 | 6 | 5.7 | COc1ccc(Cc2nnc(CN(c3cccc(Cl)c3Cl)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44568183 | 12629 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 461 | 8 | 2 | 5 | 5.2 | Cc1cc(C(=O)Nc2ccc(CO)cc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1187781 | 12629 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 461 | 8 | 2 | 5 | 5.2 | Cc1cc(C(=O)Nc2ccc(CO)cc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL520438 | 12629 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 461 | 8 | 2 | 5 | 5.2 | Cc1cc(C(=O)Nc2ccc(CO)cc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.05.118 | ||
44432866 | 86315 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 447 | 8 | 0 | 5 | 4.9 | CCc1ccccc1N(Cc1nnc(Cc2ccccc2)o1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL231964 | 86315 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 447 | 8 | 0 | 5 | 4.9 | CCc1ccccc1N(Cc1nnc(Cc2ccccc2)o1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44432872 | 86362 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 531 | 8 | 0 | 6 | 5.7 | COc1ccc(Cc2nnc(CN(c3cccc(C(F)(F)F)c3C)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL232160 | 86362 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 531 | 8 | 0 | 6 | 5.7 | COc1ccc(Cc2nnc(CN(c3cccc(C(F)(F)F)c3C)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44432896 | 86597 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 501 | 7 | 0 | 5 | 6.0 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3ccccc3Cl)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL232531 | 86597 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 501 | 7 | 0 | 5 | 6.0 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3ccccc3Cl)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
9844175 | 76756 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 404 | 6 | 1 | 2 | 6.7 | O=C(O)c1cccc(C2=C(c3cc(Cl)ccc3OCc3ccccc3)CCC2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
CHEMBL207577 | 76756 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 404 | 6 | 1 | 2 | 6.7 | O=C(O)c1cccc(C2=C(c3cc(Cl)ccc3OCc3ccccc3)CCC2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
11305124 | 80715 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 434 | 6 | 1 | 4 | 4.9 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1cccc(Cl)c1 | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL215667 | 80715 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 434 | 6 | 1 | 4 | 4.9 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1cccc(Cl)c1 | 10.1016/j.bmcl.2006.06.086 | ||
44439608 | 90931 | 0 | None | - | 0 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 506 | 9 | 1 | 4 | 5.0 | CCc1ccccc1N(CC(=O)NCc1cccc(OC(F)(F)F)c1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL240248 | 90931 | 0 | None | - | 0 | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 506 | 9 | 1 | 4 | 5.0 | CCc1ccccc1N(CC(=O)NCc1cccc(OC(F)(F)F)c1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
11962967 | 94788 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 413 | 7 | 1 | 5 | 5.4 | Cc1cc(NC(=O)OC(C)C)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL256092 | 94788 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 413 | 7 | 1 | 5 | 5.4 | Cc1cc(NC(=O)OC(C)C)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
44432876 | 86275 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 511 | 9 | 0 | 6 | 5.7 | CCOc1ccc(Cc2nnc(CN(c3cccc(Cl)c3C)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL231759 | 86275 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 511 | 9 | 0 | 6 | 5.7 | CCOc1ccc(Cc2nnc(CN(c3cccc(Cl)c3C)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44432921 | 144703 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 518 | 8 | 1 | 7 | 5.8 | COc1ccc(Nc2nnc(CN(c3cccc(Cl)c3Cl)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL391270 | 144703 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 518 | 8 | 1 | 7 | 5.8 | COc1ccc(Nc2nnc(CN(c3cccc(Cl)c3Cl)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44568663 | 12556 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 494 | 8 | 1 | 5 | 5.6 | CCN1CCc2ccc(C(=O)Nc3cc(C)n(Cc4cc(Cl)ccc4OCC(C)C)n3)cc2CC1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1187258 | 12556 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 494 | 8 | 1 | 5 | 5.6 | CCN1CCc2ccc(C(=O)Nc3cc(C)n(Cc4cc(Cl)ccc4OCC(C)C)n3)cc2CC1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL495091 | 12556 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 494 | 8 | 1 | 5 | 5.6 | CCN1CCc2ccc(C(=O)Nc3cc(C)n(Cc4cc(Cl)ccc4OCC(C)C)n3)cc2CC1 | 10.1016/j.bmcl.2008.05.118 | ||
44432907 | 86801 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Functional | ChEMBL | 535 | 7 | 0 | 5 | 6.6 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3c(Cl)cccc3Cl)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL232925 | 86801 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Functional | ChEMBL | 535 | 7 | 0 | 5 | 6.6 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3c(Cl)cccc3Cl)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44432888 | 147403 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Functional | ChEMBL | 485 | 7 | 0 | 5 | 5.5 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3ccc(F)cc3)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL393376 | 147403 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Functional | ChEMBL | 485 | 7 | 0 | 5 | 5.5 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3ccc(F)cc3)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44432892 | 154209 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Functional | ChEMBL | 485 | 7 | 0 | 5 | 5.5 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3cccc(F)c3)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL400025 | 154209 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Functional | ChEMBL | 485 | 7 | 0 | 5 | 5.5 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3cccc(F)c3)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44410931 | 76724 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 415 | 6 | 1 | 3 | 6.3 | O=C(O)c1cccc(-c2cccnc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
CHEMBL207395 | 76724 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 415 | 6 | 1 | 3 | 6.3 | O=C(O)c1cccc(-c2cccnc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
11269978 | 79558 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Functional | ChEMBL | 414 | 6 | 1 | 4 | 4.6 | Cc1cccc(COc2ccc(Br)cc2Cn2nc(C(=O)O)cc2C)c1 | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL212667 | 79558 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Functional | ChEMBL | 414 | 6 | 1 | 4 | 4.6 | Cc1cccc(COc2ccc(Br)cc2Cn2nc(C(=O)O)cc2C)c1 | 10.1016/j.bmcl.2006.06.086 | ||
11372607 | 79745 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 386 | 6 | 1 | 4 | 4.0 | O=C(O)c1ccn(Cc2cc(Br)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL213412 | 79745 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 386 | 6 | 1 | 4 | 4.0 | O=C(O)c1ccn(Cc2cc(Br)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2006.06.086 | ||
44439629 | 90786 | 0 | None | - | 0 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 432 | 7 | 1 | 5 | 2.9 | Cc1ccc(S(=O)(=O)N(CC(=O)NCc2ccc(Cl)cc2)c2ccnn2C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL240028 | 90786 | 0 | None | - | 0 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 432 | 7 | 1 | 5 | 2.9 | Cc1ccc(S(=O)(=O)N(CC(=O)NCc2ccc(Cl)cc2)c2ccnn2C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
1812712 | 154471 | 15 | None | - | 0 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 468 | 10 | 1 | 5 | 3.6 | COc1ccc(CCNC(=O)CN(c2ccccc2)S(=O)(=O)c2ccc(C)cc2)cc1OC | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL401452 | 154471 | 15 | None | - | 0 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 468 | 10 | 1 | 5 | 3.6 | COc1ccc(CCNC(=O)CN(c2ccccc2)S(=O)(=O)c2ccc(C)cc2)cc1OC | 10.1016/j.bmcl.2006.12.060 | ||
23661678 | 86943 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 585 | 9 | 0 | 6 | 6.8 | CCOc1ccc(Cc2nnc(CN(c3cccc(Cl)c3Cl)S(=O)(=O)c3ccc(C(F)(F)F)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL233335 | 86943 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 585 | 9 | 0 | 6 | 6.8 | CCOc1ccc(Cc2nnc(CN(c3cccc(Cl)c3Cl)S(=O)(=O)c3ccc(C(F)(F)F)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
11235389 | 76183 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 415 | 6 | 1 | 3 | 6.3 | O=C(O)c1cccc(-c2ncccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
CHEMBL206096 | 76183 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 415 | 6 | 1 | 3 | 6.3 | O=C(O)c1cccc(-c2ncccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
3689365 | 89853 | 7 | None | - | 0 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 482 | 10 | 1 | 5 | 3.9 | COc1ccc(CCNC(=O)CN(c2cccc(C)c2)S(=O)(=O)c2ccc(C)cc2)cc1OC | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL238512 | 89853 | 7 | None | - | 0 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 482 | 10 | 1 | 5 | 3.9 | COc1ccc(CCNC(=O)CN(c2cccc(C)c2)S(=O)(=O)c2ccc(C)cc2)cc1OC | 10.1016/j.bmcl.2006.12.060 | ||
44439589 | 89859 | 1 | None | - | 0 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 502 | 10 | 1 | 5 | 4.2 | COc1ccc(CCNC(=O)CN(c2cccc(Cl)c2)S(=O)(=O)c2ccc(C)cc2)cc1OC | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL238513 | 89859 | 1 | None | - | 0 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 502 | 10 | 1 | 5 | 4.2 | COc1ccc(CCNC(=O)CN(c2cccc(Cl)c2)S(=O)(=O)c2ccc(C)cc2)cc1OC | 10.1016/j.bmcl.2006.12.060 | ||
11317344 | 80151 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 468 | 7 | 1 | 5 | 5.7 | O=C(O)c1cc(-c2cccs2)n(Cc2cc(Br)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL214900 | 80151 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 468 | 7 | 1 | 5 | 5.7 | O=C(O)c1cc(-c2cccs2)n(Cc2cc(Br)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2006.06.086 | ||
24760394 | 14712 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 368 | 4 | 1 | 4 | 5.0 | O=C(O)c1csc(-n2cc(Cc3ccccc3)c3ccc(Cl)cc32)n1 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1207751 | 14712 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 368 | 4 | 1 | 4 | 5.0 | O=C(O)c1csc(-n2cc(Cc3ccccc3)c3ccc(Cl)cc32)n1 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL436656 | 14712 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 368 | 4 | 1 | 4 | 5.0 | O=C(O)c1csc(-n2cc(Cc3ccccc3)c3ccc(Cl)cc32)n1 | 10.1016/j.bmcl.2008.03.018 | ||
44432922 | 86815 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 572 | 8 | 1 | 7 | 6.5 | COc1ccc(Nc2nnc(CN(c3cccc(Cl)c3Cl)S(=O)(=O)c3ccc(C(F)(F)F)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL232950 | 86815 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 572 | 8 | 1 | 7 | 6.5 | COc1ccc(Nc2nnc(CN(c3cccc(Cl)c3Cl)S(=O)(=O)c3ccc(C(F)(F)F)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44432910 | 86838 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 537 | 8 | 0 | 6 | 6.0 | COc1ccc(Cc2nnc(CN(c3cccc(Cl)c3Cl)S(=O)(=O)c3ccc(Cl)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL233134 | 86838 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 537 | 8 | 0 | 6 | 6.0 | COc1ccc(Cc2nnc(CN(c3cccc(Cl)c3Cl)S(=O)(=O)c3ccc(Cl)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44432869 | 86360 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 477 | 9 | 0 | 6 | 4.9 | CCc1ccccc1N(Cc1nnc(Cc2ccc(OC)cc2)o1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL232158 | 86360 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 477 | 9 | 0 | 6 | 4.9 | CCc1ccccc1N(Cc1nnc(Cc2ccc(OC)cc2)o1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44432890 | 87372 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 485 | 7 | 0 | 5 | 5.5 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3ccccc3F)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL233808 | 87372 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 485 | 7 | 0 | 5 | 5.5 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3ccccc3F)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
10402929 | 57239 | 0 | None | - | 0 | Human | 4.2 | pKi | = | 4.2 | Functional | ChEMBL | 306 | 4 | 1 | 1 | 4.7 | O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00056-7 | ||
CHEMBL166351 | 57239 | 0 | None | - | 0 | Human | 4.2 | pKi | = | 4.2 | Functional | ChEMBL | 306 | 4 | 1 | 1 | 4.7 | O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(01)00056-7 | ||
44439585 | 154294 | 0 | None | - | 0 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 500 | 10 | 1 | 5 | 4.0 | COc1ccc(CCNC(=O)CN(c2ccccc2C)S(=O)(=O)c2ccc(C)cc2)c(F)c1OC | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL400423 | 154294 | 0 | None | - | 0 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 500 | 10 | 1 | 5 | 4.0 | COc1ccc(CCNC(=O)CN(c2ccccc2C)S(=O)(=O)c2ccc(C)cc2)c(F)c1OC | 10.1016/j.bmcl.2006.12.060 | ||
3508209 | 86258 | 10 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 456 | 8 | 1 | 3 | 4.5 | Cc1ccc(S(=O)(=O)N(CC(=O)NCCc2ccc(Cl)cc2)c2ccccc2C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL231699 | 86258 | 10 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 456 | 8 | 1 | 3 | 4.5 | Cc1ccc(S(=O)(=O)N(CC(=O)NCCc2ccc(Cl)cc2)c2ccccc2C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
44439620 | 91273 | 0 | None | - | 0 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 443 | 7 | 1 | 4 | 3.9 | Cc1ccc(S(=O)(=O)N(CC(=O)NCc2ccc(Cl)cc2)c2cccnc2C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL240866 | 91273 | 0 | None | - | 0 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 443 | 7 | 1 | 4 | 3.9 | Cc1ccc(S(=O)(=O)N(CC(=O)NCc2ccc(Cl)cc2)c2cccnc2C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
11281855 | 79465 | 0 | None | - | 0 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 430 | 7 | 1 | 5 | 4.3 | COc1ccccc1COc1ccc(Br)cc1Cn1nc(C(=O)O)cc1C | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL212300 | 79465 | 0 | None | - | 0 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 430 | 7 | 1 | 5 | 4.3 | COc1ccccc1COc1ccc(Br)cc1Cn1nc(C(=O)O)cc1C | 10.1016/j.bmcl.2006.06.086 | ||
44439593 | 90206 | 0 | None | - | 0 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 566 | 12 | 1 | 6 | 4.7 | CCc1ccccc1N(CC(=O)NCCc1ccc(OC)c(OC)c1)S(=O)(=O)c1ccc(OC(F)(F)F)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL238930 | 90206 | 0 | None | - | 0 | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 566 | 12 | 1 | 6 | 4.7 | CCc1ccccc1N(CC(=O)NCCc1ccc(OC)c(OC)c1)S(=O)(=O)c1ccc(OC(F)(F)F)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
44416110 | 79798 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 404 | 6 | 1 | 4 | 4.1 | O=C(O)c1nn(Cc2cc(Br)ccc2OCc2ccccc2)cc1F | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL213669 | 79798 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 404 | 6 | 1 | 4 | 4.1 | O=C(O)c1nn(Cc2cc(Br)ccc2OCc2ccccc2)cc1F | 10.1016/j.bmcl.2006.06.086 | ||
11406237 | 80155 | 0 | None | - | 0 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 376 | 6 | 1 | 4 | 3.9 | Cc1cc(C(=O)O)nn1Cc1cc(F)ccc1OCc1ccc(F)cc1F | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL214914 | 80155 | 0 | None | - | 0 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 376 | 6 | 1 | 4 | 3.9 | Cc1cc(C(=O)O)nn1Cc1cc(F)ccc1OCc1ccc(F)cc1F | 10.1016/j.bmcl.2006.06.086 | ||
11495634 | 14736 | 7 | None | 100 | 3 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 405 | 6 | 1 | 3 | 5.4 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL1207972 | 14736 | 7 | None | 100 | 3 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 405 | 6 | 1 | 3 | 5.4 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL467114 | 14736 | 7 | None | 100 | 3 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 405 | 6 | 1 | 3 | 5.4 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2009.02.112 | ||
44439597 | 90520 | 0 | None | - | 0 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 566 | 12 | 1 | 6 | 4.7 | CCc1ccccc1N(CC(=O)NCCc1ccc(OC)c(OC)c1)S(=O)(=O)c1cccc(OC(F)(F)F)c1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL239363 | 90520 | 0 | None | - | 0 | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 566 | 12 | 1 | 6 | 4.7 | CCc1ccccc1N(CC(=O)NCCc1ccc(OC)c(OC)c1)S(=O)(=O)c1cccc(OC(F)(F)F)c1 | 10.1016/j.bmcl.2006.12.060 | ||
44439630 | 90787 | 0 | None | - | 0 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 446 | 8 | 1 | 5 | 3.4 | CCn1nccc1N(CC(=O)NCc1ccc(Cl)cc1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL240029 | 90787 | 0 | None | - | 0 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 446 | 8 | 1 | 5 | 3.4 | CCn1nccc1N(CC(=O)NCc1ccc(Cl)cc1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
3686645 | 90076 | 4 | None | - | 0 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 468 | 10 | 1 | 5 | 3.6 | COc1ccc(CCNC(=O)CN(c2ccccc2C)S(=O)(=O)c2ccccc2)cc1OC | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL238726 | 90076 | 4 | None | - | 0 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 468 | 10 | 1 | 5 | 3.6 | COc1ccc(CCNC(=O)CN(c2ccccc2C)S(=O)(=O)c2ccccc2)cc1OC | 10.1016/j.bmcl.2006.12.060 | ||
44432926 | 86971 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 512 | 9 | 1 | 7 | 5.4 | COc1ccc(NCc2nnc(CN(c3cccc(Cl)c3C)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL233356 | 86971 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 512 | 9 | 1 | 7 | 5.4 | COc1ccc(NCc2nnc(CN(c3cccc(Cl)c3C)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44432919 | 87130 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 498 | 8 | 1 | 7 | 5.5 | COc1ccc(Nc2nnc(CN(c3cccc(Cl)c3C)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL233545 | 87130 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 498 | 8 | 1 | 7 | 5.5 | COc1ccc(Nc2nnc(CN(c3cccc(Cl)c3C)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44568304 | 12467 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 530 | 9 | 1 | 6 | 5.6 | Cc1cc(C(=O)Nc2ccc(CN3CCOCC3)cc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1186812 | 12467 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 530 | 9 | 1 | 6 | 5.6 | Cc1cc(C(=O)Nc2ccc(CN3CCOCC3)cc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL479591 | 12467 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 530 | 9 | 1 | 6 | 5.6 | Cc1cc(C(=O)Nc2ccc(CN3CCOCC3)cc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.05.118 | ||
44568703 | 12532 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 440 | 9 | 2 | 5 | 4.9 | CNCc1ccc(NC(=O)c2cc(C)n(Cc3cc(Cl)ccc3OCC(C)C)n2)cc1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1187164 | 12532 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 440 | 9 | 2 | 5 | 4.9 | CNCc1ccc(NC(=O)c2cc(C)n(Cc3cc(Cl)ccc3OCC(C)C)n2)cc1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL492237 | 12532 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 440 | 9 | 2 | 5 | 4.9 | CNCc1ccc(NC(=O)c2cc(C)n(Cc3cc(Cl)ccc3OCC(C)C)n2)cc1 | 10.1016/j.bmcl.2008.05.118 | ||
44568762 | 12643 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 514 | 13 | 3 | 7 | 4.0 | Cc1cc(C(=O)Nc2ccc(CN(CCO)CCO)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1187830 | 12643 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 514 | 13 | 3 | 7 | 4.0 | Cc1cc(C(=O)Nc2ccc(CN(CCO)CCO)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL523216 | 12643 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 514 | 13 | 3 | 7 | 4.0 | Cc1cc(C(=O)Nc2ccc(CN(CCO)CCO)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
44432925 | 86851 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 492 | 10 | 1 | 7 | 5.0 | CCc1ccccc1N(Cc1nnc(CNc2ccc(OC)cc2)o1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL233157 | 86851 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 492 | 10 | 1 | 7 | 5.0 | CCc1ccccc1N(Cc1nnc(CNc2ccc(OC)cc2)o1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
11257814 | 79845 | 0 | None | - | 0 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 390 | 6 | 1 | 4 | 4.8 | Cc1cc(C(=O)O)nn1Cc1ccccc1OCc1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL213875 | 79845 | 0 | None | - | 0 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 390 | 6 | 1 | 4 | 4.8 | Cc1cc(C(=O)O)nn1Cc1ccccc1OCc1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2006.06.086 | ||
59179917 | 161060 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 390 | 3 | 1 | 6 | 4.3 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3ccc(C(F)(F)F)nc32)n1 | 10.1016/j.bmcl.2018.06.022 | ||
CHEMBL4129609 | 161060 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 390 | 3 | 1 | 6 | 4.3 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3ccc(C(F)(F)F)nc32)n1 | 10.1016/j.bmcl.2018.06.022 | ||
11178058 | 80644 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 434 | 6 | 1 | 4 | 4.9 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccc(Cl)cc1 | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL215400 | 80644 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 434 | 6 | 1 | 4 | 4.9 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccc(Cl)cc1 | 10.1016/j.bmcl.2006.06.086 | ||
44439584 | 91569 | 0 | None | - | 0 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 515 | 10 | 2 | 5 | 3.2 | Cc1ccc(S(=O)(=O)N(CC(=O)NCCc2ccc(NS(C)(=O)=O)cc2)c2ccccc2C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL241670 | 91569 | 0 | None | - | 0 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 515 | 10 | 2 | 5 | 3.2 | Cc1ccc(S(=O)(=O)N(CC(=O)NCCc2ccc(NS(C)(=O)=O)cc2)c2ccccc2C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
11476911 | 81042 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 468 | 6 | 1 | 4 | 5.3 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccc(C(F)(F)F)cc1 | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL215956 | 81042 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 468 | 6 | 1 | 4 | 5.3 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccc(C(F)(F)F)cc1 | 10.1016/j.bmcl.2006.06.086 | ||
44415969 | 79530 | 0 | None | - | 0 | Human | 6.0 | pKi | = | 6.0 | Functional | ChEMBL | 442 | 9 | 1 | 4 | 5.3 | CCCCc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL212563 | 79530 | 0 | None | - | 0 | Human | 6.0 | pKi | = | 6.0 | Functional | ChEMBL | 442 | 9 | 1 | 4 | 5.3 | CCCCc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2006.06.086 | ||
138 | 3032 | 84 | None | -4 | 9 | Human | 8.2 | pEC50 | = | 8.2 | Functional | Drug Central | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | None | ||
1882 | 3032 | 84 | None | -4 | 9 | Human | 8.2 | pEC50 | = | 8.2 | Functional | Drug Central | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | None | ||
5280723 | 3032 | 84 | None | -4 | 9 | Human | 8.2 | pEC50 | = | 8.2 | Functional | Drug Central | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | None | ||
CHEMBL495 | 3032 | 84 | None | -4 | 9 | Human | 8.2 | pEC50 | = | 8.2 | Functional | Drug Central | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | None | ||
DB00770 | 3032 | 84 | None | -4 | 9 | Human | 8.2 | pEC50 | = | 8.2 | Functional | Drug Central | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | None | ||
91798918 | 214292 | 0 | None | 1 | 2 | Human | 8.1 | pEC50 | = | 8.1 | Functional | Drug Central | 400 | 10 | 2 | 6 | 2.6 | COC(=O)CCC=C=CCC1C(C(CC1=O)O)C=CC(COC2=CC=CC=C2)O | None | ||
138107701 | 186881 | 39 | None | 1 | 7 | Human | 8.1 | pEC50 | = | 8.1 | Functional | Drug Central | 360 | 8 | 3 | 3 | 3.5 | CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O | None | ||
5311181 | 186881 | 39 | None | 1 | 7 | Human | 8.1 | pEC50 | = | 8.1 | Functional | Drug Central | 360 | 8 | 3 | 3 | 3.5 | CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O | None | ||
CHEMBL494 | 186881 | 39 | None | 1 | 7 | Human | 8.1 | pEC50 | = | 8.1 | Functional | Drug Central | 360 | 8 | 3 | 3 | 3.5 | CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O | None | ||
2474 | 215964 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 288 | 5 | 1 | 2 | 3.9 | CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C | None | ||
11536 | 2891 | 25 | None | - | 1 | Mouse | 8.0 | pIC50 | = | 8.0 | Functional | Guide to Pharmacology | 500 | 9 | 1 | 6 | 5.1 | CC(CN(S(=O)(=O)c1scc(n1)C)c1cc2CCCc2cc1OCc1ccc(cc1)C(=O)O)C | None | ||
9827317 | 2891 | 25 | None | - | 1 | Mouse | 8.0 | pIC50 | = | 8.0 | Functional | Guide to Pharmacology | 500 | 9 | 1 | 6 | 5.1 | CC(CN(S(=O)(=O)c1scc(n1)C)c1cc2CCCc2cc1OCc1ccc(cc1)C(=O)O)C | None | ||
CHEMBL3939289 | 2891 | 25 | None | - | 1 | Mouse | 8.0 | pIC50 | = | 8.0 | Functional | Guide to Pharmacology | 500 | 9 | 1 | 6 | 5.1 | CC(CN(S(=O)(=O)c1scc(n1)C)c1cc2CCCc2cc1OCc1ccc(cc1)C(=O)O)C | None | ||
10238338 | 1870 | 23 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 441 | 6 | 1 | 3 | 6.4 | Clc1ccc(c(c1)C1=C(CCC1)c1cccc(n1)C(=O)O)OCc1ccc(cc1F)F | 17084082 | ||
3360 | 1870 | 23 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 441 | 6 | 1 | 3 | 6.4 | Clc1ccc(c(c1)C1=C(CCC1)c1cccc(n1)C(=O)O)OCc1ccc(cc1F)F | 17084082 | ||
CHEMBL234940 | 1870 | 23 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 441 | 6 | 1 | 3 | 6.4 | Clc1ccc(c(c1)C1=C(CCC1)c1cccc(n1)C(=O)O)OCc1ccc(cc1F)F | 17084082 |
Ligands | Receptor | Assay information | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name |
GPCRdb ID | #Vendors | Reference ligand |
Fold selectivity (Affinity) |
# tested GPCRs (Affinity) |
Species | p-value (-log) |
Type | Activity Relation |
Activity Value |
Assay Type | Assay Description | Source | Mol weight |
Rot Bonds |
H don | H acc | LogP | Smiles | DOI |
10409554 | 148989 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 414 | 11 | 3 | 4 | 3.9 | CC1(C)C(=O)[C@H](C/C=C\CCCC(=O)O)[C@@H](/C=C/C(O)CCc2ccccc2)[C@@H]1O | nan | ||
CHEMBL3946494 | 148989 | 0 | None | - | 0 | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 414 | 11 | 3 | 4 | 3.9 | CC1(C)C(=O)[C@H](C/C=C\CCCC(=O)O)[C@@H](/C=C/C(O)CCc2ccccc2)[C@@H]1O | nan | ||
10409554 | 148989 | 0 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 414 | 11 | 3 | 4 | 3.9 | CC1(C)C(=O)[C@H](C/C=C\CCCC(=O)O)[C@@H](/C=C/C(O)CCc2ccccc2)[C@@H]1O | nan | ||
CHEMBL3946494 | 148989 | 0 | None | - | 0 | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 414 | 11 | 3 | 4 | 3.9 | CC1(C)C(=O)[C@H](C/C=C\CCCC(=O)O)[C@@H](/C=C/C(O)CCc2ccccc2)[C@@H]1O | nan | ||
11340370 | 80170 | 7 | None | - | 1 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 468 | 6 | 1 | 4 | 5.6 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL2110364 | 80170 | 7 | None | - | 1 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 468 | 6 | 1 | 4 | 5.6 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL214971 | 80170 | 7 | None | - | 1 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 468 | 6 | 1 | 4 | 5.6 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2009.02.112 | ||
11340370 | 80170 | 7 | None | - | 1 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 468 | 6 | 1 | 4 | 5.6 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL2110364 | 80170 | 7 | None | - | 1 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 468 | 6 | 1 | 4 | 5.6 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL214971 | 80170 | 7 | None | - | 1 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 468 | 6 | 1 | 4 | 5.6 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2006.06.086 | ||
10007859 | 165936 | 0 | None | 5011 | 2 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 554 | 7 | 2 | 4 | 6.7 | CC(=O)Nc1cc(C(=O)O)cc(-n2c(C)ccc2-c2cc(Br)ccc2OCc2ccc(F)cc2F)c1 | 10.1016/j.bmcl.2006.10.078 | ||
CHEMBL427844 | 165936 | 0 | None | 5011 | 2 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 554 | 7 | 2 | 4 | 6.7 | CC(=O)Nc1cc(C(=O)O)cc(-n2c(C)ccc2-c2cc(Br)ccc2OCc2ccc(F)cc2F)c1 | 10.1016/j.bmcl.2006.10.078 | ||
10459580 | 85246 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 527 | 7 | 1 | 4 | 6.8 | COc1ccc(-n2c(C)ccc2-c2cc(Br)ccc2OCc2ccc(F)cc2F)cc1C(=O)O | 10.1016/j.bmcl.2006.11.059 | ||
CHEMBL228586 | 85246 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 527 | 7 | 1 | 4 | 6.8 | COc1ccc(-n2c(C)ccc2-c2cc(Br)ccc2OCc2ccc(F)cc2F)cc1C(=O)O | 10.1016/j.bmcl.2006.11.059 | ||
44426669 | 141538 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 554 | 7 | 2 | 4 | 6.7 | CC(=O)Nc1ccc(-n2c(C)ccc2-c2cc(Br)ccc2OCc2ccc(F)cc2F)cc1C(=O)O | 10.1016/j.bmcl.2006.11.059 | ||
CHEMBL387969 | 141538 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 554 | 7 | 2 | 4 | 6.7 | CC(=O)Nc1ccc(-n2c(C)ccc2-c2cc(Br)ccc2OCc2ccc(F)cc2F)cc1C(=O)O | 10.1016/j.bmcl.2006.11.059 | ||
44430700 | 143363 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 512 | 6 | 2 | 4 | 6.4 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1cc(N)cc(C(=O)O)c1 | 10.1016/j.bmcl.2006.10.078 | ||
CHEMBL390189 | 143363 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 512 | 6 | 2 | 4 | 6.4 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1cc(N)cc(C(=O)O)c1 | 10.1016/j.bmcl.2006.10.078 | ||
11189804 | 80168 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 436 | 6 | 1 | 4 | 4.6 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccc(F)cc1F | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL214967 | 80168 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 436 | 6 | 1 | 4 | 4.6 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccc(F)cc1F | 10.1016/j.bmcl.2006.06.086 | ||
59179887 | 105355 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 389 | 3 | 1 | 5 | 4.9 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3ccc(C(F)(F)F)cc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
CHEMBL3127163 | 105355 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 389 | 3 | 1 | 5 | 4.9 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3ccc(C(F)(F)F)cc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
10099424 | 141528 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 563 | 8 | 1 | 4 | 7.4 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1ccc(OC(F)F)c(C(=O)O)c1 | 10.1016/j.bmcl.2006.11.059 | ||
CHEMBL387878 | 141528 | 0 | None | - | 0 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 563 | 8 | 1 | 4 | 7.4 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1ccc(OC(F)F)c(C(=O)O)c1 | 10.1016/j.bmcl.2006.11.059 | ||
44430704 | 167201 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 536 | 7 | 2 | 4 | 6.6 | CC(=O)Nc1cc(C(=O)O)cc(-n2c(C)ccc2-c2cc(Br)ccc2OCc2ccc(F)cc2)c1 | 10.1016/j.bmcl.2006.10.078 | ||
CHEMBL430360 | 167201 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 536 | 7 | 2 | 4 | 6.6 | CC(=O)Nc1cc(C(=O)O)cc(-n2c(C)ccc2-c2cc(Br)ccc2OCc2ccc(F)cc2)c1 | 10.1016/j.bmcl.2006.10.078 | ||
10324022 | 85248 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 508 | 6 | 2 | 4 | 6.5 | Cc1c(N)cc(-n2c(C)ccc2-c2cc(Br)ccc2OCc2ccc(F)cc2)cc1C(=O)O | 10.1016/j.bmcl.2006.11.059 | ||
CHEMBL228593 | 85248 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 508 | 6 | 2 | 4 | 6.5 | Cc1c(N)cc(-n2c(C)ccc2-c2cc(Br)ccc2OCc2ccc(F)cc2)cc1C(=O)O | 10.1016/j.bmcl.2006.11.059 | ||
59179305 | 103408 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 359 | 3 | 1 | 5 | 4.3 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3c2-c2ccccc2C3)n1 | 10.1016/j.bmcl.2013.10.065 | ||
CHEMBL3092131 | 103408 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 359 | 3 | 1 | 5 | 4.3 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3c2-c2ccccc2C3)n1 | 10.1016/j.bmcl.2013.10.065 | ||
68258993 | 105349 | 1 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 335 | 3 | 1 | 5 | 4.2 | Cc1ccc2c(-c3ccccc3)nn(-c3nc(C(=O)O)cs3)c2c1 | 10.1016/j.bmcl.2014.01.052 | ||
CHEMBL3127157 | 105349 | 1 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 335 | 3 | 1 | 5 | 4.2 | Cc1ccc2c(-c3ccccc3)nn(-c3nc(C(=O)O)cs3)c2c1 | 10.1016/j.bmcl.2014.01.052 | ||
10051605 | 79271 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 497 | 6 | 1 | 3 | 6.8 | Cc1ccc(-c2cc(Br)ccc2OCc2c(F)cccc2F)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL211534 | 79271 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 497 | 6 | 1 | 3 | 6.8 | Cc1ccc(-c2cc(Br)ccc2OCc2c(F)cccc2F)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
59179936 | 105351 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 351 | 4 | 1 | 6 | 3.9 | COc1ccc2c(-c3ccccc3)nn(-c3nc(C(=O)O)cs3)c2c1 | 10.1016/j.bmcl.2014.01.052 | ||
CHEMBL3127159 | 105351 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 351 | 4 | 1 | 6 | 3.9 | COc1ccc2c(-c3ccccc3)nn(-c3nc(C(=O)O)cs3)c2c1 | 10.1016/j.bmcl.2014.01.052 | ||
1883 | 3033 | 71 | None | -12 | 24 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1021/jm9018756 | ||
1916 | 3033 | 71 | None | -12 | 24 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1021/jm9018756 | ||
5280360 | 3033 | 71 | None | -12 | 24 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1021/jm9018756 | ||
913 | 3033 | 71 | None | -12 | 24 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1021/jm9018756 | ||
CHEMBL548 | 3033 | 71 | None | -12 | 24 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1021/jm9018756 | ||
DB00917 | 3033 | 71 | None | -12 | 24 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1021/jm9018756 | ||
44430703 | 87620 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 518 | 7 | 2 | 4 | 6.5 | CC(=O)Nc1cc(C(=O)O)cc(-n2c(C)ccc2-c2cc(Br)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.10.078 | ||
CHEMBL234519 | 87620 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 518 | 7 | 2 | 4 | 6.5 | CC(=O)Nc1cc(C(=O)O)cc(-n2c(C)ccc2-c2cc(Br)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.10.078 | ||
44430706 | 87739 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 508 | 7 | 2 | 4 | 6.7 | CC(=O)Nc1cc(C(=O)O)cc(-n2c(C)ccc2-c2cc(C(F)(F)F)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.10.078 | ||
CHEMBL234727 | 87739 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 508 | 7 | 2 | 4 | 6.7 | CC(=O)Nc1cc(C(=O)O)cc(-n2c(C)ccc2-c2cc(C(F)(F)F)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.10.078 | ||
44430708 | 143414 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 568 | 7 | 1 | 4 | 6.8 | CC(=O)N(C)c1cc(C(=O)O)cc(-n2c(C)ccc2-c2cc(Br)ccc2OCc2ccc(F)cc2F)c1 | 10.1016/j.bmcl.2006.10.078 | ||
CHEMBL390238 | 143414 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 568 | 7 | 1 | 4 | 6.8 | CC(=O)N(C)c1cc(C(=O)O)cc(-n2c(C)ccc2-c2cc(Br)ccc2OCc2ccc(F)cc2F)c1 | 10.1016/j.bmcl.2006.10.078 | ||
44430710 | 166207 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 594 | 7 | 1 | 4 | 7.3 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1cc(C(=O)O)cc(N2CCCCC2=O)c1 | 10.1016/j.bmcl.2006.10.078 | ||
CHEMBL428367 | 166207 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 594 | 7 | 1 | 4 | 7.3 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1cc(C(=O)O)cc(N2CCCCC2=O)c1 | 10.1016/j.bmcl.2006.10.078 | ||
10456789 | 85299 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 456 | 6 | 2 | 3 | 6.9 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cc(C(=O)O)c2cc[nH]c2c1 | 10.1016/j.bmcl.2006.11.059 | ||
CHEMBL228963 | 85299 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 456 | 6 | 2 | 3 | 6.9 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cc(C(=O)O)c2cc[nH]c2c1 | 10.1016/j.bmcl.2006.11.059 | ||
10345789 | 85617 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 497 | 6 | 1 | 3 | 6.8 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2)n1-c1ccc(F)c(C(=O)O)c1 | 10.1016/j.bmcl.2006.11.059 | ||
CHEMBL230765 | 85617 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 497 | 6 | 1 | 3 | 6.8 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2)n1-c1ccc(F)c(C(=O)O)c1 | 10.1016/j.bmcl.2006.11.059 | ||
10346309 | 149728 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 511 | 6 | 1 | 3 | 7.1 | Cc1ccc(-n2c(C)ccc2-c2cc(Br)ccc2OCc2ccc(F)cc2F)cc1C(=O)O | 10.1016/j.bmcl.2006.11.059 | ||
CHEMBL395248 | 149728 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 511 | 6 | 1 | 3 | 7.1 | Cc1ccc(-n2c(C)ccc2-c2cc(Br)ccc2OCc2ccc(F)cc2F)cc1C(=O)O | 10.1016/j.bmcl.2006.11.059 | ||
44430707 | 87977 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 528 | 8 | 2 | 5 | 5.9 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccc(F)cc2)n1-c1cc(NS(C)(=O)=O)cc(C(=O)O)c1 | 10.1016/j.bmcl.2006.10.078 | ||
CHEMBL234945 | 87977 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 528 | 8 | 2 | 5 | 5.9 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccc(F)cc2)n1-c1cc(NS(C)(=O)=O)cc(C(=O)O)c1 | 10.1016/j.bmcl.2006.10.078 | ||
44430705 | 143178 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 602 | 7 | 2 | 4 | 6.6 | CC(=O)Nc1cc(C(=O)O)cc(-n2c(C)ccc2-c2cc(I)ccc2OCc2ccc(F)cc2F)c1 | 10.1016/j.bmcl.2006.10.078 | ||
CHEMBL390038 | 143178 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 602 | 7 | 2 | 4 | 6.6 | CC(=O)Nc1cc(C(=O)O)cc(-n2c(C)ccc2-c2cc(I)ccc2OCc2ccc(F)cc2F)c1 | 10.1016/j.bmcl.2006.10.078 | ||
44432367 | 87329 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 520 | 8 | 1 | 3 | 8.2 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1ccc(C(=O)N[C@H](C)c2ccccc2)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL233768 | 87329 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 520 | 8 | 1 | 3 | 8.2 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1ccc(C(=O)N[C@H](C)c2ccccc2)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
10481653 | 77793 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 515 | 6 | 1 | 3 | 6.9 | Cc1ccc(-c2cc(Br)ccc2OCc2c(F)cc(F)cc2F)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL210394 | 77793 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 515 | 6 | 1 | 3 | 6.9 | Cc1ccc(-c2cc(Br)ccc2OCc2c(F)cc(F)cc2F)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
44430775 | 142868 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 437 | 6 | 1 | 3 | 6.6 | Cc1ncc(C2=C(c3cc(Cl)ccc3OCc3ccc(F)cc3)CCC2)cc1C(=O)O | 10.1016/j.bmcl.2006.10.041 | ||
CHEMBL389796 | 142868 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 437 | 6 | 1 | 3 | 6.6 | Cc1ncc(C2=C(c3cc(Cl)ccc3OCc3ccc(F)cc3)CCC2)cc1C(=O)O | 10.1016/j.bmcl.2006.10.041 | ||
10051678 | 189212 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 499 | 9 | 2 | 3 | 7.7 | CCCC(=O)Nc1cc(C(=O)O)cc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL516324 | 189212 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 499 | 9 | 2 | 3 | 7.7 | CCCC(=O)Nc1cc(C(=O)O)cc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2008.11.032 | ||
57399080 | 67854 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 366 | 4 | 1 | 4 | 5.0 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
CHEMBL1915252 | 67854 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 366 | 4 | 1 | 4 | 5.0 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
44430702 | 87619 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 474 | 7 | 2 | 4 | 6.3 | CC(=O)Nc1cc(C(=O)O)cc(-n2c(C)ccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.10.078 | ||
CHEMBL234518 | 87619 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 474 | 7 | 2 | 4 | 6.3 | CC(=O)Nc1cc(C(=O)O)cc(-n2c(C)ccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.10.078 | ||
44430709 | 87978 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 580 | 7 | 1 | 4 | 6.9 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1cc(C(=O)O)cc(N2CCCC2=O)c1 | 10.1016/j.bmcl.2006.10.078 | ||
CHEMBL234946 | 87978 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 580 | 7 | 1 | 4 | 6.9 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1cc(C(=O)O)cc(N2CCCC2=O)c1 | 10.1016/j.bmcl.2006.10.078 | ||
44426668 | 85254 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 545 | 8 | 1 | 4 | 7.2 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2)n1-c1ccc(OC(F)F)c(C(=O)O)c1 | 10.1016/j.bmcl.2006.11.059 | ||
CHEMBL228638 | 85254 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 545 | 8 | 1 | 4 | 7.2 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2)n1-c1ccc(OC(F)F)c(C(=O)O)c1 | 10.1016/j.bmcl.2006.11.059 | ||
44426661 | 85618 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 469 | 6 | 1 | 3 | 6.9 | Cc1ccc(-c2cc(C(F)(F)F)ccc2OCc2ccccc2)n1-c1ccc(F)c(C(=O)O)c1 | 10.1016/j.bmcl.2006.11.059 | ||
CHEMBL230766 | 85618 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 469 | 6 | 1 | 3 | 6.9 | Cc1ccc(-c2cc(C(F)(F)F)ccc2OCc2ccccc2)n1-c1ccc(F)c(C(=O)O)c1 | 10.1016/j.bmcl.2006.11.059 | ||
44426666 | 150024 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 513 | 6 | 2 | 4 | 6.5 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1ccc(O)c(C(=O)O)c1 | 10.1016/j.bmcl.2006.11.059 | ||
CHEMBL395488 | 150024 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 513 | 6 | 2 | 4 | 6.5 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1ccc(O)c(C(=O)O)c1 | 10.1016/j.bmcl.2006.11.059 | ||
10253022 | 165712 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 446 | 6 | 2 | 4 | 6.3 | Cc1c(N)cc(-n2c(C)ccc2-c2cc(Cl)ccc2OCc2ccccc2)cc1C(=O)O | 10.1016/j.bmcl.2006.11.059 | ||
CHEMBL426913 | 165712 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 446 | 6 | 2 | 4 | 6.3 | Cc1c(N)cc(-n2c(C)ccc2-c2cc(Cl)ccc2OCc2ccccc2)cc1C(=O)O | 10.1016/j.bmcl.2006.11.059 | ||
21112869 | 143127 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 442 | 6 | 1 | 4 | 5.8 | O=C(O)c1cncc(C2=C(c3cc(Cl)ccc3OCc3ccc(F)cc3F)CCC2)n1 | 10.1016/j.bmcl.2006.10.041 | ||
CHEMBL389996 | 143127 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 442 | 6 | 1 | 4 | 5.8 | O=C(O)c1cncc(C2=C(c3cc(Cl)ccc3OCc3ccc(F)cc3F)CCC2)n1 | 10.1016/j.bmcl.2006.10.041 | ||
11754541 | 174349 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 471 | 7 | 2 | 3 | 6.9 | CC(=O)Nc1cc(C(=O)O)cc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL456495 | 174349 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 471 | 7 | 2 | 3 | 6.9 | CC(=O)Nc1cc(C(=O)O)cc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2008.11.032 | ||
10413628 | 175232 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 499 | 8 | 2 | 3 | 7.5 | CC(C)C(=O)Nc1cc(C(=O)O)cc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL458448 | 175232 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 499 | 8 | 2 | 3 | 7.5 | CC(C)C(=O)Nc1cc(C(=O)O)cc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2008.11.032 | ||
10454544 | 189170 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 415 | 6 | 1 | 3 | 6.3 | O=C(O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL515981 | 189170 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 415 | 6 | 1 | 3 | 6.3 | O=C(O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.11.032 | ||
25007720 | 67855 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 407 | 5 | 1 | 4 | 5.4 | Cc1cc(C(=O)NC(C)C)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
CHEMBL1915253 | 67855 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 407 | 5 | 1 | 4 | 5.4 | Cc1cc(C(=O)NC(C)C)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
25002703 | 67857 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 421 | 4 | 1 | 4 | 5.8 | Cc1cc(C(=O)NC(C)(C)C)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
CHEMBL1915255 | 67857 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 421 | 4 | 1 | 4 | 5.8 | Cc1cc(C(=O)NC(C)(C)C)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
57393869 | 67866 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 450 | 5 | 1 | 6 | 4.3 | Cc1cc(C(=O)NN2CCOCC2)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
CHEMBL1915264 | 67866 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 450 | 5 | 1 | 6 | 4.3 | Cc1cc(C(=O)NN2CCOCC2)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
11393812 | 14580 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 322 | 6 | 1 | 4 | 3.6 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL1206405 | 14580 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 322 | 6 | 1 | 4 | 3.6 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL270208 | 14580 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 322 | 6 | 1 | 4 | 3.6 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.01.071 | ||
11245245 | 14683 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 356 | 6 | 1 | 4 | 4.2 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL1207422 | 14683 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 356 | 6 | 1 | 4 | 4.2 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL404525 | 14683 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 356 | 6 | 1 | 4 | 4.2 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.01.071 | ||
15604741 | 14689 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 356 | 6 | 1 | 3 | 5.1 | Cc1cc(C(=O)O)oc1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL1207453 | 14689 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 356 | 6 | 1 | 3 | 5.1 | Cc1cc(C(=O)O)oc1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL407175 | 14689 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 356 | 6 | 1 | 3 | 5.1 | Cc1cc(C(=O)O)oc1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.01.071 | ||
11719237 | 14740 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 421 | 6 | 1 | 3 | 5.9 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL1207976 | 14740 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 421 | 6 | 1 | 3 | 5.9 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL467720 | 14740 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 421 | 6 | 1 | 3 | 5.9 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2Cl)n1 | 10.1016/j.bmcl.2009.02.112 | ||
21112865 | 86829 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 439 | 6 | 1 | 3 | 6.5 | O=C(O)c1cncc(C2=C(c3cc(C(F)(F)F)ccc3OCc3ccccc3)CCC2)c1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL233043 | 86829 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 439 | 6 | 1 | 3 | 6.5 | O=C(O)c1cncc(C2=C(c3cc(C(F)(F)F)ccc3OCc3ccccc3)CCC2)c1 | 10.1016/j.bmcl.2009.02.112 | ||
11211840 | 140727 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 403 | 6 | 1 | 3 | 6.1 | O=C(O)c1cccc(-n2cccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
CHEMBL383090 | 140727 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 403 | 6 | 1 | 3 | 6.1 | O=C(O)c1cccc(-n2cccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
44449061 | 14671 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 314 | 4 | 1 | 4 | 4.3 | Cc1ccc2c(CC(C)C)cn(-c3nc(C(=O)O)cs3)c2c1 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1207398 | 14671 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 314 | 4 | 1 | 4 | 4.3 | Cc1ccc2c(CC(C)C)cn(-c3nc(C(=O)O)cs3)c2c1 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL402656 | 14671 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 314 | 4 | 1 | 4 | 4.3 | Cc1ccc2c(CC(C)C)cn(-c3nc(C(=O)O)cs3)c2c1 | 10.1016/j.bmcl.2008.03.018 | ||
11314715 | 14562 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 370 | 6 | 1 | 4 | 4.7 | Cc1cc(C(=O)O)nn1C(C)c1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL1206281 | 14562 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 370 | 6 | 1 | 4 | 4.7 | Cc1cc(C(=O)O)nn1C(C)c1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL256785 | 14562 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 370 | 6 | 1 | 4 | 4.7 | Cc1cc(C(=O)O)nn1C(C)c1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
11963140 | 94453 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 425 | 7 | 1 | 4 | 5.8 | Cc1cc(NC(=O)CC(C)(C)C)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL254150 | 94453 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 425 | 7 | 1 | 4 | 5.8 | Cc1cc(NC(=O)CC(C)(C)C)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
44448561 | 155100 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 467 | 7 | 1 | 4 | 6.0 | Cc1cc(C(=O)Nc2c(F)cccc2F)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL404711 | 155100 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 467 | 7 | 1 | 4 | 6.0 | Cc1cc(C(=O)Nc2c(F)cccc2F)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
44430695 | 166692 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 521 | 6 | 1 | 3 | 7.7 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccc(F)cc2F)n1-c1cc(C(=O)O)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.10.078 | ||
CHEMBL429259 | 166692 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 521 | 6 | 1 | 3 | 7.7 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccc(F)cc2F)n1-c1cc(C(=O)O)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.10.078 | ||
23583060 | 86266 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 524 | 6 | 0 | 3 | 6.8 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1cccc(C(=O)N(C)C)c1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL231723 | 86266 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 524 | 6 | 0 | 3 | 6.8 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1cccc(C(=O)N(C)C)c1 | 10.1016/j.bmcl.2006.12.021 | ||
44568304 | 12467 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 530 | 9 | 1 | 6 | 5.6 | Cc1cc(C(=O)Nc2ccc(CN3CCOCC3)cc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1186812 | 12467 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 530 | 9 | 1 | 6 | 5.6 | Cc1cc(C(=O)Nc2ccc(CN3CCOCC3)cc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL479591 | 12467 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 530 | 9 | 1 | 6 | 5.6 | Cc1cc(C(=O)Nc2ccc(CN3CCOCC3)cc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.05.118 | ||
11245245 | 14683 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 356 | 6 | 1 | 4 | 4.2 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1207422 | 14683 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 356 | 6 | 1 | 4 | 4.2 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL404525 | 14683 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 356 | 6 | 1 | 4 | 4.2 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.05.118 | ||
44413124 | 77751 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 495 | 6 | 1 | 3 | 7.1 | Cc1ccc(-c2cc(Br)ccc2OCc2cccc(Cl)c2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL210261 | 77751 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 495 | 6 | 1 | 3 | 7.1 | Cc1ccc(-c2cc(Br)ccc2OCc2cccc(Cl)c2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
44413129 | 79335 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 495 | 6 | 1 | 3 | 7.1 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(Cl)cc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL211700 | 79335 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 495 | 6 | 1 | 3 | 7.1 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(Cl)cc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
11211840 | 140727 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 403 | 6 | 1 | 3 | 6.1 | O=C(O)c1cccc(-n2cccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL383090 | 140727 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 403 | 6 | 1 | 3 | 6.1 | O=C(O)c1cccc(-n2cccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.04.073 | ||
21112865 | 86829 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 439 | 6 | 1 | 3 | 6.5 | O=C(O)c1cncc(C2=C(c3cc(C(F)(F)F)ccc3OCc3ccccc3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
CHEMBL233043 | 86829 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 439 | 6 | 1 | 3 | 6.5 | O=C(O)c1cncc(C2=C(c3cc(C(F)(F)F)ccc3OCc3ccccc3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
59180001 | 105352 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 365 | 5 | 1 | 6 | 4.2 | CCOc1ccc2c(-c3ccccc3)nn(-c3nc(C(=O)O)cs3)c2c1 | 10.1016/j.bmcl.2014.01.052 | ||
CHEMBL3127160 | 105352 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 365 | 5 | 1 | 6 | 4.2 | CCOc1ccc2c(-c3ccccc3)nn(-c3nc(C(=O)O)cs3)c2c1 | 10.1016/j.bmcl.2014.01.052 | ||
59179287 | 103414 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 379 | 4 | 1 | 5 | 4.8 | Cc1c(-c2ccccc2)nn(-c2nc(C(=O)O)cs2)c1-c1ccc(F)cc1 | 10.1016/j.bmcl.2013.10.065 | ||
CHEMBL3092141 | 103414 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 379 | 4 | 1 | 5 | 4.8 | Cc1c(-c2ccccc2)nn(-c2nc(C(=O)O)cs2)c1-c1ccc(F)cc1 | 10.1016/j.bmcl.2013.10.065 | ||
11554210 | 14724 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 428 | 6 | 1 | 2 | 7.3 | Cc1cccc(-c2cc(Cl)ccc2OCc2ccccc2)c1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL1207925 | 14724 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 428 | 6 | 1 | 2 | 7.3 | Cc1cccc(-c2cc(Cl)ccc2OCc2ccccc2)c1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL458008 | 14724 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 428 | 6 | 1 | 2 | 7.3 | Cc1cccc(-c2cc(Cl)ccc2OCc2ccccc2)c1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2008.11.032 | ||
11654306 | 14760 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 381 | 7 | 1 | 3 | 5.9 | CCCCOc1ccc(Cl)cc1-c1ccccc1-c1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL1208125 | 14760 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 381 | 7 | 1 | 3 | 5.9 | CCCCOc1ccc(Cl)cc1-c1ccccc1-c1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL499155 | 14760 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 381 | 7 | 1 | 3 | 5.9 | CCCCOc1ccc(Cl)cc1-c1ccccc1-c1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2008.11.032 | ||
57393867 | 67860 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 448 | 5 | 2 | 5 | 5.2 | Cc1cc(NC(=O)C2CCNCC2)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
CHEMBL1915258 | 67860 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 448 | 5 | 2 | 5 | 5.2 | Cc1cc(NC(=O)C2CCNCC2)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
11653819 | 14741 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 359 | 6 | 1 | 3 | 5.0 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCC2CCCCC2)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL1207979 | 14741 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 359 | 6 | 1 | 3 | 5.0 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCC2CCCCC2)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL468723 | 14741 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 359 | 6 | 1 | 3 | 5.0 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCC2CCCCC2)n1 | 10.1016/j.bmcl.2009.02.112 | ||
11589267 | 14769 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 371 | 6 | 1 | 3 | 4.7 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(F)cc2)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL1208250 | 14769 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 371 | 6 | 1 | 3 | 4.7 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(F)cc2)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL511733 | 14769 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 371 | 6 | 1 | 3 | 4.7 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(F)cc2)n1 | 10.1016/j.bmcl.2009.02.112 | ||
11235389 | 76183 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 415 | 6 | 1 | 3 | 6.3 | O=C(O)c1cccc(-c2ncccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
CHEMBL206096 | 76183 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 415 | 6 | 1 | 3 | 6.3 | O=C(O)c1cccc(-c2ncccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
44449012 | 14662 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 4.6 | CC(C)Cc1cn(-c2ncc(C(=O)O)s2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1207380 | 14662 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 4.6 | CC(C)Cc1cn(-c2ncc(C(=O)O)s2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL401698 | 14662 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 4.6 | CC(C)Cc1cn(-c2ncc(C(=O)O)s2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
24760393 | 14681 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 348 | 4 | 1 | 5 | 4.3 | CC(C)C(=O)c1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1207420 | 14681 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 348 | 4 | 1 | 5 | 4.3 | CC(C)C(=O)c1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL404309 | 14681 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 348 | 4 | 1 | 5 | 4.3 | CC(C)C(=O)c1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
44448599 | 95245 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.8 | CNC(=O)c1cc(C)n(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL258171 | 95245 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 3.8 | CNC(=O)c1cc(C)n(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.04.018 | ||
24784839 | 67852 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 414 | 5 | 1 | 5 | 4.9 | Cc1cc(C(=O)NN2CCCCC2)nn1Cc1cc(Cl)cc2cc(C(C)C)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
CHEMBL1915250 | 67852 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 414 | 5 | 1 | 5 | 4.9 | Cc1cc(C(=O)NN2CCCCC2)nn1Cc1cc(Cl)cc2cc(C(C)C)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
44568595 | 12483 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 454 | 9 | 1 | 5 | 5.2 | Cc1cc(NC(=O)c2ccc(CN(C)C)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1186877 | 12483 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 454 | 9 | 1 | 5 | 5.2 | Cc1cc(NC(=O)c2ccc(CN(C)C)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL481519 | 12483 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 454 | 9 | 1 | 5 | 5.2 | Cc1cc(NC(=O)c2ccc(CN(C)C)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
24894000 | 12486 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 454 | 10 | 2 | 5 | 5.3 | CCNCc1ccc(C(=O)Nc2cc(C)n(Cc3cc(Cl)ccc3OCC(C)C)n2)cc1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1186890 | 12486 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 454 | 10 | 2 | 5 | 5.3 | CCNCc1ccc(C(=O)Nc2cc(C)n(Cc3cc(Cl)ccc3OCC(C)C)n2)cc1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL481870 | 12486 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 454 | 10 | 2 | 5 | 5.3 | CCNCc1ccc(C(=O)Nc2cc(C)n(Cc3cc(Cl)ccc3OCC(C)C)n2)cc1 | 10.1016/j.bmcl.2008.05.118 | ||
44568659 | 12538 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 494 | 8 | 1 | 5 | 5.9 | Cc1cc(NC(=O)c2ccc3c(c2)CCN(C(C)C)C3)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1187184 | 12538 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 494 | 8 | 1 | 5 | 5.9 | Cc1cc(NC(=O)c2ccc3c(c2)CCN(C(C)C)C3)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL492840 | 12538 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 494 | 8 | 1 | 5 | 5.9 | Cc1cc(NC(=O)c2ccc3c(c2)CCN(C(C)C)C3)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
44568634 | 12553 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 466 | 8 | 2 | 5 | 5.6 | Cc1cc(NC(=O)c2ccc(C3CCCN3)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1187235 | 12553 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 466 | 8 | 2 | 5 | 5.6 | Cc1cc(NC(=O)c2ccc(C3CCCN3)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL494466 | 12553 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 466 | 8 | 2 | 5 | 5.6 | Cc1cc(NC(=O)c2ccc(C3CCCN3)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
11398071 | 77032 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 507 | 6 | 1 | 3 | 7.4 | O=C(O)c1cccc(-n2c(-c3cc(Cl)ccc3OCc3ccc(F)cc3F)ccc2C(F)(F)F)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL208660 | 77032 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 507 | 6 | 1 | 3 | 7.4 | O=C(O)c1cccc(-n2c(-c3cc(Cl)ccc3OCc3ccc(F)cc3F)ccc2C(F)(F)F)c1 | 10.1016/j.bmcl.2006.04.073 | ||
44413014 | 77309 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 547 | 6 | 1 | 3 | 7.7 | Cc1ccc(-c2cc(Br)ccc2OCc2c(F)cccc2C(F)(F)F)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL208891 | 77309 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 547 | 6 | 1 | 3 | 7.7 | Cc1ccc(-c2cc(Br)ccc2OCc2c(F)cccc2C(F)(F)F)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
44413360 | 138416 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 529 | 6 | 1 | 3 | 7.8 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(Cl)c(Cl)c2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL378464 | 138416 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 529 | 6 | 1 | 3 | 7.8 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(Cl)c(Cl)c2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
44413079 | 138756 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 431 | 7 | 1 | 3 | 6.6 | CCc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL379143 | 138756 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 431 | 7 | 1 | 3 | 6.6 | CCc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
10150770 | 87426 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 400 | 7 | 1 | 3 | 6.1 | COc1ccc(COc2ccccc2C2=C(c3cccc(C(=O)O)c3)CCC2)cc1 | 10.1016/j.bmcl.2006.10.041 | ||
CHEMBL233858 | 87426 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 400 | 7 | 1 | 3 | 6.1 | COc1ccc(COc2ccccc2C2=C(c3cccc(C(=O)O)c3)CCC2)cc1 | 10.1016/j.bmcl.2006.10.041 | ||
10174660 | 87519 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 516 | 6 | 1 | 2 | 8.1 | O=C(O)c1cccc(C2=C(c3cc(Br)ccc3OCc3ccc(Cl)c(Cl)c3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
CHEMBL234069 | 87519 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 516 | 6 | 1 | 2 | 8.1 | O=C(O)c1cccc(C2=C(c3cc(Br)ccc3OCc3ccc(Cl)c(Cl)c3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
10216080 | 87932 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 395 | 6 | 1 | 3 | 5.9 | N#Cc1ccc(OCc2ccccc2)c(C2=C(c3cccc(C(=O)O)c3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
CHEMBL234924 | 87932 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 395 | 6 | 1 | 3 | 5.9 | N#Cc1ccc(OCc2ccccc2)c(C2=C(c3cccc(C(=O)O)c3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
59179992 | 105369 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 339 | 3 | 1 | 5 | 4.0 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3c2CCCCC3)n1 | 10.1016/j.bmcl.2014.01.052 | ||
CHEMBL3127178 | 105369 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 339 | 3 | 1 | 5 | 4.0 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3c2CCCCC3)n1 | 10.1016/j.bmcl.2014.01.052 | ||
1498200 | 92635 | 8 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 369 | 4 | 1 | 6 | 3.7 | COc1ccc(-c2cc(C(F)(F)F)nn2-c2nc(C(=O)O)cs2)cc1 | 10.1016/j.bmcl.2013.09.032 | ||
CHEMBL2442485 | 92635 | 8 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 369 | 4 | 1 | 6 | 3.7 | COc1ccc(-c2cc(C(F)(F)F)nn2-c2nc(C(=O)O)cs2)cc1 | 10.1016/j.bmcl.2013.09.032 | ||
59179237 | 103415 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 360 | 4 | 1 | 4 | 5.3 | Cc1c(-c2ccccc2)nn(-c2ccc(C(=O)O)s2)c1-c1ccccc1 | 10.1016/j.bmcl.2013.10.065 | ||
CHEMBL3092146 | 103415 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 360 | 4 | 1 | 4 | 5.3 | Cc1c(-c2ccccc2)nn(-c2ccc(C(=O)O)s2)c1-c1ccccc1 | 10.1016/j.bmcl.2013.10.065 | ||
44449207 | 14551 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 349 | 3 | 1 | 5 | 3.1 | CN(C)C(=O)c1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1206260 | 14551 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 349 | 3 | 1 | 5 | 3.1 | CN(C)C(=O)c1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL255319 | 14551 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 349 | 3 | 1 | 5 | 3.1 | CN(C)C(=O)c1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
44432866 | 86315 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 447 | 8 | 0 | 5 | 4.9 | CCc1ccccc1N(Cc1nnc(Cc2ccccc2)o1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL231964 | 86315 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 447 | 8 | 0 | 5 | 4.9 | CCc1ccccc1N(Cc1nnc(Cc2ccccc2)o1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
10001608 | 99885 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 410 | 13 | 4 | 4 | 3.7 | O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1cccc(F)c1 | 10.1016/s0960-894x(00)00273-0 | ||
CHEMBL289568 | 99885 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 410 | 13 | 4 | 4 | 3.7 | O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1cccc(F)c1 | 10.1016/s0960-894x(00)00273-0 | ||
44285146 | 134710 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 406 | 13 | 4 | 4 | 3.9 | Cc1ccccc1CC[C@H](O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1CCCCCCC(=O)O | 10.1016/s0960-894x(00)00273-0 | ||
CHEMBL37244 | 134710 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 406 | 13 | 4 | 4 | 3.9 | Cc1ccccc1CC[C@H](O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1CCCCCCC(=O)O | 10.1016/s0960-894x(00)00273-0 | ||
10047541 | 131989 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 416 | 13 | 4 | 6 | 3.8 | O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1cccs1 | 10.1021/jm990542v | ||
CHEMBL369797 | 131989 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 416 | 13 | 4 | 6 | 3.8 | O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1cccs1 | 10.1021/jm990542v | ||
15486806 | 100021 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 392 | 13 | 4 | 4 | 3.5 | O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1 | 10.1016/s0960-894x(00)00273-0 | ||
CHEMBL290969 | 100021 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 392 | 13 | 4 | 4 | 3.5 | O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1 | 10.1016/s0960-894x(00)00273-0 | ||
11305124 | 80715 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 434 | 6 | 1 | 4 | 4.9 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1cccc(Cl)c1 | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL215667 | 80715 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 434 | 6 | 1 | 4 | 4.9 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1cccc(Cl)c1 | 10.1016/j.bmcl.2006.06.086 | ||
44570712 | 182496 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 572 | 6 | 1 | 4 | 5.6 | CC12CCCC(/C=C/C(=O)NS(=O)(=O)c3cc(F)c(F)cc3F)=C1N(Cc1ccc(Cl)cc1Cl)C(=O)C2 | 10.1016/j.bmcl.2008.12.027 | ||
CHEMBL479439 | 182496 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 572 | 6 | 1 | 4 | 5.6 | CC12CCCC(/C=C/C(=O)NS(=O)(=O)c3cc(F)c(F)cc3F)=C1N(Cc1ccc(Cl)cc1Cl)C(=O)C2 | 10.1016/j.bmcl.2008.12.027 | ||
59179971 | 105358 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 355 | 3 | 1 | 5 | 4.5 | O=C(O)c1csc(-n2nc(-c3ccc(Cl)cc3)c3ccccc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
CHEMBL3127166 | 105358 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 355 | 3 | 1 | 5 | 4.5 | O=C(O)c1csc(-n2nc(-c3ccc(Cl)cc3)c3ccccc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
11720139 | 14734 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 469 | 6 | 1 | 3 | 6.8 | O=C(O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCc2c(F)cc(F)cc2F)n1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL1207968 | 14734 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 469 | 6 | 1 | 3 | 6.8 | O=C(O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCc2c(F)cc(F)cc2F)n1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL466549 | 14734 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 469 | 6 | 1 | 3 | 6.8 | O=C(O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCc2c(F)cc(F)cc2F)n1 | 10.1016/j.bmcl.2008.11.032 | ||
9844175 | 76756 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 404 | 6 | 1 | 2 | 6.7 | O=C(O)c1cccc(C2=C(c3cc(Cl)ccc3OCc3ccccc3)CCC2)c1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL207577 | 76756 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 404 | 6 | 1 | 2 | 6.7 | O=C(O)c1cccc(C2=C(c3cc(Cl)ccc3OCc3ccccc3)CCC2)c1 | 10.1016/j.bmcl.2008.01.071 | ||
11495634 | 14736 | 7 | None | 1 | 4 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 405 | 6 | 1 | 3 | 5.4 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL1207972 | 14736 | 7 | None | 1 | 4 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 405 | 6 | 1 | 3 | 5.4 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL467114 | 14736 | 7 | None | 1 | 4 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 405 | 6 | 1 | 3 | 5.4 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2009.02.112 | ||
11697614 | 14772 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 405 | 6 | 1 | 3 | 5.4 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(F)cc2Cl)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL1208255 | 14772 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 405 | 6 | 1 | 3 | 5.4 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(F)cc2Cl)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL513491 | 14772 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 405 | 6 | 1 | 3 | 5.4 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(F)cc2Cl)n1 | 10.1016/j.bmcl.2009.02.112 | ||
9844175 | 76756 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 404 | 6 | 1 | 2 | 6.7 | O=C(O)c1cccc(C2=C(c3cc(Cl)ccc3OCc3ccccc3)CCC2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
CHEMBL207577 | 76756 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 404 | 6 | 1 | 2 | 6.7 | O=C(O)c1cccc(C2=C(c3cc(Cl)ccc3OCc3ccccc3)CCC2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
24760466 | 14669 | 0 | None | 7943 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 368 | 4 | 1 | 4 | 5.0 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2cc(C(F)(F)F)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1207394 | 14669 | 0 | None | 7943 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 368 | 4 | 1 | 4 | 5.0 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2cc(C(F)(F)F)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL402392 | 14669 | 0 | None | 7943 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 368 | 4 | 1 | 4 | 5.0 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2cc(C(F)(F)F)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
44448324 | 94962 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 445 | 8 | 1 | 4 | 5.7 | Cc1cc(NC(=O)Cc2ccccc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL256933 | 94962 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 445 | 8 | 1 | 4 | 5.7 | Cc1cc(NC(=O)Cc2ccccc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
44448326 | 154939 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 467 | 7 | 1 | 4 | 6.0 | Cc1cc(NC(=O)c2c(F)cccc2F)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL404026 | 154939 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 467 | 7 | 1 | 4 | 6.0 | Cc1cc(NC(=O)c2c(F)cccc2F)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
44432883 | 168477 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 510 | 8 | 0 | 6 | 5.4 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3ccc(N(C)C)cc3)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL439559 | 168477 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 510 | 8 | 0 | 6 | 5.4 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3ccc(N(C)C)cc3)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44430697 | 141572 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 565 | 6 | 1 | 3 | 7.8 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1cc(C(=O)O)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.10.078 | ||
CHEMBL388243 | 141572 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 565 | 6 | 1 | 3 | 7.8 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1cc(C(=O)O)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.10.078 | ||
44432350 | 154391 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 7.0 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1ccc(C(=O)NCc2cccnc2)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL401023 | 154391 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 7.0 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1ccc(C(=O)NCc2cccnc2)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
44426664 | 85645 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 437 | 6 | 1 | 3 | 6.1 | Cc1ccc(-c2cc(F)ccc2OCc2ccc(F)cc2)n1-c1ccc(F)c(C(=O)O)c1 | 10.1016/j.bmcl.2006.11.059 | ||
CHEMBL230874 | 85645 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 437 | 6 | 1 | 3 | 6.1 | Cc1ccc(-c2cc(F)ccc2OCc2ccc(F)cc2)n1-c1ccc(F)c(C(=O)O)c1 | 10.1016/j.bmcl.2006.11.059 | ||
44426671 | 143222 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 511 | 6 | 1 | 3 | 7.6 | Cc1ccc(-c2cc(Br)ccc2OCc2ccccc2)n1-c1cc(C(=O)O)c2ccccc2c1 | 10.1016/j.bmcl.2006.11.059 | ||
CHEMBL390081 | 143222 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 511 | 6 | 1 | 3 | 7.6 | Cc1ccc(-c2cc(Br)ccc2OCc2ccccc2)n1-c1cc(C(=O)O)c2ccccc2c1 | 10.1016/j.bmcl.2006.11.059 | ||
44568556 | 12341 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 427 | 8 | 2 | 5 | 4.7 | Cc1cc(NC(=O)c2ccc(CO)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1186061 | 12341 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 427 | 8 | 2 | 5 | 4.7 | Cc1cc(NC(=O)c2ccc(CO)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL447709 | 12341 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 427 | 8 | 2 | 5 | 4.7 | Cc1cc(NC(=O)c2ccc(CO)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
44568217 | 12472 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 514 | 9 | 1 | 5 | 6.3 | Cc1cc(C(=O)Nc2ccc(CN3CCCC3)cc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1186827 | 12472 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 514 | 9 | 1 | 5 | 6.3 | Cc1cc(C(=O)Nc2ccc(CN3CCCC3)cc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL479989 | 12472 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 514 | 9 | 1 | 5 | 6.3 | Cc1cc(C(=O)Nc2ccc(CN3CCCC3)cc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.05.118 | ||
44568302 | 12475 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 528 | 9 | 1 | 5 | 6.7 | Cc1cc(C(=O)Nc2ccc(CN3CCCCC3)cc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1186833 | 12475 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 528 | 9 | 1 | 5 | 6.7 | Cc1cc(C(=O)Nc2ccc(CN3CCCCC3)cc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL480181 | 12475 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 528 | 9 | 1 | 5 | 6.7 | Cc1cc(C(=O)Nc2ccc(CN3CCCCC3)cc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.05.118 | ||
24894002 | 12476 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 474 | 9 | 2 | 5 | 5.4 | CNCc1ccc(NC(=O)c2cc(C)n(Cc3cc(Cl)ccc3OCc3ccccc3)n2)cc1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1186852 | 12476 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 474 | 9 | 2 | 5 | 5.4 | CNCc1ccc(NC(=O)c2cc(C)n(Cc3cc(Cl)ccc3OCc3ccccc3)n2)cc1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL480789 | 12476 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 474 | 9 | 2 | 5 | 5.4 | CNCc1ccc(NC(=O)c2cc(C)n(Cc3cc(Cl)ccc3OCc3ccccc3)n2)cc1 | 10.1016/j.bmcl.2008.05.118 | ||
44568186 | 12477 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 488 | 10 | 2 | 5 | 5.8 | CCNCc1ccc(NC(=O)c2cc(C)n(Cc3cc(Cl)ccc3OCc3ccccc3)n2)cc1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1186853 | 12477 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 488 | 10 | 2 | 5 | 5.8 | CCNCc1ccc(NC(=O)c2cc(C)n(Cc3cc(Cl)ccc3OCc3ccccc3)n2)cc1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL480790 | 12477 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 488 | 10 | 2 | 5 | 5.8 | CCNCc1ccc(NC(=O)c2cc(C)n(Cc3cc(Cl)ccc3OCc3ccccc3)n2)cc1 | 10.1016/j.bmcl.2008.05.118 | ||
44413013 | 79508 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 547 | 6 | 1 | 3 | 7.7 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(C(F)(F)F)cc2F)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL212471 | 79508 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 547 | 6 | 1 | 3 | 7.7 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(C(F)(F)F)cc2F)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
44413003 | 139083 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 513 | 6 | 1 | 3 | 7.3 | Cc1ccc(-c2cc(Br)ccc2OCc2c(F)cccc2Cl)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL379753 | 139083 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 513 | 6 | 1 | 3 | 7.3 | Cc1ccc(-c2cc(Br)ccc2OCc2c(F)cccc2Cl)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
44413123 | 139539 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 495 | 6 | 1 | 3 | 7.1 | Cc1ccc(-c2cc(Br)ccc2OCc2ccccc2Cl)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL380046 | 139539 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 495 | 6 | 1 | 3 | 7.1 | Cc1ccc(-c2cc(Br)ccc2OCc2ccccc2Cl)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
10195119 | 152636 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 448 | 6 | 1 | 2 | 6.8 | O=C(O)c1cccc(C2=C(c3cc(Br)ccc3OCc3ccccc3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
CHEMBL397687 | 152636 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 448 | 6 | 1 | 2 | 6.8 | O=C(O)c1cccc(C2=C(c3cc(Br)ccc3OCc3ccccc3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
10128061 | 166210 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 482 | 6 | 1 | 2 | 7.5 | O=C(O)c1cccc(C2=C(c3cc(Br)ccc3OCc3ccc(Cl)cc3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
CHEMBL428370 | 166210 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 482 | 6 | 1 | 2 | 7.5 | O=C(O)c1cccc(C2=C(c3cc(Br)ccc3OCc3ccc(Cl)cc3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
11545879 | 14737 | 2 | None | - | 3 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 381 | 6 | 1 | 3 | 5.8 | CC(C)COc1ccc(Cl)cc1-c1ccccc1-c1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL1207973 | 14737 | 2 | None | - | 3 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 381 | 6 | 1 | 3 | 5.8 | CC(C)COc1ccc(Cl)cc1-c1ccccc1-c1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL467510 | 14737 | 2 | None | - | 3 | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 381 | 6 | 1 | 3 | 5.8 | CC(C)COc1ccc(Cl)cc1-c1ccccc1-c1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2008.11.032 | ||
59179932 | 105367 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 320 | 3 | 1 | 4 | 4.5 | O=C(O)c1csc(-n2cc(-c3ccccc3)c3ccccc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
CHEMBL3127176 | 105367 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 320 | 3 | 1 | 4 | 4.5 | O=C(O)c1csc(-n2cc(-c3ccccc3)c3ccccc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
59179283 | 103411 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 367 | 4 | 1 | 6 | 4.7 | Cc1c(-c2ccccc2)nn(-c2nc(C(=O)O)cs2)c1-c1cccs1 | 10.1016/j.bmcl.2013.10.065 | ||
CHEMBL3092134 | 103411 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 367 | 4 | 1 | 6 | 4.7 | Cc1c(-c2ccccc2)nn(-c2nc(C(=O)O)cs2)c1-c1cccs1 | 10.1016/j.bmcl.2013.10.065 | ||
44416110 | 79798 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 404 | 6 | 1 | 4 | 4.1 | O=C(O)c1nn(Cc2cc(Br)ccc2OCc2ccccc2)cc1F | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL213669 | 79798 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 404 | 6 | 1 | 4 | 4.1 | O=C(O)c1nn(Cc2cc(Br)ccc2OCc2ccccc2)cc1F | 10.1016/j.bmcl.2006.06.086 | ||
44416211 | 141325 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 456 | 6 | 1 | 4 | 5.6 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccc(C(C)(C)C)cc1 | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL386532 | 141325 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 456 | 6 | 1 | 4 | 5.6 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccc(C(C)(C)C)cc1 | 10.1016/j.bmcl.2006.06.086 | ||
44581656 | 174941 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 414 | 6 | 1 | 2 | 7.0 | O=C(O)c1cc(-c2ccccc2-c2ccccc2OCc2ccccc2)ccc1Cl | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL457797 | 174941 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 414 | 6 | 1 | 2 | 7.0 | O=C(O)c1cc(-c2ccccc2-c2ccccc2OCc2ccccc2)ccc1Cl | 10.1016/j.bmcl.2008.11.032 | ||
11269978 | 79558 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 414 | 6 | 1 | 4 | 4.6 | Cc1cccc(COc2ccc(Br)cc2Cn2nc(C(=O)O)cc2C)c1 | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL212667 | 79558 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 414 | 6 | 1 | 4 | 4.6 | Cc1cccc(COc2ccc(Br)cc2Cn2nc(C(=O)O)cc2C)c1 | 10.1016/j.bmcl.2006.06.086 | ||
10046844 | 76707 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 404 | 6 | 1 | 4 | 5.5 | O=C(O)c1cccc(-n2cncc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
CHEMBL207293 | 76707 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 404 | 6 | 1 | 4 | 5.5 | O=C(O)c1cccc(-n2cncc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
23653604 | 14679 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 306 | 3 | 1 | 4 | 4.0 | CCc1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1207418 | 14679 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 306 | 3 | 1 | 4 | 4.0 | CCc1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL404176 | 14679 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 306 | 3 | 1 | 4 | 4.0 | CCc1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
44448446 | 94919 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 321 | 6 | 1 | 4 | 3.0 | Cc1cc(C(N)=O)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL256737 | 94919 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 321 | 6 | 1 | 4 | 3.0 | Cc1cc(C(N)=O)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.04.018 | ||
44448523 | 95014 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 432 | 7 | 1 | 5 | 5.1 | Cc1cc(C(=O)Nc2ccccn2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL257147 | 95014 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 432 | 7 | 1 | 5 | 5.1 | Cc1cc(C(=O)Nc2ccccn2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
44448597 | 95206 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 397 | 7 | 1 | 4 | 4.6 | Cc1cc(C(=O)NC(C)C)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL257970 | 95206 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 397 | 7 | 1 | 4 | 4.6 | Cc1cc(C(=O)NC(C)C)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
44448636 | 168209 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 355 | 6 | 1 | 4 | 3.6 | Cc1cc(C(N)=O)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL437399 | 168209 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 355 | 6 | 1 | 4 | 3.6 | Cc1cc(C(N)=O)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
57400734 | 67822 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 331 | 4 | 1 | 4 | 4.0 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cn2cc(C(C)C)cc12 | 10.1016/j.bmcl.2011.05.047 | ||
CHEMBL1915018 | 67822 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 331 | 4 | 1 | 4 | 4.0 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cn2cc(C(C)C)cc12 | 10.1016/j.bmcl.2011.05.047 | ||
44432869 | 86360 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 477 | 9 | 0 | 6 | 4.9 | CCc1ccccc1N(Cc1nnc(Cc2ccc(OC)cc2)o1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL232158 | 86360 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 477 | 9 | 0 | 6 | 4.9 | CCc1ccccc1N(Cc1nnc(Cc2ccc(OC)cc2)o1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44432870 | 86361 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 491 | 10 | 0 | 6 | 5.3 | CCOc1ccc(Cc2nnc(CN(c3ccccc3CC)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL232159 | 86361 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 491 | 10 | 0 | 6 | 5.3 | CCOc1ccc(Cc2nnc(CN(c3ccccc3CC)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44430678 | 87452 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 461 | 8 | 1 | 4 | 6.8 | CCOc1ccc(C(=O)O)cc1-n1c(C)ccc1-c1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2006.10.078 | ||
CHEMBL233872 | 87452 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 461 | 8 | 1 | 4 | 6.8 | CCOc1ccc(C(=O)O)cc1-n1c(C)ccc1-c1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2006.10.078 | ||
44432332 | 86769 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 451 | 6 | 0 | 4 | 6.1 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(S(C)(=O)=O)c1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL232733 | 86769 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 451 | 6 | 0 | 4 | 6.1 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(S(C)(=O)=O)c1 | 10.1016/j.bmcl.2006.12.021 | ||
44432372 | 87540 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 530 | 6 | 0 | 3 | 8.1 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1cccc(-c2cccnc2)c1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL234182 | 87540 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 530 | 6 | 0 | 3 | 8.1 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1cccc(-c2cccnc2)c1 | 10.1016/j.bmcl.2006.12.021 | ||
44432374 | 147847 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 531 | 6 | 0 | 4 | 7.5 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1cccc(-c2ncccn2)c1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL393743 | 147847 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 531 | 6 | 0 | 4 | 7.5 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1cccc(-c2ncccn2)c1 | 10.1016/j.bmcl.2006.12.021 | ||
44568512 | 12480 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 480 | 9 | 1 | 5 | 5.8 | Cc1cc(NC(=O)c2cccc(CN3CCCC3)c2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1186862 | 12480 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 480 | 9 | 1 | 5 | 5.8 | Cc1cc(NC(=O)c2cccc(CN3CCCC3)c2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL481137 | 12480 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 480 | 9 | 1 | 5 | 5.8 | Cc1cc(NC(=O)c2cccc(CN3CCCC3)c2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
44413205 | 138156 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 423 | 6 | 1 | 3 | 6.8 | Cc1ccc(-c2cc(Cl)ccc2OCC2CCCCC2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL377831 | 138156 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 423 | 6 | 1 | 3 | 6.8 | Cc1ccc(-c2cc(Cl)ccc2OCC2CCCCC2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
44432869 | 86360 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 477 | 9 | 0 | 6 | 4.9 | CCc1ccccc1N(Cc1nnc(Cc2ccc(OC)cc2)o1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL232158 | 86360 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 477 | 9 | 0 | 6 | 4.9 | CCc1ccccc1N(Cc1nnc(Cc2ccc(OC)cc2)o1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
68318287 | 103423 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 473 | 4 | 1 | 5 | 5.0 | O=C(O)c1csc(-n2nc(-c3ccccc3)c(I)c2-c2ccccc2)n1 | 10.1016/j.bmcl.2013.10.065 | ||
CHEMBL3092154 | 103423 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 473 | 4 | 1 | 5 | 5.0 | O=C(O)c1csc(-n2nc(-c3ccccc3)c(I)c2-c2ccccc2)n1 | 10.1016/j.bmcl.2013.10.065 | ||
1955 | 16 | 1 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 428 | 13 | 4 | 5 | 3.6 | O[C@@H](COc1cccc(c1)Cl)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1CCCCCCC(=O)O)O | 10.1021/jm990542v | ||
5311240 | 16 | 1 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 428 | 13 | 4 | 5 | 3.6 | O[C@@H](COc1cccc(c1)Cl)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1CCCCCCC(=O)O)O | 10.1021/jm990542v | ||
CHEMBL36041 | 16 | 1 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 428 | 13 | 4 | 5 | 3.6 | O[C@@H](COc1cccc(c1)Cl)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1CCCCCCC(=O)O)O | 10.1021/jm990542v | ||
44564990 | 192049 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 538 | 6 | 1 | 5 | 5.7 | Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)c(F)c3)cccc21 | 10.1016/j.bmcl.2008.12.112 | ||
CHEMBL521777 | 192049 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 538 | 6 | 1 | 5 | 5.7 | Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)c(F)c3)cccc21 | 10.1016/j.bmcl.2008.12.112 | ||
11407950 | 80685 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 436 | 6 | 1 | 4 | 4.6 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1c(F)cccc1F | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL215573 | 80685 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 436 | 6 | 1 | 4 | 4.6 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1c(F)cccc1F | 10.1016/j.bmcl.2006.06.086 | ||
136003254 | 105350 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 337 | 3 | 2 | 6 | 3.6 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3ccc(O)cc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
CHEMBL3127158 | 105350 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 337 | 3 | 2 | 6 | 3.6 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3ccc(O)cc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
68259112 | 105360 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 389 | 3 | 1 | 5 | 4.9 | O=C(O)c1csc(-n2nc(-c3ccc(C(F)(F)F)cc3)c3ccccc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
CHEMBL3127168 | 105360 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 389 | 3 | 1 | 5 | 4.9 | O=C(O)c1csc(-n2nc(-c3ccc(C(F)(F)F)cc3)c3ccccc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
44571354 | 183487 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 516 | 7 | 1 | 5 | 4.2 | COc1cccc(CN2C(=O)CC3(C)CCCC(/C=C/C(=O)NS(=O)(=O)c4ccc(F)c(F)c4)=C23)c1 | 10.1016/j.bmcl.2008.12.027 | ||
CHEMBL482330 | 183487 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 516 | 7 | 1 | 5 | 4.2 | COc1cccc(CN2C(=O)CC3(C)CCCC(/C=C/C(=O)NS(=O)(=O)c4ccc(F)c(F)c4)=C23)c1 | 10.1016/j.bmcl.2008.12.027 | ||
44157014 | 192017 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 518 | 6 | 1 | 5 | 5.9 | Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc4ccccc4c3)cccc21 | 10.1016/j.bmcl.2008.12.112 | ||
CHEMBL521609 | 192017 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 518 | 6 | 1 | 5 | 5.9 | Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc4ccccc4c3)cccc21 | 10.1016/j.bmcl.2008.12.112 | ||
11545879 | 14737 | 2 | None | 125 | 3 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 381 | 6 | 1 | 3 | 5.8 | CC(C)COc1ccc(Cl)cc1-c1ccccc1-c1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL1207973 | 14737 | 2 | None | 125 | 3 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 381 | 6 | 1 | 3 | 5.8 | CC(C)COc1ccc(Cl)cc1-c1ccccc1-c1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL467510 | 14737 | 2 | None | 125 | 3 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 381 | 6 | 1 | 3 | 5.8 | CC(C)COc1ccc(Cl)cc1-c1ccccc1-c1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2008.11.032 | ||
11545879 | 14737 | 2 | None | 125 | 3 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 381 | 6 | 1 | 3 | 5.8 | CC(C)COc1ccc(Cl)cc1-c1ccccc1-c1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL1207973 | 14737 | 2 | None | 125 | 3 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 381 | 6 | 1 | 3 | 5.8 | CC(C)COc1ccc(Cl)cc1-c1ccccc1-c1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL467510 | 14737 | 2 | None | 125 | 3 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 381 | 6 | 1 | 3 | 5.8 | CC(C)COc1ccc(Cl)cc1-c1ccccc1-c1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2009.02.112 | ||
44448405 | 94454 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 423 | 7 | 1 | 4 | 5.6 | Cc1cc(NC(=O)C2CCCC2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL254151 | 94454 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 423 | 7 | 1 | 4 | 5.6 | Cc1cc(NC(=O)C2CCCC2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
44448347 | 94585 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 431 | 7 | 1 | 4 | 5.7 | Cc1cc(NC(=O)c2ccccc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL254990 | 94585 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 431 | 7 | 1 | 4 | 5.7 | Cc1cc(NC(=O)c2ccccc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
44448742 | 168264 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 474 | 8 | 1 | 5 | 5.8 | Cc1cc(NC(=O)C(C)(C)c2ccccn2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL437796 | 168264 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 474 | 8 | 1 | 5 | 5.8 | Cc1cc(NC(=O)C(C)(C)c2ccccn2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
44432341 | 86841 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 524 | 6 | 0 | 3 | 6.8 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1ccc(C(=O)N(C)C)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL233138 | 86841 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 524 | 6 | 0 | 3 | 6.8 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1ccc(C(=O)N(C)C)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
44432344 | 168457 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 552 | 6 | 1 | 3 | 7.6 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1ccc(C(=O)NC(C)(C)C)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL439381 | 168457 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 552 | 6 | 1 | 3 | 7.6 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1ccc(C(=O)NC(C)(C)C)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
44426663 | 85644 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 433 | 6 | 1 | 3 | 6.3 | Cc1ccc(OCc2ccc(F)cc2)c(-c2ccc(C)n2-c2ccc(F)c(C(=O)O)c2)c1 | 10.1016/j.bmcl.2006.11.059 | ||
CHEMBL230873 | 85644 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 433 | 6 | 1 | 3 | 6.3 | Cc1ccc(OCc2ccc(F)cc2)c(-c2ccc(C)n2-c2ccc(F)c(C(=O)O)c2)c1 | 10.1016/j.bmcl.2006.11.059 | ||
9980905 | 141752 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 444 | 6 | 2 | 4 | 6.1 | Cc1ccc(OCc2ccc(F)cc2)c(-c2ccc(C)n2-c2cc(N)c(C)c(C(=O)O)c2)c1 | 10.1016/j.bmcl.2006.11.059 | ||
CHEMBL388510 | 141752 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 444 | 6 | 2 | 4 | 6.1 | Cc1ccc(OCc2ccc(F)cc2)c(-c2ccc(C)n2-c2cc(N)c(C)c(C(=O)O)c2)c1 | 10.1016/j.bmcl.2006.11.059 | ||
44568762 | 12643 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 514 | 13 | 3 | 7 | 4.0 | Cc1cc(C(=O)Nc2ccc(CN(CCO)CCO)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1187830 | 12643 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 514 | 13 | 3 | 7 | 4.0 | Cc1cc(C(=O)Nc2ccc(CN(CCO)CCO)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL523216 | 12643 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 514 | 13 | 3 | 7 | 4.0 | Cc1cc(C(=O)Nc2ccc(CN(CCO)CCO)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
44448347 | 94585 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 431 | 7 | 1 | 4 | 5.7 | Cc1cc(NC(=O)c2ccccc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL254990 | 94585 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 431 | 7 | 1 | 4 | 5.7 | Cc1cc(NC(=O)c2ccccc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.05.118 | ||
11213683 | 77087 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 453 | 6 | 1 | 3 | 6.5 | Cc1ccc(-c2cc(Br)ccc2OCC2CCCC2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL208684 | 77087 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 453 | 6 | 1 | 3 | 6.5 | Cc1ccc(-c2cc(Br)ccc2OCC2CCCC2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
44413383 | 77306 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 513 | 6 | 1 | 3 | 7.3 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2Cl)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL208882 | 77306 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 513 | 6 | 1 | 3 | 7.3 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2Cl)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
44413128 | 138169 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 545 | 7 | 1 | 4 | 7.4 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(OC(F)(F)F)cc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL377910 | 138169 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 545 | 7 | 1 | 4 | 7.4 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(OC(F)(F)F)cc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
10288374 | 87729 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 452 | 7 | 1 | 3 | 7.1 | CSc1ccc(OCc2ccc(F)cc2F)c(C2=C(c3cccc(C(=O)O)c3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
CHEMBL234709 | 87729 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 452 | 7 | 1 | 3 | 7.1 | CSc1ccc(OCc2ccc(F)cc2F)c(C2=C(c3cccc(C(=O)O)c3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
10152107 | 87730 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 484 | 7 | 1 | 4 | 5.7 | CS(=O)(=O)c1ccc(OCc2ccc(F)cc2F)c(C2=C(c3cccc(C(=O)O)c3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
CHEMBL234710 | 87730 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 484 | 7 | 1 | 4 | 5.7 | CS(=O)(=O)c1ccc(OCc2ccc(F)cc2F)c(C2=C(c3cccc(C(=O)O)c3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
68329608 | 103419 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 415 | 4 | 1 | 5 | 5.4 | O=C(O)c1csc(-n2nc(-c3ccccc3)c(C(F)(F)F)c2-c2ccccc2)n1 | 10.1016/j.bmcl.2013.10.065 | ||
CHEMBL3092150 | 103419 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 415 | 4 | 1 | 5 | 5.4 | O=C(O)c1csc(-n2nc(-c3ccccc3)c(C(F)(F)F)c2-c2ccccc2)n1 | 10.1016/j.bmcl.2013.10.065 | ||
11633350 | 14725 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 407 | 6 | 1 | 3 | 6.3 | O=C(O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCC2CCCC2)n1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL1207928 | 14725 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 407 | 6 | 1 | 3 | 6.3 | O=C(O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCC2CCCC2)n1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL458858 | 14725 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 407 | 6 | 1 | 3 | 6.3 | O=C(O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCC2CCCC2)n1 | 10.1016/j.bmcl.2008.11.032 | ||
11559437 | 97017 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 353 | 6 | 1 | 3 | 4.6 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL258041 | 97017 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 353 | 6 | 1 | 3 | 4.6 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL270174 | 97017 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 353 | 6 | 1 | 3 | 4.6 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.01.071 | ||
44455299 | 154840 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 355 | 6 | 1 | 3 | 4.8 | Cc1cc(C(=O)O)cn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL403459 | 154840 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 355 | 6 | 1 | 3 | 4.8 | Cc1cc(C(=O)O)cn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.01.071 | ||
11559437 | 97017 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 353 | 6 | 1 | 3 | 4.6 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL258041 | 97017 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 353 | 6 | 1 | 3 | 4.6 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL270174 | 97017 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 353 | 6 | 1 | 3 | 4.6 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2009.02.112 | ||
24760468 | 14566 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 348 | 5 | 1 | 4 | 4.6 | CC(C)Cc1cn(-c2nc(CC(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1206288 | 14566 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 348 | 5 | 1 | 4 | 4.6 | CC(C)Cc1cn(-c2nc(CC(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL257413 | 14566 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 348 | 5 | 1 | 4 | 4.6 | CC(C)Cc1cn(-c2nc(CC(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
24760396 | 14664 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 300 | 4 | 1 | 4 | 4.0 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2ccccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1207383 | 14664 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 300 | 4 | 1 | 4 | 4.0 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2ccccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL401785 | 14664 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 300 | 4 | 1 | 4 | 4.0 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2ccccc12 | 10.1016/j.bmcl.2008.03.018 | ||
24760394 | 14712 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 368 | 4 | 1 | 4 | 5.0 | O=C(O)c1csc(-n2cc(Cc3ccccc3)c3ccc(Cl)cc32)n1 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1207751 | 14712 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 368 | 4 | 1 | 4 | 5.0 | O=C(O)c1csc(-n2cc(Cc3ccccc3)c3ccc(Cl)cc32)n1 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL436656 | 14712 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 368 | 4 | 1 | 4 | 5.0 | O=C(O)c1csc(-n2cc(Cc3ccccc3)c3ccc(Cl)cc32)n1 | 10.1016/j.bmcl.2008.03.018 | ||
11559437 | 97017 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 353 | 6 | 1 | 3 | 4.6 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL258041 | 97017 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 353 | 6 | 1 | 3 | 4.6 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL270174 | 97017 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 353 | 6 | 1 | 3 | 4.6 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.03.018 | ||
44448595 | 95205 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 431 | 8 | 1 | 4 | 5.3 | O=C(Cc1ccccc1)Nc1ccn(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL257969 | 95205 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 431 | 8 | 1 | 4 | 5.3 | O=C(Cc1ccccc1)Nc1ccn(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.04.018 | ||
44432905 | 86800 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 501 | 7 | 0 | 5 | 6.0 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3cccc(Cl)c3)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL232924 | 86800 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 501 | 7 | 0 | 5 | 6.0 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3cccc(Cl)c3)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44430676 | 150366 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 487 | 6 | 1 | 3 | 7.3 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccc(F)cc2F)n1-c1cc(C(=O)O)ccc1Cl | 10.1016/j.bmcl.2006.10.078 | ||
CHEMBL395756 | 150366 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 487 | 6 | 1 | 3 | 7.3 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccc(F)cc2F)n1-c1cc(C(=O)O)ccc1Cl | 10.1016/j.bmcl.2006.10.078 | ||
44432382 | 87330 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 522 | 5 | 1 | 4 | 6.0 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1ccc2c(c1)C(=O)NC2=O | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL233772 | 87330 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 522 | 5 | 1 | 4 | 6.0 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1ccc2c(c1)C(=O)NC2=O | 10.1016/j.bmcl.2006.12.021 | ||
10150866 | 87976 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 406 | 6 | 1 | 4 | 5.5 | O=C(O)c1ccnc(C2=C(c3cc(Cl)ccc3OCc3ccccc3)CCC2)n1 | 10.1016/j.bmcl.2006.10.041 | ||
CHEMBL234939 | 87976 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 406 | 6 | 1 | 4 | 5.5 | O=C(O)c1ccnc(C2=C(c3cc(Cl)ccc3OCc3ccccc3)CCC2)n1 | 10.1016/j.bmcl.2006.10.041 | ||
59179928 | 105364 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 328 | 3 | 1 | 6 | 3.2 | O=C(O)c1csc(-n2nc(N3CCCCC3)c3ccccc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
CHEMBL3127173 | 105364 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 328 | 3 | 1 | 6 | 3.2 | O=C(O)c1csc(-n2nc(N3CCCCC3)c3ccccc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
59179923 | 105368 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 325 | 3 | 1 | 5 | 3.6 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3c2CCCC3)n1 | 10.1016/j.bmcl.2014.01.052 | ||
CHEMBL3127177 | 105368 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 325 | 3 | 1 | 5 | 3.6 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3c2CCCC3)n1 | 10.1016/j.bmcl.2014.01.052 | ||
11545879 | 14737 | 2 | None | 125 | 3 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 381 | 6 | 1 | 3 | 5.8 | CC(C)COc1ccc(Cl)cc1-c1ccccc1-c1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL1207973 | 14737 | 2 | None | 125 | 3 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 381 | 6 | 1 | 3 | 5.8 | CC(C)COc1ccc(Cl)cc1-c1ccccc1-c1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL467510 | 14737 | 2 | None | 125 | 3 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 381 | 6 | 1 | 3 | 5.8 | CC(C)COc1ccc(Cl)cc1-c1ccccc1-c1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2008.11.032 | ||
11271578 | 141465 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 478 | 6 | 1 | 4 | 5.0 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1cccc(Br)c1 | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL387454 | 141465 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 478 | 6 | 1 | 4 | 5.0 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1cccc(Br)c1 | 10.1016/j.bmcl.2006.06.086 | ||
1498314 | 92640 | 9 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 355 | 3 | 2 | 6 | 3.4 | O=C(O)c1csc(-n2nc(-c3ccccc3O)cc2C(F)(F)F)n1 | 10.1016/j.bmcl.2013.09.032 | ||
CHEMBL2442490 | 92640 | 9 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 355 | 3 | 2 | 6 | 3.4 | O=C(O)c1csc(-n2nc(-c3ccccc3O)cc2C(F)(F)F)n1 | 10.1016/j.bmcl.2013.09.032 | ||
44409910 | 140378 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 477 | 11 | 2 | 4 | 5.4 | O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2cccc(-c3ccccc3)c2)s1 | 10.1016/j.bmcl.2006.01.018 | ||
CHEMBL382197 | 140378 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 477 | 11 | 2 | 4 | 5.4 | O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2cccc(-c3ccccc3)c2)s1 | 10.1016/j.bmcl.2006.01.018 | ||
59179973 | 105353 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 336 | 3 | 2 | 6 | 3.4 | Nc1ccc2c(-c3ccccc3)nn(-c3nc(C(=O)O)cs3)c2c1 | 10.1016/j.bmcl.2014.01.052 | ||
CHEMBL3127161 | 105353 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 336 | 3 | 2 | 6 | 3.4 | Nc1ccc2c(-c3ccccc3)nn(-c3nc(C(=O)O)cs3)c2c1 | 10.1016/j.bmcl.2014.01.052 | ||
11691669 | 14739 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 467 | 6 | 1 | 3 | 7.1 | O=C(O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL1207975 | 14739 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 467 | 6 | 1 | 3 | 7.1 | O=C(O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL467579 | 14739 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 467 | 6 | 1 | 3 | 7.1 | O=C(O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1 | 10.1016/j.bmcl.2008.11.032 | ||
44581620 | 174441 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 414 | 6 | 1 | 2 | 7.0 | O=C(O)c1ccccc1-c1ccccc1-c1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL456707 | 174441 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 414 | 6 | 1 | 2 | 7.0 | O=C(O)c1ccccc1-c1ccccc1-c1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.11.032 | ||
10362377 | 189268 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 380 | 6 | 1 | 2 | 6.3 | O=C(O)c1cccc(-c2ccccc2-c2ccccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL516787 | 189268 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 380 | 6 | 1 | 2 | 6.3 | O=C(O)c1cccc(-c2ccccc2-c2ccccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2008.11.032 | ||
57397404 | 67858 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 462 | 6 | 2 | 5 | 5.0 | Cc1cc(C(=O)NCC2CCNCC2)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
CHEMBL1915256 | 67858 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 462 | 6 | 2 | 5 | 5.0 | Cc1cc(C(=O)NCC2CCNCC2)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
11978148 | 14567 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 343 | 6 | 1 | 4 | 4.2 | O=C(O)c1coc(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL1206289 | 14567 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 343 | 6 | 1 | 4 | 4.2 | O=C(O)c1coc(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL257464 | 14567 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 343 | 6 | 1 | 4 | 4.2 | O=C(O)c1coc(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.01.071 | ||
44448325 | 95008 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 446 | 8 | 1 | 5 | 5.0 | Cc1cc(NC(=O)Cc2ccccn2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL257138 | 95008 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 446 | 8 | 1 | 5 | 5.0 | Cc1cc(NC(=O)Cc2ccccn2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
44432910 | 86838 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 537 | 8 | 0 | 6 | 6.0 | COc1ccc(Cc2nnc(CN(c3cccc(Cl)c3Cl)S(=O)(=O)c3ccc(Cl)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL233134 | 86838 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 537 | 8 | 0 | 6 | 6.0 | COc1ccc(Cc2nnc(CN(c3cccc(Cl)c3Cl)S(=O)(=O)c3ccc(Cl)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44432926 | 86971 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 512 | 9 | 1 | 7 | 5.4 | COc1ccc(NCc2nnc(CN(c3cccc(Cl)c3C)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL233356 | 86971 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 512 | 9 | 1 | 7 | 5.4 | COc1ccc(NCc2nnc(CN(c3cccc(Cl)c3C)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44432359 | 86265 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 510 | 6 | 1 | 3 | 6.4 | CNC(=O)c1cccc(-n2c(C)ccc2-c2cc(Br)ccc2OCc2ccc(F)cc2F)c1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL231722 | 86265 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 510 | 6 | 1 | 3 | 6.4 | CNC(=O)c1cccc(-n2c(C)ccc2-c2cc(Br)ccc2OCc2ccc(F)cc2F)c1 | 10.1016/j.bmcl.2006.12.021 | ||
44432335 | 86806 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 451 | 6 | 0 | 4 | 6.1 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1ccc(S(C)(=O)=O)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL232930 | 86806 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 451 | 6 | 0 | 4 | 6.1 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1ccc(S(C)(=O)=O)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
44432337 | 147153 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 452 | 6 | 1 | 4 | 5.3 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1ccc(S(N)(=O)=O)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL393187 | 147153 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 452 | 6 | 1 | 4 | 5.3 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1ccc(S(N)(=O)=O)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
44413140 | 77233 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 475 | 6 | 1 | 3 | 6.8 | Cc1ccccc1COc1ccc(Br)cc1-c1ccc(C)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL208797 | 77233 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 475 | 6 | 1 | 3 | 6.8 | Cc1ccccc1COc1ccc(Br)cc1-c1ccc(C)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
44413109 | 79351 | 5 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 383 | 6 | 1 | 3 | 5.7 | Cc1ccc(-c2ccccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL211776 | 79351 | 5 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 383 | 6 | 1 | 3 | 5.7 | Cc1ccc(-c2ccccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
10127791 | 149770 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 466 | 6 | 1 | 2 | 7.0 | O=C(O)c1cccc(C2=C(c3cc(Br)ccc3OCc3ccc(F)cc3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
CHEMBL395284 | 149770 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 466 | 6 | 1 | 2 | 7.0 | O=C(O)c1cccc(C2=C(c3cc(Br)ccc3OCc3ccc(F)cc3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
11317344 | 80151 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 468 | 7 | 1 | 5 | 5.7 | O=C(O)c1cc(-c2cccs2)n(Cc2cc(Br)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL214900 | 80151 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 468 | 7 | 1 | 5 | 5.7 | O=C(O)c1cc(-c2cccs2)n(Cc2cc(Br)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2006.06.086 | ||
11695790 | 14770 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 317 | 6 | 1 | 3 | 3.8 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCC2CC2)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL1208252 | 14770 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 317 | 6 | 1 | 3 | 3.8 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCC2CC2)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL511919 | 14770 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 317 | 6 | 1 | 3 | 3.8 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCC2CC2)n1 | 10.1016/j.bmcl.2009.02.112 | ||
11750434 | 76772 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 417 | 6 | 1 | 3 | 6.4 | Cc1ccc(-c2cccc(C(=O)O)c2)n1-c1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2006.02.014 | ||
CHEMBL207688 | 76772 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 417 | 6 | 1 | 3 | 6.4 | Cc1ccc(-c2cccc(C(=O)O)c2)n1-c1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2006.02.014 | ||
44448562 | 94572 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 449 | 7 | 1 | 4 | 5.9 | Cc1cc(C(=O)Nc2cccc(F)c2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL254958 | 94572 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 449 | 7 | 1 | 4 | 5.9 | Cc1cc(C(=O)Nc2cccc(F)c2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
44448443 | 94878 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 404 | 7 | 1 | 5 | 4.1 | Cc1cc(C(=O)NN2CCCCC2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL256532 | 94878 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 404 | 7 | 1 | 5 | 4.1 | Cc1cc(C(=O)NN2CCCCC2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.04.018 | ||
44448680 | 95308 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 385 | 6 | 1 | 5 | 4.7 | COC(=O)Nc1cc(C)n(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL258439 | 95308 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 385 | 6 | 1 | 5 | 4.7 | COC(=O)Nc1cc(C)n(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.04.018 | ||
44432888 | 147403 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 485 | 7 | 0 | 5 | 5.5 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3ccc(F)cc3)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL393376 | 147403 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 485 | 7 | 0 | 5 | 5.5 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3ccc(F)cc3)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44432333 | 86770 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 495 | 6 | 0 | 4 | 6.2 | Cc1ccc(-c2cc(Br)ccc2OCc2ccccc2)n1-c1cccc(S(C)(=O)=O)c1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL232734 | 86770 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 495 | 6 | 0 | 4 | 6.2 | Cc1ccc(-c2cc(Br)ccc2OCc2ccccc2)n1-c1cccc(S(C)(=O)=O)c1 | 10.1016/j.bmcl.2006.12.021 | ||
44432377 | 86974 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 535 | 6 | 0 | 5 | 7.4 | Cc1nc(-c2cccc(-n3c(C)ccc3-c3cc(Br)ccc3OCc3ccc(F)cc3F)c2)no1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL233359 | 86974 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 535 | 6 | 0 | 5 | 7.4 | Cc1nc(-c2cccc(-n3c(C)ccc3-c3cc(Br)ccc3OCc3ccc(F)cc3F)c2)no1 | 10.1016/j.bmcl.2006.12.021 | ||
11294771 | 77518 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 489 | 6 | 1 | 3 | 7.2 | O=C(O)c1cccc(-n2c(-c3cc(Cl)ccc3OCc3ccc(F)cc3)ccc2C(F)(F)F)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL209326 | 77518 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 489 | 6 | 1 | 3 | 7.2 | O=C(O)c1cccc(-n2c(-c3cc(Cl)ccc3OCc3ccc(F)cc3)ccc2C(F)(F)F)c1 | 10.1016/j.bmcl.2006.04.073 | ||
44413199 | 79562 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 480 | 6 | 1 | 5 | 6.1 | Cc1noc(C)c1COc1ccc(Br)cc1-c1ccc(C)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL212679 | 79562 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 480 | 6 | 1 | 5 | 6.1 | Cc1noc(C)c1COc1ccc(Br)cc1-c1ccc(C)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
44430774 | 87567 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 429 | 6 | 1 | 3 | 6.6 | N#Cc1ccc(OCc2ccc(Cl)cc2)c(C2=C(c3cccc(C(=O)O)c3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
CHEMBL234289 | 87567 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 429 | 6 | 1 | 3 | 6.6 | N#Cc1ccc(OCc2ccc(Cl)cc2)c(C2=C(c3cccc(C(=O)O)c3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
44430777 | 143123 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 406 | 6 | 1 | 4 | 5.5 | O=C(O)c1cc(C2=C(c3cc(Cl)ccc3OCc3ccccc3)CCC2)ncn1 | 10.1016/j.bmcl.2006.10.041 | ||
CHEMBL389994 | 143123 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 406 | 6 | 1 | 4 | 5.5 | O=C(O)c1cc(C2=C(c3cc(Cl)ccc3OCc3ccccc3)CCC2)ncn1 | 10.1016/j.bmcl.2006.10.041 | ||
59179904 | 105348 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 339 | 3 | 1 | 5 | 4.0 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3ccc(F)cc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
CHEMBL3127156 | 105348 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 339 | 3 | 1 | 5 | 4.0 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3ccc(F)cc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
59179268 | 103410 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 373 | 3 | 1 | 5 | 4.5 | O=C(O)c1csc(-n2nc3c(c2-c2ccccc2)CCc2ccccc2-3)n1 | 10.1016/j.bmcl.2013.10.065 | ||
CHEMBL3092133 | 103410 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 373 | 3 | 1 | 5 | 4.5 | O=C(O)c1csc(-n2nc3c(c2-c2ccccc2)CCc2ccccc2-3)n1 | 10.1016/j.bmcl.2013.10.065 | ||
46220500 | 105366 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 321 | 3 | 1 | 5 | 3.8 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3ccccc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
CHEMBL3127175 | 105366 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 321 | 3 | 1 | 5 | 3.8 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3ccccc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
10238338 | 1870 | 23 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 441 | 6 | 1 | 3 | 6.4 | Clc1ccc(c(c1)C1=C(CCC1)c1cccc(n1)C(=O)O)OCc1ccc(cc1F)F | 10.1016/j.bmcl.2008.01.071 | ||
3360 | 1870 | 23 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 441 | 6 | 1 | 3 | 6.4 | Clc1ccc(c(c1)C1=C(CCC1)c1cccc(n1)C(=O)O)OCc1ccc(cc1F)F | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL234940 | 1870 | 23 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 441 | 6 | 1 | 3 | 6.4 | Clc1ccc(c(c1)C1=C(CCC1)c1cccc(n1)C(=O)O)OCc1ccc(cc1F)F | 10.1016/j.bmcl.2008.01.071 | ||
10238338 | 1870 | 23 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 441 | 6 | 1 | 3 | 6.4 | Clc1ccc(c(c1)C1=C(CCC1)c1cccc(n1)C(=O)O)OCc1ccc(cc1F)F | 10.1016/j.bmcl.2009.02.112 | ||
3360 | 1870 | 23 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 441 | 6 | 1 | 3 | 6.4 | Clc1ccc(c(c1)C1=C(CCC1)c1cccc(n1)C(=O)O)OCc1ccc(cc1F)F | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL234940 | 1870 | 23 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 441 | 6 | 1 | 3 | 6.4 | Clc1ccc(c(c1)C1=C(CCC1)c1cccc(n1)C(=O)O)OCc1ccc(cc1F)F | 10.1016/j.bmcl.2009.02.112 | ||
44432348 | 86348 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 7.0 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1ccc(C(=O)NCc2ccccn2)cc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL232117 | 86348 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 7.0 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1ccc(C(=O)NCc2ccccn2)cc1 | 10.1016/j.bmcl.2008.04.018 | ||
23661678 | 86943 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 9 | 0 | 6 | 6.8 | CCOc1ccc(Cc2nnc(CN(c3cccc(Cl)c3Cl)S(=O)(=O)c3ccc(C(F)(F)F)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL233335 | 86943 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 9 | 0 | 6 | 6.8 | CCOc1ccc(Cc2nnc(CN(c3cccc(Cl)c3Cl)S(=O)(=O)c3ccc(C(F)(F)F)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
10345568 | 143364 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 492 | 7 | 2 | 4 | 6.5 | CC(=O)Nc1cc(C(=O)O)cc(-n2c(C)ccc2-c2cc(Cl)ccc2OCc2ccc(F)cc2)c1 | 10.1016/j.bmcl.2006.10.078 | ||
CHEMBL390190 | 143364 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 492 | 7 | 2 | 4 | 6.5 | CC(=O)Nc1cc(C(=O)O)cc(-n2c(C)ccc2-c2cc(Cl)ccc2OCc2ccc(F)cc2)c1 | 10.1016/j.bmcl.2006.10.078 | ||
44432348 | 86348 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 7.0 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1ccc(C(=O)NCc2ccccn2)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL232117 | 86348 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 7.0 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1ccc(C(=O)NCc2ccccn2)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
10030627 | 86518 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 556 | 8 | 1 | 5 | 6.8 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)NS(=O)(=O)c2ccccc2)c1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL232340 | 86518 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 556 | 8 | 1 | 5 | 6.8 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)NS(=O)(=O)c2ccccc2)c1 | 10.1016/j.bmcl.2006.12.021 | ||
44432327 | 86519 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 522 | 8 | 1 | 5 | 6.2 | Cc1ccc(-c2ccccc2OCc2ccccc2)n1-c1cccc(C(=O)NS(=O)(=O)c2ccccc2)c1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL232341 | 86519 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 522 | 8 | 1 | 5 | 6.2 | Cc1ccc(-c2ccccc2OCc2ccccc2)n1-c1cccc(C(=O)NS(=O)(=O)c2ccccc2)c1 | 10.1016/j.bmcl.2006.12.021 | ||
44426665 | 85646 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 513 | 6 | 1 | 3 | 7.3 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2)n1-c1ccc(Cl)c(C(=O)O)c1 | 10.1016/j.bmcl.2006.11.059 | ||
CHEMBL230875 | 85646 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 513 | 6 | 1 | 3 | 7.3 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2)n1-c1ccc(Cl)c(C(=O)O)c1 | 10.1016/j.bmcl.2006.11.059 | ||
10322359 | 152602 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 467 | 6 | 1 | 3 | 7.0 | Cc1ccc(-n2c(C)ccc2-c2cc(Cl)ccc2OCc2ccc(F)cc2F)cc1C(=O)O | 10.1016/j.bmcl.2006.11.059 | ||
CHEMBL397655 | 152602 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 467 | 6 | 1 | 3 | 7.0 | Cc1ccc(-n2c(C)ccc2-c2cc(Cl)ccc2OCc2ccc(F)cc2F)cc1C(=O)O | 10.1016/j.bmcl.2006.11.059 | ||
44426673 | 161324 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 547 | 6 | 1 | 3 | 7.9 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1cc(C(=O)O)c2ccccc2c1 | 10.1016/j.bmcl.2006.11.059 | ||
CHEMBL414978 | 161324 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 547 | 6 | 1 | 3 | 7.9 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1cc(C(=O)O)c2ccccc2c1 | 10.1016/j.bmcl.2006.11.059 | ||
44413152 | 77631 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 475 | 6 | 1 | 3 | 6.8 | Cc1ccc(COc2ccc(Br)cc2-c2ccc(C)n2-c2cccc(C(=O)O)c2)cc1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL209685 | 77631 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 475 | 6 | 1 | 3 | 6.8 | Cc1ccc(COc2ccc(Br)cc2-c2ccc(C)n2-c2cccc(C(=O)O)c2)cc1 | 10.1016/j.bmcl.2006.04.073 | ||
10238338 | 1870 | 23 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 441 | 6 | 1 | 3 | 6.4 | Clc1ccc(c(c1)C1=C(CCC1)c1cccc(n1)C(=O)O)OCc1ccc(cc1F)F | 10.1016/j.bmcl.2006.10.041 | ||
3360 | 1870 | 23 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 441 | 6 | 1 | 3 | 6.4 | Clc1ccc(c(c1)C1=C(CCC1)c1cccc(n1)C(=O)O)OCc1ccc(cc1F)F | 10.1016/j.bmcl.2006.10.041 | ||
CHEMBL234940 | 1870 | 23 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 441 | 6 | 1 | 3 | 6.4 | Clc1ccc(c(c1)C1=C(CCC1)c1cccc(n1)C(=O)O)OCc1ccc(cc1F)F | 10.1016/j.bmcl.2006.10.041 | ||
10311325 | 143359 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 500 | 6 | 1 | 2 | 7.6 | O=C(O)c1cccc(C2=C(c3cc(Br)ccc3OCc3ccc(Cl)cc3F)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
CHEMBL390188 | 143359 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 500 | 6 | 1 | 2 | 7.6 | O=C(O)c1cccc(C2=C(c3cc(Br)ccc3OCc3ccc(Cl)cc3F)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
44611364 | 105357 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 339 | 3 | 1 | 5 | 4.0 | O=C(O)c1csc(-n2nc(-c3cccc(F)c3)c3ccccc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
CHEMBL3127165 | 105357 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 339 | 3 | 1 | 5 | 4.0 | O=C(O)c1csc(-n2nc(-c3cccc(F)c3)c3ccccc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
59179260 | 103407 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 362 | 4 | 2 | 6 | 3.9 | Nc1c(-c2ccccc2)nn(-c2nc(C(=O)O)cs2)c1-c1ccccc1 | 10.1016/j.bmcl.2013.10.065 | ||
CHEMBL3092130 | 103407 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 362 | 4 | 2 | 6 | 3.9 | Nc1c(-c2ccccc2)nn(-c2nc(C(=O)O)cs2)c1-c1ccccc1 | 10.1016/j.bmcl.2013.10.065 | ||
59179280 | 103409 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 361 | 3 | 1 | 6 | 4.6 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3oc4ccccc4c32)n1 | 10.1016/j.bmcl.2013.10.065 | ||
CHEMBL3092132 | 103409 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 361 | 3 | 1 | 6 | 4.6 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3oc4ccccc4c32)n1 | 10.1016/j.bmcl.2013.10.065 | ||
59179265 | 103422 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 425 | 4 | 1 | 5 | 5.1 | O=C(O)c1csc(-n2nc(-c3ccccc3)c(Br)c2-c2ccccc2)n1 | 10.1016/j.bmcl.2013.10.065 | ||
CHEMBL3092153 | 103422 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 425 | 4 | 1 | 5 | 5.1 | O=C(O)c1csc(-n2nc(-c3ccccc3)c(Br)c2-c2ccccc2)n1 | 10.1016/j.bmcl.2013.10.065 | ||
59180015 | 105344 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 322 | 3 | 1 | 6 | 3.2 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3cccnc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
CHEMBL3127151 | 105344 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 322 | 3 | 1 | 6 | 3.2 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3cccnc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
10434119 | 149905 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 454 | 8 | 3 | 5 | 4.2 | CC1(C)C(=O)[C@H](CC#CCCCC(=O)O)[C@@H](/C=C/C(O)Cc2cc3ccccc3s2)[C@@H]1O | nan | ||
CHEMBL3954031 | 149905 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 454 | 8 | 3 | 5 | 4.2 | CC1(C)C(=O)[C@H](CC#CCCCC(=O)O)[C@@H](/C=C/C(O)Cc2cc3ccccc3s2)[C@@H]1O | nan | ||
10229275 | 146489 | 0 | None | - | 0 | Mouse | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 509 | 10 | 1 | 5 | 5.6 | Cc1ccc(S(=O)(=O)N(CC(C)C)c2cc3c(cc2OCc2ccc(/C=C/C(=O)O)cc2)CCC3)o1 | nan | ||
CHEMBL3926646 | 146489 | 0 | None | - | 0 | Mouse | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 509 | 10 | 1 | 5 | 5.6 | Cc1ccc(S(=O)(=O)N(CC(C)C)c2cc3c(cc2OCc2ccc(/C=C/C(=O)O)cc2)CCC3)o1 | nan | ||
1884 | 3034 | 46 | None | -169 | 22 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 10.1021/jm010264b | ||
5280363 | 3034 | 46 | None | -169 | 22 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 10.1021/jm010264b | ||
912 | 3034 | 46 | None | -169 | 22 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 10.1021/jm010264b | ||
CHEMBL815 | 3034 | 46 | None | -169 | 22 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 10.1021/jm010264b | ||
DB12789 | 3034 | 46 | None | -169 | 22 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 10.1021/jm010264b | ||
10434119 | 149905 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 454 | 8 | 3 | 5 | 4.2 | CC1(C)C(=O)[C@H](CC#CCCCC(=O)O)[C@@H](/C=C/C(O)Cc2cc3ccccc3s2)[C@@H]1O | nan | ||
CHEMBL3954031 | 149905 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 454 | 8 | 3 | 5 | 4.2 | CC1(C)C(=O)[C@H](CC#CCCCC(=O)O)[C@@H](/C=C/C(O)Cc2cc3ccccc3s2)[C@@H]1O | nan | ||
1009982 | 87589 | 16 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 452 | 9 | 1 | 4 | 4.1 | CCc1ccccc1N(CC(=O)NCc1ccc(OC)cc1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL234398 | 87589 | 16 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 452 | 9 | 1 | 4 | 4.1 | CCc1ccccc1N(CC(=O)NCc1ccc(OC)cc1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
10144088 | 153603 | 0 | None | - | 0 | Mouse | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 554 | 10 | 1 | 6 | 6.0 | Cc1csc(S(=O)(=O)N(CC(C)C)c2ccc(C(F)(F)F)cc2OCc2ccc(/C=C/C(=O)O)cc2)n1 | nan | ||
CHEMBL3985387 | 153603 | 0 | None | - | 0 | Mouse | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 554 | 10 | 1 | 6 | 6.0 | Cc1csc(S(=O)(=O)N(CC(C)C)c2ccc(C(F)(F)F)cc2OCc2ccc(/C=C/C(=O)O)cc2)n1 | nan | ||
24785588 | 67818 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 332 | 5 | 1 | 4 | 4.3 | CCCc1cc2cc(Cl)cc(Cn3nc(C(=O)O)cc3C)c2o1 | 10.1016/j.bmcl.2011.05.047 | ||
CHEMBL1915014 | 67818 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 332 | 5 | 1 | 4 | 4.3 | CCCc1cc2cc(Cl)cc(Cn3nc(C(=O)O)cc3C)c2o1 | 10.1016/j.bmcl.2011.05.047 | ||
57393868 | 67862 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 530 | 6 | 1 | 5 | 6.5 | Cc1cc(NC(=O)C2CCN(CC(F)(F)F)CC2)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
CHEMBL1915260 | 67862 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 530 | 6 | 1 | 5 | 6.5 | Cc1cc(NC(=O)C2CCN(CC(F)(F)F)CC2)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
25005134 | 67865 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 477 | 6 | 2 | 5 | 5.0 | Cc1cc(C(=O)NCC(O)C(F)(F)F)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
CHEMBL1915263 | 67865 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 477 | 6 | 2 | 5 | 5.0 | Cc1cc(C(=O)NCC(O)C(F)(F)F)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
11978144 | 14571 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 359 | 6 | 1 | 4 | 4.7 | O=C(O)c1nc(Cc2cc(Cl)ccc2OCc2ccccc2)cs1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL1206295 | 14571 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 359 | 6 | 1 | 4 | 4.7 | O=C(O)c1nc(Cc2cc(Cl)ccc2OCc2ccccc2)cs1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL258057 | 14571 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 359 | 6 | 1 | 4 | 4.7 | O=C(O)c1nc(Cc2cc(Cl)ccc2OCc2ccccc2)cs1 | 10.1016/j.bmcl.2008.01.071 | ||
11978142 | 14663 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 360 | 6 | 2 | 5 | 4.8 | O=C(O)c1csc(Nc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL1207382 | 14663 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 360 | 6 | 2 | 5 | 4.8 | O=C(O)c1csc(Nc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL401768 | 14663 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 360 | 6 | 2 | 5 | 4.8 | O=C(O)c1csc(Nc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.01.071 | ||
11690100 | 14731 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 389 | 6 | 1 | 3 | 4.9 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(F)cc2F)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL1207965 | 14731 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 389 | 6 | 1 | 3 | 4.9 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(F)cc2F)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL466101 | 14731 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 389 | 6 | 1 | 3 | 4.9 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(F)cc2F)n1 | 10.1016/j.bmcl.2009.02.112 | ||
11978142 | 14663 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 360 | 6 | 2 | 5 | 4.8 | O=C(O)c1csc(Nc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1207382 | 14663 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 360 | 6 | 2 | 5 | 4.8 | O=C(O)c1csc(Nc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL401768 | 14663 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 360 | 6 | 2 | 5 | 4.8 | O=C(O)c1csc(Nc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.03.018 | ||
24760471 | 14675 | 0 | None | 316 | 3 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 317 | 4 | 1 | 3 | 4.8 | CC(C)Cc1cn(-c2ccc(C(=O)O)o2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1207406 | 14675 | 0 | None | 316 | 3 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 317 | 4 | 1 | 3 | 4.8 | CC(C)Cc1cn(-c2ccc(C(=O)O)o2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL403407 | 14675 | 0 | None | 316 | 3 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 317 | 4 | 1 | 3 | 4.8 | CC(C)Cc1cn(-c2ccc(C(=O)O)o2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
44432361 | 86843 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 506 | 8 | 1 | 3 | 7.6 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)NCc2ccccc2)c1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL233140 | 86843 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 506 | 8 | 1 | 3 | 7.6 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)NCc2ccccc2)c1 | 10.1016/j.bmcl.2008.04.018 | ||
44448407 | 94455 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 397 | 7 | 1 | 4 | 5.1 | Cc1cc(NC(=O)C(C)C)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL254152 | 94455 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 397 | 7 | 1 | 4 | 5.1 | Cc1cc(NC(=O)C(C)C)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
44448488 | 94520 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 446 | 8 | 1 | 5 | 4.8 | Cc1cc(C(=O)NCc2ccccn2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL254554 | 94520 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 446 | 8 | 1 | 5 | 4.8 | Cc1cc(C(=O)NCc2ccccn2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
11962969 | 94886 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 427 | 8 | 1 | 5 | 5.7 | Cc1cc(NC(=O)OCC(C)C)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL256560 | 94886 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 427 | 8 | 1 | 5 | 5.7 | Cc1cc(NC(=O)OCC(C)C)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
11963255 | 95252 | 12 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 427 | 6 | 1 | 5 | 5.8 | Cc1cc(NC(=O)OC(C)(C)C)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL258199 | 95252 | 12 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 427 | 6 | 1 | 5 | 5.8 | Cc1cc(NC(=O)OC(C)(C)C)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
11963102 | 95305 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 389 | 7 | 1 | 4 | 5.1 | Cc1cc(NC(=O)C2CCCC2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL258413 | 95305 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 389 | 7 | 1 | 4 | 5.1 | Cc1cc(NC(=O)C2CCCC2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.04.018 | ||
44448721 | 154858 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 482 | 8 | 1 | 5 | 5.6 | Cc1cc(NC(=O)C(F)(F)c2ccccn2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL403580 | 154858 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 482 | 8 | 1 | 5 | 5.6 | Cc1cc(NC(=O)C(F)(F)c2ccccn2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
44432923 | 86849 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 493 | 10 | 0 | 7 | 4.9 | CCc1ccccc1N(Cc1nnc(COc2ccc(OC)cc2)o1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL233155 | 86849 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 493 | 10 | 0 | 7 | 4.9 | CCc1ccccc1N(Cc1nnc(COc2ccc(OC)cc2)o1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
1009982 | 87589 | 16 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 452 | 9 | 1 | 4 | 4.1 | CCc1ccccc1N(CC(=O)NCc1ccc(OC)cc1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL234398 | 87589 | 16 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 452 | 9 | 1 | 4 | 4.1 | CCc1ccccc1N(CC(=O)NCc1ccc(OC)cc1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44432330 | 86606 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 619 | 6 | 1 | 3 | 8.4 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1cccc(C(O)(C(F)(F)F)C(F)(F)F)c1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL232544 | 86606 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 619 | 6 | 1 | 3 | 8.4 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1cccc(C(O)(C(F)(F)F)C(F)(F)F)c1 | 10.1016/j.bmcl.2006.12.021 | ||
44432361 | 86843 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 506 | 8 | 1 | 3 | 7.6 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)NCc2ccccc2)c1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL233140 | 86843 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 506 | 8 | 1 | 3 | 7.6 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)NCc2ccccc2)c1 | 10.1016/j.bmcl.2006.12.021 | ||
44432369 | 87510 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 414 | 5 | 1 | 4 | 6.0 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1ccc2nn[nH]c2c1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL233975 | 87510 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 414 | 5 | 1 | 4 | 6.0 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1ccc2nn[nH]c2c1 | 10.1016/j.bmcl.2006.12.021 | ||
44432346 | 87535 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 506 | 8 | 1 | 3 | 7.6 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1ccc(C(=O)NCc2ccccc2)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL234176 | 87535 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 506 | 8 | 1 | 3 | 7.6 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1ccc(C(=O)NCc2ccccc2)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
44426675 | 152098 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 469 | 6 | 1 | 3 | 7.2 | Cc1ccc(-c2cc(F)ccc2OCc2ccc(F)cc2)n1-c1cc(C(=O)O)c2ccccc2c1 | 10.1016/j.bmcl.2006.11.059 | ||
CHEMBL397226 | 152098 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 469 | 6 | 1 | 3 | 7.2 | Cc1ccc(-c2cc(F)ccc2OCc2ccc(F)cc2)n1-c1cc(C(=O)O)c2ccccc2c1 | 10.1016/j.bmcl.2006.11.059 | ||
44568506 | 12473 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 427 | 8 | 2 | 5 | 4.7 | Cc1cc(NC(=O)c2ccccc2CO)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1186828 | 12473 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 427 | 8 | 2 | 5 | 4.7 | Cc1cc(NC(=O)c2ccccc2CO)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL480002 | 12473 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 427 | 8 | 2 | 5 | 4.7 | Cc1cc(NC(=O)c2ccccc2CO)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
44568760 | 12557 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 470 | 11 | 3 | 6 | 4.3 | Cc1cc(C(=O)Nc2ccc(CNCCO)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1187259 | 12557 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 470 | 11 | 3 | 6 | 4.3 | Cc1cc(C(=O)Nc2ccc(CNCCO)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL495107 | 12557 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 470 | 11 | 3 | 6 | 4.3 | Cc1cc(C(=O)Nc2ccc(CNCCO)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
44413173 | 77652 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 466 | 6 | 1 | 5 | 5.8 | Cc1cc(COc2ccc(Br)cc2-c2ccc(C)n2-c2cccc(C(=O)O)c2)no1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL209746 | 77652 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 466 | 6 | 1 | 5 | 5.8 | Cc1cc(COc2ccc(Br)cc2-c2ccc(C)n2-c2cccc(C(=O)O)c2)no1 | 10.1016/j.bmcl.2006.04.073 | ||
44413102 | 79577 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 461 | 7 | 1 | 5 | 5.1 | Cc1ccc(-c2cc(S(C)(=O)=O)ccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL212742 | 79577 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 461 | 7 | 1 | 5 | 5.1 | Cc1ccc(-c2cc(S(C)(=O)=O)ccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
44413078 | 137877 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 437 | 6 | 1 | 3 | 6.7 | O=C(O)c1cccc(-n2c(Cl)ccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL377338 | 137877 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 437 | 6 | 1 | 3 | 6.7 | O=C(O)c1cccc(-n2c(Cl)ccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.04.073 | ||
11224226 | 139605 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 409 | 6 | 1 | 3 | 6.4 | Cc1ccc(-c2cc(Cl)ccc2OCC2CCCC2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL380197 | 139605 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 409 | 6 | 1 | 3 | 6.4 | Cc1ccc(-c2cc(Cl)ccc2OCC2CCCC2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
10173065 | 86897 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 406 | 6 | 1 | 2 | 6.3 | O=C(O)c1cccc(C2=C(c3ccccc3OCc3ccc(F)cc3F)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
CHEMBL233230 | 86897 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 406 | 6 | 1 | 2 | 6.3 | O=C(O)c1cccc(C2=C(c3ccccc3OCc3ccc(F)cc3F)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
11581886 | 14723 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 367 | 6 | 1 | 3 | 5.6 | CCCOc1ccc(Cl)cc1-c1ccccc1-c1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL1207922 | 14723 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 367 | 6 | 1 | 3 | 5.6 | CCCOc1ccc(Cl)cc1-c1ccccc1-c1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL456679 | 14723 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 367 | 6 | 1 | 3 | 5.6 | CCCOc1ccc(Cl)cc1-c1ccccc1-c1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2008.11.032 | ||
57395493 | 67821 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 332 | 4 | 1 | 4 | 4.5 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2oc(C(C)C)cc12 | 10.1016/j.bmcl.2011.05.047 | ||
CHEMBL1915017 | 67821 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 332 | 4 | 1 | 4 | 4.5 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2oc(C(C)C)cc12 | 10.1016/j.bmcl.2011.05.047 | ||
24760395 | 14558 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 360 | 3 | 1 | 4 | 4.5 | O=C(O)c1csc(-n2cc(CC(F)(F)F)c3ccc(Cl)cc32)n1 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1206275 | 14558 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 360 | 3 | 1 | 4 | 4.5 | O=C(O)c1csc(-n2cc(CC(F)(F)F)c3ccc(Cl)cc32)n1 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL256336 | 14558 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 360 | 3 | 1 | 4 | 4.5 | O=C(O)c1csc(-n2cc(CC(F)(F)F)c3ccc(Cl)cc32)n1 | 10.1016/j.bmcl.2008.03.018 | ||
44448634 | 94666 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 417 | 7 | 1 | 4 | 5.4 | O=C(Nc1ccn(Cc2cc(Cl)ccc2OCc2ccccc2)n1)c1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL255485 | 94666 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 417 | 7 | 1 | 4 | 5.4 | O=C(Nc1ccn(Cc2cc(Cl)ccc2OCc2ccccc2)n1)c1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
44448444 | 154619 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 406 | 7 | 1 | 6 | 2.9 | Cc1cc(C(=O)NN2CCOCC2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL402202 | 154619 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 406 | 7 | 1 | 6 | 2.9 | Cc1cc(C(=O)NN2CCOCC2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.04.018 | ||
3508209 | 86258 | 10 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 456 | 8 | 1 | 3 | 4.5 | Cc1ccc(S(=O)(=O)N(CC(=O)NCCc2ccc(Cl)cc2)c2ccccc2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL231699 | 86258 | 10 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 456 | 8 | 1 | 3 | 4.5 | Cc1ccc(S(=O)(=O)N(CC(=O)NCCc2ccc(Cl)cc2)c2ccccc2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44430677 | 87445 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 6.4 | COc1ccc(C(=O)O)cc1-n1c(C)ccc1-c1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2006.10.078 | ||
CHEMBL233871 | 87445 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 6.4 | COc1ccc(C(=O)O)cc1-n1c(C)ccc1-c1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2006.10.078 | ||
44432373 | 87541 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 530 | 6 | 0 | 3 | 8.1 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1cccc(-c2ccccn2)c1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL234183 | 87541 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 530 | 6 | 0 | 3 | 8.1 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1cccc(-c2ccccn2)c1 | 10.1016/j.bmcl.2006.12.021 | ||
44568554 | 12632 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 496 | 9 | 1 | 6 | 5.0 | Cc1cc(NC(=O)c2cccc(CN3CCOCC3)c2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1187787 | 12632 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 496 | 9 | 1 | 6 | 5.0 | Cc1cc(NC(=O)c2cccc(CN3CCOCC3)c2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL520950 | 12632 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 496 | 9 | 1 | 6 | 5.0 | Cc1cc(NC(=O)c2cccc(CN3CCOCC3)c2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
44413153 | 137683 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 529 | 6 | 1 | 3 | 7.5 | Cc1ccc(-c2cc(Br)ccc2OCc2cccc(C(F)(F)F)c2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL376996 | 137683 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 529 | 6 | 1 | 3 | 7.5 | Cc1ccc(-c2cc(Br)ccc2OCc2cccc(C(F)(F)F)c2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
44416027 | 138347 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 454 | 6 | 1 | 4 | 5.0 | O=C(O)c1nn(Cc2cc(Br)ccc2OCc2ccccc2)cc1C(F)(F)F | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL378197 | 138347 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 454 | 6 | 1 | 4 | 5.0 | O=C(O)c1nn(Cc2cc(Br)ccc2OCc2ccccc2)cc1C(F)(F)F | 10.1016/j.bmcl.2006.06.086 | ||
10648334 | 59373 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 478 | 13 | 4 | 5 | 4.7 | O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1cccc(C(F)(F)F)c1 | 10.1021/jm990542v | ||
CHEMBL172250 | 59373 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 478 | 13 | 4 | 5 | 4.7 | O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1cccc(C(F)(F)F)c1 | 10.1021/jm990542v | ||
10046549 | 151203 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 400 | 10 | 3 | 4 | 3.6 | CC1(C)C(=O)[C@H](C/C=C\CCCC(=O)O)[C@@H](/C=C/C(O)Cc2ccccc2)[C@@H]1O | nan | ||
CHEMBL3964563 | 151203 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 400 | 10 | 3 | 4 | 3.6 | CC1(C)C(=O)[C@H](C/C=C\CCCC(=O)O)[C@@H](/C=C/C(O)Cc2ccccc2)[C@@H]1O | nan | ||
15604659 | 14674 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 308 | 6 | 1 | 3 | 4.3 | CC(C)COc1ccc(Cl)cc1Cc1ccc(C(=O)O)o1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL1207404 | 14674 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 308 | 6 | 1 | 3 | 4.3 | CC(C)COc1ccc(Cl)cc1Cc1ccc(C(=O)O)o1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL403330 | 14674 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 308 | 6 | 1 | 3 | 4.3 | CC(C)COc1ccc(Cl)cc1Cc1ccc(C(=O)O)o1 | 10.1016/j.bmcl.2008.01.071 | ||
11178059 | 154741 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 434 | 6 | 1 | 4 | 4.9 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccccc1Cl | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL402880 | 154741 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 434 | 6 | 1 | 4 | 4.9 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccccc1Cl | 10.1016/j.bmcl.2006.06.086 | ||
44430699 | 87573 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 476 | 6 | 2 | 4 | 6.1 | Cc1ccc(-c2cc(Br)ccc2OCc2ccccc2)n1-c1cc(N)cc(C(=O)O)c1 | 10.1016/j.bmcl.2006.10.078 | ||
CHEMBL234302 | 87573 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 476 | 6 | 2 | 4 | 6.1 | Cc1ccc(-c2cc(Br)ccc2OCc2ccccc2)n1-c1cc(N)cc(C(=O)O)c1 | 10.1016/j.bmcl.2006.10.078 | ||
10458324 | 141580 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 490 | 6 | 2 | 4 | 6.4 | Cc1c(N)cc(-n2c(C)ccc2-c2cc(Br)ccc2OCc2ccccc2)cc1C(=O)O | 10.1016/j.bmcl.2006.11.059 | ||
CHEMBL388294 | 141580 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 490 | 6 | 2 | 4 | 6.4 | Cc1c(N)cc(-n2c(C)ccc2-c2cc(Br)ccc2OCc2ccccc2)cc1C(=O)O | 10.1016/j.bmcl.2006.11.059 | ||
10480281 | 79560 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 479 | 6 | 1 | 3 | 6.6 | Cc1ccc(-c2cc(Br)ccc2OCc2ccccc2F)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL212672 | 79560 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 479 | 6 | 1 | 3 | 6.6 | Cc1ccc(-c2cc(Br)ccc2OCc2ccccc2F)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
10151840 | 150097 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 467 | 6 | 1 | 3 | 6.4 | O=C(O)c1ccnc(C2=C(c3cc(Br)ccc3OCc3ccc(F)cc3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
CHEMBL395542 | 150097 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 467 | 6 | 1 | 3 | 6.4 | O=C(O)c1ccnc(C2=C(c3cc(Br)ccc3OCc3ccc(F)cc3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
9868012 | 123331 | 0 | None | 50 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 420 | 6 | 1 | 3 | 7.0 | O=C(O)c1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL362543 | 123331 | 0 | None | 50 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 420 | 6 | 1 | 3 | 7.0 | O=C(O)c1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.06.086 | ||
23106418 | 147445 | 0 | None | - | 0 | Mouse | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 512 | 8 | 1 | 7 | 4.7 | Cc1cc(OCc2ccc(-c3nnn[nH]3)cc2Cl)c(N(C(C)C)S(=O)(=O)c2cccnc2)cc1C | nan | ||
CHEMBL3934138 | 147445 | 0 | None | - | 0 | Mouse | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 512 | 8 | 1 | 7 | 4.7 | Cc1cc(OCc2ccc(-c3nnn[nH]3)cc2Cl)c(N(C(C)C)S(=O)(=O)c2cccnc2)cc1C | nan | ||
9983512 | 175237 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 501 | 9 | 2 | 4 | 6.5 | COCC(=O)Nc1cc(C(=O)O)cc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL458452 | 175237 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 501 | 9 | 2 | 4 | 6.5 | COCC(=O)Nc1cc(C(=O)O)cc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2008.11.032 | ||
10411538 | 188987 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 451 | 6 | 1 | 3 | 6.6 | O=C(O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccc(F)cc2F)n1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL514574 | 188987 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 451 | 6 | 1 | 3 | 6.6 | O=C(O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccc(F)cc2F)n1 | 10.1016/j.bmcl.2008.11.032 | ||
24785594 | 67819 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 372 | 4 | 1 | 4 | 5.4 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(C3CCCCC3)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
CHEMBL1915015 | 67819 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 372 | 4 | 1 | 4 | 5.4 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(C3CCCCC3)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
24760390 | 14564 | 0 | None | 251 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 378 | 4 | 1 | 4 | 4.7 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2cc(Br)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1206284 | 14564 | 0 | None | 251 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 378 | 4 | 1 | 4 | 4.7 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2cc(Br)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL257134 | 14564 | 0 | None | 251 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 378 | 4 | 1 | 4 | 4.7 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2cc(Br)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
44432876 | 86275 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 511 | 9 | 0 | 6 | 5.7 | CCOc1ccc(Cc2nnc(CN(c3cccc(Cl)c3C)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL231759 | 86275 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 511 | 9 | 0 | 6 | 5.7 | CCOc1ccc(Cc2nnc(CN(c3cccc(Cl)c3C)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44430698 | 87572 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 432 | 6 | 2 | 4 | 6.0 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cc(N)cc(C(=O)O)c1 | 10.1016/j.bmcl.2006.10.078 | ||
CHEMBL234301 | 87572 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 432 | 6 | 2 | 4 | 6.0 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cc(N)cc(C(=O)O)c1 | 10.1016/j.bmcl.2006.10.078 | ||
44430701 | 87574 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 476 | 7 | 2 | 4 | 6.0 | CC(=O)Nc1cc(C(=O)O)cc(-n2c(C)ccc2-c2cc(F)ccc2OCc2ccc(F)cc2)c1 | 10.1016/j.bmcl.2006.10.078 | ||
CHEMBL234303 | 87574 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 476 | 7 | 2 | 4 | 6.0 | CC(=O)Nc1cc(C(=O)O)cc(-n2c(C)ccc2-c2cc(F)ccc2OCc2ccc(F)cc2)c1 | 10.1016/j.bmcl.2006.10.078 | ||
44430689 | 87732 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 487 | 6 | 1 | 3 | 7.3 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccc(F)cc2F)n1-c1cc(Cl)cc(C(=O)O)c1 | 10.1016/j.bmcl.2006.10.078 | ||
CHEMBL234721 | 87732 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 487 | 6 | 1 | 3 | 7.3 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccc(F)cc2F)n1-c1cc(Cl)cc(C(=O)O)c1 | 10.1016/j.bmcl.2006.10.078 | ||
44430690 | 143124 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 531 | 6 | 1 | 3 | 7.4 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1cc(Cl)cc(C(=O)O)c1 | 10.1016/j.bmcl.2006.10.078 | ||
CHEMBL389995 | 143124 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 531 | 6 | 1 | 3 | 7.4 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1cc(Cl)cc(C(=O)O)c1 | 10.1016/j.bmcl.2006.10.078 | ||
44432339 | 86840 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 510 | 6 | 1 | 3 | 6.4 | CNC(=O)c1ccc(-n2c(C)ccc2-c2cc(Br)ccc2OCc2ccc(F)cc2F)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL233137 | 86840 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 510 | 6 | 1 | 3 | 6.4 | CNC(=O)c1ccc(-n2c(C)ccc2-c2cc(Br)ccc2OCc2ccc(F)cc2F)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
44432326 | 144724 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 574 | 7 | 1 | 5 | 5.8 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1cccc(C(=O)NS(C)(=O)=O)c1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL391286 | 144724 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 574 | 7 | 1 | 5 | 5.8 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1cccc(C(=O)NS(C)(=O)=O)c1 | 10.1016/j.bmcl.2006.12.021 | ||
10028117 | 85247 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 480 | 6 | 2 | 4 | 6.6 | Cc1c(N)cc(-n2c(C)ccc2-c2cc(C(F)(F)F)ccc2OCc2ccccc2)cc1C(=O)O | 10.1016/j.bmcl.2006.11.059 | ||
CHEMBL228592 | 85247 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 480 | 6 | 2 | 4 | 6.6 | Cc1c(N)cc(-n2c(C)ccc2-c2cc(C(F)(F)F)ccc2OCc2ccccc2)cc1C(=O)O | 10.1016/j.bmcl.2006.11.059 | ||
11755633 | 85255 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 498 | 6 | 2 | 4 | 6.8 | Cc1c(N)cc(-n2c(C)ccc2-c2cc(C(F)(F)F)ccc2OCc2ccc(F)cc2)cc1C(=O)O | 10.1016/j.bmcl.2006.11.059 | ||
CHEMBL228644 | 85255 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 498 | 6 | 2 | 4 | 6.8 | Cc1c(N)cc(-n2c(C)ccc2-c2cc(C(F)(F)F)ccc2OCc2ccc(F)cc2)cc1C(=O)O | 10.1016/j.bmcl.2006.11.059 | ||
44413188 | 77993 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 453 | 6 | 1 | 3 | 6.7 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccc(F)cc2F)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL211088 | 77993 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 453 | 6 | 1 | 3 | 6.7 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccc(F)cc2F)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
59179969 | 105363 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 327 | 3 | 1 | 6 | 3.9 | O=C(O)c1csc(-n2nc(-c3ccsc3)c3ccccc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
CHEMBL3127171 | 105363 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 327 | 3 | 1 | 6 | 3.9 | O=C(O)c1csc(-n2nc(-c3ccsc3)c3ccccc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
44611763 | 103420 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 365 | 4 | 1 | 5 | 4.5 | O=C(O)c1csc(-n2nc(-c3ccccc3)c(F)c2-c2ccccc2)n1 | 10.1016/j.bmcl.2013.10.065 | ||
CHEMBL3092151 | 103420 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 365 | 4 | 1 | 5 | 4.5 | O=C(O)c1csc(-n2nc(-c3ccccc3)c(F)c2-c2ccccc2)n1 | 10.1016/j.bmcl.2013.10.065 | ||
1496733 | 92637 | 7 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 353 | 3 | 1 | 5 | 4.0 | Cc1ccc(-c2cc(C(F)(F)F)n(-c3nc(C(=O)O)cs3)n2)cc1 | 10.1016/j.bmcl.2013.09.032 | ||
CHEMBL2442487 | 92637 | 7 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 353 | 3 | 1 | 5 | 4.0 | Cc1ccc(-c2cc(C(F)(F)F)n(-c3nc(C(=O)O)cs3)n2)cc1 | 10.1016/j.bmcl.2013.09.032 | ||
10479215 | 145928 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 456 | 10 | 3 | 5 | 4.8 | CC1(C)C(=O)[C@H](C/C=C\CCCC(=O)O)[C@@H](/C=C/C(O)Cc2cc3ccccc3s2)[C@@H]1O | nan | ||
CHEMBL3922155 | 145928 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 456 | 10 | 3 | 5 | 4.8 | CC1(C)C(=O)[C@H](C/C=C\CCCC(=O)O)[C@@H](/C=C/C(O)Cc2cc3ccccc3s2)[C@@H]1O | nan | ||
44416198 | 165383 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 468 | 6 | 1 | 4 | 5.3 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL425076 | 165383 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 468 | 6 | 1 | 4 | 5.3 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.086 | ||
11494376 | 14768 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 345 | 6 | 1 | 3 | 4.6 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCC2CCCC2)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL1208248 | 14768 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 345 | 6 | 1 | 3 | 4.6 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCC2CCCC2)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL511252 | 14768 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 345 | 6 | 1 | 3 | 4.6 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCC2CCCC2)n1 | 10.1016/j.bmcl.2009.02.112 | ||
24760465 | 14549 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 348 | 3 | 1 | 4 | 5.0 | CC(C)(C)Cc1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1206255 | 14549 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 348 | 3 | 1 | 4 | 5.0 | CC(C)(C)Cc1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL254764 | 14549 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 348 | 3 | 1 | 4 | 5.0 | CC(C)(C)Cc1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
24760321 | 14554 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 320 | 4 | 1 | 4 | 4.4 | CCCc1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1206267 | 14554 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 320 | 4 | 1 | 4 | 4.4 | CCCc1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL255880 | 14554 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 320 | 4 | 1 | 4 | 4.4 | CCCc1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
11962967 | 94788 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 413 | 7 | 1 | 5 | 5.4 | Cc1cc(NC(=O)OC(C)C)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL256092 | 94788 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 413 | 7 | 1 | 5 | 5.4 | Cc1cc(NC(=O)OC(C)C)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
11963134 | 95253 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 403 | 7 | 1 | 4 | 5.4 | Cc1cc(NC(=O)C2CCCCC2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL258200 | 95253 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 403 | 7 | 1 | 4 | 5.4 | Cc1cc(NC(=O)C2CCCCC2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.04.018 | ||
11963296 | 154710 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 393 | 6 | 1 | 5 | 5.3 | Cc1cc(NC(=O)OC(C)(C)C)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL402770 | 154710 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 393 | 6 | 1 | 5 | 5.3 | Cc1cc(NC(=O)OC(C)(C)C)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.04.018 | ||
44432919 | 87130 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 498 | 8 | 1 | 7 | 5.5 | COc1ccc(Nc2nnc(CN(c3cccc(Cl)c3C)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL233545 | 87130 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 498 | 8 | 1 | 7 | 5.5 | COc1ccc(Nc2nnc(CN(c3cccc(Cl)c3C)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44432336 | 86807 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 495 | 6 | 0 | 4 | 6.2 | Cc1ccc(-c2cc(Br)ccc2OCc2ccccc2)n1-c1ccc(S(C)(=O)=O)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL232931 | 86807 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 495 | 6 | 0 | 4 | 6.2 | Cc1ccc(-c2cc(Br)ccc2OCc2ccccc2)n1-c1ccc(S(C)(=O)=O)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
44568665 | 12559 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 427 | 8 | 2 | 5 | 4.7 | Cc1cc(C(=O)Nc2ccc(CO)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1187262 | 12559 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 427 | 8 | 2 | 5 | 4.7 | Cc1cc(C(=O)Nc2ccc(CO)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL495294 | 12559 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 427 | 8 | 2 | 5 | 4.7 | Cc1cc(C(=O)Nc2ccc(CO)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
44413218 | 138359 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 457 | 6 | 1 | 3 | 7.1 | Cc1ccc(-c2cc(C(F)(F)F)ccc2OCC2CCCCC2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL378226 | 138359 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 457 | 6 | 1 | 3 | 7.1 | Cc1ccc(-c2cc(C(F)(F)F)ccc2OCC2CCCCC2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
10151282 | 142632 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 434 | 7 | 1 | 3 | 6.9 | CSc1ccc(OCc2ccc(F)cc2)c(C2=C(c3cccc(C(=O)O)c3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
CHEMBL389596 | 142632 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 434 | 7 | 1 | 3 | 6.9 | CSc1ccc(OCc2ccc(F)cc2)c(C2=C(c3cccc(C(=O)O)c3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
9909510 | 99855 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 410 | 13 | 4 | 4 | 3.7 | O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1F | 10.1016/s0960-894x(00)00273-0 | ||
CHEMBL289373 | 99855 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 410 | 13 | 4 | 4 | 3.7 | O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1F | 10.1016/s0960-894x(00)00273-0 | ||
44581576 | 176154 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 414 | 6 | 1 | 2 | 7.0 | O=C(O)c1cccc(-c2ccccc2-c2ccc(Cl)cc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL460168 | 176154 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 414 | 6 | 1 | 2 | 7.0 | O=C(O)c1cccc(-c2ccccc2-c2ccc(Cl)cc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2008.11.032 | ||
24783314 | 67850 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 443 | 6 | 1 | 5 | 5.5 | CO[C@H]1CC[C@H](NC(=O)c2cc(C)n(Cc3cc(Cl)cc4cc(C(C)C)oc34)n2)CC1 | 10.1016/j.bmcl.2011.05.047 | ||
CHEMBL1915248 | 67850 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 443 | 6 | 1 | 5 | 5.5 | CO[C@H]1CC[C@H](NC(=O)c2cc(C)n(Cc3cc(Cl)cc4cc(C(C)C)oc34)n2)CC1 | 10.1016/j.bmcl.2011.05.047 | ||
44455203 | 12699 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 356 | 6 | 1 | 4 | 3.9 | Cn1cc(C(=O)O)nc1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL1188223 | 12699 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 356 | 6 | 1 | 4 | 3.9 | Cn1cc(C(=O)O)nc1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL535640 | 12699 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 356 | 6 | 1 | 4 | 3.9 | Cn1cc(C(=O)O)nc1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.01.071 | ||
44455092 | 14680 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 352 | 6 | 1 | 2 | 5.2 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL1207419 | 14680 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 352 | 6 | 1 | 2 | 5.2 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL404239 | 14680 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 352 | 6 | 1 | 2 | 5.2 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2008.01.071 | ||
11350546 | 77752 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 415 | 6 | 1 | 3 | 6.3 | O=C(O)c1cccc(-c2cnccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
CHEMBL210268 | 77752 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 415 | 6 | 1 | 3 | 6.3 | O=C(O)c1cccc(-c2cnccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
44448406 | 154679 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 4.4 | CC(=O)Nc1cc(C)n(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL402604 | 154679 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 4.4 | CC(=O)Nc1cc(C)n(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.04.018 | ||
44432892 | 154209 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 485 | 7 | 0 | 5 | 5.5 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3cccc(F)c3)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL400025 | 154209 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 485 | 7 | 0 | 5 | 5.5 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3cccc(F)c3)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44430675 | 87296 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 469 | 6 | 1 | 3 | 7.2 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccc(F)cc2)n1-c1cc(C(=O)O)ccc1Cl | 10.1016/j.bmcl.2006.10.078 | ||
CHEMBL233665 | 87296 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 469 | 6 | 1 | 3 | 7.2 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccc(F)cc2)n1-c1cc(C(=O)O)ccc1Cl | 10.1016/j.bmcl.2006.10.078 | ||
10369424 | 144639 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 520 | 8 | 1 | 3 | 8.2 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)N[C@@H](C)c2ccccc2)c1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL391228 | 144639 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 520 | 8 | 1 | 3 | 8.2 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)N[C@@H](C)c2ccccc2)c1 | 10.1016/j.bmcl.2006.12.021 | ||
59179977 | 105365 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 342 | 3 | 1 | 6 | 3.4 | CC1CCN(c2nn(-c3nc(C(=O)O)cs3)c3ccccc23)CC1 | 10.1016/j.bmcl.2014.01.052 | ||
CHEMBL3127174 | 105365 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 342 | 3 | 1 | 6 | 3.4 | CC1CCN(c2nn(-c3nc(C(=O)O)cs3)c3ccccc23)CC1 | 10.1016/j.bmcl.2014.01.052 | ||
1498318 | 39828 | 9 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 339 | 3 | 1 | 5 | 3.7 | O=C(O)c1csc(-n2nc(-c3ccccc3)cc2C(F)(F)F)n1 | 10.1016/j.bmcl.2013.09.032 | ||
CHEMBL1479261 | 39828 | 9 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 339 | 3 | 1 | 5 | 3.7 | O=C(O)c1csc(-n2nc(-c3ccccc3)cc2C(F)(F)F)n1 | 10.1016/j.bmcl.2013.09.032 | ||
1496731 | 92638 | 8 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 355 | 3 | 2 | 6 | 3.4 | O=C(O)c1csc(-n2nc(-c3ccc(O)cc3)cc2C(F)(F)F)n1 | 10.1016/j.bmcl.2013.09.032 | ||
CHEMBL2442488 | 92638 | 8 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 355 | 3 | 2 | 6 | 3.4 | O=C(O)c1csc(-n2nc(-c3ccc(O)cc3)cc2C(F)(F)F)n1 | 10.1016/j.bmcl.2013.09.032 | ||
59179219 | 103416 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 375 | 4 | 1 | 5 | 5.0 | Cc1sc(-n2nc(-c3ccccc3)c(C)c2-c2ccccc2)nc1C(=O)O | 10.1016/j.bmcl.2013.10.065 | ||
CHEMBL3092147 | 103416 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 375 | 4 | 1 | 5 | 5.0 | Cc1sc(-n2nc(-c3ccccc3)c(C)c2-c2ccccc2)nc1C(=O)O | 10.1016/j.bmcl.2013.10.065 | ||
44285328 | 130929 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 410 | 13 | 4 | 4 | 3.7 | O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccc(F)cc1 | 10.1016/s0960-894x(00)00273-0 | ||
CHEMBL36911 | 130929 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 410 | 13 | 4 | 4 | 3.7 | O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccc(F)cc1 | 10.1016/s0960-894x(00)00273-0 | ||
11476911 | 81042 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 468 | 6 | 1 | 4 | 5.3 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccc(C(F)(F)F)cc1 | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL215956 | 81042 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 468 | 6 | 1 | 4 | 5.3 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccc(C(F)(F)F)cc1 | 10.1016/j.bmcl.2006.06.086 | ||
11281276 | 141168 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 408 | 6 | 1 | 4 | 5.0 | Cc1cc(C(=O)O)nn1Cc1cc(F)ccc1OCc1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL385620 | 141168 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 408 | 6 | 1 | 4 | 5.0 | Cc1cc(C(=O)O)nn1Cc1cc(F)ccc1OCc1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2006.06.086 | ||
44627515 | 195162 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 572 | 6 | 1 | 5 | 7.2 | Cc1cn(Cc2ccc3ccccc3c2)c2c(/C=C/C(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)cc(F)cc12 | 10.1021/jm9005912 | ||
CHEMBL565799 | 195162 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 572 | 6 | 1 | 5 | 7.2 | Cc1cn(Cc2ccc3ccccc3c2)c2c(/C=C/C(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)cc(F)cc12 | 10.1021/jm9005912 | ||
10741197 | 59696 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 428 | 13 | 4 | 5 | 3.8 | O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1cccc(F)c1 | 10.1021/jm990542v | ||
CHEMBL173499 | 59696 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 428 | 13 | 4 | 5 | 3.8 | O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1cccc(F)c1 | 10.1021/jm990542v | ||
1884 | 3034 | 46 | None | -169 | 22 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 10.1021/jm990542v | ||
5280363 | 3034 | 46 | None | -169 | 22 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 10.1021/jm990542v | ||
912 | 3034 | 46 | None | -169 | 22 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 10.1021/jm990542v | ||
CHEMBL815 | 3034 | 46 | None | -169 | 22 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 10.1021/jm990542v | ||
DB12789 | 3034 | 46 | None | -169 | 22 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 10.1021/jm990542v | ||
44564804 | 176126 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 536 | 6 | 1 | 5 | 6.1 | Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(Cl)cc3Cl)cccc21 | 10.1016/j.bmcl.2008.12.112 | ||
CHEMBL459885 | 176126 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 536 | 6 | 1 | 5 | 6.1 | Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(Cl)cc3Cl)cccc21 | 10.1016/j.bmcl.2008.12.112 | ||
59179967 | 105345 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 322 | 3 | 1 | 6 | 3.2 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3ccncc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
CHEMBL3127152 | 105345 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 322 | 3 | 1 | 6 | 3.2 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3ccncc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
11691044 | 14727 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 433 | 6 | 1 | 3 | 6.5 | O=C(O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccccc2F)n1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL1207931 | 14727 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 433 | 6 | 1 | 3 | 6.5 | O=C(O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccccc2F)n1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL459537 | 14727 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 433 | 6 | 1 | 3 | 6.5 | O=C(O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccccc2F)n1 | 10.1016/j.bmcl.2008.11.032 | ||
57392102 | 67861 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 466 | 5 | 2 | 5 | 5.3 | Cc1cc(NC(=O)C2(F)CCNCC2)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
CHEMBL1915259 | 67861 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 466 | 5 | 2 | 5 | 5.3 | Cc1cc(NC(=O)C2(F)CCNCC2)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
44455132 | 14559 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 358 | 6 | 1 | 3 | 5.3 | O=C(O)c1csc(Cc2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL1206278 | 14559 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 358 | 6 | 1 | 3 | 5.3 | O=C(O)c1csc(Cc2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL256674 | 14559 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 358 | 6 | 1 | 3 | 5.3 | O=C(O)c1csc(Cc2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2008.01.071 | ||
11595316 | 154820 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 319 | 6 | 1 | 3 | 4.1 | CC(C)COc1ccc(Cl)cc1Cc1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL257998 | 154820 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 319 | 6 | 1 | 3 | 4.1 | CC(C)COc1ccc(Cl)cc1Cc1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL403329 | 154820 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 319 | 6 | 1 | 3 | 4.1 | CC(C)COc1ccc(Cl)cc1Cc1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2008.01.071 | ||
11495224 | 14733 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 387 | 6 | 1 | 3 | 5.3 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccccc2Cl)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL1207967 | 14733 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 387 | 6 | 1 | 3 | 5.3 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccccc2Cl)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL466103 | 14733 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 387 | 6 | 1 | 3 | 5.3 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccccc2Cl)n1 | 10.1016/j.bmcl.2009.02.112 | ||
11509774 | 14735 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 387 | 6 | 1 | 3 | 5.3 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL1207971 | 14735 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 387 | 6 | 1 | 3 | 5.3 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL467113 | 14735 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 387 | 6 | 1 | 3 | 5.3 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2)n1 | 10.1016/j.bmcl.2009.02.112 | ||
11595316 | 154820 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 319 | 6 | 1 | 3 | 4.1 | CC(C)COc1ccc(Cl)cc1Cc1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL257998 | 154820 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 319 | 6 | 1 | 3 | 4.1 | CC(C)COc1ccc(Cl)cc1Cc1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL403329 | 154820 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 319 | 6 | 1 | 3 | 4.1 | CC(C)COc1ccc(Cl)cc1Cc1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2009.02.112 | ||
44448886 | 14557 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 4.6 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2ccc(Cl)cc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1206274 | 14557 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 4.6 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2ccc(Cl)cc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL256334 | 14557 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 4.6 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2ccc(Cl)cc12 | 10.1016/j.bmcl.2008.03.018 | ||
24760469 | 14565 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 318 | 4 | 1 | 4 | 4.1 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2cc(F)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1206285 | 14565 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 318 | 4 | 1 | 4 | 4.1 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2cc(F)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL257135 | 14565 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 318 | 4 | 1 | 4 | 4.1 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2cc(F)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
44448888 | 14673 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 348 | 4 | 1 | 4 | 4.9 | Cc1c(CC(C)C)c2ccc(Cl)cc2n1-c1nc(C(=O)O)cs1 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1207401 | 14673 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 348 | 4 | 1 | 4 | 4.9 | Cc1c(CC(C)C)c2ccc(Cl)cc2n1-c1nc(C(=O)O)cs1 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL403082 | 14673 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 348 | 4 | 1 | 4 | 4.9 | Cc1c(CC(C)C)c2ccc(Cl)cc2n1-c1nc(C(=O)O)cs1 | 10.1016/j.bmcl.2008.03.018 | ||
24760323 | 14677 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 320 | 3 | 1 | 4 | 4.6 | CC(C)c1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1207413 | 14677 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 320 | 3 | 1 | 4 | 4.6 | CC(C)c1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL403890 | 14677 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 320 | 3 | 1 | 4 | 4.6 | CC(C)c1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
11595316 | 154820 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 319 | 6 | 1 | 3 | 4.1 | CC(C)COc1ccc(Cl)cc1Cc1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL257998 | 154820 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 319 | 6 | 1 | 3 | 4.1 | CC(C)COc1ccc(Cl)cc1Cc1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL403329 | 154820 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 319 | 6 | 1 | 3 | 4.1 | CC(C)COc1ccc(Cl)cc1Cc1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2008.03.018 | ||
44448743 | 94521 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 481 | 8 | 1 | 4 | 6.2 | Cc1cc(NC(=O)C(F)(F)c2ccccc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL254558 | 94521 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 481 | 8 | 1 | 4 | 6.2 | Cc1cc(NC(=O)C(F)(F)c2ccccc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
44448371 | 94917 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 425 | 7 | 1 | 5 | 4.6 | Cc1cc(NC(=O)C2CCCO2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL256731 | 94917 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 425 | 7 | 1 | 5 | 4.6 | Cc1cc(NC(=O)C2CCCO2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
44448521 | 95013 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 445 | 8 | 1 | 4 | 5.4 | Cc1cc(C(=O)NCc2ccccc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL257146 | 95013 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 445 | 8 | 1 | 4 | 5.4 | Cc1cc(C(=O)NCc2ccccc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
44448301 | 95099 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 446 | 8 | 1 | 5 | 5.0 | Cc1cc(NC(=O)Cc2cccnc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL257544 | 95099 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 446 | 8 | 1 | 5 | 5.0 | Cc1cc(NC(=O)Cc2cccnc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
44448349 | 154930 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 425 | 7 | 1 | 5 | 4.4 | Cc1cc(NC(=O)C2CCOC2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL403940 | 154930 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 425 | 7 | 1 | 5 | 4.4 | Cc1cc(NC(=O)C2CCOC2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
44448598 | 155096 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 431 | 7 | 1 | 4 | 5.7 | Cc1cc(C(=O)Nc2ccccc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL404698 | 155096 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 431 | 7 | 1 | 4 | 5.7 | Cc1cc(C(=O)Nc2ccccc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
44432921 | 144703 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 518 | 8 | 1 | 7 | 5.8 | COc1ccc(Nc2nnc(CN(c3cccc(Cl)c3Cl)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL391270 | 144703 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 518 | 8 | 1 | 7 | 5.8 | COc1ccc(Nc2nnc(CN(c3cccc(Cl)c3Cl)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44432376 | 86854 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 535 | 6 | 0 | 5 | 7.4 | Cc1nnc(-c2cccc(-n3c(C)ccc3-c3cc(Br)ccc3OCc3ccc(F)cc3F)c2)o1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL233160 | 86854 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 535 | 6 | 0 | 5 | 7.4 | Cc1nnc(-c2cccc(-n3c(C)ccc3-c3cc(Br)ccc3OCc3ccc(F)cc3F)c2)o1 | 10.1016/j.bmcl.2006.12.021 | ||
44432380 | 87138 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 519 | 6 | 1 | 3 | 7.5 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1ccc(-c2cnc[nH]2)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL233565 | 87138 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 519 | 6 | 1 | 3 | 7.5 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1ccc(-c2cnc[nH]2)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
44432370 | 87539 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 413 | 5 | 1 | 3 | 6.6 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1ccc2cn[nH]c2c1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL234181 | 87539 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 413 | 5 | 1 | 3 | 6.6 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1ccc2cn[nH]c2c1 | 10.1016/j.bmcl.2006.12.021 | ||
44432366 | 145561 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 520 | 8 | 1 | 3 | 8.2 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)N[C@H](C)c2ccccc2)c1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL391931 | 145561 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 520 | 8 | 1 | 3 | 8.2 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)N[C@H](C)c2ccccc2)c1 | 10.1016/j.bmcl.2006.12.021 | ||
44432371 | 145711 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 413 | 5 | 1 | 3 | 6.6 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1ccc2[nH]ncc2c1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL392047 | 145711 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 413 | 5 | 1 | 3 | 6.6 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1ccc2[nH]ncc2c1 | 10.1016/j.bmcl.2006.12.021 | ||
44568598 | 12537 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 494 | 9 | 1 | 5 | 6.2 | Cc1cc(NC(=O)c2ccc(CN3CCCCC3)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1187183 | 12537 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 494 | 9 | 1 | 5 | 6.2 | Cc1cc(NC(=O)c2ccc(CN3CCCCC3)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL492829 | 12537 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 494 | 9 | 1 | 5 | 6.2 | Cc1cc(NC(=O)c2ccc(CN3CCCCC3)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
44568636 | 12547 | 1 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 452 | 7 | 2 | 5 | 4.8 | Cc1cc(NC(=O)c2ccc3c(c2)CCNC3)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1187203 | 12547 | 1 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 452 | 7 | 2 | 5 | 4.8 | Cc1cc(NC(=O)c2ccc3c(c2)CCNC3)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL493254 | 12547 | 1 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 452 | 7 | 2 | 5 | 4.8 | Cc1cc(NC(=O)c2ccc3c(c2)CCNC3)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
44448598 | 155096 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 431 | 7 | 1 | 4 | 5.7 | Cc1cc(C(=O)Nc2ccccc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL404698 | 155096 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 431 | 7 | 1 | 4 | 5.7 | Cc1cc(C(=O)Nc2ccccc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.05.118 | ||
44413206 | 77933 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 467 | 6 | 1 | 3 | 6.9 | Cc1ccc(-c2cc(Br)ccc2OCC2CCCCC2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL210987 | 77933 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 467 | 6 | 1 | 3 | 6.9 | Cc1ccc(-c2cc(Br)ccc2OCC2CCCCC2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
44413200 | 79563 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 425 | 6 | 1 | 4 | 5.6 | Cc1ccc(-c2cc(Cl)ccc2OCC2CCOCC2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL212680 | 79563 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 425 | 6 | 1 | 4 | 5.6 | Cc1ccc(-c2cc(Cl)ccc2OCC2CCOCC2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
44413181 | 138268 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 411 | 6 | 1 | 4 | 5.4 | Cc1ccc(-c2cc(Cl)ccc2OCC2CCCO2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL378090 | 138268 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 411 | 6 | 1 | 4 | 5.4 | Cc1ccc(-c2cc(Cl)ccc2OCC2CCCO2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
44413163 | 138990 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 529 | 6 | 1 | 3 | 7.5 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(C(F)(F)F)cc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL379514 | 138990 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 529 | 6 | 1 | 3 | 7.5 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(C(F)(F)F)cc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
44430776 | 86830 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 406 | 6 | 1 | 4 | 5.5 | O=C(O)c1cc(C2=C(c3cc(Cl)ccc3OCc3ccccc3)CCC2)cnn1 | 10.1016/j.bmcl.2006.10.041 | ||
CHEMBL233044 | 86830 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 406 | 6 | 1 | 4 | 5.5 | O=C(O)c1cc(C2=C(c3cc(Cl)ccc3OCc3ccccc3)CCC2)cnn1 | 10.1016/j.bmcl.2006.10.041 | ||
10238855 | 87565 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 478 | 7 | 1 | 3 | 6.8 | COc1ccc(COc2ccc(Br)cc2C2=C(c3cccc(C(=O)O)c3)CCC2)cc1 | 10.1016/j.bmcl.2006.10.041 | ||
CHEMBL234280 | 87565 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 478 | 7 | 1 | 3 | 6.8 | COc1ccc(COc2ccc(Br)cc2C2=C(c3cccc(C(=O)O)c3)CCC2)cc1 | 10.1016/j.bmcl.2006.10.041 | ||
10310313 | 87568 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 439 | 6 | 1 | 3 | 6.5 | O=C(O)c1cc(C2=C(c3cc(C(F)(F)F)ccc3OCc3ccccc3)CCC2)ccn1 | 10.1016/j.bmcl.2006.10.041 | ||
CHEMBL234290 | 87568 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 439 | 6 | 1 | 3 | 6.5 | O=C(O)c1cc(C2=C(c3cc(C(F)(F)F)ccc3OCc3ccccc3)CCC2)ccn1 | 10.1016/j.bmcl.2006.10.041 | ||
10310187 | 152941 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 431 | 6 | 1 | 3 | 6.2 | N#Cc1ccc(OCc2ccc(F)cc2F)c(C2=C(c3cccc(C(=O)O)c3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
CHEMBL397957 | 152941 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 431 | 6 | 1 | 3 | 6.2 | N#Cc1ccc(OCc2ccc(F)cc2F)c(C2=C(c3cccc(C(=O)O)c3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
11429983 | 76682 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 416 | 6 | 1 | 4 | 5.7 | O=C(O)c1cccc(-c2nccnc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
CHEMBL207175 | 76682 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 416 | 6 | 1 | 4 | 5.7 | O=C(O)c1cccc(-c2nccnc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
44448596 | 154636 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 432 | 8 | 1 | 5 | 4.7 | O=C(Cc1ccccn1)Nc1ccn(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL402326 | 154636 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 432 | 8 | 1 | 5 | 4.7 | O=C(Cc1ccccn1)Nc1ccn(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.04.018 | ||
44432868 | 154467 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 481 | 8 | 0 | 5 | 5.6 | CCc1ccccc1N(Cc1nnc(Cc2ccc(Cl)cc2)o1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL401432 | 154467 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 481 | 8 | 0 | 5 | 5.6 | CCc1ccccc1N(Cc1nnc(Cc2ccc(Cl)cc2)o1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44413110 | 137856 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 459 | 7 | 1 | 3 | 7.4 | Cc1ccc(-c2cc(-c3ccccc3)ccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL377245 | 137856 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 459 | 7 | 1 | 3 | 7.4 | Cc1ccc(-c2cc(-c3ccccc3)ccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
44430772 | 86898 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 438 | 6 | 1 | 2 | 7.4 | O=C(O)c1cccc(C2=C(c3ccccc3OCc3ccc(Cl)c(Cl)c3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
CHEMBL233231 | 86898 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 438 | 6 | 1 | 2 | 7.4 | O=C(O)c1cccc(C2=C(c3ccccc3OCc3ccc(Cl)c(Cl)c3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
44430773 | 87522 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 413 | 6 | 1 | 3 | 6.1 | N#Cc1ccc(OCc2ccc(F)cc2)c(C2=C(c3cccc(C(=O)O)c3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
CHEMBL234082 | 87522 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 413 | 6 | 1 | 3 | 6.1 | N#Cc1ccc(OCc2ccc(F)cc2)c(C2=C(c3cccc(C(=O)O)c3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
59179878 | 105359 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 351 | 4 | 1 | 6 | 3.9 | COc1ccc(-c2nn(-c3nc(C(=O)O)cs3)c3ccccc23)cc1 | 10.1016/j.bmcl.2014.01.052 | ||
CHEMBL3127167 | 105359 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 351 | 4 | 1 | 6 | 3.9 | COc1ccc(-c2nn(-c3nc(C(=O)O)cs3)c3ccccc23)cc1 | 10.1016/j.bmcl.2014.01.052 | ||
59179924 | 105362 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 325 | 3 | 1 | 5 | 4.1 | O=C(O)c1csc(-n2nc(C3=CCCCC3)c3ccccc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
CHEMBL3127170 | 105362 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 325 | 3 | 1 | 5 | 4.1 | O=C(O)c1csc(-n2nc(C3=CCCCC3)c3ccccc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
10185239 | 149848 | 0 | None | - | 0 | Mouse | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 497 | 9 | 1 | 5 | 5.5 | Cc1ccc(S(=O)(=O)N(CC(C)C)c2cc3c(cc2OCc2ccc(C(=O)O)cc2C)CCC3)o1 | nan | ||
CHEMBL3953379 | 149848 | 0 | None | - | 0 | Mouse | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 497 | 9 | 1 | 5 | 5.5 | Cc1ccc(S(=O)(=O)N(CC(C)C)c2cc3c(cc2OCc2ccc(C(=O)O)cc2C)CCC3)o1 | nan | ||
59179908 | 105356 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 339 | 3 | 1 | 5 | 4.0 | O=C(O)c1csc(-n2nc(-c3ccc(F)cc3)c3ccccc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
CHEMBL3127164 | 105356 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 339 | 3 | 1 | 5 | 4.0 | O=C(O)c1csc(-n2nc(-c3ccc(F)cc3)c3ccccc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
58891900 | 151531 | 0 | None | - | 0 | Mouse | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 532 | 8 | 1 | 8 | 5.1 | Cc1csc(S(=O)(=O)N(c2cc(C)c(Cl)cc2OCc2ccc(-c3nnn[nH]3)cc2C)C(C)C)n1 | nan | ||
CHEMBL3967376 | 151531 | 0 | None | - | 0 | Mouse | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 532 | 8 | 1 | 8 | 5.1 | Cc1csc(S(=O)(=O)N(c2cc(C)c(Cl)cc2OCc2ccc(-c3nnn[nH]3)cc2C)C(C)C)n1 | nan | ||
44416127 | 139630 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 400 | 6 | 1 | 4 | 4.3 | Cc1cn(Cc2cc(Br)ccc2OCc2ccccc2)nc1C(=O)O | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL380297 | 139630 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 400 | 6 | 1 | 4 | 4.3 | Cc1cn(Cc2cc(Br)ccc2OCc2ccccc2)nc1C(=O)O | 10.1016/j.bmcl.2006.06.086 | ||
1498267 | 92636 | 8 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 369 | 4 | 1 | 6 | 3.7 | COc1ccc(-c2cc(C(F)(F)F)n(-c3nc(C(=O)O)cs3)n2)cc1 | 10.1016/j.bmcl.2013.09.032 | ||
CHEMBL2442486 | 92636 | 8 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 369 | 4 | 1 | 6 | 3.7 | COc1ccc(-c2cc(C(F)(F)F)n(-c3nc(C(=O)O)cs3)n2)cc1 | 10.1016/j.bmcl.2013.09.032 | ||
44416141 | 80722 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 464 | 6 | 1 | 4 | 4.7 | O=C(O)c1nn(Cc2cc(Br)ccc2OCc2ccccc2)cc1Br | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL215690 | 80722 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 464 | 6 | 1 | 4 | 4.7 | O=C(O)c1nn(Cc2cc(Br)ccc2OCc2ccccc2)cc1Br | 10.1016/j.bmcl.2006.06.086 | ||
10741017 | 60959 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 424 | 13 | 4 | 5 | 4.0 | Cc1cccc(SCC(O)CC[C@H]2[C@H](O)C[C@H](O)[C@@H]2CCCCCCC(=O)O)c1 | 10.1021/jm990542v | ||
CHEMBL176692 | 60959 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 424 | 13 | 4 | 5 | 4.0 | Cc1cccc(SCC(O)CC[C@H]2[C@H](O)C[C@H](O)[C@@H]2CCCCCCC(=O)O)c1 | 10.1021/jm990542v | ||
1894 | 943 | 35 | None | -257 | 5 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 424 | 11 | 4 | 5 | 3.2 | OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O | 10.1021/jm990542v | ||
5311053 | 943 | 35 | None | -257 | 5 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 424 | 11 | 4 | 5 | 3.2 | OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O | 10.1021/jm990542v | ||
CHEMBL37853 | 943 | 35 | None | -257 | 5 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 424 | 11 | 4 | 5 | 3.2 | OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O | 10.1021/jm990542v | ||
DB11507 | 943 | 35 | None | -257 | 5 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 424 | 11 | 4 | 5 | 3.2 | OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O | 10.1021/jm990542v | ||
9868012 | 123331 | 0 | None | 50 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 420 | 6 | 1 | 3 | 7.0 | O=C(O)c1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
CHEMBL362543 | 123331 | 0 | None | 50 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 420 | 6 | 1 | 3 | 7.0 | O=C(O)c1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
10003006 | 174651 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 433 | 6 | 1 | 3 | 6.5 | O=C(O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccc(F)cc2)n1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL457142 | 174651 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 433 | 6 | 1 | 3 | 6.5 | O=C(O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccc(F)cc2)n1 | 10.1016/j.bmcl.2008.11.032 | ||
25005499 | 67700 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 405 | 5 | 1 | 4 | 5.2 | Cc1cc(C(=O)NC2CC2)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
CHEMBL1914467 | 67700 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 405 | 5 | 1 | 4 | 5.2 | Cc1cc(C(=O)NC2CC2)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
25002355 | 67856 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 365 | 4 | 1 | 4 | 4.4 | Cc1cc(C(N)=O)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
CHEMBL1915254 | 67856 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 365 | 4 | 1 | 4 | 4.4 | Cc1cc(C(N)=O)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
11258250 | 77662 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 383 | 6 | 1 | 3 | 5.8 | Cc1ccc(-c2cc(Cl)ccc2OCC(C)C)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL209800 | 77662 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 383 | 6 | 1 | 3 | 5.8 | Cc1ccc(-c2cc(Cl)ccc2OCC(C)C)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2008.01.071 | ||
24784836 | 67816 | 0 | None | 2511 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 332 | 4 | 1 | 4 | 4.5 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(C(C)C)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
CHEMBL1915012 | 67816 | 0 | None | 2511 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 332 | 4 | 1 | 4 | 4.5 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(C(C)C)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
44430691 | 87733 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 495 | 6 | 1 | 3 | 7.1 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cc(Br)cc(C(=O)O)c1 | 10.1016/j.bmcl.2006.10.078 | ||
CHEMBL234722 | 87733 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 495 | 6 | 1 | 3 | 7.1 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cc(Br)cc(C(=O)O)c1 | 10.1016/j.bmcl.2006.10.078 | ||
10390894 | 87740 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 490 | 7 | 2 | 5 | 6.6 | COC(=O)Nc1cc(C(=O)O)cc(-n2c(C)ccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.10.078 | ||
CHEMBL234728 | 87740 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 490 | 7 | 2 | 5 | 6.6 | COC(=O)Nc1cc(C(=O)O)cc(-n2c(C)ccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.10.078 | ||
44430693 | 141571 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 531 | 6 | 1 | 3 | 7.4 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccc(F)cc2F)n1-c1cc(Br)cc(C(=O)O)c1 | 10.1016/j.bmcl.2006.10.078 | ||
CHEMBL388242 | 141571 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 531 | 6 | 1 | 3 | 7.4 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccc(F)cc2F)n1-c1cc(Br)cc(C(=O)O)c1 | 10.1016/j.bmcl.2006.10.078 | ||
44430711 | 143926 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 536 | 7 | 1 | 5 | 5.9 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cc(C(=O)O)cc(N2CCCS2(=O)=O)c1 | 10.1016/j.bmcl.2006.10.078 | ||
CHEMBL390660 | 143926 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 536 | 7 | 1 | 5 | 5.9 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cc(C(=O)O)cc(N2CCCS2(=O)=O)c1 | 10.1016/j.bmcl.2006.10.078 | ||
44432355 | 144387 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 520 | 8 | 1 | 3 | 8.2 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1ccc(C(=O)N[C@@H](C)c2ccccc2)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL391026 | 144387 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 520 | 8 | 1 | 3 | 8.2 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1ccc(C(=O)N[C@@H](C)c2ccccc2)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
10347276 | 144727 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 541 | 8 | 1 | 7 | 5.8 | Cc1noc(C)c1S(=O)(=O)NC(=O)c1cccc(-n2c(C)ccc2-c2ccccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL391287 | 144727 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 541 | 8 | 1 | 7 | 5.8 | Cc1noc(C)c1S(=O)(=O)NC(=O)c1cccc(-n2c(C)ccc2-c2ccccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.12.021 | ||
44426672 | 85267 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 529 | 6 | 1 | 3 | 7.8 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2)n1-c1cc(C(=O)O)c2ccccc2c1 | 10.1016/j.bmcl.2006.11.059 | ||
CHEMBL228746 | 85267 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 529 | 6 | 1 | 3 | 7.8 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2)n1-c1cc(C(=O)O)c2ccccc2c1 | 10.1016/j.bmcl.2006.11.059 | ||
10095268 | 85729 | 0 | None | 15 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 449 | 6 | 1 | 3 | 6.8 | Cc1ccc(-n2c(C)ccc2-c2cc(Cl)ccc2OCc2ccc(F)cc2)cc1C(=O)O | 10.1016/j.bmcl.2006.11.059 | ||
CHEMBL231184 | 85729 | 0 | None | 15 | 4 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 449 | 6 | 1 | 3 | 6.8 | Cc1ccc(-n2c(C)ccc2-c2cc(Cl)ccc2OCc2ccc(F)cc2)cc1C(=O)O | 10.1016/j.bmcl.2006.11.059 | ||
44426667 | 136657 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 527 | 8 | 1 | 4 | 7.1 | Cc1ccc(-c2cc(Br)ccc2OCc2ccccc2)n1-c1ccc(OC(F)F)c(C(=O)O)c1 | 10.1016/j.bmcl.2006.11.059 | ||
CHEMBL374824 | 136657 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 527 | 8 | 1 | 4 | 7.1 | Cc1ccc(-c2cc(Br)ccc2OCc2ccccc2)n1-c1ccc(OC(F)F)c(C(=O)O)c1 | 10.1016/j.bmcl.2006.11.059 | ||
44568707 | 12533 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 454 | 9 | 1 | 5 | 5.2 | Cc1cc(C(=O)Nc2ccc(CN(C)C)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1187165 | 12533 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 454 | 9 | 1 | 5 | 5.2 | Cc1cc(C(=O)Nc2ccc(CN(C)C)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL492238 | 12533 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 454 | 9 | 1 | 5 | 5.2 | Cc1cc(C(=O)Nc2ccc(CN(C)C)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
44413135 | 77366 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 497 | 6 | 1 | 3 | 6.8 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)c(F)c2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL208934 | 77366 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 497 | 6 | 1 | 3 | 6.8 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)c(F)c2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
11258250 | 77662 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 383 | 6 | 1 | 3 | 5.8 | Cc1ccc(-c2cc(Cl)ccc2OCC(C)C)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL209800 | 77662 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 383 | 6 | 1 | 3 | 5.8 | Cc1ccc(-c2cc(Cl)ccc2OCC(C)C)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
10052747 | 77984 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 529 | 6 | 1 | 3 | 7.8 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(Cl)cc2Cl)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL211059 | 77984 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 529 | 6 | 1 | 3 | 7.8 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(Cl)cc2Cl)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
44413101 | 79565 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 451 | 6 | 1 | 3 | 6.7 | Cc1ccc(-c2cc(C(F)(F)F)ccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL212688 | 79565 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 451 | 6 | 1 | 3 | 6.7 | Cc1ccc(-c2cc(C(F)(F)F)ccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
11224723 | 138291 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 427 | 6 | 1 | 3 | 5.9 | Cc1ccc(-c2cc(Br)ccc2OCC(C)C)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL378120 | 138291 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 427 | 6 | 1 | 3 | 5.9 | Cc1ccc(-c2cc(Br)ccc2OCC(C)C)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
9844175 | 76756 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 404 | 6 | 1 | 2 | 6.7 | O=C(O)c1cccc(C2=C(c3cc(Cl)ccc3OCc3ccccc3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
CHEMBL207577 | 76756 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 404 | 6 | 1 | 2 | 6.7 | O=C(O)c1cccc(C2=C(c3cc(Cl)ccc3OCc3ccccc3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
10195696 | 141490 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 484 | 6 | 1 | 2 | 7.1 | O=C(O)c1cccc(C2=C(c3cc(Br)ccc3OCc3ccc(F)cc3F)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
CHEMBL387605 | 141490 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 484 | 6 | 1 | 2 | 7.1 | O=C(O)c1cccc(C2=C(c3cc(Br)ccc3OCc3ccc(F)cc3F)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
68259031 | 105354 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 350 | 4 | 2 | 6 | 3.9 | CNc1ccc2c(-c3ccccc3)nn(-c3nc(C(=O)O)cs3)c2c1 | 10.1016/j.bmcl.2014.01.052 | ||
CHEMBL3127162 | 105354 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 350 | 4 | 2 | 6 | 3.9 | CNc1ccc2c(-c3ccccc3)nn(-c3nc(C(=O)O)cs3)c2c1 | 10.1016/j.bmcl.2014.01.052 | ||
46220498 | 92642 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 361 | 4 | 1 | 5 | 4.7 | Cc1c(-c2ccccc2)nn(-c2nc(C(=O)O)cs2)c1-c1ccccc1 | 10.1016/j.bmcl.2013.09.032 | ||
CHEMBL2442495 | 92642 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 361 | 4 | 1 | 5 | 4.7 | Cc1c(-c2ccccc2)nn(-c2nc(C(=O)O)cs2)c1-c1ccccc1 | 10.1016/j.bmcl.2013.09.032 | ||
46220498 | 92642 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 361 | 4 | 1 | 5 | 4.7 | Cc1c(-c2ccccc2)nn(-c2nc(C(=O)O)cs2)c1-c1ccccc1 | 10.1016/j.bmcl.2013.10.065 | ||
CHEMBL2442495 | 92642 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 361 | 4 | 1 | 5 | 4.7 | Cc1c(-c2ccccc2)nn(-c2nc(C(=O)O)cs2)c1-c1ccccc1 | 10.1016/j.bmcl.2013.10.065 | ||
44611764 | 103413 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 379 | 4 | 1 | 5 | 4.8 | Cc1c(-c2ccccc2)nn(-c2nc(C(=O)O)cs2)c1-c1cccc(F)c1 | 10.1016/j.bmcl.2013.10.065 | ||
CHEMBL3092140 | 103413 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 379 | 4 | 1 | 5 | 4.8 | Cc1c(-c2ccccc2)nn(-c2nc(C(=O)O)cs2)c1-c1cccc(F)c1 | 10.1016/j.bmcl.2013.10.065 | ||
11656705 | 14738 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 511 | 6 | 1 | 3 | 7.2 | O=C(O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccc(Br)cc2F)n1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL1207974 | 14738 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 511 | 6 | 1 | 3 | 7.2 | O=C(O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccc(Br)cc2F)n1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL467578 | 14738 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 511 | 6 | 1 | 3 | 7.2 | O=C(O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccc(Br)cc2F)n1 | 10.1016/j.bmcl.2008.11.032 | ||
9866503 | 76681 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 414 | 6 | 1 | 2 | 7.0 | O=C(O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL207174 | 76681 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 414 | 6 | 1 | 2 | 7.0 | O=C(O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2008.11.032 | ||
24785591 | 67817 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 330 | 4 | 1 | 4 | 4.2 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(C3CC3)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
CHEMBL1915013 | 67817 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 330 | 4 | 1 | 4 | 4.2 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(C3CC3)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
11978138 | 14685 | 1 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 359 | 6 | 1 | 4 | 4.7 | O=C(O)Cc1csc(-c2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL1207426 | 14685 | 1 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 359 | 6 | 1 | 4 | 4.7 | O=C(O)Cc1csc(-c2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL404760 | 14685 | 1 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 359 | 6 | 1 | 4 | 4.7 | O=C(O)Cc1csc(-c2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.01.071 | ||
44455168 | 14691 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 358 | 6 | 1 | 3 | 5.3 | O=C(O)c1ccc(Cc2cc(Cl)ccc2OCc2ccccc2)s1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL1207466 | 14691 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 358 | 6 | 1 | 3 | 5.3 | O=C(O)c1ccc(Cc2cc(Cl)ccc2OCc2ccccc2)s1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL408367 | 14691 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 358 | 6 | 1 | 3 | 5.3 | O=C(O)c1ccc(Cc2cc(Cl)ccc2OCc2ccccc2)s1 | 10.1016/j.bmcl.2008.01.071 | ||
9866503 | 76681 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 414 | 6 | 1 | 2 | 7.0 | O=C(O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL207174 | 76681 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 414 | 6 | 1 | 2 | 7.0 | O=C(O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2008.11.032 | ||
9866503 | 76681 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 414 | 6 | 1 | 2 | 7.0 | O=C(O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
CHEMBL207174 | 76681 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 414 | 6 | 1 | 2 | 7.0 | O=C(O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
44448981 | 14670 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 333 | 4 | 1 | 3 | 5.2 | CC(C)Cc1cn(-c2ccc(C(=O)O)s2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1207396 | 14670 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 333 | 4 | 1 | 3 | 5.2 | CC(C)Cc1cn(-c2ccc(C(=O)O)s2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL402608 | 14670 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 333 | 4 | 1 | 3 | 5.2 | CC(C)Cc1cn(-c2ccc(C(=O)O)s2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
44448486 | 94519 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 446 | 8 | 1 | 5 | 4.8 | Cc1cc(C(=O)NCc2cccnc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL254553 | 94519 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 446 | 8 | 1 | 5 | 4.8 | Cc1cc(C(=O)NCc2cccnc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
11963338 | 94743 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 447 | 7 | 1 | 5 | 5.8 | Cc1cc(NC(=O)OC(C)(C)C(F)(F)F)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL255876 | 94743 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 447 | 7 | 1 | 5 | 5.8 | Cc1cc(NC(=O)OC(C)(C)C(F)(F)F)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.04.018 | ||
11963297 | 95249 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 379 | 7 | 1 | 5 | 4.9 | Cc1cc(NC(=O)OC(C)C)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL258183 | 95249 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 379 | 7 | 1 | 5 | 4.9 | Cc1cc(NC(=O)OC(C)C)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.04.018 | ||
44448300 | 155049 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 446 | 8 | 1 | 5 | 5.0 | Cc1cc(NC(=O)Cc2ccncc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL404481 | 155049 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 446 | 8 | 1 | 5 | 5.0 | Cc1cc(NC(=O)Cc2ccncc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
135581997 | 67847 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 404 | 4 | 1 | 4 | 6.3 | Cc1cc(-c2nc3ccccc3[nH]2)nn1Cc1cc(Cl)cc2cc(C(C)C)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
CHEMBL1915245 | 67847 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 404 | 4 | 1 | 4 | 6.3 | Cc1cc(-c2nc3ccccc3[nH]2)nn1Cc1cc(Cl)cc2cc(C(C)C)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
24784840 | 67853 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 416 | 5 | 1 | 6 | 3.7 | Cc1cc(C(=O)NN2CCOCC2)nn1Cc1cc(Cl)cc2cc(C(C)C)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
CHEMBL1915251 | 67853 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 416 | 5 | 1 | 6 | 3.7 | Cc1cc(C(=O)NN2CCOCC2)nn1Cc1cc(Cl)cc2cc(C(C)C)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
44432886 | 86570 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 535 | 7 | 0 | 5 | 6.3 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3ccc(C(F)(F)F)cc3)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL232389 | 86570 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 535 | 7 | 0 | 5 | 6.3 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3ccc(C(F)(F)F)cc3)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44432343 | 87533 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 552 | 8 | 0 | 3 | 7.6 | CCN(CC)C(=O)c1ccc(-n2c(C)ccc2-c2cc(Br)ccc2OCc2ccc(F)cc2F)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL234174 | 87533 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 552 | 8 | 0 | 3 | 7.6 | CCN(CC)C(=O)c1ccc(-n2c(C)ccc2-c2cc(Br)ccc2OCc2ccc(F)cc2F)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
10051975 | 154171 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 7.0 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)NCc2ccccn2)c1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL399800 | 154171 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 7.0 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)NCc2ccccn2)c1 | 10.1016/j.bmcl.2006.12.021 | ||
24894001 | 12484 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 480 | 9 | 1 | 5 | 5.8 | Cc1cc(NC(=O)c2ccc(CN3CCCC3)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1186882 | 12484 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 480 | 9 | 1 | 5 | 5.8 | Cc1cc(NC(=O)c2ccc(CN3CCCC3)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL481689 | 12484 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 480 | 9 | 1 | 5 | 5.8 | Cc1cc(NC(=O)c2ccc(CN3CCCC3)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
44568630 | 12550 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 496 | 11 | 2 | 5 | 6.5 | Cc1cc(NC(=O)c2ccc(C(C)NCC(C)C)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1187224 | 12550 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 496 | 11 | 2 | 5 | 6.5 | Cc1cc(NC(=O)c2ccc(C(C)NCC(C)C)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL494268 | 12550 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 496 | 11 | 2 | 5 | 6.5 | Cc1cc(NC(=O)c2ccc(C(C)NCC(C)C)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
44568632 | 12551 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 494 | 9 | 1 | 5 | 6.3 | Cc1cc(NC(=O)c2ccc(C(C)N3CCCC3)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1187225 | 12551 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 494 | 9 | 1 | 5 | 6.3 | Cc1cc(NC(=O)c2ccc(C(C)N3CCCC3)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL494269 | 12551 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 494 | 9 | 1 | 5 | 6.3 | Cc1cc(NC(=O)c2ccc(C(C)N3CCCC3)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
44568663 | 12556 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 494 | 8 | 1 | 5 | 5.6 | CCN1CCc2ccc(C(=O)Nc3cc(C)n(Cc4cc(Cl)ccc4OCC(C)C)n3)cc2CC1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1187258 | 12556 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 494 | 8 | 1 | 5 | 5.6 | CCN1CCc2ccc(C(=O)Nc3cc(C)n(Cc4cc(Cl)ccc4OCC(C)C)n3)cc2CC1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL495091 | 12556 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 494 | 8 | 1 | 5 | 5.6 | CCN1CCc2ccc(C(=O)Nc3cc(C)n(Cc4cc(Cl)ccc4OCC(C)C)n3)cc2CC1 | 10.1016/j.bmcl.2008.05.118 | ||
44568600 | 12637 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 496 | 9 | 1 | 6 | 5.0 | Cc1cc(NC(=O)c2ccc(CN3CCOCC3)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1187804 | 12637 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 496 | 9 | 1 | 6 | 5.0 | Cc1cc(NC(=O)c2ccc(CN3CCOCC3)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL521988 | 12637 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 496 | 9 | 1 | 6 | 5.0 | Cc1cc(NC(=O)c2ccc(CN3CCOCC3)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
44413172 | 137716 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 491 | 7 | 1 | 4 | 6.5 | COc1ccc(COc2ccc(Br)cc2-c2ccc(C)n2-c2cccc(C(=O)O)c2)cc1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL377034 | 137716 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 491 | 7 | 1 | 4 | 6.5 | COc1ccc(COc2ccc(Br)cc2-c2ccc(C)n2-c2cccc(C(=O)O)c2)cc1 | 10.1016/j.bmcl.2006.04.073 | ||
44413164 | 137809 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 491 | 7 | 1 | 4 | 6.5 | COc1cccc(COc2ccc(Br)cc2-c2ccc(C)n2-c2cccc(C(=O)O)c2)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL377134 | 137809 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 491 | 7 | 1 | 4 | 6.5 | COc1cccc(COc2ccc(Br)cc2-c2ccc(C)n2-c2cccc(C(=O)O)c2)c1 | 10.1016/j.bmcl.2006.04.073 | ||
10216528 | 141810 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 6 | 1 | 2 | 6.9 | O=C(O)c1cccc(C2=C(c3ccccc3OCc3ccc(Cl)cc3F)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
CHEMBL388655 | 141810 | 0 | None | - | 0 | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 6 | 1 | 2 | 6.9 | O=C(O)c1cccc(C2=C(c3ccccc3OCc3ccc(Cl)cc3F)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
59179970 | 105346 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 339 | 3 | 1 | 5 | 4.0 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3c(F)cccc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
CHEMBL3127154 | 105346 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 339 | 3 | 1 | 5 | 4.0 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3c(F)cccc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
72543866 | 92643 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 361 | 4 | 1 | 5 | 4.6 | Cn1c(-c2ccccc2)nc(-c2nc(C(=O)O)cs2)c1-c1ccccc1 | 10.1016/j.bmcl.2013.09.032 | ||
CHEMBL2442497 | 92643 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 361 | 4 | 1 | 5 | 4.6 | Cn1c(-c2ccccc2)nc(-c2nc(C(=O)O)cs2)c1-c1ccccc1 | 10.1016/j.bmcl.2013.09.032 | ||
59179264 | 103417 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 387 | 5 | 1 | 5 | 5.1 | Cc1c(-c2ccccc2)nn(-c2nc(/C=C/C(=O)O)cs2)c1-c1ccccc1 | 10.1016/j.bmcl.2013.10.065 | ||
CHEMBL3092148 | 103417 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 387 | 5 | 1 | 5 | 5.1 | Cc1c(-c2ccccc2)nn(-c2nc(/C=C/C(=O)O)cs2)c1-c1ccccc1 | 10.1016/j.bmcl.2013.10.065 | ||
10739351 | 167753 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 393 | 13 | 5 | 5 | 3.0 | O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CNc1ccccc1 | 10.1021/jm990542v | ||
CHEMBL434173 | 167753 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 393 | 13 | 5 | 5 | 3.0 | O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CNc1ccccc1 | 10.1021/jm990542v | ||
44581654 | 189136 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 394 | 6 | 1 | 2 | 6.6 | Cc1c(C(=O)O)cccc1-c1ccccc1-c1ccccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL515697 | 189136 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 394 | 6 | 1 | 2 | 6.6 | Cc1c(C(=O)O)cccc1-c1ccccc1-c1ccccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.11.032 | ||
57399015 | 67823 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 332 | 4 | 1 | 5 | 3.4 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cn2cc(C(C)C)nc12 | 10.1016/j.bmcl.2011.05.047 | ||
CHEMBL1915019 | 67823 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 332 | 4 | 1 | 5 | 3.4 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cn2cc(C(C)C)nc12 | 10.1016/j.bmcl.2011.05.047 | ||
44432925 | 86851 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 492 | 10 | 1 | 7 | 5.0 | CCc1ccccc1N(Cc1nnc(CNc2ccc(OC)cc2)o1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL233157 | 86851 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 492 | 10 | 1 | 7 | 5.0 | CCc1ccccc1N(Cc1nnc(CNc2ccc(OC)cc2)o1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44432890 | 87372 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 485 | 7 | 0 | 5 | 5.5 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3ccccc3F)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL233808 | 87372 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 485 | 7 | 0 | 5 | 5.5 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3ccccc3F)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44432381 | 144950 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 440 | 6 | 0 | 5 | 6.3 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1ccc(-n2cncn2)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL391456 | 144950 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 440 | 6 | 0 | 5 | 6.3 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1ccc(-n2cncn2)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
44432360 | 145558 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 572 | 7 | 1 | 3 | 8.3 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1cccc(C(=O)Nc2ccccc2)c1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL391930 | 145558 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 572 | 7 | 1 | 3 | 8.3 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1cccc(C(=O)Nc2ccccc2)c1 | 10.1016/j.bmcl.2006.12.021 | ||
44432357 | 147397 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 418 | 6 | 1 | 3 | 5.4 | Cc1ccc(-c2ccccc2OCc2ccc(F)cc2F)n1-c1cccc(C(N)=O)c1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL393374 | 147397 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 418 | 6 | 1 | 3 | 5.4 | Cc1ccc(-c2ccccc2OCc2ccc(F)cc2F)n1-c1cccc(C(N)=O)c1 | 10.1016/j.bmcl.2006.12.021 | ||
44432334 | 168459 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 417 | 6 | 0 | 4 | 5.4 | Cc1ccc(-c2ccccc2OCc2ccccc2)n1-c1ccc(S(C)(=O)=O)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL439388 | 168459 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 417 | 6 | 0 | 4 | 5.4 | Cc1ccc(-c2ccccc2OCc2ccccc2)n1-c1ccc(S(C)(=O)=O)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
44568552 | 12487 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 494 | 9 | 1 | 5 | 6.2 | Cc1cc(NC(=O)c2cccc(CN3CCCCC3)c2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1186901 | 12487 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 494 | 9 | 1 | 5 | 6.2 | Cc1cc(NC(=O)c2cccc(CN3CCCCC3)c2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL482132 | 12487 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 494 | 9 | 1 | 5 | 6.2 | Cc1cc(NC(=O)c2cccc(CN3CCCCC3)c2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
44568508 | 12624 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 454 | 10 | 2 | 5 | 5.3 | CCNCc1cccc(C(=O)Nc2cc(C)n(Cc3cc(Cl)ccc3OCC(C)C)n2)c1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1187726 | 12624 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 454 | 10 | 2 | 5 | 5.3 | CCNCc1cccc(C(=O)Nc2cc(C)n(Cc3cc(Cl)ccc3OCC(C)C)n2)c1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL516608 | 12624 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 454 | 10 | 2 | 5 | 5.3 | CCNCc1cccc(C(=O)Nc2cc(C)n(Cc3cc(Cl)ccc3OCC(C)C)n2)c1 | 10.1016/j.bmcl.2008.05.118 | ||
44416229 | 138446 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 536 | 6 | 1 | 4 | 6.3 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL378533 | 138446 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 536 | 6 | 1 | 4 | 6.3 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.086 | ||
44564892 | 179940 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 554 | 6 | 1 | 5 | 6.2 | Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)c(Cl)c3)cccc21 | 10.1016/j.bmcl.2008.12.112 | ||
CHEMBL475348 | 179940 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 554 | 6 | 1 | 5 | 6.2 | Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)c(Cl)c3)cccc21 | 10.1016/j.bmcl.2008.12.112 | ||
15486806 | 100021 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 392 | 13 | 4 | 4 | 3.5 | O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1 | 10.1021/jm990542v | ||
CHEMBL290969 | 100021 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 392 | 13 | 4 | 4 | 3.5 | O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1 | 10.1021/jm990542v | ||
44416210 | 80720 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 502 | 6 | 1 | 4 | 6.0 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccc(Cl)c(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL215687 | 80720 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 502 | 6 | 1 | 4 | 6.0 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccc(Cl)c(C(F)(F)F)c1 | 10.1016/j.bmcl.2006.06.086 | ||
1498274 | 92639 | 9 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 355 | 3 | 2 | 6 | 3.4 | O=C(O)c1csc(-n2nc(-c3cccc(O)c3)cc2C(F)(F)F)n1 | 10.1016/j.bmcl.2013.09.032 | ||
CHEMBL2442489 | 92639 | 9 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 355 | 3 | 2 | 6 | 3.4 | O=C(O)c1csc(-n2nc(-c3cccc(O)c3)cc2C(F)(F)F)n1 | 10.1016/j.bmcl.2013.09.032 | ||
24760470 | 14570 | 0 | None | 63 | 3 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 4.6 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1206294 | 14570 | 0 | None | 63 | 3 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 4.6 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL257997 | 14570 | 0 | None | 63 | 3 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 4.6 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
10028359 | 174351 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 485 | 8 | 2 | 3 | 7.3 | CCC(=O)Nc1cc(C(=O)O)cc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL456496 | 174351 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 485 | 8 | 2 | 3 | 7.3 | CCC(=O)Nc1cc(C(=O)O)cc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2008.11.032 | ||
25005494 | 67864 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 449 | 6 | 1 | 5 | 5.2 | Cc1cc(C(=O)NC[C@H]2CCCO2)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
CHEMBL1915262 | 67864 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 449 | 6 | 1 | 5 | 5.2 | Cc1cc(C(=O)NC[C@H]2CCCO2)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
44449014 | 14552 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 359 | 6 | 1 | 4 | 4.7 | O=C(O)c1csc(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL1206263 | 14552 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 359 | 6 | 1 | 4 | 4.7 | O=C(O)c1csc(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL255652 | 14552 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 359 | 6 | 1 | 4 | 4.7 | O=C(O)c1csc(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.01.071 | ||
15604737 | 14585 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 342 | 6 | 1 | 3 | 4.8 | O=C(O)c1ccc(Cc2cc(Cl)ccc2OCc2ccccc2)o1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL1206426 | 14585 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 342 | 6 | 1 | 3 | 4.8 | O=C(O)c1ccc(Cc2cc(Cl)ccc2OCc2ccccc2)o1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL272793 | 14585 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 342 | 6 | 1 | 3 | 4.8 | O=C(O)c1ccc(Cc2cc(Cl)ccc2OCc2ccccc2)o1 | 10.1016/j.bmcl.2008.01.071 | ||
11235004 | 79703 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 400 | 6 | 1 | 4 | 4.3 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL213221 | 79703 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 400 | 6 | 1 | 4 | 4.3 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL258184 | 79703 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 400 | 6 | 1 | 4 | 4.3 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.01.071 | ||
9868012 | 123331 | 0 | None | 50 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 420 | 6 | 1 | 3 | 7.0 | O=C(O)c1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
CHEMBL362543 | 123331 | 0 | None | 50 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 420 | 6 | 1 | 3 | 7.0 | O=C(O)c1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
44449014 | 14552 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 359 | 6 | 1 | 4 | 4.7 | O=C(O)c1csc(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1206263 | 14552 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 359 | 6 | 1 | 4 | 4.7 | O=C(O)c1csc(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL255652 | 14552 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 359 | 6 | 1 | 4 | 4.7 | O=C(O)c1csc(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.03.018 | ||
24760322 | 14553 | 0 | None | 19 | 3 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 362 | 4 | 1 | 4 | 5.4 | CC(C)(C)CCc1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1206265 | 14553 | 0 | None | 19 | 3 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 362 | 4 | 1 | 4 | 5.4 | CC(C)(C)CCc1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL255675 | 14553 | 0 | None | 19 | 3 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 362 | 4 | 1 | 4 | 5.4 | CC(C)(C)CCc1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
24760470 | 14570 | 0 | None | 63 | 3 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 4.6 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1206294 | 14570 | 0 | None | 63 | 3 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 4.6 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL257997 | 14570 | 0 | None | 63 | 3 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 334 | 4 | 1 | 4 | 4.6 | CC(C)Cc1cn(-c2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
24760392 | 14678 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 348 | 5 | 1 | 4 | 4.7 | CC(C)Cc1cn(Cc2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1207414 | 14678 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 348 | 5 | 1 | 4 | 4.7 | CC(C)Cc1cn(Cc2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL403892 | 14678 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 348 | 5 | 1 | 4 | 4.7 | CC(C)Cc1cn(Cc2nc(C(=O)O)cs2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
11235004 | 79703 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 400 | 6 | 1 | 4 | 4.3 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL213221 | 79703 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 400 | 6 | 1 | 4 | 4.3 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL258184 | 79703 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 400 | 6 | 1 | 4 | 4.3 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.03.018 | ||
11235004 | 79703 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 400 | 6 | 1 | 4 | 4.3 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL213221 | 79703 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 400 | 6 | 1 | 4 | 4.3 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL258184 | 79703 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 400 | 6 | 1 | 4 | 4.3 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
44448372 | 155010 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 451 | 8 | 1 | 4 | 6.4 | Cc1cc(NC(=O)CC2CCCCC2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL404297 | 155010 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 451 | 8 | 1 | 4 | 6.4 | Cc1cc(NC(=O)CC2CCCCC2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
44432875 | 154128 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 497 | 8 | 0 | 6 | 5.3 | COc1ccc(Cc2nnc(CN(c3cccc(Cl)c3C)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL399613 | 154128 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 497 | 8 | 0 | 6 | 5.3 | COc1ccc(Cc2nnc(CN(c3cccc(Cl)c3C)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44432879 | 168683 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 531 | 9 | 0 | 6 | 6.1 | CCOc1ccc(Cc2nnc(CN(c3cccc(Cl)c3Cl)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL441126 | 168683 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 531 | 9 | 0 | 6 | 6.1 | CCOc1ccc(Cc2nnc(CN(c3cccc(Cl)c3Cl)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
9956808 | 77232 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 479 | 6 | 1 | 3 | 6.6 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.10.078 | ||
CHEMBL208791 | 77232 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 479 | 6 | 1 | 3 | 6.6 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.10.078 | ||
44430672 | 96510 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 471 | 6 | 1 | 3 | 6.8 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccc(F)cc2F)n1-c1cc(C(=O)O)ccc1F | 10.1016/j.bmcl.2006.10.078 | ||
CHEMBL266258 | 96510 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 471 | 6 | 1 | 3 | 6.8 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccc(F)cc2F)n1-c1cc(C(=O)O)ccc1F | 10.1016/j.bmcl.2006.10.078 | ||
44430674 | 149812 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 497 | 6 | 1 | 3 | 6.8 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2)n1-c1cc(C(=O)O)ccc1F | 10.1016/j.bmcl.2006.10.078 | ||
CHEMBL395310 | 149812 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 497 | 6 | 1 | 3 | 6.8 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2)n1-c1cc(C(=O)O)ccc1F | 10.1016/j.bmcl.2006.10.078 | ||
44430673 | 150073 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 469 | 6 | 1 | 3 | 6.9 | Cc1ccc(-c2cc(C(F)(F)F)ccc2OCc2ccccc2)n1-c1cc(C(=O)O)ccc1F | 10.1016/j.bmcl.2006.10.078 | ||
CHEMBL395523 | 150073 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 469 | 6 | 1 | 3 | 6.9 | Cc1ccc(-c2cc(C(F)(F)F)ccc2OCc2ccccc2)n1-c1cc(C(=O)O)ccc1F | 10.1016/j.bmcl.2006.10.078 | ||
9956808 | 77232 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 479 | 6 | 1 | 3 | 6.6 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.11.059 | ||
CHEMBL208791 | 77232 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 479 | 6 | 1 | 3 | 6.6 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.11.059 | ||
44426670 | 85261 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 467 | 6 | 1 | 3 | 7.5 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cc(C(=O)O)c2ccccc2c1 | 10.1016/j.bmcl.2006.11.059 | ||
CHEMBL228695 | 85261 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 467 | 6 | 1 | 3 | 7.5 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cc(C(=O)O)c2ccccc2c1 | 10.1016/j.bmcl.2006.11.059 | ||
44568756 | 12542 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 494 | 9 | 1 | 5 | 6.2 | Cc1cc(C(=O)Nc2ccc(CN3CCCCC3)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1187191 | 12542 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 494 | 9 | 1 | 5 | 6.2 | Cc1cc(C(=O)Nc2ccc(CN3CCCCC3)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL493065 | 12542 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 494 | 9 | 1 | 5 | 6.2 | Cc1cc(C(=O)Nc2ccc(CN3CCCCC3)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
44568709 | 12552 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 480 | 9 | 1 | 5 | 5.8 | Cc1cc(C(=O)Nc2ccc(CN3CCCC3)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1187226 | 12552 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 480 | 9 | 1 | 5 | 5.8 | Cc1cc(C(=O)Nc2ccc(CN3CCCC3)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL494282 | 12552 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 480 | 9 | 1 | 5 | 5.8 | Cc1cc(C(=O)Nc2ccc(CN3CCCC3)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
44568183 | 12629 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 461 | 8 | 2 | 5 | 5.2 | Cc1cc(C(=O)Nc2ccc(CO)cc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1187781 | 12629 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 461 | 8 | 2 | 5 | 5.2 | Cc1cc(C(=O)Nc2ccc(CO)cc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL520438 | 12629 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 461 | 8 | 2 | 5 | 5.2 | Cc1cc(C(=O)Nc2ccc(CO)cc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.05.118 | ||
9956808 | 77232 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 479 | 6 | 1 | 3 | 6.6 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL208791 | 77232 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 479 | 6 | 1 | 3 | 6.6 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
44413092 | 77317 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 435 | 6 | 1 | 3 | 6.5 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccc(F)cc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL208912 | 77317 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 435 | 6 | 1 | 3 | 6.5 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccc(F)cc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
44413104 | 138545 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 497 | 6 | 1 | 3 | 6.8 | Cc1ccc(-c2cc(Br)ccc2OCc2cccc(F)c2F)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL378641 | 138545 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 497 | 6 | 1 | 3 | 6.8 | Cc1ccc(-c2cc(Br)ccc2OCc2cccc(F)c2F)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
21112870 | 86902 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 442 | 6 | 1 | 4 | 5.8 | O=C(O)c1cnnc(C2=C(c3cc(Cl)ccc3OCc3ccc(F)cc3F)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
CHEMBL233245 | 86902 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 442 | 6 | 1 | 4 | 5.8 | O=C(O)c1cnnc(C2=C(c3cc(Cl)ccc3OCc3ccc(F)cc3F)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
10215735 | 150147 | 4 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 370 | 6 | 1 | 2 | 6.1 | O=C(O)c1cccc(C2=C(c3ccccc3OCc3ccccc3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
CHEMBL395582 | 150147 | 4 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 370 | 6 | 1 | 2 | 6.1 | O=C(O)c1cccc(C2=C(c3ccccc3OCc3ccccc3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
11235004 | 79703 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 400 | 6 | 1 | 4 | 4.3 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL213221 | 79703 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 400 | 6 | 1 | 4 | 4.3 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL258184 | 79703 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 400 | 6 | 1 | 4 | 4.3 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2006.06.086 | ||
23106477 | 144630 | 3 | None | - | 0 | Mouse | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 500 | 9 | 1 | 6 | 5.1 | Cc1cc(C(=O)O)ccc1COc1cc2c(cc1N(CC(C)C)S(=O)(=O)c1nccs1)CCC2 | nan | ||
CHEMBL3912251 | 144630 | 3 | None | - | 0 | Mouse | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 500 | 9 | 1 | 6 | 5.1 | Cc1cc(C(=O)O)ccc1COc1cc2c(cc1N(CC(C)C)S(=O)(=O)c1nccs1)CCC2 | nan | ||
44611633 | 103421 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 381 | 4 | 1 | 5 | 5.0 | O=C(O)c1csc(-n2nc(-c3ccccc3)c(Cl)c2-c2ccccc2)n1 | 10.1016/j.bmcl.2013.10.065 | ||
CHEMBL3092152 | 103421 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 381 | 4 | 1 | 5 | 5.0 | O=C(O)c1csc(-n2nc(-c3ccccc3)c(Cl)c2-c2ccccc2)n1 | 10.1016/j.bmcl.2013.10.065 | ||
44611631 | 103424 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 363 | 4 | 2 | 6 | 4.1 | O=C(O)c1csc(-n2nc(-c3ccccc3)c(O)c2-c2ccccc2)n1 | 10.1016/j.bmcl.2013.10.065 | ||
CHEMBL3092155 | 103424 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 363 | 4 | 2 | 6 | 4.1 | O=C(O)c1csc(-n2nc(-c3ccccc3)c(O)c2-c2ccccc2)n1 | 10.1016/j.bmcl.2013.10.065 | ||
44432865 | 87633 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 453 | 9 | 0 | 5 | 4.5 | CCc1ccccc1N(CC(=O)OCc1ccc(OC)cc1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL234600 | 87633 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 453 | 9 | 0 | 5 | 4.5 | CCc1ccccc1N(CC(=O)OCc1ccc(OC)cc1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
11698825 | 14771 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 467 | 6 | 1 | 3 | 7.1 | O=C(O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccc(F)cc2Cl)n1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL1208253 | 14771 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 467 | 6 | 1 | 3 | 7.1 | O=C(O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccc(F)cc2Cl)n1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL512617 | 14771 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 467 | 6 | 1 | 3 | 7.1 | O=C(O)c1cccc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccc(F)cc2Cl)n1 | 10.1016/j.bmcl.2008.11.032 | ||
10000919 | 188969 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 398 | 6 | 1 | 2 | 6.4 | O=C(O)c1cc(F)cc(-c2ccccc2-c2ccccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL514425 | 188969 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 398 | 6 | 1 | 2 | 6.4 | O=C(O)c1cc(F)cc(-c2ccccc2-c2ccccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2008.11.032 | ||
24785595 | 67820 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 346 | 3 | 1 | 4 | 4.6 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(C(C)(C)C)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
CHEMBL1915016 | 67820 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 346 | 3 | 1 | 4 | 4.6 | Cc1cc(C(=O)O)nn1Cc1cc(Cl)cc2cc(C(C)(C)C)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
57395595 | 67859 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 462 | 6 | 2 | 5 | 5.6 | Cc1cc(NC(=O)CC2CCNCC2)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
CHEMBL1915257 | 67859 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 462 | 6 | 2 | 5 | 5.6 | Cc1cc(NC(=O)CC2CCNCC2)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
24760472 | 14548 | 0 | None | 39 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 328 | 4 | 1 | 3 | 4.6 | CC(C)Cc1cn(-c2cccc(C(=O)O)n2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1206254 | 14548 | 0 | None | 39 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 328 | 4 | 1 | 3 | 4.6 | CC(C)Cc1cn(-c2cccc(C(=O)O)n2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL254763 | 14548 | 0 | None | 39 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 328 | 4 | 1 | 3 | 4.6 | CC(C)Cc1cn(-c2cccc(C(=O)O)n2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
11963176 | 94522 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 473 | 8 | 1 | 4 | 6.4 | Cc1cc(NC(=O)C(C)(C)c2ccccc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL254559 | 94522 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 473 | 8 | 1 | 4 | 6.4 | Cc1cc(NC(=O)C(C)(C)c2ccccc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
44448638 | 94707 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 421 | 7 | 1 | 6 | 4.7 | Cc1cc(NC(=O)OC2CCOCC2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL255701 | 94707 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 421 | 7 | 1 | 6 | 4.7 | Cc1cc(NC(=O)OC2CCOCC2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.04.018 | ||
44448346 | 154929 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 439 | 7 | 1 | 5 | 4.8 | Cc1cc(NC(=O)C2CCOCC2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL403939 | 154929 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 439 | 7 | 1 | 5 | 4.8 | Cc1cc(NC(=O)C2CCOCC2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
24785079 | 67848 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 450 | 7 | 2 | 5 | 5.7 | CNCc1ccc(NC(=O)c2cc(C)n(Cc3cc(Cl)cc4cc(C(C)C)oc34)n2)cc1 | 10.1016/j.bmcl.2011.05.047 | ||
CHEMBL1915246 | 67848 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 450 | 7 | 2 | 5 | 5.7 | CNCc1ccc(NC(=O)c2cc(C)n(Cc3cc(Cl)cc4cc(C(C)C)oc34)n2)cc1 | 10.1016/j.bmcl.2011.05.047 | ||
57395594 | 67849 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 415 | 5 | 1 | 5 | 4.7 | Cc1cc(C(=O)NC2CCOCC2)nn1Cc1cc(Cl)cc2cc(C(C)C)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
CHEMBL1915247 | 67849 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 415 | 5 | 1 | 5 | 4.7 | Cc1cc(C(=O)NC2CCOCC2)nn1Cc1cc(Cl)cc2cc(C(C)C)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
44432872 | 86362 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 531 | 8 | 0 | 6 | 5.7 | COc1ccc(Cc2nnc(CN(c3cccc(C(F)(F)F)c3C)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL232160 | 86362 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 531 | 8 | 0 | 6 | 5.7 | COc1ccc(Cc2nnc(CN(c3cccc(C(F)(F)F)c3C)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44432907 | 86801 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 535 | 7 | 0 | 5 | 6.6 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3c(Cl)cccc3Cl)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL232925 | 86801 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 535 | 7 | 0 | 5 | 6.6 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3c(Cl)cccc3Cl)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44432908 | 86802 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 535 | 7 | 0 | 5 | 6.6 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3ccc(Cl)cc3Cl)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL232926 | 86802 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 535 | 7 | 0 | 5 | 6.6 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3ccc(Cl)cc3Cl)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44432865 | 87633 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 453 | 9 | 0 | 5 | 4.5 | CCc1ccccc1N(CC(=O)OCc1ccc(OC)cc1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL234600 | 87633 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 453 | 9 | 0 | 5 | 4.5 | CCc1ccccc1N(CC(=O)OCc1ccc(OC)cc1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44432353 | 86602 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 7.0 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1ccc(C(=O)NCc2ccncc2)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL232537 | 86602 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 7.0 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1ccc(C(=O)NCc2ccncc2)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
44432362 | 86844 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 7.0 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)NCc2cccnc2)c1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL233141 | 86844 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 7.0 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)NCc2cccnc2)c1 | 10.1016/j.bmcl.2006.12.021 | ||
44432365 | 86846 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 7.0 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)NCc2ccncc2)c1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL233146 | 86846 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 7.0 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)NCc2ccncc2)c1 | 10.1016/j.bmcl.2006.12.021 | ||
44432375 | 86852 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 569 | 6 | 1 | 3 | 8.6 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1cccc(-c2nc3ccccc3[nH]2)c1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL233159 | 86852 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 569 | 6 | 1 | 3 | 8.6 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1cccc(-c2nc3ccccc3[nH]2)c1 | 10.1016/j.bmcl.2006.12.021 | ||
44432378 | 86981 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 430 | 6 | 1 | 3 | 6.6 | CC(=O)Nc1cccc(-n2c(C)ccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL233361 | 86981 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 430 | 6 | 1 | 3 | 6.6 | CC(=O)Nc1cccc(-n2c(C)ccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.12.021 | ||
44432358 | 147447 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 416 | 6 | 1 | 3 | 5.8 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(N)=O)c1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL393416 | 147447 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 416 | 6 | 1 | 3 | 5.8 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(N)=O)c1 | 10.1016/j.bmcl.2006.12.021 | ||
44432379 | 168291 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 454 | 5 | 1 | 3 | 6.8 | Cc1cc(=O)[nH]c2cc(-n3c(C)ccc3-c3cc(Cl)ccc3OCc3ccccc3)ccc12 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL438126 | 168291 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 454 | 5 | 1 | 3 | 6.8 | Cc1cc(=O)[nH]c2cc(-n3c(C)ccc3-c3cc(Cl)ccc3OCc3ccccc3)ccc12 | 10.1016/j.bmcl.2006.12.021 | ||
10194556 | 87566 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 416 | 7 | 1 | 3 | 6.8 | CSc1ccc(OCc2ccccc2)c(C2=C(c3cccc(C(=O)O)c3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
CHEMBL234281 | 87566 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 416 | 7 | 1 | 3 | 6.8 | CSc1ccc(OCc2ccccc2)c(C2=C(c3cccc(C(=O)O)c3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
44455244 | 14569 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 359 | 6 | 1 | 4 | 4.7 | O=C(O)c1cnc(Cc2cc(Cl)ccc2OCc2ccccc2)s1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL1206293 | 14569 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 359 | 6 | 1 | 4 | 4.7 | O=C(O)c1cnc(Cc2cc(Cl)ccc2OCc2ccccc2)s1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL257846 | 14569 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 359 | 6 | 1 | 4 | 4.7 | O=C(O)c1cnc(Cc2cc(Cl)ccc2OCc2ccccc2)s1 | 10.1016/j.bmcl.2008.01.071 | ||
11646506 | 14572 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 353 | 6 | 1 | 3 | 4.6 | O=C(O)c1cncc(Cc2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL1206296 | 14572 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 353 | 6 | 1 | 3 | 4.6 | O=C(O)c1cncc(Cc2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL258303 | 14572 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 353 | 6 | 1 | 3 | 4.6 | O=C(O)c1cncc(Cc2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2008.01.071 | ||
22684069 | 14579 | 1 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 345 | 5 | 1 | 4 | 4.7 | O=C(O)c1csc(-c2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL1206404 | 14579 | 1 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 345 | 5 | 1 | 4 | 4.7 | O=C(O)c1csc(-c2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL270162 | 14579 | 1 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 345 | 5 | 1 | 4 | 4.7 | O=C(O)c1csc(-c2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.01.071 | ||
24760467 | 14555 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 327 | 4 | 1 | 2 | 5.2 | CC(C)Cc1cn(-c2cccc(C(=O)O)c2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1206270 | 14555 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 327 | 4 | 1 | 2 | 5.2 | CC(C)Cc1cn(-c2cccc(C(=O)O)c2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL255928 | 14555 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 327 | 4 | 1 | 2 | 5.2 | CC(C)Cc1cn(-c2cccc(C(=O)O)c2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
44432368 | 87508 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 416 | 5 | 1 | 4 | 5.6 | Cc1ccc(-c2ccccc2OCc2ccc(F)cc2F)n1-c1ccc2nn[nH]c2c1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL233971 | 87508 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 416 | 5 | 1 | 4 | 5.6 | Cc1ccc(-c2ccccc2OCc2ccc(F)cc2F)n1-c1ccc2nn[nH]c2c1 | 10.1016/j.bmcl.2006.12.021 | ||
44568510 | 12479 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 454 | 9 | 1 | 5 | 5.2 | Cc1cc(NC(=O)c2cccc(CN(C)C)c2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1186856 | 12479 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 454 | 9 | 1 | 5 | 5.2 | Cc1cc(NC(=O)c2cccc(CN(C)C)c2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL480979 | 12479 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 454 | 9 | 1 | 5 | 5.2 | Cc1cc(NC(=O)c2cccc(CN(C)C)c2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
44413120 | 138761 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 465 | 7 | 1 | 4 | 7.5 | Cc1ccc(-c2cc(-c3ccsc3)ccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL379163 | 138761 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 465 | 7 | 1 | 4 | 7.5 | Cc1ccc(-c2cc(-c3ccsc3)ccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
44570000 | 178074 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 544 | 7 | 2 | 5 | 6.2 | O=C(COc1cccc2[nH]cc(Cc3ccc4ccccc4c3)c12)NS(=O)(=O)c1cc(Cl)c(Cl)s1 | 10.1021/jm9005912 | ||
CHEMBL467632 | 178074 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 544 | 7 | 2 | 5 | 6.2 | O=C(COc1cccc2[nH]cc(Cc3ccc4ccccc4c3)c12)NS(=O)(=O)c1cc(Cl)c(Cl)s1 | 10.1021/jm9005912 | ||
10432730 | 146736 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 428 | 11 | 2 | 5 | 4.0 | COC(=O)CCC/C=C\C[C@H]1C(=O)C(C)(C)[C@@H](O)[C@@H]1/C=C/C(O)CCc1ccccc1 | nan | ||
CHEMBL3928703 | 146736 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 428 | 11 | 2 | 5 | 4.0 | COC(=O)CCC/C=C\C[C@H]1C(=O)C(C)(C)[C@@H](O)[C@@H]1/C=C/C(O)CCc1ccccc1 | nan | ||
44415850 | 80018 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 416 | 7 | 2 | 5 | 3.5 | O=C(O)c1nn(Cc2cc(Br)ccc2OCc2ccccc2)cc1CO | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL214639 | 80018 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 416 | 7 | 2 | 5 | 3.5 | O=C(O)c1nn(Cc2cc(Br)ccc2OCc2ccccc2)cc1CO | 10.1016/j.bmcl.2006.06.086 | ||
44571206 | 183407 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 574 | 6 | 1 | 5 | 6.4 | CC12CCCC(/C=C/C(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)=C1N(Cc1ccc3ccccc3c1)C(=O)C2 | 10.1016/j.bmcl.2008.12.027 | ||
CHEMBL481813 | 183407 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 574 | 6 | 1 | 5 | 6.4 | CC12CCCC(/C=C/C(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)=C1N(Cc1ccc3ccccc3c1)C(=O)C2 | 10.1016/j.bmcl.2008.12.027 | ||
135738668 | 152139 | 0 | None | - | 0 | Mouse | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 514 | 8 | 1 | 8 | 4.6 | Cc1csc(S(=O)(=O)N(c2cc(C)c(C)cc2OCc2ccc(-c3noc(=O)[nH]3)cc2)C(C)C)n1 | nan | ||
CHEMBL3972679 | 152139 | 0 | None | - | 0 | Mouse | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 514 | 8 | 1 | 8 | 4.6 | Cc1csc(S(=O)(=O)N(c2cc(C)c(C)cc2OCc2ccc(-c3noc(=O)[nH]3)cc2)C(C)C)n1 | nan | ||
9826036 | 142954 | 0 | None | - | 0 | Mouse | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 471 | 9 | 1 | 5 | 5.3 | Cc1ccc(S(=O)(=O)N(CC(C)C)c2cc(C)c(C)cc2OCc2ccc(C(=O)O)cc2)o1 | nan | ||
CHEMBL3898609 | 142954 | 0 | None | - | 0 | Mouse | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 471 | 9 | 1 | 5 | 5.3 | Cc1ccc(S(=O)(=O)N(CC(C)C)c2cc(C)c(C)cc2OCc2ccc(C(=O)O)cc2)o1 | nan | ||
23106384 | 150199 | 0 | None | - | 0 | Mouse | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 482 | 9 | 1 | 5 | 5.1 | Cc1cc(OCc2ccc(C(=O)O)cc2C)c(N(CC(C)C)S(=O)(=O)c2ccccn2)cc1C | nan | ||
CHEMBL3956272 | 150199 | 0 | None | - | 0 | Mouse | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 482 | 9 | 1 | 5 | 5.1 | Cc1cc(OCc2ccc(C(=O)O)cc2C)c(N(CC(C)C)S(=O)(=O)c2ccccn2)cc1C | nan | ||
11384586 | 80658 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 418 | 6 | 1 | 4 | 4.4 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccc(F)cc1 | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL215453 | 80658 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 418 | 6 | 1 | 4 | 4.4 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccc(F)cc1 | 10.1016/j.bmcl.2006.06.086 | ||
10299802 | 151342 | 0 | None | - | 0 | Mouse | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 485 | 9 | 1 | 5 | 5.6 | Cc1ccc(S(=O)(=O)N(CC(C)C)c2cc(C)c(C)cc2OCc2ccc(C(=O)O)cc2C)o1 | nan | ||
CHEMBL3965638 | 151342 | 0 | None | - | 0 | Mouse | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 485 | 9 | 1 | 5 | 5.6 | Cc1ccc(S(=O)(=O)N(CC(C)C)c2cc(C)c(C)cc2OCc2ccc(C(=O)O)cc2C)o1 | nan | ||
25005495 | 67863 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 463 | 5 | 2 | 5 | 5.3 | Cc1cc(C(=O)N[C@H]2CC[C@H](O)CC2)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
CHEMBL1915261 | 67863 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 463 | 5 | 2 | 5 | 5.3 | Cc1cc(C(=O)N[C@H]2CC[C@H](O)CC2)nn1Cc1cc(Cl)cc2cc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
11979188 | 14550 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 325 | 6 | 1 | 4 | 4.1 | CC(C)COc1ccc(Cl)cc1Cc1nc(C(=O)O)cs1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL1206258 | 14550 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 325 | 6 | 1 | 4 | 4.1 | CC(C)COc1ccc(Cl)cc1Cc1nc(C(=O)O)cs1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL255009 | 14550 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 325 | 6 | 1 | 4 | 4.1 | CC(C)COc1ccc(Cl)cc1Cc1nc(C(=O)O)cs1 | 10.1016/j.bmcl.2008.01.071 | ||
11640317 | 138160 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 417 | 6 | 1 | 3 | 6.4 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL377852 | 138160 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 417 | 6 | 1 | 3 | 6.4 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2008.01.071 | ||
44410874 | 138123 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 461 | 6 | 1 | 3 | 6.5 | Cc1ccc(-c2cc(Br)ccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.02.014 | ||
CHEMBL377649 | 138123 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 461 | 6 | 1 | 3 | 6.5 | Cc1ccc(-c2cc(Br)ccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.02.014 | ||
11640317 | 138160 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 417 | 6 | 1 | 3 | 6.4 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.02.014 | ||
CHEMBL377852 | 138160 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 417 | 6 | 1 | 3 | 6.4 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.02.014 | ||
11979188 | 14550 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 325 | 6 | 1 | 4 | 4.1 | CC(C)COc1ccc(Cl)cc1Cc1nc(C(=O)O)cs1 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1206258 | 14550 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 325 | 6 | 1 | 4 | 4.1 | CC(C)COc1ccc(Cl)cc1Cc1nc(C(=O)O)cs1 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL255009 | 14550 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 325 | 6 | 1 | 4 | 4.1 | CC(C)COc1ccc(Cl)cc1Cc1nc(C(=O)O)cs1 | 10.1016/j.bmcl.2008.03.018 | ||
24760391 | 14668 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 318 | 4 | 1 | 4 | 4.2 | CC(C)Cc1cn(-c2nc(C(=O)O)co2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL1207393 | 14668 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 318 | 4 | 1 | 4 | 4.2 | CC(C)Cc1cn(-c2nc(C(=O)O)co2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
CHEMBL402338 | 14668 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 318 | 4 | 1 | 4 | 4.2 | CC(C)Cc1cn(-c2nc(C(=O)O)co2)c2cc(Cl)ccc12 | 10.1016/j.bmcl.2008.03.018 | ||
11640317 | 138160 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 417 | 6 | 1 | 3 | 6.4 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL377852 | 138160 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 417 | 6 | 1 | 3 | 6.4 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2008.04.018 | ||
44432922 | 86815 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 572 | 8 | 1 | 7 | 6.5 | COc1ccc(Nc2nnc(CN(c3cccc(Cl)c3Cl)S(=O)(=O)c3ccc(C(F)(F)F)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL232950 | 86815 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 572 | 8 | 1 | 7 | 6.5 | COc1ccc(Nc2nnc(CN(c3cccc(Cl)c3Cl)S(=O)(=O)c3ccc(C(F)(F)F)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
2288900 | 87590 | 11 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 496 | 11 | 1 | 5 | 4.1 | CCc1ccccc1N(CC(=O)NCCc1ccc(OC)c(OC)c1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL234399 | 87590 | 11 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 496 | 11 | 1 | 5 | 4.1 | CCc1ccccc1N(CC(=O)NCCc1ccc(OC)c(OC)c1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44432878 | 154129 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 517 | 8 | 0 | 6 | 5.7 | COc1ccc(Cc2nnc(CN(c3cccc(Cl)c3Cl)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL399614 | 154129 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 517 | 8 | 0 | 6 | 5.7 | COc1ccc(Cc2nnc(CN(c3cccc(Cl)c3Cl)S(=O)(=O)c3ccc(C)cc3)o2)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44430712 | 141547 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 588 | 7 | 1 | 5 | 6.4 | Cc1ccc(-c2cc(C(F)(F)F)ccc2OCc2ccc(F)cc2)n1-c1cc(C(=O)O)cc(N2CCCS2(=O)=O)c1 | 10.1016/j.bmcl.2006.10.078 | ||
CHEMBL388038 | 141547 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 588 | 7 | 1 | 5 | 6.4 | Cc1ccc(-c2cc(C(F)(F)F)ccc2OCc2ccc(F)cc2)n1-c1cc(C(=O)O)cc(N2CCCS2(=O)=O)c1 | 10.1016/j.bmcl.2006.10.078 | ||
44432329 | 86605 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 556 | 8 | 1 | 5 | 6.8 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1ccc(S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL232543 | 86605 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 556 | 8 | 1 | 5 | 6.8 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1ccc(S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
44432338 | 86808 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 496 | 6 | 1 | 3 | 6.2 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1ccc(C(N)=O)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL232932 | 86808 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 496 | 6 | 1 | 3 | 6.2 | Cc1ccc(-c2cc(Br)ccc2OCc2ccc(F)cc2F)n1-c1ccc(C(N)=O)cc1 | 10.1016/j.bmcl.2006.12.021 | ||
11640317 | 138160 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 417 | 6 | 1 | 3 | 6.4 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL377852 | 138160 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 417 | 6 | 1 | 3 | 6.4 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.12.021 | ||
44426662 | 141717 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 487 | 6 | 1 | 3 | 7.0 | Cc1ccc(-c2cc(C(F)(F)F)ccc2OCc2ccc(F)cc2)n1-c1ccc(F)c(C(=O)O)c1 | 10.1016/j.bmcl.2006.11.059 | ||
CHEMBL388478 | 141717 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 487 | 6 | 1 | 3 | 7.0 | Cc1ccc(-c2cc(C(F)(F)F)ccc2OCc2ccc(F)cc2)n1-c1ccc(F)c(C(=O)O)c1 | 10.1016/j.bmcl.2006.11.059 | ||
44568188 | 12478 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 488 | 9 | 1 | 5 | 5.8 | Cc1cc(C(=O)Nc2ccc(CN(C)C)cc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1186855 | 12478 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 488 | 9 | 1 | 5 | 5.8 | Cc1cc(C(=O)Nc2ccc(CN(C)C)cc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL480950 | 12478 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 488 | 9 | 1 | 5 | 5.8 | Cc1cc(C(=O)Nc2ccc(CN(C)C)cc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.05.118 | ||
44568703 | 12532 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 440 | 9 | 2 | 5 | 4.9 | CNCc1ccc(NC(=O)c2cc(C)n(Cc3cc(Cl)ccc3OCC(C)C)n2)cc1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1187164 | 12532 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 440 | 9 | 2 | 5 | 4.9 | CNCc1ccc(NC(=O)c2cc(C)n(Cc3cc(Cl)ccc3OCC(C)C)n2)cc1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL492237 | 12532 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 440 | 9 | 2 | 5 | 4.9 | CNCc1ccc(NC(=O)c2cc(C)n(Cc3cc(Cl)ccc3OCC(C)C)n2)cc1 | 10.1016/j.bmcl.2008.05.118 | ||
44568705 | 12641 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 454 | 10 | 2 | 5 | 5.3 | CCNCc1ccc(NC(=O)c2cc(C)n(Cc3cc(Cl)ccc3OCC(C)C)n2)cc1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1187829 | 12641 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 454 | 10 | 2 | 5 | 5.3 | CCNCc1ccc(NC(=O)c2cc(C)n(Cc3cc(Cl)ccc3OCC(C)C)n2)cc1 | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL523158 | 12641 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 454 | 10 | 2 | 5 | 5.3 | CCNCc1ccc(NC(=O)c2cc(C)n(Cc3cc(Cl)ccc3OCC(C)C)n2)cc1 | 10.1016/j.bmcl.2008.05.118 | ||
44568758 | 12646 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 496 | 9 | 1 | 6 | 5.0 | Cc1cc(C(=O)Nc2ccc(CN3CCOCC3)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1187841 | 12646 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 496 | 9 | 1 | 6 | 5.0 | Cc1cc(C(=O)Nc2ccc(CN3CCOCC3)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL523679 | 12646 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 496 | 9 | 1 | 6 | 5.0 | Cc1cc(C(=O)Nc2ccc(CN3CCOCC3)cc2)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
44413141 | 77409 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 497 | 6 | 1 | 3 | 6.8 | Cc1ccc(-c2cc(Br)ccc2OCc2cc(F)ccc2F)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL209078 | 77409 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 497 | 6 | 1 | 3 | 6.8 | Cc1ccc(-c2cc(Br)ccc2OCc2cc(F)ccc2F)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
44410874 | 138123 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 461 | 6 | 1 | 3 | 6.5 | Cc1ccc(-c2cc(Br)ccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL377649 | 138123 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 461 | 6 | 1 | 3 | 6.5 | Cc1ccc(-c2cc(Br)ccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
11640317 | 138160 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 417 | 6 | 1 | 3 | 6.4 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL377852 | 138160 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 417 | 6 | 1 | 3 | 6.4 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
15486805 | 165500 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 394 | 13 | 4 | 5 | 3.0 | O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)COc1ccccc1 | 10.1021/jm990542v | ||
CHEMBL425681 | 165500 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 394 | 13 | 4 | 5 | 3.0 | O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)COc1ccccc1 | 10.1021/jm990542v | ||
10479215 | 145928 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 456 | 10 | 3 | 5 | 4.8 | CC1(C)C(=O)[C@H](C/C=C\CCCC(=O)O)[C@@H](/C=C/C(O)Cc2cc3ccccc3s2)[C@@H]1O | nan | ||
CHEMBL3922155 | 145928 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 456 | 10 | 3 | 5 | 4.8 | CC1(C)C(=O)[C@H](C/C=C\CCCC(=O)O)[C@@H](/C=C/C(O)Cc2cc3ccccc3s2)[C@@H]1O | nan | ||
10339756 | 142553 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 380 | 12 | 3 | 4 | 3.9 | CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C(C)(C)C(=O)[C@@H]1C/C=C\CCCC(=O)O | nan | ||
CHEMBL3895324 | 142553 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 380 | 12 | 3 | 4 | 3.9 | CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C(C)(C)C(=O)[C@@H]1C/C=C\CCCC(=O)O | nan | ||
44581655 | 175493 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 398 | 6 | 1 | 2 | 6.4 | O=C(O)c1ccc(F)c(-c2ccccc2-c2ccccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL459091 | 175493 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 398 | 6 | 1 | 2 | 6.4 | O=C(O)c1ccc(F)c(-c2ccccc2-c2ccccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2008.11.032 | ||
11163691 | 14676 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 342 | 6 | 1 | 4 | 3.9 | O=C(O)c1ccn(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL1207409 | 14676 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 342 | 6 | 1 | 4 | 3.9 | O=C(O)c1ccn(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL403460 | 14676 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 342 | 6 | 1 | 4 | 3.9 | O=C(O)c1ccn(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.01.071 | ||
11690510 | 14732 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 407 | 6 | 1 | 3 | 5.0 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2c(F)cc(F)cc2F)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL1207966 | 14732 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 407 | 6 | 1 | 3 | 5.0 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2c(F)cc(F)cc2F)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL466102 | 14732 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 407 | 6 | 1 | 3 | 5.0 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2c(F)cc(F)cc2F)n1 | 10.1016/j.bmcl.2009.02.112 | ||
11703881 | 14765 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 371 | 6 | 1 | 3 | 4.7 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccccc2F)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL1208226 | 14765 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 371 | 6 | 1 | 3 | 4.7 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccccc2F)n1 | 10.1016/j.bmcl.2009.02.112 | ||
CHEMBL508276 | 14765 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 371 | 6 | 1 | 3 | 4.7 | O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccccc2F)n1 | 10.1016/j.bmcl.2009.02.112 | ||
11154379 | 76916 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 420 | 6 | 1 | 4 | 5.1 | O=C1OCC(c2cc(Cl)ccc2OCc2ccccc2)=C1c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.02.014 | ||
CHEMBL208030 | 76916 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 420 | 6 | 1 | 4 | 5.1 | O=C1OCC(c2cc(Cl)ccc2OCc2ccccc2)=C1c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.02.014 | ||
11464169 | 77442 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 415 | 6 | 1 | 3 | 6.3 | O=C(O)c1cccc(-c2ccncc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
CHEMBL209244 | 77442 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 415 | 6 | 1 | 3 | 6.3 | O=C(O)c1cccc(-c2ccncc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
11281168 | 139798 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 404 | 6 | 1 | 4 | 5.5 | O=C(O)c1cccc(-n2nccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
CHEMBL380667 | 139798 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 404 | 6 | 1 | 4 | 5.5 | O=C(O)c1cccc(-n2nccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2006.02.014 | ||
11963340 | 94380 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 462 | 8 | 1 | 6 | 5.6 | Cc1cc(NC(=O)OCc2ccccn2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL253538 | 94380 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 462 | 8 | 1 | 6 | 5.6 | Cc1cc(NC(=O)OCc2ccccn2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
11962970 | 94575 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 461 | 8 | 1 | 5 | 6.2 | Cc1cc(NC(=O)OCc2ccccc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL254963 | 94575 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 461 | 8 | 1 | 5 | 6.2 | Cc1cc(NC(=O)OCc2ccccc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
44448560 | 94888 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 449 | 7 | 1 | 4 | 5.9 | Cc1cc(C(=O)Nc2ccc(F)cc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL256579 | 94888 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 449 | 7 | 1 | 4 | 5.9 | Cc1cc(C(=O)Nc2ccc(F)cc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
44448445 | 94918 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 446 | 8 | 1 | 5 | 4.8 | Cc1cc(C(=O)NCc2ccncc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL256736 | 94918 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 446 | 8 | 1 | 5 | 4.8 | Cc1cc(C(=O)NCc2ccncc2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
11962968 | 95256 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 399 | 7 | 1 | 5 | 5.0 | CCOC(=O)Nc1cc(C)n(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL258226 | 95256 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 399 | 7 | 1 | 5 | 5.0 | CCOC(=O)Nc1cc(C)n(Cc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.04.018 | ||
44448679 | 166719 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 441 | 7 | 1 | 6 | 4.8 | Cc1cc(NC(=O)O[C@H]2CCOC2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
CHEMBL429321 | 166719 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 441 | 7 | 1 | 6 | 4.8 | Cc1cc(NC(=O)O[C@H]2CCOC2)nn1Cc1cc(Cl)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2008.04.018 | ||
44432896 | 86597 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 501 | 7 | 0 | 5 | 6.0 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3ccccc3Cl)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
CHEMBL232531 | 86597 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 501 | 7 | 0 | 5 | 6.0 | Cc1ccc(S(=O)(=O)N(Cc2nnc(Cc3ccccc3Cl)o2)c2cccc(Cl)c2C)cc1 | 10.1016/j.bmcl.2007.06.014 | ||
44432328 | 148376 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 556 | 8 | 1 | 5 | 6.8 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(S(=O)(=O)NC(=O)c2ccccc2)c1 | 10.1016/j.bmcl.2006.12.021 | ||
CHEMBL394173 | 148376 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 556 | 8 | 1 | 5 | 6.8 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(S(=O)(=O)NC(=O)c2ccccc2)c1 | 10.1016/j.bmcl.2006.12.021 | ||
44426674 | 96909 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 465 | 6 | 1 | 3 | 7.3 | Cc1ccc(OCc2ccc(F)cc2)c(-c2ccc(C)n2-c2cc(C(=O)O)c3ccccc3c2)c1 | 10.1016/j.bmcl.2006.11.059 | ||
CHEMBL269514 | 96909 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 465 | 6 | 1 | 3 | 7.3 | Cc1ccc(OCc2ccc(F)cc2)c(-c2ccc(C)n2-c2cc(C(=O)O)c3ccccc3c2)c1 | 10.1016/j.bmcl.2006.11.059 | ||
44568661 | 12555 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 466 | 7 | 2 | 5 | 4.9 | Cc1cc(NC(=O)c2ccc3c(c2)CCNCC3)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL1187257 | 12555 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 466 | 7 | 2 | 5 | 4.9 | Cc1cc(NC(=O)c2ccc3c(c2)CCNCC3)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
CHEMBL495090 | 12555 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 466 | 7 | 2 | 5 | 4.9 | Cc1cc(NC(=O)c2ccc3c(c2)CCNCC3)nn1Cc1cc(Cl)ccc1OCC(C)C | 10.1016/j.bmcl.2008.05.118 | ||
44413122 | 77934 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 527 | 8 | 1 | 4 | 7.1 | Cc1ccc(-c2cc(Br)ccc2OCc2cccc(OC(F)F)c2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL210994 | 77934 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 527 | 8 | 1 | 4 | 7.1 | Cc1ccc(-c2cc(Br)ccc2OCc2cccc(OC(F)F)c2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
44413091 | 138760 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 475 | 7 | 1 | 3 | 6.7 | CCc1ccc(-c2cc(Br)ccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL379155 | 138760 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 475 | 7 | 1 | 3 | 6.7 | CCc1ccc(-c2cc(Br)ccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
10216958 | 96371 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 448 | 7 | 1 | 4 | 5.5 | CS(=O)(=O)c1ccc(OCc2ccccc2)c(C2=C(c3cccc(C(=O)O)c3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
CHEMBL265086 | 96371 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 448 | 7 | 1 | 4 | 5.5 | CS(=O)(=O)c1ccc(OCc2ccccc2)c(C2=C(c3cccc(C(=O)O)c3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
10127780 | 149813 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 466 | 7 | 1 | 4 | 5.6 | CS(=O)(=O)c1ccc(OCc2ccc(F)cc2)c(C2=C(c3cccc(C(=O)O)c3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
CHEMBL395311 | 149813 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 466 | 7 | 1 | 4 | 5.6 | CS(=O)(=O)c1ccc(OCc2ccc(F)cc2)c(C2=C(c3cccc(C(=O)O)c3)CCC2)c1 | 10.1016/j.bmcl.2006.10.041 | ||
44581621 | 174539 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 414 | 6 | 1 | 2 | 7.0 | O=C(O)c1ccc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccccc2)cc1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL456919 | 174539 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 414 | 6 | 1 | 2 | 7.0 | O=C(O)c1ccc(-c2ccccc2-c2cc(Cl)ccc2OCc2ccccc2)cc1 | 10.1016/j.bmcl.2008.11.032 | ||
44455411 | 97604 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 355 | 6 | 1 | 4 | 4.8 | O=C(O)c1cccc(Oc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.01.071 | ||
CHEMBL273145 | 97604 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 355 | 6 | 1 | 4 | 4.8 | O=C(O)c1cccc(Oc2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2008.01.071 | ||
24785862 | 67851 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 414 | 5 | 2 | 5 | 4.2 | Cc1cc(C(=O)NC2CCNCC2)nn1Cc1cc(Cl)cc2cc(C(C)C)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
CHEMBL1915249 | 67851 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 414 | 5 | 2 | 5 | 4.2 | Cc1cc(C(=O)NC2CCNCC2)nn1Cc1cc(Cl)cc2cc(C(C)C)oc12 | 10.1016/j.bmcl.2011.05.047 | ||
44413197 | 137810 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 495 | 6 | 1 | 3 | 7.1 | Cc1c(Br)cc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL377135 | 137810 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 495 | 6 | 1 | 3 | 7.1 | Cc1c(Br)cc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
44627395 | 195197 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 563 | 7 | 1 | 7 | 5.6 | O=C(COc1cccc2ncn(Cc3ccc(Cl)cc3Cl)c12)NS(=O)(=O)c1cc(Cl)c(Cl)s1 | 10.1021/jm9005912 | ||
CHEMBL565992 | 195197 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 563 | 7 | 1 | 7 | 5.6 | O=C(COc1cccc2ncn(Cc3ccc(Cl)cc3Cl)c12)NS(=O)(=O)c1cc(Cl)c(Cl)s1 | 10.1021/jm9005912 | ||
11178058 | 80644 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 434 | 6 | 1 | 4 | 4.9 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccc(Cl)cc1 | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL215400 | 80644 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 434 | 6 | 1 | 4 | 4.9 | Cc1cc(C(=O)O)nn1Cc1cc(Br)ccc1OCc1ccc(Cl)cc1 | 10.1016/j.bmcl.2006.06.086 | ||
59179893 | 105347 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 339 | 3 | 1 | 5 | 4.0 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3cc(F)ccc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
CHEMBL3127155 | 105347 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 339 | 3 | 1 | 5 | 4.0 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3cc(F)ccc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
59179968 | 105361 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 311 | 3 | 1 | 5 | 3.7 | O=C(O)c1csc(-n2nc(C3=CCCC3)c3ccccc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
CHEMBL3127169 | 105361 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 311 | 3 | 1 | 5 | 3.7 | O=C(O)c1csc(-n2nc(C3=CCCC3)c3ccccc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
59179256 | 103412 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 367 | 4 | 1 | 6 | 4.7 | Cc1c(-c2ccccc2)nn(-c2nc(C(=O)O)cs2)c1-c1ccsc1 | 10.1016/j.bmcl.2013.10.065 | ||
CHEMBL3092135 | 103412 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 367 | 4 | 1 | 6 | 4.7 | Cc1c(-c2ccccc2)nn(-c2nc(C(=O)O)cs2)c1-c1ccsc1 | 10.1016/j.bmcl.2013.10.065 | ||
44626877 | 197324 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 490 | 6 | 1 | 5 | 5.6 | O=C(/C=C/c1cccc2ccn(Cc3ccc(Cl)cc3Cl)c12)NS(=O)(=O)c1cccs1 | 10.1021/jm9005912 | ||
CHEMBL585581 | 197324 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 490 | 6 | 1 | 5 | 5.6 | O=C(/C=C/c1cccc2ccn(Cc3ccc(Cl)cc3Cl)c12)NS(=O)(=O)c1cccs1 | 10.1021/jm9005912 | ||
72547455 | 92641 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 353 | 3 | 1 | 5 | 4.0 | Cc1c(-c2ccccc2)nn(-c2nc(C(=O)O)cs2)c1C(F)(F)F | 10.1016/j.bmcl.2013.09.032 | ||
CHEMBL2442494 | 92641 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 353 | 3 | 1 | 5 | 4.0 | Cc1c(-c2ccccc2)nn(-c2nc(C(=O)O)cs2)c1C(F)(F)F | 10.1016/j.bmcl.2013.09.032 | ||
23106360 | 146737 | 0 | None | - | 0 | Mouse | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 508 | 10 | 1 | 5 | 5.5 | Cc1cc(OCc2ccc(/C=C/C(=O)O)cc2C)c(N(CC(C)C)S(=O)(=O)c2cccnc2)cc1C | nan | ||
CHEMBL3928704 | 146737 | 0 | None | - | 0 | Mouse | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 508 | 10 | 1 | 5 | 5.5 | Cc1cc(OCc2ccc(/C=C/C(=O)O)cc2C)c(N(CC(C)C)S(=O)(=O)c2cccnc2)cc1C | nan | ||
11536 | 2891 | 25 | None | - | 0 | Mouse | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 500 | 9 | 1 | 6 | 5.1 | CC(CN(S(=O)(=O)c1scc(n1)C)c1cc2CCCc2cc1OCc1ccc(cc1)C(=O)O)C | nan | ||
9827317 | 2891 | 25 | None | - | 0 | Mouse | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 500 | 9 | 1 | 6 | 5.1 | CC(CN(S(=O)(=O)c1scc(n1)C)c1cc2CCCc2cc1OCc1ccc(cc1)C(=O)O)C | nan | ||
CHEMBL3939289 | 2891 | 25 | None | - | 0 | Mouse | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 500 | 9 | 1 | 6 | 5.1 | CC(CN(S(=O)(=O)c1scc(n1)C)c1cc2CCCc2cc1OCc1ccc(cc1)C(=O)O)C | nan | ||
11372607 | 79745 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 386 | 6 | 1 | 4 | 4.0 | O=C(O)c1ccn(Cc2cc(Br)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2006.06.086 | ||
CHEMBL213412 | 79745 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 386 | 6 | 1 | 4 | 4.0 | O=C(O)c1ccn(Cc2cc(Br)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2006.06.086 | ||
10251023 | 59646 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 410 | 13 | 4 | 5 | 3.7 | O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1ccccc1 | 10.1021/jm990542v | ||
CHEMBL173299 | 59646 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 410 | 13 | 4 | 5 | 3.7 | O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1ccccc1 | 10.1021/jm990542v | ||
10046549 | 151203 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 400 | 10 | 3 | 4 | 3.6 | CC1(C)C(=O)[C@H](C/C=C\CCCC(=O)O)[C@@H](/C=C/C(O)Cc2ccccc2)[C@@H]1O | nan | ||
CHEMBL3964563 | 151203 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 400 | 10 | 3 | 4 | 3.6 | CC1(C)C(=O)[C@H](C/C=C\CCCC(=O)O)[C@@H](/C=C/C(O)Cc2ccccc2)[C@@H]1O | nan | ||
59179887 | 105355 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 389 | 3 | 1 | 5 | 4.9 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3ccc(C(F)(F)F)cc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
CHEMBL3127163 | 105355 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 389 | 3 | 1 | 5 | 4.9 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3ccc(C(F)(F)F)cc32)n1 | 10.1016/j.bmcl.2014.01.052 | ||
11640317 | 138160 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 417 | 6 | 1 | 3 | 6.4 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
CHEMBL377852 | 138160 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 417 | 6 | 1 | 3 | 6.4 | Cc1ccc(-c2cc(Cl)ccc2OCc2ccccc2)n1-c1cccc(C(=O)O)c1 | 10.1016/j.bmcl.2006.04.073 | ||
9809136 | 106406 | 0 | None | 239 | 8 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 614 | 7 | 1 | 4 | 7.1 | CC(C)(C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1 | 10.1016/s0960-894x(99)00465-5 | ||
CHEMBL314533 | 106406 | 0 | None | 239 | 8 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 614 | 7 | 1 | 4 | 7.1 | CC(C)(C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1 | 10.1016/s0960-894x(99)00465-5 | ||
1283333 | 91104 | 7 | None | 74 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 456 | 8 | 1 | 3 | 4.7 | CCc1ccccc1N(CC(=O)NCc1ccc(Cl)cc1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL240436 | 91104 | 7 | None | 74 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 456 | 8 | 1 | 3 | 4.7 | CCc1ccccc1N(CC(=O)NCc1ccc(Cl)cc1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
9938995 | 111214 | 0 | None | 21 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 621 | 8 | 2 | 5 | 6.6 | O=C(NCCc1cccs1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 | 10.1016/s0960-894x(99)00465-5 | ||
CHEMBL328697 | 111214 | 0 | None | 21 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 621 | 8 | 2 | 5 | 6.6 | O=C(NCCc1cccs1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 | 10.1016/s0960-894x(99)00465-5 | ||
138 | 3032 | 84 | None | -23 | 18 | Mouse | 7.0 | pKi | = | 7 | Binding | ChEMBL | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 10.1016/s0960-894x(01)00359-6 | ||
1882 | 3032 | 84 | None | -23 | 18 | Mouse | 7.0 | pKi | = | 7 | Binding | ChEMBL | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 10.1016/s0960-894x(01)00359-6 | ||
5280723 | 3032 | 84 | None | -23 | 18 | Mouse | 7.0 | pKi | = | 7 | Binding | ChEMBL | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 10.1016/s0960-894x(01)00359-6 | ||
CHEMBL495 | 3032 | 84 | None | -23 | 18 | Mouse | 7.0 | pKi | = | 7 | Binding | ChEMBL | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 10.1016/s0960-894x(01)00359-6 | ||
DB00770 | 3032 | 84 | None | -23 | 18 | Mouse | 7.0 | pKi | = | 7 | Binding | ChEMBL | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 10.1016/s0960-894x(01)00359-6 | ||
22990263 | 16614 | 0 | None | -6 | 3 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 292 | 3 | 1 | 1 | 4.8 | O=C(O)/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(03)00794-7 | ||
CHEMBL124574 | 16614 | 0 | None | -6 | 3 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 292 | 3 | 1 | 1 | 4.8 | O=C(O)/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1 | 10.1016/s0960-894x(03)00794-7 | ||
9975502 | 94053 | 0 | None | -74 | 4 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 355 | 9 | 1 | 2 | 4.6 | CCCC/C(C)=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1 | 10.1016/j.bmcl.2007.05.025 | ||
CHEMBL251504 | 94053 | 0 | None | -74 | 4 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 355 | 9 | 1 | 2 | 4.6 | CCCC/C(C)=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1 | 10.1016/j.bmcl.2007.05.025 | ||
44442331 | 94054 | 0 | None | -2511 | 4 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 355 | 9 | 1 | 2 | 4.6 | CCCC/C(C)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1 | 10.1016/j.bmcl.2007.05.025 | ||
CHEMBL251505 | 94054 | 0 | None | -2511 | 4 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 355 | 9 | 1 | 2 | 4.6 | CCCC/C(C)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1 | 10.1016/j.bmcl.2007.05.025 | ||
11294085 | 136728 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 458 | 12 | 2 | 7 | 4.0 | O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCCCF)CCC2)n1 | 10.1016/j.bmcl.2015.12.039 | ||
CHEMBL3751951 | 136728 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 458 | 12 | 2 | 7 | 4.0 | O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCCCF)CCC2)n1 | 10.1016/j.bmcl.2015.12.039 | ||
44324302 | 205260 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 609 | 8 | 2 | 6 | 6.6 | O=C(NCCc1cccs1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3Oc3ccccc32)cc1 | 10.1016/s0960-894x(99)00465-5 | ||
CHEMBL91377 | 205260 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 609 | 8 | 2 | 6 | 6.6 | O=C(NCCc1cccs1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3Oc3ccccc32)cc1 | 10.1016/s0960-894x(99)00465-5 | ||
44304436 | 201629 | 0 | None | -27 | 5 | Mouse | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 400 | 14 | 3 | 5 | 3.8 | CCCC[C@H](C)C[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O | 10.1016/s0960-894x(01)00364-x | ||
CHEMBL64854 | 201629 | 0 | None | -27 | 5 | Mouse | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 400 | 14 | 3 | 5 | 3.8 | CCCC[C@H](C)C[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O | 10.1016/s0960-894x(01)00364-x | ||
10227492 | 16718 | 0 | None | -52 | 4 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 476 | 8 | 1 | 2 | 7.9 | O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2OCc2c(Cl)cccc2Cl)c1 | 10.1016/s0960-894x(03)00794-7 | ||
CHEMBL125087 | 16718 | 0 | None | -52 | 4 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 476 | 8 | 1 | 2 | 7.9 | O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2OCc2c(Cl)cccc2Cl)c1 | 10.1016/s0960-894x(03)00794-7 | ||
3356 | 2248 | 68 | None | -144 | 8 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 435 | 5 | 1 | 4 | 4.4 | OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F | 10.1021/jm0603668 | ||
4326 | 2248 | 68 | None | -144 | 8 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 435 | 5 | 1 | 4 | 4.4 | OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F | 10.1021/jm0603668 | ||
9867642 | 2248 | 68 | None | -144 | 8 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 435 | 5 | 1 | 4 | 4.4 | OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F | 10.1021/jm0603668 | ||
CHEMBL426559 | 2248 | 68 | None | -144 | 8 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 435 | 5 | 1 | 4 | 4.4 | OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F | 10.1021/jm0603668 | ||
DB11629 | 2248 | 68 | None | -144 | 8 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 435 | 5 | 1 | 4 | 4.4 | OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F | 10.1021/jm0603668 | ||
21362910 | 16744 | 0 | None | -20 | 4 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 422 | 9 | 1 | 2 | 7.0 | O=C(O)CCCc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1 | 10.1016/s0960-894x(03)00794-7 | ||
CHEMBL125269 | 16744 | 0 | None | -20 | 4 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 422 | 9 | 1 | 2 | 7.0 | O=C(O)CCCc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1 | 10.1016/s0960-894x(03)00794-7 | ||
9939791 | 161369 | 0 | None | 107 | 8 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 684 | 8 | 1 | 5 | 7.2 | CO[C@](C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)(c1ccccc1)C(F)(F)F | 10.1016/s0960-894x(99)00465-5 | ||
CHEMBL415310 | 161369 | 0 | None | 107 | 8 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 684 | 8 | 1 | 5 | 7.2 | CO[C@](C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)(c1ccccc1)C(F)(F)F | 10.1016/s0960-894x(99)00465-5 | ||
44392460 | 123427 | 0 | None | 3 | 3 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 421 | 6 | 1 | 4 | 6.4 | O=C(O)c1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2004.12.005 | ||
CHEMBL362851 | 123427 | 0 | None | 3 | 3 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 421 | 6 | 1 | 4 | 6.4 | O=C(O)c1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2004.12.005 | ||
9830442 | 205064 | 0 | None | 426 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 615 | 8 | 2 | 4 | 6.5 | O=C(NCCc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 | 10.1016/s0960-894x(99)00465-5 | ||
CHEMBL90269 | 205064 | 0 | None | 426 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 615 | 8 | 2 | 4 | 6.5 | O=C(NCCc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 | 10.1016/s0960-894x(99)00465-5 | ||
13231966 | 100484 | 0 | None | -169 | 5 | Mouse | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 372 | 13 | 3 | 5 | 3.2 | CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O | 10.1016/s0960-894x(01)00365-1 | ||
CHEMBL294108 | 100484 | 0 | None | -169 | 5 | Mouse | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 372 | 13 | 3 | 5 | 3.2 | CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O | 10.1016/s0960-894x(01)00365-1 | ||
59554824 | 136950 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 428 | 11 | 2 | 7 | 3.9 | CCCCC(C)(C)[C@H](O)/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1 | 10.1016/j.bmcl.2015.12.039 | ||
CHEMBL3753853 | 136950 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 428 | 11 | 2 | 7 | 3.9 | CCCCC(C)(C)[C@H](O)/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1 | 10.1016/j.bmcl.2015.12.039 | ||
13231966 | 100484 | 0 | None | -169 | 5 | Mouse | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 372 | 13 | 3 | 5 | 3.2 | CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O | 10.1016/s0960-894x(01)00364-x | ||
CHEMBL294108 | 100484 | 0 | None | -169 | 5 | Mouse | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 372 | 13 | 3 | 5 | 3.2 | CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O | 10.1016/s0960-894x(01)00364-x | ||
21974331 | 126025 | 0 | None | -19 | 4 | Mouse | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 399 | 6 | 1 | 4 | 4.8 | Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCc2ccccc2)cc1 | 10.1016/j.bmcl.2004.07.039 | ||
CHEMBL365243 | 126025 | 0 | None | -19 | 4 | Mouse | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 399 | 6 | 1 | 4 | 4.8 | Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCc2ccccc2)cc1 | 10.1016/j.bmcl.2004.07.039 | ||
44324310 | 106059 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 593 | 8 | 2 | 6 | 6.2 | O=C(NCCc1cccs1)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(=O)c3ccccc3c3ccccc32)cc1 | 10.1016/s0960-894x(99)00465-5 | ||
CHEMBL314097 | 106059 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 593 | 8 | 2 | 6 | 6.2 | O=C(NCCc1cccs1)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(=O)c3ccccc3c3ccccc32)cc1 | 10.1016/s0960-894x(99)00465-5 | ||
10046356 | 69012 | 0 | None | -60 | 3 | Mouse | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 397 | 11 | 2 | 5 | 2.7 | O=C(O)CCCSCCN1C(=O)OC[C@@H]1/C=C/[C@@H](O)Cc1cccc(F)c1 | 10.1016/j.bmc.2011.12.009 | ||
CHEMBL1929534 | 69012 | 0 | None | -60 | 3 | Mouse | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 397 | 11 | 2 | 5 | 2.7 | O=C(O)CCCSCCN1C(=O)OC[C@@H]1/C=C/[C@@H](O)Cc1cccc(F)c1 | 10.1016/j.bmc.2011.12.009 | ||
44304058 | 201487 | 0 | None | -524 | 5 | Mouse | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 374 | 13 | 3 | 6 | 2.0 | CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCOCC(=O)O | 10.1016/s0960-894x(01)00364-x | ||
CHEMBL64254 | 201487 | 0 | None | -524 | 5 | Mouse | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 374 | 13 | 3 | 6 | 2.0 | CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCOCC(=O)O | 10.1016/s0960-894x(01)00364-x | ||
10178073 | 16382 | 0 | None | -1698 | 4 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 384 | 8 | 1 | 2 | 5.9 | Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1 | 10.1016/s0960-894x(03)00794-7 | ||
CHEMBL123794 | 16382 | 0 | None | -1698 | 4 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 384 | 8 | 1 | 2 | 5.9 | Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1 | 10.1016/s0960-894x(03)00794-7 | ||
10178073 | 16382 | 0 | None | -1698 | 4 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 384 | 8 | 1 | 2 | 5.9 | Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1 | 10.1016/j.bmcl.2004.11.051 | ||
CHEMBL123794 | 16382 | 0 | None | -1698 | 4 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 384 | 8 | 1 | 2 | 5.9 | Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1 | 10.1016/j.bmcl.2004.11.051 | ||
1932 | 2897 | 4 | None | -758 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 410 | 12 | 3 | 3 | 4.8 | C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O | 10.1021/jm401431x | ||
5311228 | 2897 | 4 | None | -758 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 410 | 12 | 3 | 3 | 4.8 | C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O | 10.1021/jm401431x | ||
CHEMBL3286796 | 2897 | 4 | None | -758 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 410 | 12 | 3 | 3 | 4.8 | C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O | 10.1021/jm401431x | ||
58932681 | 74822 | 0 | None | -6165 | 3 | Mouse | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 549 | 10 | 2 | 8 | 5.2 | Cc1ccc2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc2c1 | 10.1016/j.bmc.2012.04.008 | ||
CHEMBL2036326 | 74822 | 0 | None | -6165 | 3 | Mouse | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 549 | 10 | 2 | 8 | 5.2 | Cc1ccc2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc2c1 | 10.1016/j.bmc.2012.04.008 | ||
23017297 | 8378 | 0 | None | -6456 | 3 | Mouse | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 525 | 11 | 1 | 6 | 4.3 | O=C(CCc1ccc(Cn2cccn2)cc1OCCc1ccccc1)NS(=O)(=O)c1ccc(F)c(F)c1 | 10.1016/j.bmcl.2010.02.034 | ||
CHEMBL1093820 | 8378 | 0 | None | -6456 | 3 | Mouse | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 525 | 11 | 1 | 6 | 4.3 | O=C(CCc1ccc(Cn2cccn2)cc1OCCc1ccccc1)NS(=O)(=O)c1ccc(F)c(F)c1 | 10.1016/j.bmcl.2010.02.034 | ||
56668527 | 64477 | 0 | None | -1 | 4 | Mouse | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 460 | 8 | 1 | 5 | 4.3 | CCN(C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1)c1cccc(CC(=O)O)c1 | 10.1016/j.bmc.2011.08.007 | ||
CHEMBL1819607 | 64477 | 0 | None | -1 | 4 | Mouse | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 460 | 8 | 1 | 5 | 4.3 | CCN(C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1)c1cccc(CC(=O)O)c1 | 10.1016/j.bmc.2011.08.007 | ||
21362905 | 170741 | 0 | None | -20 | 4 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 428 | 8 | 1 | 3 | 6.9 | CC(Cc1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1)C(=O)O | 10.1016/s0960-894x(03)00794-7 | ||
CHEMBL446098 | 170741 | 0 | None | -20 | 4 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 428 | 8 | 1 | 3 | 6.9 | CC(Cc1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1)C(=O)O | 10.1016/s0960-894x(03)00794-7 | ||
10168694 | 204626 | 0 | None | -812 | 4 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 671 | 17 | 1 | 7 | 8.2 | O=C(CCc1ccccc1-c1ccc(OCCCOc2cccc(CSCCc3ccccc3)c2)cc1)NS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)00518-8 | ||
CHEMBL87366 | 204626 | 0 | None | -812 | 4 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 671 | 17 | 1 | 7 | 8.2 | O=C(CCc1ccccc1-c1ccc(OCCCOc2cccc(CSCCc3ccccc3)c2)cc1)NS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)00518-8 | ||
22009003 | 122101 | 0 | None | -1445 | 4 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 468 | 8 | 2 | 3 | 6.7 | Cc1cccc(C(O)/C=C/c2ccccc2/C=C/C(=O)O)c1OCc1c(Cl)cccc1Cl | 10.1016/j.bmcl.2004.11.051 | ||
CHEMBL360290 | 122101 | 0 | None | -1445 | 4 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 468 | 8 | 2 | 3 | 6.7 | Cc1cccc(C(O)/C=C/c2ccccc2/C=C/C(=O)O)c1OCc1c(Cl)cccc1Cl | 10.1016/j.bmcl.2004.11.051 | ||
11156167 | 136995 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 494 | 11 | 2 | 7 | 5.2 | O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCC3CCCCC3)CCC2)n1 | 10.1016/j.bmcl.2015.12.039 | ||
CHEMBL3754197 | 136995 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 494 | 11 | 2 | 7 | 5.2 | O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCC3CCCCC3)CCC2)n1 | 10.1016/j.bmcl.2015.12.039 | ||
15907748 | 110976 | 0 | None | 33 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 615 | 7 | 2 | 4 | 7.0 | C[C@H](NC(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1 | 10.1016/s0960-894x(99)00465-5 | ||
CHEMBL327597 | 110976 | 0 | None | 33 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 615 | 7 | 2 | 4 | 7.0 | C[C@H](NC(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1 | 10.1016/s0960-894x(99)00465-5 | ||
9938669 | 167495 | 0 | None | 33 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 602 | 8 | 1 | 5 | 6.2 | O=C(COc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 | 10.1016/s0960-894x(99)00465-5 | ||
CHEMBL432380 | 167495 | 0 | None | 33 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 602 | 8 | 1 | 5 | 6.2 | O=C(COc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 | 10.1016/s0960-894x(99)00465-5 | ||
52945421 | 16359 | 0 | None | -794 | 4 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 740 | 16 | 2 | 4 | 11.2 | O=C(O)/C=C/c1ccccc1/C=C/Cc1cccc(OCc2ccccc2)c1.O=C(O)/C=C/c1ccccc1C/C=C\c1cccc(OCc2ccccc2)c1 | 10.1016/j.bmcl.2004.11.051 | ||
CHEMBL1237298 | 16359 | 0 | None | -794 | 4 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 740 | 16 | 2 | 4 | 11.2 | O=C(O)/C=C/c1ccccc1/C=C/Cc1cccc(OCc2ccccc2)c1.O=C(O)/C=C/c1ccccc1C/C=C\c1cccc(OCc2ccccc2)c1 | 10.1016/j.bmcl.2004.11.051 | ||
11476788 | 160727 | 0 | None | 1 | 6 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 463 | 5 | 1 | 5 | 4.4 | CS(=O)(=O)c1cc(F)cc2c1c(C(=O)c1ccc(Cl)cc1)c1n2CCC[C@@H]1CC(=O)O | 10.1016/j.bmcl.2008.03.015 | ||
CHEMBL412070 | 160727 | 0 | None | 1 | 6 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 463 | 5 | 1 | 5 | 4.4 | CS(=O)(=O)c1cc(F)cc2c1c(C(=O)c1ccc(Cl)cc1)c1n2CCC[C@@H]1CC(=O)O | 10.1016/j.bmcl.2008.03.015 | ||
66857738 | 136776 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 468 | 10 | 2 | 7 | 4.7 | CC(C)(C)CCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1 | 10.1016/j.bmcl.2015.12.039 | ||
CHEMBL3752435 | 136776 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 468 | 10 | 2 | 7 | 4.7 | CC(C)(C)CCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1 | 10.1016/j.bmcl.2015.12.039 | ||
9910826 | 65960 | 0 | None | 2 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 434 | 7 | 1 | 3 | 6.9 | O=C(O)Cc1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2004.12.005 | ||
CHEMBL184779 | 65960 | 0 | None | 2 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 434 | 7 | 1 | 3 | 6.9 | O=C(O)Cc1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2004.12.005 | ||
9873528 | 205203 | 0 | None | 15 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 602 | 7 | 1 | 5 | 6.9 | O=C(NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)OCc1ccccc1 | 10.1016/s0960-894x(99)00465-5 | ||
CHEMBL91063 | 205203 | 0 | None | 15 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 602 | 7 | 1 | 5 | 6.9 | O=C(NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)OCc1ccccc1 | 10.1016/s0960-894x(99)00465-5 | ||
22009008 | 82744 | 0 | None | -954 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 545 | 11 | 1 | 6 | 6.1 | COc1cc(/C=C/Cc2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2006.08.025 | ||
CHEMBL218280 | 82744 | 0 | None | -954 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 545 | 11 | 1 | 6 | 6.1 | COc1cc(/C=C/Cc2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2006.08.025 | ||
22009004 | 141219 | 0 | None | -1230 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 545 | 11 | 1 | 6 | 6.1 | COc1cc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2006.08.025 | ||
CHEMBL385955 | 141219 | 0 | None | -1230 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 545 | 11 | 1 | 6 | 6.1 | COc1cc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2006.08.025 | ||
44320388 | 204682 | 0 | None | -100 | 4 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 536 | 11 | 2 | 6 | 5.8 | Cc1cccc(OCCCOc2ccc(-c3ccccc3CNC(=O)NS(=O)(=O)c3cccs3)cc2)c1 | 10.1016/s0960-894x(02)00518-8 | ||
CHEMBL87797 | 204682 | 0 | None | -100 | 4 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 536 | 11 | 2 | 6 | 5.8 | Cc1cccc(OCCCOc2ccc(-c3ccccc3CNC(=O)NS(=O)(=O)c3cccs3)cc2)c1 | 10.1016/s0960-894x(02)00518-8 | ||
44439630 | 90787 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 446 | 8 | 1 | 5 | 3.4 | CCn1nccc1N(CC(=O)NCc1ccc(Cl)cc1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL240029 | 90787 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 446 | 8 | 1 | 5 | 3.4 | CCn1nccc1N(CC(=O)NCc1ccc(Cl)cc1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
71462285 | 81468 | 0 | None | -891 | 4 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 478 | 10 | 1 | 5 | 6.0 | COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCCn1cc2ccccc2c1C#N | 10.1021/ml300191g | ||
CHEMBL2164608 | 81468 | 0 | None | -891 | 4 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 478 | 10 | 1 | 5 | 6.0 | COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCCn1cc2ccccc2c1C#N | 10.1021/ml300191g | ||
9938626 | 205106 | 0 | None | 177 | 7 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 600 | 7 | 1 | 4 | 6.9 | CC(C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1 | 10.1016/s0960-894x(99)00465-5 | ||
CHEMBL90491 | 205106 | 0 | None | 177 | 7 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 600 | 7 | 1 | 4 | 6.9 | CC(C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1 | 10.1016/s0960-894x(99)00465-5 | ||
44392512 | 64893 | 0 | None | 6 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 432 | 6 | 1 | 5 | 6.3 | N#CC(O)c1cncc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2004.12.005 | ||
CHEMBL182623 | 64893 | 0 | None | 6 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 432 | 6 | 1 | 5 | 6.3 | N#CC(O)c1cncc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2004.12.005 | ||
44303952 | 100419 | 0 | None | -79 | 4 | Mouse | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 420 | 14 | 3 | 4 | 4.8 | CCCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1 | 10.1016/s0960-894x(01)00359-6 | ||
CHEMBL293697 | 100419 | 0 | None | -79 | 4 | Mouse | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 420 | 14 | 3 | 4 | 4.8 | CCCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1 | 10.1016/s0960-894x(01)00359-6 | ||
52945419 | 16357 | 0 | None | -1445 | 4 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 772 | 16 | 4 | 6 | 10.7 | O=C(O)/C=C/c1ccccc1/C=C/Cc1cccc(O)c1OCc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C\c1cccc(O)c1OCc1ccccc1 | 10.1016/j.bmcl.2004.11.051 | ||
CHEMBL1237296 | 16357 | 0 | None | -1445 | 4 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 772 | 16 | 4 | 6 | 10.7 | O=C(O)/C=C/c1ccccc1/C=C/Cc1cccc(O)c1OCc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C\c1cccc(O)c1OCc1ccccc1 | 10.1016/j.bmcl.2004.11.051 | ||
52943002 | 16362 | 0 | None | -5 | 4 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 716 | 14 | 2 | 4 | 11.1 | Cc1cccc(/C=C\Cc2ccccc2C(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2C(=O)O)c1OCc1ccccc1 | 10.1016/j.bmcl.2004.11.051 | ||
CHEMBL1237301 | 16362 | 0 | None | -5 | 4 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 716 | 14 | 2 | 4 | 11.1 | Cc1cccc(/C=C\Cc2ccccc2C(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2C(=O)O)c1OCc1ccccc1 | 10.1016/j.bmcl.2004.11.051 | ||
9874010 | 205461 | 0 | None | 64 | 8 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 629 | 8 | 1 | 4 | 6.9 | CN(CCc1ccccc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 | 10.1016/s0960-894x(99)00465-5 | ||
CHEMBL92539 | 205461 | 0 | None | 64 | 8 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 629 | 8 | 1 | 4 | 6.9 | CN(CCc1ccccc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 | 10.1016/s0960-894x(99)00465-5 | ||
44392527 | 122386 | 0 | None | 97 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 524 | 8 | 1 | 4 | 8.2 | CC(NC(=O)c1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1)c1cccnc1 | 10.1016/j.bmcl.2004.12.005 | ||
CHEMBL360592 | 122386 | 0 | None | 97 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 524 | 8 | 1 | 4 | 8.2 | CC(NC(=O)c1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1)c1cccnc1 | 10.1016/j.bmcl.2004.12.005 | ||
44304403 | 168531 | 0 | None | -501 | 4 | Mouse | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 420 | 12 | 3 | 4 | 3.8 | COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](F)[C@@H]2C/C=C/CCCC(=O)O)c1 | 10.1016/s0960-894x(01)00365-1 | ||
CHEMBL439934 | 168531 | 0 | None | -501 | 4 | Mouse | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 420 | 12 | 3 | 4 | 3.8 | COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](F)[C@@H]2C/C=C/CCCC(=O)O)c1 | 10.1016/s0960-894x(01)00365-1 | ||
21362900 | 204125 | 0 | None | -37 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 521 | 11 | 1 | 5 | 6.3 | O=C(CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)00518-8 | ||
CHEMBL83518 | 204125 | 0 | None | -37 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 521 | 11 | 1 | 5 | 6.3 | O=C(CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)00518-8 | ||
23017414 | 8174 | 0 | None | -10715 | 3 | Mouse | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 602 | 12 | 1 | 6 | 6.2 | O=C(CCc1ccc(COc2cccnc2)cc1OCCc1ccc2ccccc2c1)NS(=O)(=O)c1ccc(F)c(F)c1 | 10.1016/j.bmcl.2010.02.034 | ||
CHEMBL1092432 | 8174 | 0 | None | -10715 | 3 | Mouse | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 602 | 12 | 1 | 6 | 6.2 | O=C(CCc1ccc(COc2cccnc2)cc1OCCc1ccc2ccccc2c1)NS(=O)(=O)c1ccc(F)c(F)c1 | 10.1016/j.bmcl.2010.02.034 | ||
44390831 | 63306 | 0 | None | -2398 | 4 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 402 | 8 | 1 | 2 | 6.1 | Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccc(F)cc1 | 10.1016/j.bmcl.2004.11.051 | ||
CHEMBL180089 | 63306 | 0 | None | -2398 | 4 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 402 | 8 | 1 | 2 | 6.1 | Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccc(F)cc1 | 10.1016/j.bmcl.2004.11.051 | ||
21362879 | 16391 | 0 | None | -645 | 4 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 414 | 8 | 1 | 3 | 6.7 | O=C(O)CCc1ccccc1-c1cc(-c2ccccc2OCc2ccccc2)cs1 | 10.1016/s0960-894x(03)00794-7 | ||
CHEMBL123855 | 16391 | 0 | None | -645 | 4 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 414 | 8 | 1 | 3 | 6.7 | O=C(O)CCc1ccccc1-c1cc(-c2ccccc2OCc2ccccc2)cs1 | 10.1016/s0960-894x(03)00794-7 | ||
10158725 | 16649 | 0 | None | -776 | 4 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 414 | 8 | 1 | 3 | 6.7 | O=C(O)CCc1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1 | 10.1016/s0960-894x(03)00794-7 | ||
CHEMBL124738 | 16649 | 0 | None | -776 | 4 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 414 | 8 | 1 | 3 | 6.7 | O=C(O)CCc1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1 | 10.1016/s0960-894x(03)00794-7 | ||
9895436 | 106533 | 0 | None | 61 | 7 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 628 | 8 | 1 | 4 | 7.4 | CC(C)(Cc1ccccc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 | 10.1016/s0960-894x(99)00465-5 | ||
CHEMBL315391 | 106533 | 0 | None | 61 | 7 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 628 | 8 | 1 | 4 | 7.4 | CC(C)(Cc1ccccc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 | 10.1016/s0960-894x(99)00465-5 | ||
11374485 | 78559 | 0 | None | 32 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 455 | 6 | 1 | 4 | 6.0 | NS(=O)(=O)c1cccc(-c2ccsc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2004.12.005 | ||
CHEMBL2113029 | 78559 | 0 | None | 32 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 455 | 6 | 1 | 4 | 6.0 | NS(=O)(=O)c1cccc(-c2ccsc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2004.12.005 | ||
1883 | 3033 | 71 | None | -12 | 24 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1021/jm401431x | ||
1916 | 3033 | 71 | None | -12 | 24 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1021/jm401431x | ||
5280360 | 3033 | 71 | None | -12 | 24 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1021/jm401431x | ||
913 | 3033 | 71 | None | -12 | 24 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1021/jm401431x | ||
CHEMBL548 | 3033 | 71 | None | -12 | 24 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1021/jm401431x | ||
DB00917 | 3033 | 71 | None | -12 | 24 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1021/jm401431x | ||
5283086 | 201619 | 19 | None | -125 | 5 | Mouse | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O | 10.1016/s0960-894x(01)00359-6 | ||
CHEMBL64804 | 201619 | 19 | None | -125 | 5 | Mouse | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O | 10.1016/s0960-894x(01)00359-6 | ||
44320321 | 204708 | 0 | None | -4 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 563 | 12 | 1 | 6 | 6.6 | Cc1cccc(OCCCOc2ccc(-c3ccccc3CC(C)(C)C(=O)NS(=O)(=O)c3cccs3)cc2)c1 | 10.1016/s0960-894x(02)00518-8 | ||
CHEMBL87975 | 204708 | 0 | None | -4 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 563 | 12 | 1 | 6 | 6.6 | Cc1cccc(OCCCOc2ccc(-c3ccccc3CC(C)(C)C(=O)NS(=O)(=O)c3cccs3)cc2)c1 | 10.1016/s0960-894x(02)00518-8 | ||
12137443 | 84279 | 0 | None | -19054 | 4 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 491 | 9 | 2 | 3 | 6.1 | Cc1cc(Cl)ccc1-c1cccc([C@H](O)CC[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1 | 10.1021/jm049290a | ||
CHEMBL222677 | 84279 | 0 | None | -19054 | 4 | Human | 4.8 | pKi | = | 4.8 | Binding | ChEMBL | 491 | 9 | 2 | 3 | 6.1 | Cc1cc(Cl)ccc1-c1cccc([C@H](O)CC[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1 | 10.1021/jm049290a | ||
57393340 | 69132 | 0 | None | -1348 | 4 | Mouse | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 530 | 12 | 2 | 7 | 4.2 | O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(COCC(F)(F)F)c2)n1 | 10.1016/j.bmcl.2011.10.109 | ||
CHEMBL1933726 | 69132 | 0 | None | -1348 | 4 | Mouse | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 530 | 12 | 2 | 7 | 4.2 | O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(COCC(F)(F)F)c2)n1 | 10.1016/j.bmcl.2011.10.109 | ||
52944193 | 16356 | 0 | None | -1778 | 4 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 768 | 16 | 2 | 4 | 11.9 | Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2/C=C/C(=O)O)c1OCc1ccccc1 | 10.1016/j.bmcl.2004.11.051 | ||
CHEMBL1237295 | 16356 | 0 | None | -1778 | 4 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 768 | 16 | 2 | 4 | 11.9 | Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2/C=C/C(=O)O)c1OCc1ccccc1 | 10.1016/j.bmcl.2004.11.051 | ||
44419374 | 82582 | 0 | None | -2137 | 4 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 384 | 8 | 1 | 2 | 5.9 | Cc1ccc(OCc2ccccc2)c(/C=C/Cc2ccccc2/C=C/C(=O)O)c1 | 10.1016/j.bmcl.2006.08.025 | ||
CHEMBL218123 | 82582 | 0 | None | -2137 | 4 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 384 | 8 | 1 | 2 | 5.9 | Cc1ccc(OCc2ccccc2)c(/C=C/Cc2ccccc2/C=C/C(=O)O)c1 | 10.1016/j.bmcl.2006.08.025 | ||
44419379 | 137338 | 0 | None | -2137 | 4 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 384 | 8 | 1 | 2 | 5.9 | Cc1ccc(OCc2ccccc2)c(C/C=C/c2ccccc2/C=C/C(=O)O)c1 | 10.1016/j.bmcl.2006.08.025 | ||
CHEMBL376053 | 137338 | 0 | None | -2137 | 4 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 384 | 8 | 1 | 2 | 5.9 | Cc1ccc(OCc2ccccc2)c(C/C=C/c2ccccc2/C=C/C(=O)O)c1 | 10.1016/j.bmcl.2006.08.025 | ||
44439620 | 91273 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 443 | 7 | 1 | 4 | 3.9 | Cc1ccc(S(=O)(=O)N(CC(=O)NCc2ccc(Cl)cc2)c2cccnc2C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL240866 | 91273 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 443 | 7 | 1 | 4 | 3.9 | Cc1ccc(S(=O)(=O)N(CC(=O)NCc2ccc(Cl)cc2)c2cccnc2C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
11545879 | 14737 | 2 | None | 125 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 381 | 6 | 1 | 3 | 5.8 | CC(C)COc1ccc(Cl)cc1-c1ccccc1-c1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL1207973 | 14737 | 2 | None | 125 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 381 | 6 | 1 | 3 | 5.8 | CC(C)COc1ccc(Cl)cc1-c1ccccc1-c1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2008.11.032 | ||
CHEMBL467510 | 14737 | 2 | None | 125 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 381 | 6 | 1 | 3 | 5.8 | CC(C)COc1ccc(Cl)cc1-c1ccccc1-c1cccc(C(=O)O)n1 | 10.1016/j.bmcl.2008.11.032 | ||
9916766 | 205056 | 0 | None | 64 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 601 | 7 | 2 | 4 | 6.5 | O=C(NCc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 | 10.1016/s0960-894x(99)00465-5 | ||
CHEMBL90226 | 205056 | 0 | None | 64 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 601 | 7 | 2 | 4 | 6.5 | O=C(NCc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 | 10.1016/s0960-894x(99)00465-5 | ||
44304389 | 201463 | 0 | None | -165 | 4 | Mouse | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 372 | 13 | 3 | 5 | 3.0 | CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCSCC(=O)O | 10.1016/s0960-894x(01)00365-1 | ||
CHEMBL64188 | 201463 | 0 | None | -165 | 4 | Mouse | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 372 | 13 | 3 | 5 | 3.0 | CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCSCC(=O)O | 10.1016/s0960-894x(01)00365-1 | ||
58932683 | 74937 | 0 | None | -1258 | 3 | Mouse | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 549 | 10 | 2 | 8 | 5.2 | Cc1ccc2nc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)oc2c1 | 10.1016/j.bmc.2012.04.008 | ||
CHEMBL2037289 | 74937 | 0 | None | -1258 | 3 | Mouse | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 549 | 10 | 2 | 8 | 5.2 | Cc1ccc2nc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)oc2c1 | 10.1016/j.bmc.2012.04.008 | ||
44394380 | 124909 | 0 | None | -199 | 4 | Mouse | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 457 | 6 | 1 | 6 | 4.5 | Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2COc3ccccc3O2)cc1 | 10.1016/j.bmcl.2004.07.039 | ||
CHEMBL364593 | 124909 | 0 | None | -199 | 4 | Mouse | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 457 | 6 | 1 | 6 | 4.5 | Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2COc3ccccc3O2)cc1 | 10.1016/j.bmcl.2004.07.039 | ||
25003075 | 6760 | 12 | None | -70794 | 7 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 478 | 6 | 2 | 3 | 5.8 | O=C(O)c1ccc(C2(NC(=O)c3cccc4ccn(Cc5ccc(C(F)(F)F)cc5)c34)CC2)cc1 | 10.1016/j.bmcl.2010.04.065 | ||
CHEMBL1084009 | 6760 | 12 | None | -70794 | 7 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 478 | 6 | 2 | 3 | 5.8 | O=C(O)c1ccc(C2(NC(=O)c3cccc4ccn(Cc5ccc(C(F)(F)F)cc5)c34)CC2)cc1 | 10.1016/j.bmcl.2010.04.065 | ||
71455094 | 81469 | 0 | None | -776 | 4 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 623 | 12 | 1 | 8 | 6.4 | COc1cc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCCn1cc2ccccc2c1C#N | 10.1021/ml300191g | ||
CHEMBL2164609 | 81469 | 0 | None | -776 | 4 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 623 | 12 | 1 | 8 | 6.4 | COc1cc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCCn1cc2ccccc2c1C#N | 10.1021/ml300191g | ||
23017788 | 8050 | 0 | None | -24547 | 3 | Mouse | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 575 | 11 | 1 | 6 | 5.4 | O=C(CCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1)NS(=O)(=O)c1ccc(F)c(F)c1 | 10.1016/j.bmcl.2010.02.034 | ||
CHEMBL1091741 | 8050 | 0 | None | -24547 | 3 | Mouse | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 575 | 11 | 1 | 6 | 5.4 | O=C(CCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1)NS(=O)(=O)c1ccc(F)c(F)c1 | 10.1016/j.bmcl.2010.02.034 | ||
11224239 | 64473 | 0 | None | -6 | 4 | Mouse | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 432 | 7 | 2 | 5 | 3.8 | CN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21 | 10.1016/j.bmc.2011.08.007 | ||
CHEMBL1819603 | 64473 | 0 | None | -6 | 4 | Mouse | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 432 | 7 | 2 | 5 | 3.8 | CN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21 | 10.1016/j.bmc.2011.08.007 | ||
44324368 | 96071 | 0 | None | -4 | 4 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 587 | 6 | 2 | 4 | 6.8 | O=C(Nc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 | 10.1016/s0960-894x(99)00465-5 | ||
CHEMBL262690 | 96071 | 0 | None | -4 | 4 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 587 | 6 | 2 | 4 | 6.8 | O=C(Nc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 | 10.1016/s0960-894x(99)00465-5 | ||
52950151 | 16360 | 0 | None | -33 | 4 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 768 | 16 | 2 | 4 | 11.9 | Cc1cccc(/C=C/Cc2cccc(/C=C/C(=O)O)c2)c1OCc1ccccc1.Cc1cccc(C/C=C/c2cccc(/C=C/C(=O)O)c2)c1OCc1ccccc1 | 10.1016/j.bmcl.2004.11.051 | ||
CHEMBL1237299 | 16360 | 0 | None | -33 | 4 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 768 | 16 | 2 | 4 | 11.9 | Cc1cccc(/C=C/Cc2cccc(/C=C/C(=O)O)c2)c1OCc1ccccc1.Cc1cccc(C/C=C/c2cccc(/C=C/C(=O)O)c2)c1OCc1ccccc1 | 10.1016/j.bmcl.2004.11.051 | ||
52941777 | 16363 | 0 | None | -7 | 4 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 744 | 16 | 2 | 4 | 10.9 | Cc1cccc(/C=C/Cc2ccccc2CC(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2CC(=O)O)c1OCc1ccccc1 | 10.1016/j.bmcl.2004.11.051 | ||
CHEMBL1237302 | 16363 | 0 | None | -7 | 4 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 744 | 16 | 2 | 4 | 10.9 | Cc1cccc(/C=C/Cc2ccccc2CC(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2CC(=O)O)c1OCc1ccccc1 | 10.1016/j.bmcl.2004.11.051 | ||
44450497 | 160007 | 0 | None | 3 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 463 | 5 | 1 | 5 | 4.4 | CS(=O)(=O)c1cc(F)cc2c1c(C(=O)c1ccc(Cl)cc1)c1n2CCC[C@H]1CC(=O)O | 10.1016/j.bmcl.2008.03.015 | ||
CHEMBL411255 | 160007 | 0 | None | 3 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 463 | 5 | 1 | 5 | 4.4 | CS(=O)(=O)c1cc(F)cc2c1c(C(=O)c1ccc(Cl)cc1)c1n2CCC[C@H]1CC(=O)O | 10.1016/j.bmcl.2008.03.015 | ||
138 | 3032 | 84 | None | -23 | 18 | Mouse | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 10.1016/s0960-894x(01)00365-1 | ||
1882 | 3032 | 84 | None | -23 | 18 | Mouse | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 10.1016/s0960-894x(01)00365-1 | ||
5280723 | 3032 | 84 | None | -23 | 18 | Mouse | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 10.1016/s0960-894x(01)00365-1 | ||
CHEMBL495 | 3032 | 84 | None | -23 | 18 | Mouse | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 10.1016/s0960-894x(01)00365-1 | ||
DB00770 | 3032 | 84 | None | -23 | 18 | Mouse | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 10.1016/s0960-894x(01)00365-1 | ||
138 | 3032 | 84 | None | -23 | 18 | Mouse | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 10.1016/s0960-894x(01)00364-x | ||
1882 | 3032 | 84 | None | -23 | 18 | Mouse | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 10.1016/s0960-894x(01)00364-x | ||
5280723 | 3032 | 84 | None | -23 | 18 | Mouse | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 10.1016/s0960-894x(01)00364-x | ||
CHEMBL495 | 3032 | 84 | None | -23 | 18 | Mouse | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 10.1016/s0960-894x(01)00364-x | ||
DB00770 | 3032 | 84 | None | -23 | 18 | Mouse | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 10.1016/s0960-894x(01)00364-x | ||
9872741 | 205234 | 0 | None | 27 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 567 | 8 | 2 | 4 | 6.1 | CCCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 | 10.1016/s0960-894x(99)00465-5 | ||
CHEMBL91270 | 205234 | 0 | None | 27 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 567 | 8 | 2 | 4 | 6.1 | CCCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 | 10.1016/s0960-894x(99)00465-5 | ||
9910826 | 65960 | 0 | None | 2 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 434 | 7 | 1 | 3 | 6.9 | O=C(O)Cc1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2004.12.005 | ||
CHEMBL184779 | 65960 | 0 | None | 2 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 434 | 7 | 1 | 3 | 6.9 | O=C(O)Cc1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2004.12.005 | ||
59554822 | 136869 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 440 | 11 | 2 | 7 | 4.0 | CCCCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1 | 10.1016/j.bmcl.2015.12.039 | ||
CHEMBL3753221 | 136869 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 440 | 11 | 2 | 7 | 4.0 | CCCCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1 | 10.1016/j.bmcl.2015.12.039 | ||
44392512 | 64893 | 0 | None | 6 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 432 | 6 | 1 | 5 | 6.3 | N#CC(O)c1cncc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2004.12.005 | ||
CHEMBL182623 | 64893 | 0 | None | 6 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 432 | 6 | 1 | 5 | 6.3 | N#CC(O)c1cncc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2004.12.005 | ||
18973764 | 16468 | 0 | None | -1 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 346 | 8 | 1 | 2 | 5.1 | O=C(O)c1ccc(CCCc2ccccc2OCc2ccccc2)cc1 | 10.1016/s0960-894x(03)00794-7 | ||
CHEMBL124199 | 16468 | 0 | None | -1 | 4 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 346 | 8 | 1 | 2 | 5.1 | O=C(O)c1ccc(CCCc2ccccc2OCc2ccccc2)cc1 | 10.1016/s0960-894x(03)00794-7 | ||
44394432 | 126804 | 0 | None | -19 | 5 | Mouse | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 457 | 6 | 1 | 6 | 4.5 | Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@H]2COc3ccccc3O2)cc1 | 10.1016/j.bmcl.2004.07.039 | ||
CHEMBL365908 | 126804 | 0 | None | -19 | 5 | Mouse | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 457 | 6 | 1 | 6 | 4.5 | Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@H]2COc3ccccc3O2)cc1 | 10.1016/j.bmcl.2004.07.039 | ||
44419380 | 82666 | 0 | None | -229 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 529 | 10 | 1 | 5 | 6.4 | Cc1ccc(OCc2ccccc2)c(/C=C/Cc2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)c1 | 10.1016/j.bmcl.2006.08.025 | ||
CHEMBL218178 | 82666 | 0 | None | -229 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 529 | 10 | 1 | 5 | 6.4 | Cc1ccc(OCc2ccccc2)c(/C=C/Cc2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)c1 | 10.1016/j.bmcl.2006.08.025 | ||
44419384 | 82667 | 0 | None | -229 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 529 | 10 | 1 | 5 | 6.4 | Cc1ccc(OCc2ccccc2)c(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)c1 | 10.1016/j.bmcl.2006.08.025 | ||
CHEMBL218179 | 82667 | 0 | None | -229 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 529 | 10 | 1 | 5 | 6.4 | Cc1ccc(OCc2ccccc2)c(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)c1 | 10.1016/j.bmcl.2006.08.025 | ||
9865111 | 63534 | 0 | None | -354 | 4 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 388 | 10 | 1 | 2 | 5.8 | Cc1cccc(CCCc2ccccc2CCC(=O)O)c1OCc1ccccc1 | 10.1016/j.bmcl.2004.11.051 | ||
CHEMBL180343 | 63534 | 0 | None | -354 | 4 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 388 | 10 | 1 | 2 | 5.8 | Cc1cccc(CCCc2ccccc2CCC(=O)O)c1OCc1ccccc1 | 10.1016/j.bmcl.2004.11.051 | ||
44419350 | 83727 | 0 | None | -354 | 4 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 388 | 10 | 1 | 2 | 5.8 | Cc1ccc(OCc2ccccc2)c(CCCc2ccccc2CCC(=O)O)c1 | 10.1016/j.bmcl.2006.08.025 | ||
CHEMBL220820 | 83727 | 0 | None | -354 | 4 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 388 | 10 | 1 | 2 | 5.8 | Cc1ccc(OCc2ccccc2)c(CCCc2ccccc2CCC(=O)O)c1 | 10.1016/j.bmcl.2006.08.025 | ||
10092823 | 69009 | 0 | None | -301 | 3 | Mouse | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 407 | 12 | 2 | 5 | 3.1 | CCc1cccc(C[C@H](O)/C=C/[C@H]2COC(=O)N2CCSCCCC(=O)O)c1 | 10.1016/j.bmc.2011.12.009 | ||
CHEMBL1929531 | 69009 | 0 | None | -301 | 3 | Mouse | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 407 | 12 | 2 | 5 | 3.1 | CCc1cccc(C[C@H](O)/C=C/[C@H]2COC(=O)N2CCSCCCC(=O)O)c1 | 10.1016/j.bmc.2011.12.009 | ||
10414412 | 74816 | 0 | None | -691 | 3 | Mouse | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 522 | 10 | 2 | 6 | 5.4 | Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)c(C)c1 | 10.1016/j.bmc.2012.04.008 | ||
CHEMBL2036320 | 74816 | 0 | None | -691 | 3 | Mouse | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 522 | 10 | 2 | 6 | 5.4 | Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)c(C)c1 | 10.1016/j.bmc.2012.04.008 | ||
52943000 | 16358 | 0 | None | -954 | 4 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 740 | 16 | 2 | 4 | 11.2 | O=C(O)/C=C/c1ccccc1/C=C/Cc1ccccc1OCc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C\c1ccccc1OCc1ccccc1 | 10.1016/j.bmcl.2004.11.051 | ||
CHEMBL1237297 | 16358 | 0 | None | -954 | 4 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 740 | 16 | 2 | 4 | 11.2 | O=C(O)/C=C/c1ccccc1/C=C/Cc1ccccc1OCc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C\c1ccccc1OCc1ccccc1 | 10.1016/j.bmcl.2004.11.051 | ||
22009004 | 141219 | 0 | None | -1230 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 545 | 11 | 1 | 6 | 6.1 | COc1cc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCc1ccccc1 | 10.1021/ml300191g | ||
CHEMBL385955 | 141219 | 0 | None | -1230 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 545 | 11 | 1 | 6 | 6.1 | COc1cc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCc1ccccc1 | 10.1021/ml300191g | ||
1009982 | 87589 | 16 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 452 | 9 | 1 | 4 | 4.1 | CCc1ccccc1N(CC(=O)NCc1ccc(OC)cc1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL234398 | 87589 | 16 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 452 | 9 | 1 | 4 | 4.1 | CCc1ccccc1N(CC(=O)NCc1ccc(OC)cc1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
28568627 | 90150 | 1 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 482 | 10 | 1 | 5 | 4.1 | CCc1ccccc1N(CC(=O)NCc1ccc(OC)c(OC)c1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL238754 | 90150 | 1 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 482 | 10 | 1 | 5 | 4.1 | CCc1ccccc1N(CC(=O)NCc1ccc(OC)c(OC)c1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
10481859 | 74817 | 0 | None | -7244 | 3 | Mouse | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 522 | 10 | 2 | 6 | 5.4 | Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1C | 10.1016/j.bmc.2012.04.008 | ||
CHEMBL2036321 | 74817 | 0 | None | -7244 | 3 | Mouse | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 522 | 10 | 2 | 6 | 5.4 | Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1C | 10.1016/j.bmc.2012.04.008 | ||
9955802 | 68842 | 0 | None | -457 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 435 | 6 | 1 | 3 | 7.1 | O=C(O)c1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 | 10.1021/jm050085k | ||
CHEMBL192613 | 68842 | 0 | None | -457 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 435 | 6 | 1 | 3 | 7.1 | O=C(O)c1cccc(C[C@@H]2CCCC=C2c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1 | 10.1021/jm050085k | ||
44439609 | 147142 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 456 | 8 | 1 | 3 | 4.7 | CCc1ccccc1N(CC(=O)NCc1cccc(Cl)c1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL393178 | 147142 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 456 | 8 | 1 | 3 | 4.7 | CCc1ccccc1N(CC(=O)NCc1cccc(Cl)c1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
44392477 | 64743 | 0 | None | -1 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 543 | 6 | 1 | 4 | 8.0 | OC(c1cncc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1)(C(F)(F)F)C(F)(F)F | 10.1016/j.bmcl.2004.12.005 | ||
CHEMBL182367 | 64743 | 0 | None | -1 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 543 | 6 | 1 | 4 | 8.0 | OC(c1cncc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1)(C(F)(F)F)C(F)(F)F | 10.1016/j.bmcl.2004.12.005 | ||
23017255 | 7964 | 0 | None | -2187 | 3 | Mouse | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 554 | 12 | 1 | 7 | 4.2 | CN(CCOc1cc(Cn2cccn2)ccc1CCC(=O)NS(=O)(=O)c1ccc(F)c(F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.02.034 | ||
CHEMBL1090937 | 7964 | 0 | None | -2187 | 3 | Mouse | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 554 | 12 | 1 | 7 | 4.2 | CN(CCOc1cc(Cn2cccn2)ccc1CCC(=O)NS(=O)(=O)c1ccc(F)c(F)c1)c1ccccc1 | 10.1016/j.bmcl.2010.02.034 | ||
44349503 | 167826 | 0 | None | -165 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 553 | 10 | 1 | 5 | 7.1 | O=C(CCc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1)NS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(03)00794-7 | ||
CHEMBL434637 | 167826 | 0 | None | -165 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 553 | 10 | 1 | 5 | 7.1 | O=C(CCc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1)NS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(03)00794-7 | ||
22008967 | 82736 | 0 | None | -1096 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 439 | 8 | 1 | 5 | 4.5 | COc1ccc(/C=C/Cc2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)cc1 | 10.1016/j.bmcl.2006.08.025 | ||
CHEMBL218228 | 82736 | 0 | None | -1096 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 439 | 8 | 1 | 5 | 4.5 | COc1ccc(/C=C/Cc2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)cc1 | 10.1016/j.bmcl.2006.08.025 | ||
22008966 | 82737 | 0 | None | -1096 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 439 | 8 | 1 | 5 | 4.5 | COc1ccc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)cc1 | 10.1016/j.bmcl.2006.08.025 | ||
CHEMBL218229 | 82737 | 0 | None | -1096 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 439 | 8 | 1 | 5 | 4.5 | COc1ccc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)cc1 | 10.1016/j.bmcl.2006.08.025 | ||
44304008 | 201551 | 0 | None | -371 | 4 | Mouse | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 410 | 11 | 3 | 6 | 2.4 | O=C(O)CSCCCS[C@H]1C(=O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)Cc1ccccc1 | 10.1016/s0960-894x(01)00364-x | ||
CHEMBL64542 | 201551 | 0 | None | -371 | 4 | Mouse | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 410 | 11 | 3 | 6 | 2.4 | O=C(O)CSCCCS[C@H]1C(=O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)Cc1ccccc1 | 10.1016/s0960-894x(01)00364-x | ||
44304474 | 201242 | 0 | None | -7 | 5 | Mouse | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 372 | 13 | 3 | 5 | 3.0 | CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCSCCC(=O)O | 10.1016/s0960-894x(01)00365-1 | ||
CHEMBL62868 | 201242 | 0 | None | -7 | 5 | Mouse | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 372 | 13 | 3 | 5 | 3.0 | CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCSCCC(=O)O | 10.1016/s0960-894x(01)00365-1 | ||
57464006 | 74818 | 0 | None | -22387 | 4 | Mouse | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 534 | 10 | 2 | 7 | 5.5 | O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3cc4ccccc4o3)c2)n1 | 10.1016/j.bmc.2012.04.008 | ||
CHEMBL2036322 | 74818 | 0 | None | -22387 | 4 | Mouse | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 534 | 10 | 2 | 7 | 5.5 | O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3cc4ccccc4o3)c2)n1 | 10.1016/j.bmc.2012.04.008 | ||
56658143 | 64474 | 0 | None | -19 | 6 | Mouse | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 468 | 8 | 2 | 6 | 3.4 | CN1C[C@@H](COc2ccc(S(=O)(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21 | 10.1016/j.bmc.2011.08.007 | ||
CHEMBL1819604 | 64474 | 0 | None | -19 | 6 | Mouse | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 468 | 8 | 2 | 6 | 3.4 | CN1C[C@@H](COc2ccc(S(=O)(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21 | 10.1016/j.bmc.2011.08.007 | ||
10112486 | 16721 | 0 | None | -51 | 4 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 414 | 8 | 1 | 3 | 6.7 | O=C(O)CCc1ccccc1-c1ccc(-c2ccccc2OCc2ccccc2)s1 | 10.1016/s0960-894x(03)00794-7 | ||
CHEMBL125110 | 16721 | 0 | None | -51 | 4 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 414 | 8 | 1 | 3 | 6.7 | O=C(O)CCc1ccccc1-c1ccc(-c2ccccc2OCc2ccccc2)s1 | 10.1016/s0960-894x(03)00794-7 | ||
21362867 | 106618 | 0 | None | -112 | 4 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 417 | 7 | 1 | 5 | 4.6 | CSc1cccc(-c2ccccc2CCC(=O)NS(=O)(=O)c2cccs2)c1 | 10.1016/s0960-894x(02)00518-8 | ||
CHEMBL315974 | 106618 | 0 | None | -112 | 4 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 417 | 7 | 1 | 5 | 4.6 | CSc1cccc(-c2ccccc2CCC(=O)NS(=O)(=O)c2cccs2)c1 | 10.1016/s0960-894x(02)00518-8 | ||
44392460 | 123427 | 0 | None | -3 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 421 | 6 | 1 | 4 | 6.4 | O=C(O)c1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2004.12.005 | ||
CHEMBL362851 | 123427 | 0 | None | -3 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 421 | 6 | 1 | 4 | 6.4 | O=C(O)c1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2004.12.005 | ||
44324309 | 106671 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 607 | 8 | 2 | 5 | 7.0 | O=C(NCCc1cccs1)NS(=O)(=O)c1ccccc1-c1ccc(CN2Cc3ccccc3CCc3ccccc32)cc1 | 10.1016/s0960-894x(99)00465-5 | ||
CHEMBL316278 | 106671 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 607 | 8 | 2 | 5 | 7.0 | O=C(NCCc1cccs1)NS(=O)(=O)c1ccccc1-c1ccc(CN2Cc3ccccc3CCc3ccccc32)cc1 | 10.1016/s0960-894x(99)00465-5 | ||
44320405 | 105685 | 0 | None | -5 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 521 | 11 | 1 | 5 | 6.2 | O=C(NS(=O)(=O)CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)c1cccs1 | 10.1016/s0960-894x(02)00518-8 | ||
CHEMBL313700 | 105685 | 0 | None | -5 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 521 | 11 | 1 | 5 | 6.2 | O=C(NS(=O)(=O)CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)c1cccs1 | 10.1016/s0960-894x(02)00518-8 | ||
44320126 | 204686 | 0 | None | -23 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 537 | 11 | 1 | 7 | 6.2 | Cc1cccc(OCCCOc2ccc(-c3ccccc3COC(=O)NS(=O)(=O)c3cccs3)cc2)c1 | 10.1016/s0960-894x(02)00518-8 | ||
CHEMBL87816 | 204686 | 0 | None | -23 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 537 | 11 | 1 | 7 | 6.2 | Cc1cccc(OCCCOc2ccc(-c3ccccc3COC(=O)NS(=O)(=O)c3cccs3)cc2)c1 | 10.1016/s0960-894x(02)00518-8 | ||
52945423 | 16364 | 0 | None | -10 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 824 | 18 | 2 | 6 | 11.6 | CC(=O)c1ccc(OCc2ccccc2)c(/C=C/Cc2ccccc2/C=C/C(=O)O)c1.CC(=O)c1ccc(OCc2ccccc2)c(C/C=C/c2ccccc2/C=C/C(=O)O)c1 | 10.1016/j.bmcl.2004.11.051 | ||
CHEMBL1237303 | 16364 | 0 | None | -10 | 4 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 824 | 18 | 2 | 6 | 11.6 | CC(=O)c1ccc(OCc2ccccc2)c(/C=C/Cc2ccccc2/C=C/C(=O)O)c1.CC(=O)c1ccc(OCc2ccccc2)c(C/C=C/c2ccccc2/C=C/C(=O)O)c1 | 10.1016/j.bmcl.2004.11.051 | ||
56949973 | 69030 | 0 | None | -5623 | 4 | Mouse | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 407 | 11 | 2 | 4 | 3.8 | Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=S)N2CCSCCCC(=O)O)c1 | 10.1016/j.bmc.2011.12.009 | ||
CHEMBL1929551 | 69030 | 0 | None | -5623 | 4 | Mouse | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 407 | 11 | 2 | 4 | 3.8 | Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=S)N2CCSCCCC(=O)O)c1 | 10.1016/j.bmc.2011.12.009 | ||
23016842 | 8266 | 0 | None | -10471 | 2 | Mouse | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 541 | 12 | 1 | 7 | 4.1 | O=C(CCc1ccc(Cn2cccn2)cc1OCCOc1ccccc1)NS(=O)(=O)c1ccc(F)c(F)c1 | 10.1016/j.bmcl.2010.02.034 | ||
CHEMBL1092976 | 8266 | 0 | None | -10471 | 2 | Mouse | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 541 | 12 | 1 | 7 | 4.1 | O=C(CCc1ccc(Cn2cccn2)cc1OCCOc1ccccc1)NS(=O)(=O)c1ccc(F)c(F)c1 | 10.1016/j.bmcl.2010.02.034 | ||
11696697 | 98575 | 0 | None | -2344 | 3 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 385 | 11 | 2 | 3 | 3.7 | O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)C1(c2ccccc2)CC1 | 10.1016/j.bmcl.2004.01.063 | ||
CHEMBL280223 | 98575 | 0 | None | -2344 | 3 | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 385 | 11 | 2 | 3 | 3.7 | O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)C1(c2ccccc2)CC1 | 10.1016/j.bmcl.2004.01.063 | ||
44138108 | 183703 | 0 | None | -89125 | 6 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 434 | 5 | 1 | 4 | 6.6 | CC(C)c1nccc2c1c(Sc1ccc(Cl)c(Cl)c1)c1n2CC[C@@H]1CC(=O)O | 10.1016/j.bmcl.2009.03.010 | ||
CHEMBL483991 | 183703 | 0 | None | -89125 | 6 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 434 | 5 | 1 | 4 | 6.6 | CC(C)c1nccc2c1c(Sc1ccc(Cl)c(Cl)c1)c1n2CC[C@@H]1CC(=O)O | 10.1016/j.bmcl.2009.03.010 | ||
24765153 | 183947 | 0 | None | -44668 | 8 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 434 | 5 | 1 | 4 | 6.6 | CC(C)c1nccc2c1c(Sc1ccc(Cl)c(Cl)c1)c1n2CC[C@H]1CC(=O)O | 10.1016/j.bmcl.2009.03.010 | ||
CHEMBL484778 | 183947 | 0 | None | -44668 | 8 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 434 | 5 | 1 | 4 | 6.6 | CC(C)c1nccc2c1c(Sc1ccc(Cl)c(Cl)c1)c1n2CC[C@H]1CC(=O)O | 10.1016/j.bmcl.2009.03.010 | ||
46220498 | 92642 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 361 | 4 | 1 | 5 | 4.7 | Cc1c(-c2ccccc2)nn(-c2nc(C(=O)O)cs2)c1-c1ccccc1 | 10.1016/j.bmcl.2013.09.032 | ||
46220498 | 92642 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 361 | 4 | 1 | 5 | 4.7 | Cc1c(-c2ccccc2)nn(-c2nc(C(=O)O)cs2)c1-c1ccccc1 | 10.1016/j.bmcl.2013.10.065 | ||
CHEMBL2442495 | 92642 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 361 | 4 | 1 | 5 | 4.7 | Cc1c(-c2ccccc2)nn(-c2nc(C(=O)O)cs2)c1-c1ccccc1 | 10.1016/j.bmcl.2013.09.032 | ||
CHEMBL2442495 | 92642 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 361 | 4 | 1 | 5 | 4.7 | Cc1c(-c2ccccc2)nn(-c2nc(C(=O)O)cs2)c1-c1ccccc1 | 10.1016/j.bmcl.2013.10.065 | ||
10299717 | 64086 | 0 | None | -831 | 6 | Mouse | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 484 | 6 | 1 | 6 | 4.9 | Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 | 10.1016/j.bmc.2011.06.014 | ||
CHEMBL1813120 | 64086 | 0 | None | -831 | 6 | Mouse | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 484 | 6 | 1 | 6 | 4.9 | Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 | 10.1016/j.bmc.2011.06.014 | ||
10294290 | 198370 | 0 | None | -239 | 4 | Mouse | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 398 | 8 | 1 | 4 | 4.8 | O=C(O)/C=C/c1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1 | 10.1016/j.bmc.2009.08.007 | ||
CHEMBL595632 | 198370 | 0 | None | -239 | 4 | Mouse | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 398 | 8 | 1 | 4 | 4.8 | O=C(O)/C=C/c1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1 | 10.1016/j.bmc.2009.08.007 | ||
10207799 | 64744 | 0 | None | 28 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 475 | 6 | 1 | 4 | 7.3 | OC(c1cncc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1)C(F)(F)F | 10.1016/j.bmcl.2004.12.005 | ||
CHEMBL182368 | 64744 | 0 | None | 28 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 475 | 6 | 1 | 4 | 7.3 | OC(c1cncc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1)C(F)(F)F | 10.1016/j.bmcl.2004.12.005 | ||
9953978 | 65987 | 0 | None | 14 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 421 | 6 | 1 | 4 | 6.4 | O=C(O)c1cncc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2004.12.005 | ||
CHEMBL184947 | 65987 | 0 | None | 14 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 421 | 6 | 1 | 4 | 6.4 | O=C(O)c1cncc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2004.12.005 | ||
21362912 | 170609 | 0 | None | -15 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 535 | 12 | 1 | 5 | 6.7 | O=C(CCCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)00518-8 | ||
CHEMBL445895 | 170609 | 0 | None | -15 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 535 | 12 | 1 | 5 | 6.7 | O=C(CCCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)00518-8 | ||
22009011 | 63742 | 0 | None | -301 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 468 | 8 | 2 | 3 | 6.7 | Cc1cccc(/C=C/C(O)c2ccccc2/C=C/C(=O)O)c1OCc1c(Cl)cccc1Cl | 10.1016/j.bmcl.2004.11.051 | ||
CHEMBL180742 | 63742 | 0 | None | -301 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 468 | 8 | 2 | 3 | 6.7 | Cc1cccc(/C=C/C(O)c2ccccc2/C=C/C(=O)O)c1OCc1c(Cl)cccc1Cl | 10.1016/j.bmcl.2004.11.051 | ||
44304335 | 201289 | 0 | None | -398 | 4 | Mouse | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 422 | 10 | 4 | 4 | 4.0 | Cc1cc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C/CCCC(=O)O)ccc1O | 10.1016/s0960-894x(01)00365-1 | ||
CHEMBL63061 | 201289 | 0 | None | -398 | 4 | Mouse | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 422 | 10 | 4 | 4 | 4.0 | Cc1cc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C/CCCC(=O)O)ccc1O | 10.1016/s0960-894x(01)00365-1 | ||
44304051 | 102287 | 0 | None | -436 | 4 | Mouse | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 440 | 12 | 3 | 7 | 2.4 | COc1ccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)cc1 | 10.1016/s0960-894x(01)00364-x | ||
CHEMBL305126 | 102287 | 0 | None | -436 | 4 | Mouse | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 440 | 12 | 3 | 7 | 2.4 | COc1ccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)cc1 | 10.1016/s0960-894x(01)00364-x | ||
10302378 | 82367 | 0 | None | -2630 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 539 | 9 | 1 | 5 | 6.6 | O=C(/C=C/c1ccccc1Cc1ccc2cc(OCc3ccccc3)ccc2c1)NS(=O)(=O)c1cccs1 | 10.1016/j.bmcl.2006.08.025 | ||
CHEMBL217991 | 82367 | 0 | None | -2630 | 4 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 539 | 9 | 1 | 5 | 6.6 | O=C(/C=C/c1ccccc1Cc1ccc2cc(OCc3ccccc3)ccc2c1)NS(=O)(=O)c1cccs1 | 10.1016/j.bmcl.2006.08.025 | ||
10076580 | 74939 | 0 | None | -20892 | 3 | Mouse | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 563 | 10 | 2 | 8 | 5.5 | Cc1cc(C)c2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc2c1 | 10.1016/j.bmc.2012.04.008 | ||
CHEMBL2037291 | 74939 | 0 | None | -20892 | 3 | Mouse | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 563 | 10 | 2 | 8 | 5.5 | Cc1cc(C)c2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc2c1 | 10.1016/j.bmc.2012.04.008 | ||
9807448 | 201482 | 0 | None | -2137 | 4 | Mouse | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 398 | 11 | 3 | 3 | 4.7 | CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1 | 10.1016/s0960-894x(01)00359-6 | ||
CHEMBL64246 | 201482 | 0 | None | -2137 | 4 | Mouse | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 398 | 11 | 3 | 3 | 4.7 | CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1 | 10.1016/s0960-894x(01)00359-6 | ||
57396825 | 69130 | 0 | None | -6760 | 4 | Mouse | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 398 | 11 | 2 | 6 | 3.4 | CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1 | 10.1016/j.bmcl.2011.10.109 | ||
CHEMBL1933724 | 69130 | 0 | None | -6760 | 4 | Mouse | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 398 | 11 | 2 | 6 | 3.4 | CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1 | 10.1016/j.bmcl.2011.10.109 | ||
57396825 | 69130 | 0 | None | -6760 | 4 | Mouse | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 398 | 11 | 2 | 6 | 3.4 | CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1 | 10.1016/j.bmc.2012.02.018 | ||
CHEMBL1933724 | 69130 | 0 | None | -6760 | 4 | Mouse | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 398 | 11 | 2 | 6 | 3.4 | CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1 | 10.1016/j.bmc.2012.02.018 | ||
9944231 | 17851 | 0 | None | -44 | 4 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 302 | 5 | 1 | 1 | 5.0 | O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2)c1 | 10.1016/s0960-894x(03)00794-7 | ||
CHEMBL126472 | 17851 | 0 | None | -44 | 4 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 302 | 5 | 1 | 1 | 5.0 | O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2)c1 | 10.1016/s0960-894x(03)00794-7 | ||
CHEMBL5074870 | 212566 | 0 | None | -954 | 3 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | None | None | None | O=C(NC/C=C1\CCCc2cnn(Cc3ccc(Cl)cc3Cl)c21)NS(=O)(=O)c1ccc(Cl)cc1 | 10.1021/acsmedchemlett.1c00594 | ||||
44349528 | 113302 | 0 | None | -1000 | 4 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 428 | 8 | 1 | 3 | 7.2 | CC(CC(=O)O)c1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1 | 10.1016/s0960-894x(03)00794-7 | ||
CHEMBL332446 | 113302 | 0 | None | -1000 | 4 | Human | 4.5 | pKi | = | 4.5 | Binding | ChEMBL | 428 | 8 | 1 | 3 | 7.2 | CC(CC(=O)O)c1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1 | 10.1016/s0960-894x(03)00794-7 | ||
15491229 | 110975 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 629 | 8 | 1 | 4 | 6.9 | CN(C(=O)NCCc1ccccc1)S(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 | 10.1016/s0960-894x(99)00465-5 | ||
CHEMBL327596 | 110975 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 629 | 8 | 1 | 4 | 6.9 | CN(C(=O)NCCc1ccccc1)S(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 | 10.1016/s0960-894x(99)00465-5 | ||
44320272 | 204539 | 0 | None | -11 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 507 | 10 | 1 | 5 | 5.9 | O=C(Cc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)00518-8 | ||
CHEMBL86886 | 204539 | 0 | None | -11 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 507 | 10 | 1 | 5 | 5.9 | O=C(Cc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)00518-8 | ||
21974374 | 126725 | 0 | None | -75 | 5 | Mouse | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 455 | 6 | 1 | 5 | 5.0 | Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2CCc3ccccc3O2)cc1 | 10.1016/j.bmcl.2004.07.039 | ||
CHEMBL365829 | 126725 | 0 | None | -75 | 5 | Mouse | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 455 | 6 | 1 | 5 | 5.0 | Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2CCc3ccccc3O2)cc1 | 10.1016/j.bmcl.2004.07.039 | ||
44393681 | 66527 | 0 | None | -2 | 3 | Mouse | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 409 | 9 | 1 | 5 | 5.2 | CCCCOc1ccc(C(=O)n2c(CCC)c(C(=O)O)c3cc(OC)ccc32)cc1 | 10.1016/j.bmcl.2004.06.006 | ||
CHEMBL186244 | 66527 | 0 | None | -2 | 3 | Mouse | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 409 | 9 | 1 | 5 | 5.2 | CCCCOc1ccc(C(=O)n2c(CCC)c(C(=O)O)c3cc(OC)ccc32)cc1 | 10.1016/j.bmcl.2004.06.006 | ||
15551229 | 2227 | 36 | None | -19498 | 3 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 535 | 7 | 1 | 4 | 5.7 | COc1ccc(cc1S(=O)(=O)NC(=O)/C=C/c1ccccc1Cc1ccc2c(c1)cccc2)Br | 10.1016/j.bmcl.2006.08.025 | ||
1941 | 2227 | 36 | None | -19498 | 3 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 535 | 7 | 1 | 4 | 5.7 | COc1ccc(cc1S(=O)(=O)NC(=O)/C=C/c1ccccc1Cc1ccc2c(c1)cccc2)Br | 10.1016/j.bmcl.2006.08.025 | ||
CHEMBL218071 | 2227 | 36 | None | -19498 | 3 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 535 | 7 | 1 | 4 | 5.7 | COc1ccc(cc1S(=O)(=O)NC(=O)/C=C/c1ccccc1Cc1ccc2c(c1)cccc2)Br | 10.1016/j.bmcl.2006.08.025 | ||
44439629 | 90786 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 432 | 7 | 1 | 5 | 2.9 | Cc1ccc(S(=O)(=O)N(CC(=O)NCc2ccc(Cl)cc2)c2ccnn2C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL240028 | 90786 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 432 | 7 | 1 | 5 | 2.9 | Cc1ccc(S(=O)(=O)N(CC(=O)NCc2ccc(Cl)cc2)c2ccnn2C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
11306423 | 2489 | 4 | None | 52 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 491 | 6 | 2 | 5 | 6.4 | Clc1ccc(c(c1)c1ccsc1c1cncc(c1)C(C(F)(F)F)(O)O)OCc1ccccc1 | 10.1016/j.bmcl.2004.12.005 | ||
6068 | 2489 | 4 | None | 52 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 491 | 6 | 2 | 5 | 6.4 | Clc1ccc(c(c1)c1ccsc1c1cncc(c1)C(C(F)(F)F)(O)O)OCc1ccccc1 | 10.1016/j.bmcl.2004.12.005 | ||
CHEMBL185346 | 2489 | 4 | None | 52 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 491 | 6 | 2 | 5 | 6.4 | Clc1ccc(c(c1)c1ccsc1c1cncc(c1)C(C(F)(F)F)(O)O)OCc1ccccc1 | 10.1016/j.bmcl.2004.12.005 | ||
44392456 | 63218 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 509 | 8 | 1 | 3 | 8.5 | O=C(Cc1ccccc1)Nc1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2004.12.005 | ||
CHEMBL180046 | 63218 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 509 | 8 | 1 | 3 | 8.5 | O=C(Cc1ccccc1)Nc1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2004.12.005 | ||
9868012 | 123331 | 0 | None | 50 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 420 | 6 | 1 | 3 | 7.0 | O=C(O)c1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2004.12.005 | ||
CHEMBL362543 | 123331 | 0 | None | 50 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 420 | 6 | 1 | 3 | 7.0 | O=C(O)c1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2004.12.005 | ||
44290266 | 161159 | 0 | None | -5 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 353 | 12 | 3 | 4 | 2.3 | CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)N1C/C=C/CCCC(=O)O | 10.1016/j.bmcl.2004.01.063 | ||
CHEMBL413509 | 161159 | 0 | None | -5 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 353 | 12 | 3 | 4 | 2.3 | CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)N1C/C=C/CCCC(=O)O | 10.1016/j.bmcl.2004.01.063 | ||
11315933 | 122778 | 4 | None | -218 | 5 | Mouse | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 413 | 7 | 1 | 4 | 4.9 | Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCCc2ccccc2)cc1 | 10.1016/j.bmcl.2004.07.039 | ||
CHEMBL361457 | 122778 | 4 | None | -218 | 5 | Mouse | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 413 | 7 | 1 | 4 | 4.9 | Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCCc2ccccc2)cc1 | 10.1016/j.bmcl.2004.07.039 | ||
9960839 | 205184 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 629 | 9 | 2 | 4 | 6.9 | O=C(NCCCc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 | 10.1016/s0960-894x(99)00465-5 | ||
CHEMBL90935 | 205184 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 629 | 9 | 2 | 4 | 6.9 | O=C(NCCCc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 | 10.1016/s0960-894x(99)00465-5 | ||
23017362 | 198295 | 0 | None | -102 | 4 | Mouse | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 414 | 10 | 1 | 4 | 5.1 | O=C(O)CCCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1 | 10.1016/j.bmc.2009.08.007 | ||
CHEMBL595157 | 198295 | 0 | None | -102 | 4 | Mouse | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 414 | 10 | 1 | 4 | 5.1 | O=C(O)CCCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1 | 10.1016/j.bmc.2009.08.007 | ||
46887090 | 8468 | 0 | None | -6025 | 3 | Mouse | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 503 | 12 | 2 | 4 | 6.4 | COc1ccccc1OCc1ccc(CCC(=O)O)c(C(=O)N[C@H](CC(C)C)c2cc(C)cc(C)c2)c1 | 10.1016/j.bmc.2010.03.028 | ||
CHEMBL1094470 | 8468 | 0 | None | -6025 | 3 | Mouse | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 503 | 12 | 2 | 4 | 6.4 | COc1ccccc1OCc1ccc(CCC(=O)O)c(C(=O)N[C@H](CC(C)C)c2cc(C)cc(C)c2)c1 | 10.1016/j.bmc.2010.03.028 | ||
21362845 | 106420 | 0 | None | -371 | 4 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 556 | 7 | 1 | 5 | 7.3 | O=C(/C=C/c1ccccc1-c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)NS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)00518-8 | ||
CHEMBL314616 | 106420 | 0 | None | -371 | 4 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 556 | 7 | 1 | 5 | 7.3 | O=C(/C=C/c1ccccc1-c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)NS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)00518-8 | ||
57394893 | 70962 | 0 | None | -4466 | 4 | Mouse | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 494 | 10 | 2 | 6 | 4.8 | O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1 | 10.1016/j.bmc.2012.02.018 | ||
CHEMBL1957435 | 70962 | 0 | None | -4466 | 4 | Mouse | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 494 | 10 | 2 | 6 | 4.8 | O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1 | 10.1016/j.bmc.2012.02.018 | ||
57394893 | 70962 | 0 | None | -4466 | 4 | Mouse | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 494 | 10 | 2 | 6 | 4.8 | O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1 | 10.1016/j.bmc.2012.04.008 | ||
CHEMBL1957435 | 70962 | 0 | None | -4466 | 4 | Mouse | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 494 | 10 | 2 | 6 | 4.8 | O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1 | 10.1016/j.bmc.2012.04.008 | ||
11362836 | 136772 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 446 | 12 | 2 | 7 | 3.8 | CC(C)(CCCCF)[C@H](O)/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1 | 10.1016/j.bmcl.2015.12.039 | ||
CHEMBL3752406 | 136772 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 446 | 12 | 2 | 7 | 3.8 | CC(C)(CCCCF)[C@H](O)/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1 | 10.1016/j.bmcl.2015.12.039 | ||
11597294 | 165623 | 4 | None | -5248 | 8 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 435 | 4 | 1 | 2 | 5.7 | O=C(O)C[C@H]1CCc2c1n(Cc1ccc(Cl)cc1)c1c(Br)cc(F)cc21 | 10.1021/jm0603668 | ||
CHEMBL426387 | 165623 | 4 | None | -5248 | 8 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 435 | 4 | 1 | 2 | 5.7 | O=C(O)C[C@H]1CCc2c1n(Cc1ccc(Cl)cc1)c1c(Br)cc(F)cc21 | 10.1021/jm0603668 | ||
10023506 | 69008 | 0 | None | -1737 | 3 | Mouse | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 393 | 11 | 2 | 5 | 2.9 | Cc1cccc(C[C@H](O)/C=C/[C@H]2COC(=O)N2CCSCCCC(=O)O)c1 | 10.1016/j.bmc.2011.12.009 | ||
CHEMBL1929530 | 69008 | 0 | None | -1737 | 3 | Mouse | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 393 | 11 | 2 | 5 | 2.9 | Cc1cccc(C[C@H](O)/C=C/[C@H]2COC(=O)N2CCSCCCC(=O)O)c1 | 10.1016/j.bmc.2011.12.009 | ||
46887058 | 8429 | 0 | None | -27542 | 3 | Mouse | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 507 | 11 | 2 | 3 | 7.1 | Cc1cc(C)cc([C@@H](CC(C)C)NC(=O)c2cc(COc3cccc(Cl)c3)ccc2CCC(=O)O)c1 | 10.1016/j.bmc.2010.03.028 | ||
CHEMBL1094156 | 8429 | 0 | None | -27542 | 3 | Mouse | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 507 | 11 | 2 | 3 | 7.1 | Cc1cc(C)cc([C@@H](CC(C)C)NC(=O)c2cc(COc3cccc(Cl)c3)ccc2CCC(=O)O)c1 | 10.1016/j.bmc.2010.03.028 | ||
46887057 | 8464 | 0 | None | -15135 | 3 | Mouse | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 507 | 11 | 2 | 3 | 7.1 | Cc1cc(C)cc([C@@H](CC(C)C)NC(=O)c2cc(COc3ccccc3Cl)ccc2CCC(=O)O)c1 | 10.1016/j.bmc.2010.03.028 | ||
CHEMBL1094464 | 8464 | 0 | None | -15135 | 3 | Mouse | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 507 | 11 | 2 | 3 | 7.1 | Cc1cc(C)cc([C@@H](CC(C)C)NC(=O)c2cc(COc3ccccc3Cl)ccc2CCC(=O)O)c1 | 10.1016/j.bmc.2010.03.028 | ||
11210487 | 63963 | 0 | None | -5623 | 4 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 356 | 7 | 1 | 2 | 5.5 | O=C(O)/C=C/c1ccccc1/C=C/c1ccccc1OCc1ccccc1 | 10.1016/j.bmcl.2004.11.051 | ||
CHEMBL181035 | 63963 | 0 | None | -5623 | 4 | Human | 4.4 | pKi | = | 4.4 | Binding | ChEMBL | 356 | 7 | 1 | 2 | 5.5 | O=C(O)/C=C/c1ccccc1/C=C/c1ccccc1OCc1ccccc1 | 10.1016/j.bmcl.2004.11.051 | ||
11488860 | 19095 | 0 | None | -10715 | 8 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 497 | 5 | 1 | 4 | 5.7 | C[C@@H](c1ccc(C(F)(F)F)cc1)n1c2c(c3cc(F)cc(S(C)(=O)=O)c31)CCC[C@@H]2CC(=O)O | 10.1016/j.bmcl.2010.10.018 | ||
CHEMBL1290413 | 19095 | 0 | None | -10715 | 8 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 497 | 5 | 1 | 4 | 5.7 | C[C@@H](c1ccc(C(F)(F)F)cc1)n1c2c(c3cc(F)cc(S(C)(=O)=O)c31)CCC[C@@H]2CC(=O)O | 10.1016/j.bmcl.2010.10.018 | ||
21362893 | 204604 | 0 | None | -87 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 535 | 12 | 1 | 6 | 6.0 | Cc1cccc(OCCCOc2ccc(-c3ccccc3CCC(=O)NS(=O)(=O)c3cccs3)cc2)c1 | 10.1016/s0960-894x(02)00518-8 | ||
CHEMBL87263 | 204604 | 0 | None | -87 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 535 | 12 | 1 | 6 | 6.0 | Cc1cccc(OCCCOc2ccc(-c3ccccc3CCC(=O)NS(=O)(=O)c3cccs3)cc2)c1 | 10.1016/s0960-894x(02)00518-8 | ||
10093793 | 69018 | 0 | None | -5248 | 3 | Mouse | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 423 | 12 | 2 | 5 | 3.8 | CCc1cccc(C[C@H](O)/C=C/[C@H]2CSC(=O)N2CCSCCCC(=O)O)c1 | 10.1016/j.bmc.2011.12.009 | ||
CHEMBL1929540 | 69018 | 0 | None | -5248 | 3 | Mouse | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 423 | 12 | 2 | 5 | 3.8 | CCc1cccc(C[C@H](O)/C=C/[C@H]2CSC(=O)N2CCSCCCC(=O)O)c1 | 10.1016/j.bmc.2011.12.009 | ||
9938625 | 205057 | 0 | None | 77 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 600 | 8 | 1 | 4 | 6.7 | O=C(CCc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 | 10.1016/s0960-894x(99)00465-5 | ||
CHEMBL90227 | 205057 | 0 | None | 77 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 600 | 8 | 1 | 4 | 6.7 | O=C(CCc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 | 10.1016/s0960-894x(99)00465-5 | ||
11743212 | 16982 | 0 | None | -15848 | 7 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 426 | 7 | 1 | 3 | 6.8 | O=C(O)C1CC1c1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1 | 10.1016/s0960-894x(03)00794-7 | ||
CHEMBL125588 | 16982 | 0 | None | -15848 | 7 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 426 | 7 | 1 | 3 | 6.8 | O=C(O)C1CC1c1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1 | 10.1016/s0960-894x(03)00794-7 | ||
71452690 | 78215 | 0 | None | -77 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 400 | 9 | 1 | 4 | 5.1 | c1ccc(CCSCc2ccc(-c3ccccc3CCc3nnn[nH]3)cc2)cc1 | 10.1016/s0960-894x(02)00518-8 | ||
CHEMBL2112332 | 78215 | 0 | None | -77 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 400 | 9 | 1 | 4 | 5.1 | c1ccc(CCSCc2ccc(-c3ccccc3CCc3nnn[nH]3)cc2)cc1 | 10.1016/s0960-894x(02)00518-8 | ||
10144273 | 204119 | 0 | None | -407 | 4 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 558 | 8 | 1 | 5 | 7.2 | O=C(CCc1ccccc1-c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)NS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)00518-8 | ||
CHEMBL83450 | 204119 | 0 | None | -407 | 4 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 558 | 8 | 1 | 5 | 7.2 | O=C(CCc1ccccc1-c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)NS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)00518-8 | ||
11306423 | 2489 | 4 | None | 52 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 491 | 6 | 2 | 5 | 6.4 | Clc1ccc(c(c1)c1ccsc1c1cncc(c1)C(C(F)(F)F)(O)O)OCc1ccccc1 | 10.1016/j.bmcl.2004.12.005 | ||
6068 | 2489 | 4 | None | 52 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 491 | 6 | 2 | 5 | 6.4 | Clc1ccc(c(c1)c1ccsc1c1cncc(c1)C(C(F)(F)F)(O)O)OCc1ccccc1 | 10.1016/j.bmcl.2004.12.005 | ||
CHEMBL185346 | 2489 | 4 | None | 52 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 491 | 6 | 2 | 5 | 6.4 | Clc1ccc(c(c1)c1ccsc1c1cncc(c1)C(C(F)(F)F)(O)O)OCc1ccccc1 | 10.1016/j.bmcl.2004.12.005 | ||
44392456 | 63218 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 509 | 8 | 1 | 3 | 8.5 | O=C(Cc1ccccc1)Nc1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2004.12.005 | ||
CHEMBL180046 | 63218 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 509 | 8 | 1 | 3 | 8.5 | O=C(Cc1ccccc1)Nc1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2004.12.005 | ||
15907747 | 205295 | 0 | None | 31 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 684 | 8 | 1 | 5 | 7.2 | CO[C@@](C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)(c1ccccc1)C(F)(F)F | 10.1016/s0960-894x(99)00465-5 | ||
CHEMBL91537 | 205295 | 0 | None | 31 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 684 | 8 | 1 | 5 | 7.2 | CO[C@@](C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)(c1ccccc1)C(F)(F)F | 10.1016/s0960-894x(99)00465-5 | ||
44304057 | 201568 | 0 | None | -14 | 4 | Mouse | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 390 | 13 | 3 | 6 | 2.6 | CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CSCCSCC(=O)O | 10.1016/s0960-894x(01)00364-x | ||
CHEMBL64598 | 201568 | 0 | None | -14 | 4 | Mouse | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 390 | 13 | 3 | 6 | 2.6 | CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CSCCSCC(=O)O | 10.1016/s0960-894x(01)00364-x | ||
11314979 | 65778 | 0 | None | -33 | 4 | Mouse | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 379 | 7 | 1 | 4 | 4.8 | CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3cc(C)ccc32)cc1 | 10.1016/j.bmcl.2004.06.006 | ||
CHEMBL183933 | 65778 | 0 | None | -33 | 4 | Mouse | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 379 | 7 | 1 | 4 | 4.8 | CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3cc(C)ccc32)cc1 | 10.1016/j.bmcl.2004.06.006 | ||
57894092 | 74808 | 0 | None | -25118 | 3 | Mouse | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 494 | 12 | 2 | 6 | 4.5 | O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2nc3ccccc3o2)c1 | 10.1016/j.bmc.2012.04.008 | ||
CHEMBL2036312 | 74808 | 0 | None | -25118 | 3 | Mouse | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 494 | 12 | 2 | 6 | 4.5 | O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2nc3ccccc3o2)c1 | 10.1016/j.bmc.2012.04.008 | ||
23016804 | 8111 | 0 | None | -4168 | 2 | Mouse | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 594 | 11 | 1 | 6 | 5.0 | O=C(CCc1ccc(CN2CCOCC2)cc1OCCc1ccc2ccccc2c1)NS(=O)(=O)c1ccc(F)c(F)c1 | 10.1016/j.bmcl.2010.02.034 | ||
CHEMBL1092097 | 8111 | 0 | None | -4168 | 2 | Mouse | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 594 | 11 | 1 | 6 | 5.0 | O=C(CCc1ccc(CN2CCOCC2)cc1OCCc1ccc2ccccc2c1)NS(=O)(=O)c1ccc(F)c(F)c1 | 10.1016/j.bmcl.2010.02.034 | ||
23017216 | 197480 | 0 | None | -4570 | 4 | Mouse | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 439 | 9 | 2 | 3 | 5.4 | O=C(O)CCc1ccc(COc2ccccc2)cc1C(=O)NCc1cccc2ccccc12 | 10.1016/j.bmc.2009.11.023 | ||
CHEMBL589411 | 197480 | 0 | None | -4570 | 4 | Mouse | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 439 | 9 | 2 | 3 | 5.4 | O=C(O)CCc1ccc(COc2ccccc2)cc1C(=O)NCc1cccc2ccccc12 | 10.1016/j.bmc.2009.11.023 | ||
44290494 | 99811 | 0 | None | -1584 | 2 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 437 | 12 | 2 | 4 | 5.1 | O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(Oc2ccccc2)c1 | 10.1016/j.bmcl.2004.01.063 | ||
CHEMBL288978 | 99811 | 0 | None | -1584 | 2 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 437 | 12 | 2 | 4 | 5.1 | O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(Oc2ccccc2)c1 | 10.1016/j.bmcl.2004.01.063 | ||
44303627 | 201515 | 0 | None | -467 | 2 | Mouse | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 364 | 11 | 3 | 3 | 4.5 | CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC[C@@H]2C/C=C\CCCC(=O)O)CCC1 | 10.1016/s0960-894x(01)00359-6 | ||
CHEMBL64358 | 201515 | 0 | None | -467 | 2 | Mouse | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 364 | 11 | 3 | 3 | 4.5 | CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC[C@@H]2C/C=C\CCCC(=O)O)CCC1 | 10.1016/s0960-894x(01)00359-6 | ||
10137386 | 70960 | 0 | None | -97 | 2 | Mouse | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 427 | 9 | 2 | 3 | 3.7 | O=C(O)Cc1cccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)c1 | 10.1016/j.bmc.2012.02.018 | ||
CHEMBL1957433 | 70960 | 0 | None | -97 | 2 | Mouse | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 427 | 9 | 2 | 3 | 3.7 | O=C(O)Cc1cccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)c1 | 10.1016/j.bmc.2012.02.018 | ||
15491230 | 205244 | 0 | None | - | 1 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 705 | 10 | 1 | 4 | 8.4 | O=C1c2ccccc2CCc2ccccc2N1Cc1ccc(-c2ccccc2S(=O)(=O)N(Cc2ccccc2)C(=O)NCCc2ccccc2)cc1 | 10.1016/s0960-894x(99)00465-5 | ||
CHEMBL91301 | 205244 | 0 | None | - | 1 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 705 | 10 | 1 | 4 | 8.4 | O=C1c2ccccc2CCc2ccccc2N1Cc1ccc(-c2ccccc2S(=O)(=O)N(Cc2ccccc2)C(=O)NCCc2ccccc2)cc1 | 10.1016/s0960-894x(99)00465-5 | ||
44304388 | 201462 | 0 | None | -104 | 5 | Mouse | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 372 | 13 | 3 | 5 | 3.0 | CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O | 10.1016/s0960-894x(01)00365-1 | ||
CHEMBL64187 | 201462 | 0 | None | -104 | 5 | Mouse | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 372 | 13 | 3 | 5 | 3.0 | CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O | 10.1016/s0960-894x(01)00365-1 | ||
44392479 | 64901 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 545 | 9 | 1 | 4 | 8.3 | O=S(=O)(Cc1ccccc1)Nc1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2004.12.005 | ||
CHEMBL182662 | 64901 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 545 | 9 | 1 | 4 | 8.3 | O=S(=O)(Cc1ccccc1)Nc1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2004.12.005 | ||
11187675 | 64883 | 0 | None | -158 | 4 | Mouse | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 365 | 7 | 1 | 4 | 4.4 | CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)cc1 | 10.1016/j.bmcl.2004.06.006 | ||
CHEMBL182572 | 64883 | 0 | None | -158 | 4 | Mouse | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 365 | 7 | 1 | 4 | 4.4 | CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)cc1 | 10.1016/j.bmcl.2004.06.006 | ||
10277744 | 64081 | 0 | None | -186 | 7 | Mouse | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 484 | 6 | 1 | 6 | 4.9 | Cc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 | 10.1016/j.bmc.2011.06.014 | ||
CHEMBL1813116 | 64081 | 0 | None | -186 | 7 | Mouse | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 484 | 6 | 1 | 6 | 4.9 | Cc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 | 10.1016/j.bmc.2011.06.014 | ||
1498314 | 92640 | 9 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 355 | 3 | 2 | 6 | 3.4 | O=C(O)c1csc(-n2nc(-c3ccccc3O)cc2C(F)(F)F)n1 | 10.1016/j.bmcl.2013.09.032 | ||
CHEMBL2442490 | 92640 | 9 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 355 | 3 | 2 | 6 | 3.4 | O=C(O)c1csc(-n2nc(-c3ccccc3O)cc2C(F)(F)F)n1 | 10.1016/j.bmcl.2013.09.032 | ||
46886451 | 8052 | 0 | None | -40738 | 3 | Mouse | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 576 | 11 | 2 | 7 | 4.9 | O=C(CCc1ccc(Cn2cccn2)cc1ONCc1cccc2ccccc12)NS(=O)(=O)c1ccc(F)c(F)c1 | 10.1016/j.bmcl.2010.02.034 | ||
CHEMBL1091743 | 8052 | 0 | None | -40738 | 3 | Mouse | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 576 | 11 | 2 | 7 | 4.9 | O=C(CCc1ccc(Cn2cccn2)cc1ONCc1cccc2ccccc12)NS(=O)(=O)c1ccc(F)c(F)c1 | 10.1016/j.bmcl.2010.02.034 | ||
44304417 | 200425 | 0 | None | -1995 | 4 | Mouse | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 438 | 13 | 3 | 4 | 4.3 | COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)c1 | 10.1016/s0960-894x(01)00365-1 | ||
CHEMBL60894 | 200425 | 0 | None | -1995 | 4 | Mouse | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 438 | 13 | 3 | 4 | 4.3 | COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)c1 | 10.1016/s0960-894x(01)00365-1 | ||
57894063 | 74815 | 0 | None | -3162 | 3 | Mouse | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 524 | 11 | 2 | 7 | 4.8 | COc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1 | 10.1016/j.bmc.2012.04.008 | ||
CHEMBL2036319 | 74815 | 0 | None | -3162 | 3 | Mouse | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 524 | 11 | 2 | 7 | 4.8 | COc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1 | 10.1016/j.bmc.2012.04.008 | ||
23017529 | 8053 | 0 | None | -1047 | 3 | Mouse | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 610 | 12 | 1 | 8 | 4.1 | O=C(CCc1ccc(Cn2cccn2)cc1OCCc1cccc(N2CCOCC2)c1)NS(=O)(=O)c1ccc(F)c(F)c1 | 10.1016/j.bmcl.2010.02.034 | ||
CHEMBL1091744 | 8053 | 0 | None | -1047 | 3 | Mouse | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 610 | 12 | 1 | 8 | 4.1 | O=C(CCc1ccc(Cn2cccn2)cc1OCCc1cccc(N2CCOCC2)c1)NS(=O)(=O)c1ccc(F)c(F)c1 | 10.1016/j.bmcl.2010.02.034 | ||
21974448 | 66629 | 0 | None | -562 | 4 | Mouse | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 429 | 8 | 1 | 5 | 4.7 | Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCCOc2ccccc2)cc1 | 10.1016/j.bmcl.2004.07.039 | ||
CHEMBL186735 | 66629 | 0 | None | -562 | 4 | Mouse | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 429 | 8 | 1 | 5 | 4.7 | Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCCOc2ccccc2)cc1 | 10.1016/j.bmcl.2004.07.039 | ||
9808508 | 111072 | 0 | None | 48 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 586 | 7 | 1 | 4 | 6.3 | O=C(Cc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 | 10.1016/s0960-894x(99)00465-5 | ||
CHEMBL328067 | 111072 | 0 | None | 48 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 586 | 7 | 1 | 4 | 6.3 | O=C(Cc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 | 10.1016/s0960-894x(99)00465-5 | ||
12112239 | 106078 | 0 | None | -16 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 549 | 12 | 1 | 6 | 6.3 | Cc1cccc(OCCCOc2ccc(-c3ccccc3CC(C)C(=O)NS(=O)(=O)c3cccs3)cc2)c1 | 10.1016/s0960-894x(02)00518-8 | ||
CHEMBL314200 | 106078 | 0 | None | -16 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 549 | 12 | 1 | 6 | 6.3 | Cc1cccc(OCCCOc2ccc(-c3ccccc3CC(C)C(=O)NS(=O)(=O)c3cccs3)cc2)c1 | 10.1016/s0960-894x(02)00518-8 | ||
138 | 3032 | 84 | None | -23 | 18 | Mouse | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 10.1016/s0960-894x(01)00365-1 | ||
1882 | 3032 | 84 | None | -23 | 18 | Mouse | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 10.1016/s0960-894x(01)00365-1 | ||
5280723 | 3032 | 84 | None | -23 | 18 | Mouse | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 10.1016/s0960-894x(01)00365-1 | ||
CHEMBL495 | 3032 | 84 | None | -23 | 18 | Mouse | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 10.1016/s0960-894x(01)00365-1 | ||
DB00770 | 3032 | 84 | None | -23 | 18 | Mouse | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 10.1016/s0960-894x(01)00365-1 | ||
10207799 | 64744 | 0 | None | 28 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 475 | 6 | 1 | 4 | 7.3 | OC(c1cncc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1)C(F)(F)F | 10.1016/j.bmcl.2004.12.005 | ||
CHEMBL182368 | 64744 | 0 | None | 28 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 475 | 6 | 1 | 4 | 7.3 | OC(c1cncc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1)C(F)(F)F | 10.1016/j.bmcl.2004.12.005 | ||
44392460 | 123427 | 0 | None | -3 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 421 | 6 | 1 | 4 | 6.4 | O=C(O)c1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2004.12.005 | ||
CHEMBL362851 | 123427 | 0 | None | -3 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 421 | 6 | 1 | 4 | 6.4 | O=C(O)c1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)n1 | 10.1016/j.bmcl.2004.12.005 | ||
1883 | 3033 | 71 | None | -11 | 24 | Mouse | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1016/j.bmcl.2011.10.109 | ||
1916 | 3033 | 71 | None | -11 | 24 | Mouse | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1016/j.bmcl.2011.10.109 | ||
5280360 | 3033 | 71 | None | -11 | 24 | Mouse | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1016/j.bmcl.2011.10.109 | ||
913 | 3033 | 71 | None | -11 | 24 | Mouse | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1016/j.bmcl.2011.10.109 | ||
CHEMBL548 | 3033 | 71 | None | -11 | 24 | Mouse | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1016/j.bmcl.2011.10.109 | ||
DB00917 | 3033 | 71 | None | -11 | 24 | Mouse | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1016/j.bmcl.2011.10.109 | ||
1883 | 3033 | 71 | None | -11 | 24 | Mouse | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1016/j.bmc.2012.02.018 | ||
1916 | 3033 | 71 | None | -11 | 24 | Mouse | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1016/j.bmc.2012.02.018 | ||
5280360 | 3033 | 71 | None | -11 | 24 | Mouse | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1016/j.bmc.2012.02.018 | ||
913 | 3033 | 71 | None | -11 | 24 | Mouse | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1016/j.bmc.2012.02.018 | ||
CHEMBL548 | 3033 | 71 | None | -11 | 24 | Mouse | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1016/j.bmc.2012.02.018 | ||
DB00917 | 3033 | 71 | None | -11 | 24 | Mouse | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1016/j.bmc.2012.02.018 | ||
44304055 | 102250 | 0 | None | -190 | 4 | Mouse | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 390 | 13 | 3 | 6 | 2.7 | CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCSCCC(=O)O | 10.1016/s0960-894x(01)00364-x | ||
CHEMBL304887 | 102250 | 0 | None | -190 | 4 | Mouse | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 390 | 13 | 3 | 6 | 2.7 | CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCSCCC(=O)O | 10.1016/s0960-894x(01)00364-x | ||
9886718 | 201473 | 0 | None | -870 | 4 | Mouse | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 390 | 13 | 3 | 6 | 2.7 | CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O | 10.1016/s0960-894x(01)00364-x | ||
CHEMBL64217 | 201473 | 0 | None | -870 | 4 | Mouse | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 390 | 13 | 3 | 6 | 2.7 | CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O | 10.1016/s0960-894x(01)00364-x | ||
57893982 | 74814 | 0 | None | -14454 | 3 | Mouse | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 508 | 10 | 2 | 6 | 5.1 | Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1 | 10.1016/j.bmc.2012.04.008 | ||
CHEMBL2036318 | 74814 | 0 | None | -14454 | 3 | Mouse | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 508 | 10 | 2 | 6 | 5.1 | Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1 | 10.1016/j.bmc.2012.04.008 | ||
10116114 | 125365 | 0 | None | -1778 | 8 | Mouse | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 470 | 6 | 1 | 6 | 4.5 | Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 | 10.1016/j.bmcl.2004.07.039 | ||
CHEMBL364841 | 125365 | 0 | None | -1778 | 8 | Mouse | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 470 | 6 | 1 | 6 | 4.5 | Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 | 10.1016/j.bmcl.2004.07.039 | ||
10116114 | 125365 | 0 | None | -1778 | 8 | Mouse | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 470 | 6 | 1 | 6 | 4.5 | Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 | 10.1016/j.bmc.2011.06.014 | ||
CHEMBL364841 | 125365 | 0 | None | -1778 | 8 | Mouse | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 470 | 6 | 1 | 6 | 4.5 | Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 | 10.1016/j.bmc.2011.06.014 | ||
10116114 | 125365 | 0 | None | -1778 | 8 | Mouse | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 470 | 6 | 1 | 6 | 4.5 | Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 | 10.1016/j.bmc.2011.08.007 | ||
CHEMBL364841 | 125365 | 0 | None | -1778 | 8 | Mouse | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 470 | 6 | 1 | 6 | 4.5 | Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 | 10.1016/j.bmc.2011.08.007 | ||
1000070 | 159656 | 6 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 422 | 8 | 1 | 3 | 4.1 | CCc1ccccc1N(CC(=O)NCc1ccccc1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL410957 | 159656 | 6 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 422 | 8 | 1 | 3 | 4.1 | CCc1ccccc1N(CC(=O)NCc1ccccc1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
57384034 | 70963 | 0 | None | -7762 | 3 | Mouse | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 528 | 10 | 2 | 6 | 5.4 | O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1 | 10.1016/j.bmc.2012.02.018 | ||
CHEMBL1957436 | 70963 | 0 | None | -7762 | 3 | Mouse | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 528 | 10 | 2 | 6 | 5.4 | O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1 | 10.1016/j.bmc.2012.02.018 | ||
57384034 | 70963 | 0 | None | -7762 | 3 | Mouse | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 528 | 10 | 2 | 6 | 5.4 | O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1 | 10.1016/j.bmc.2012.04.008 | ||
CHEMBL1957436 | 70963 | 0 | None | -7762 | 3 | Mouse | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 528 | 10 | 2 | 6 | 5.4 | O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1 | 10.1016/j.bmc.2012.04.008 | ||
10295336 | 199761 | 0 | None | -58 | 4 | Mouse | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 415 | 8 | 1 | 3 | 4.7 | O=C(O)/C=C/c1ccc(CN2CCCC2=O)cc1OCCc1ccc2ccccc2c1 | 10.1016/j.bmc.2009.08.007 | ||
CHEMBL604897 | 199761 | 0 | None | -58 | 4 | Mouse | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 415 | 8 | 1 | 3 | 4.7 | O=C(O)/C=C/c1ccc(CN2CCCC2=O)cc1OCCc1ccc2ccccc2c1 | 10.1016/j.bmc.2009.08.007 | ||
10348006 | 74940 | 0 | None | -3235 | 3 | Mouse | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 569 | 10 | 2 | 8 | 5.5 | O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4cc(Cl)ccc4o3)c2)n1 | 10.1016/j.bmc.2012.04.008 | ||
CHEMBL2037292 | 74940 | 0 | None | -3235 | 3 | Mouse | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 569 | 10 | 2 | 8 | 5.5 | O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4cc(Cl)ccc4o3)c2)n1 | 10.1016/j.bmc.2012.04.008 | ||
11406789 | 122776 | 0 | None | - | 1 | Mouse | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 395 | 8 | 1 | 5 | 4.5 | CCCCOc1ccccc1C(=O)n1c(C)c(CC(=O)O)c2cc(OC)ccc21 | 10.1016/j.bmcl.2004.06.006 | ||
CHEMBL361452 | 122776 | 0 | None | - | 1 | Mouse | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 395 | 8 | 1 | 5 | 4.5 | CCCCOc1ccccc1C(=O)n1c(C)c(CC(=O)O)c2cc(OC)ccc21 | 10.1016/j.bmcl.2004.06.006 | ||
56665068 | 64493 | 0 | None | -512 | 4 | Mouse | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 500 | 7 | 2 | 5 | 5.1 | CN1C[C@@H](COc2ccc(C(=O)Nc3cc(CC(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21 | 10.1016/j.bmc.2011.08.007 | ||
CHEMBL1819622 | 64493 | 0 | None | -512 | 4 | Mouse | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 500 | 7 | 2 | 5 | 5.1 | CN1C[C@@H](COc2ccc(C(=O)Nc3cc(CC(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21 | 10.1016/j.bmc.2011.08.007 | ||
11155228 | 65775 | 0 | None | -2238 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 452 | 8 | 1 | 2 | 7.2 | Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1c(Cl)cccc1Cl | 10.1016/j.bmcl.2004.11.051 | ||
CHEMBL183919 | 65775 | 0 | None | -2238 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 452 | 8 | 1 | 2 | 7.2 | Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1c(Cl)cccc1Cl | 10.1016/j.bmcl.2004.11.051 | ||
44419347 | 82363 | 0 | None | -2238 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 452 | 8 | 1 | 2 | 7.2 | Cc1ccc(OCc2c(Cl)cccc2Cl)c(/C=C/Cc2ccccc2/C=C/C(=O)O)c1 | 10.1016/j.bmcl.2006.08.025 | ||
CHEMBL217988 | 82363 | 0 | None | -2238 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 452 | 8 | 1 | 2 | 7.2 | Cc1ccc(OCc2c(Cl)cccc2Cl)c(/C=C/Cc2ccccc2/C=C/C(=O)O)c1 | 10.1016/j.bmcl.2006.08.025 | ||
44419351 | 83728 | 0 | None | -120 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 533 | 12 | 1 | 5 | 6.2 | Cc1ccc(OCc2ccccc2)c(CCCc2ccccc2CCC(=O)NS(=O)(=O)c2cccs2)c1 | 10.1016/j.bmcl.2006.08.025 | ||
CHEMBL220821 | 83728 | 0 | None | -120 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 533 | 12 | 1 | 5 | 6.2 | Cc1ccc(OCc2ccccc2)c(CCCc2ccccc2CCC(=O)NS(=O)(=O)c2cccs2)c1 | 10.1016/j.bmcl.2006.08.025 | ||
10348321 | 74821 | 0 | None | -2691 | 3 | Mouse | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 585 | 10 | 2 | 8 | 6.0 | O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4cc(Cl)ccc4s3)c2)n1 | 10.1016/j.bmc.2012.04.008 | ||
CHEMBL2036325 | 74821 | 0 | None | -2691 | 3 | Mouse | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 585 | 10 | 2 | 8 | 6.0 | O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4cc(Cl)ccc4s3)c2)n1 | 10.1016/j.bmc.2012.04.008 | ||
9965922 | 63546 | 0 | None | -6760 | 4 | Human | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 294 | 5 | 2 | 2 | 4.1 | Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1O | 10.1016/j.bmcl.2004.11.051 | ||
CHEMBL180389 | 63546 | 0 | None | -6760 | 4 | Human | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 294 | 5 | 2 | 2 | 4.1 | Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1O | 10.1016/j.bmcl.2004.11.051 | ||
71458758 | 120349 | 0 | None | -512 | 4 | Human | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 615 | 14 | 1 | 4 | 7.8 | COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCC[n+]1c(C)cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc1C | 10.1021/ml300191g | ||
CHEMBL2164612 | 120349 | 0 | None | -512 | 4 | Human | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 615 | 14 | 1 | 4 | 7.8 | COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCC[n+]1c(C)cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc1C | 10.1021/ml300191g | ||
CHEMBL3558858 | 120349 | 0 | None | -512 | 4 | Human | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 615 | 14 | 1 | 4 | 7.8 | COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCC[n+]1c(C)cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc1C | 10.1021/ml300191g | ||
9868012 | 123331 | 0 | None | 50 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 420 | 6 | 1 | 3 | 7.0 | O=C(O)c1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2004.12.005 | ||
CHEMBL362543 | 123331 | 0 | None | 50 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 420 | 6 | 1 | 3 | 7.0 | O=C(O)c1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2004.12.005 | ||
52944194 | 16366 | 0 | None | -549 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 936 | 18 | 4 | 6 | 12.8 | O=C(O)/C=C/c1ccccc1/C=C/Cc1cccc(CO)c1OCc1c(Cl)cccc1Cl.O=C(O)/C=C/c1ccccc1C/C=C/c1cccc(CO)c1OCc1c(Cl)cccc1Cl | 10.1016/j.bmcl.2004.11.051 | ||
CHEMBL1237305 | 16366 | 0 | None | -549 | 4 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 936 | 18 | 4 | 6 | 12.8 | O=C(O)/C=C/c1ccccc1/C=C/Cc1cccc(CO)c1OCc1c(Cl)cccc1Cl.O=C(O)/C=C/c1ccccc1C/C=C/c1cccc(CO)c1OCc1c(Cl)cccc1Cl | 10.1016/j.bmcl.2004.11.051 | ||
57894108 | 74806 | 0 | None | -1621 | 2 | Mouse | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 494 | 12 | 2 | 5 | 4.3 | O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(N2Cc3ccccc3C2)c1 | 10.1016/j.bmc.2012.04.008 | ||
CHEMBL2036310 | 74806 | 0 | None | -1621 | 2 | Mouse | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 494 | 12 | 2 | 5 | 4.3 | O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(N2Cc3ccccc3C2)c1 | 10.1016/j.bmc.2012.04.008 | ||
10157813 | 199931 | 0 | None | -446 | 4 | Mouse | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 400 | 9 | 1 | 4 | 4.7 | O=C(O)CCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1 | 10.1016/j.bmc.2009.08.007 | ||
CHEMBL605833 | 199931 | 0 | None | -446 | 4 | Mouse | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 400 | 9 | 1 | 4 | 4.7 | O=C(O)CCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1 | 10.1016/j.bmc.2009.08.007 | ||
44392479 | 64901 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 545 | 9 | 1 | 4 | 8.3 | O=S(=O)(Cc1ccccc1)Nc1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2004.12.005 | ||
CHEMBL182662 | 64901 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 545 | 9 | 1 | 4 | 8.3 | O=S(=O)(Cc1ccccc1)Nc1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2004.12.005 | ||
12112238 | 117568 | 0 | None | -870 | 4 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 406 | 7 | 1 | 2 | 6.7 | O=C(O)/C=C/c1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1 | 10.1016/s0960-894x(03)00794-7 | ||
CHEMBL340501 | 117568 | 0 | None | -870 | 4 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 406 | 7 | 1 | 2 | 6.7 | O=C(O)/C=C/c1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1 | 10.1016/s0960-894x(03)00794-7 | ||
44320294 | 105527 | 0 | None | -12 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 557 | 12 | 1 | 6 | 5.7 | O=S(=O)(CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)00518-8 | ||
CHEMBL313266 | 105527 | 0 | None | -12 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 557 | 12 | 1 | 6 | 5.7 | O=S(=O)(CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)00518-8 | ||
9959673 | 204740 | 0 | None | 1 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 567 | 5 | 2 | 4 | 6.1 | CC(C)(C)NC(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 | 10.1016/s0960-894x(99)00465-5 | ||
CHEMBL88154 | 204740 | 0 | None | 1 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 567 | 5 | 2 | 4 | 6.1 | CC(C)(C)NC(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 | 10.1016/s0960-894x(99)00465-5 | ||
21974464 | 66669 | 0 | None | -45 | 4 | Mouse | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 427 | 8 | 1 | 4 | 5.3 | Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCCCc2ccccc2)cc1 | 10.1016/j.bmcl.2004.07.039 | ||
CHEMBL186925 | 66669 | 0 | None | -45 | 4 | Mouse | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 427 | 8 | 1 | 4 | 5.3 | Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCCCc2ccccc2)cc1 | 10.1016/j.bmcl.2004.07.039 | ||
58932678 | 74938 | 0 | None | -37153 | 3 | Mouse | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 549 | 10 | 2 | 8 | 5.2 | Cc1cccc2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc12 | 10.1016/j.bmc.2012.04.008 | ||
CHEMBL2037290 | 74938 | 0 | None | -37153 | 3 | Mouse | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 549 | 10 | 2 | 8 | 5.2 | Cc1cccc2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc12 | 10.1016/j.bmc.2012.04.008 | ||
21974328 | 65938 | 0 | None | -83 | 5 | Mouse | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 443 | 6 | 1 | 6 | 4.4 | Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2Oc3ccccc3O2)cc1 | 10.1016/j.bmcl.2004.07.039 | ||
CHEMBL184684 | 65938 | 0 | None | -83 | 5 | Mouse | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 443 | 6 | 1 | 6 | 4.4 | Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2Oc3ccccc3O2)cc1 | 10.1016/j.bmcl.2004.07.039 | ||
44303711 | 101882 | 0 | None | -18 | 3 | Mouse | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 406 | 13 | 3 | 4 | 4.4 | CCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1 | 10.1016/s0960-894x(01)00359-6 | ||
CHEMBL303763 | 101882 | 0 | None | -18 | 3 | Mouse | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 406 | 13 | 3 | 4 | 4.4 | CCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1 | 10.1016/s0960-894x(01)00359-6 | ||
21974528 | 123931 | 0 | None | -389 | 5 | Mouse | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 441 | 6 | 1 | 5 | 4.6 | Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2Cc3ccccc3O2)cc1 | 10.1016/j.bmcl.2004.07.039 | ||
CHEMBL363984 | 123931 | 0 | None | -389 | 5 | Mouse | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 441 | 6 | 1 | 5 | 4.6 | Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2Cc3ccccc3O2)cc1 | 10.1016/j.bmcl.2004.07.039 | ||
44439606 | 90930 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 452 | 9 | 1 | 4 | 4.1 | CCc1ccccc1N(CC(=O)NCc1cccc(OC)c1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL240247 | 90930 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 452 | 9 | 1 | 4 | 4.1 | CCc1ccccc1N(CC(=O)NCc1cccc(OC)c1)S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
44439621 | 91338 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 443 | 7 | 1 | 4 | 3.9 | Cc1ccc(S(=O)(=O)N(CC(=O)NCc2ccc(Cl)cc2)c2ncccc2C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
CHEMBL241076 | 91338 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 443 | 7 | 1 | 4 | 3.9 | Cc1ccc(S(=O)(=O)N(CC(=O)NCc2ccc(Cl)cc2)c2ncccc2C)cc1 | 10.1016/j.bmcl.2006.12.060 | ||
11374485 | 78559 | 0 | None | 32 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 455 | 6 | 1 | 4 | 6.0 | NS(=O)(=O)c1cccc(-c2ccsc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2004.12.005 | ||
CHEMBL2113029 | 78559 | 0 | None | 32 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 455 | 6 | 1 | 4 | 6.0 | NS(=O)(=O)c1cccc(-c2ccsc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2004.12.005 | ||
59179260 | 103407 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 362 | 4 | 2 | 6 | 3.9 | Nc1c(-c2ccccc2)nn(-c2nc(C(=O)O)cs2)c1-c1ccccc1 | 10.1016/j.bmcl.2013.10.065 | ||
CHEMBL3092130 | 103407 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 362 | 4 | 2 | 6 | 3.9 | Nc1c(-c2ccccc2)nn(-c2nc(C(=O)O)cs2)c1-c1ccccc1 | 10.1016/j.bmcl.2013.10.065 | ||
57894053 | 74820 | 0 | None | -41686 | 3 | Mouse | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 551 | 10 | 2 | 8 | 5.4 | O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4s3)c2)n1 | 10.1016/j.bmc.2012.04.008 | ||
CHEMBL2036324 | 74820 | 0 | None | -41686 | 3 | Mouse | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 551 | 10 | 2 | 8 | 5.4 | O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4s3)c2)n1 | 10.1016/j.bmc.2012.04.008 | ||
66858111 | 136926 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 488 | 11 | 2 | 7 | 4.5 | O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCc3ccccc3)CCC2)n1 | 10.1016/j.bmcl.2015.12.039 | ||
CHEMBL3753622 | 136926 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 488 | 11 | 2 | 7 | 4.5 | O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCc3ccccc3)CCC2)n1 | 10.1016/j.bmcl.2015.12.039 | ||
10181606 | 204628 | 0 | None | -323 | 7 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 437 | 5 | 1 | 4 | 5.2 | O=C(/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1)NS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(03)00794-7 | ||
CHEMBL87371 | 204628 | 0 | None | -323 | 7 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 437 | 5 | 1 | 4 | 5.2 | O=C(/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1)NS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(03)00794-7 | ||
10118889 | 204550 | 0 | None | -30 | 4 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 521 | 11 | 1 | 5 | 6.3 | O=C(CCc1ccccc1-c1cccc(CSCCc2ccccc2)c1)NS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)00518-8 | ||
CHEMBL86933 | 204550 | 0 | None | -30 | 4 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 521 | 11 | 1 | 5 | 6.3 | O=C(CCc1ccccc1-c1cccc(CSCCc2ccccc2)c1)NS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)00518-8 | ||
10181606 | 204628 | 0 | None | -323 | 7 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 437 | 5 | 1 | 4 | 5.2 | O=C(/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1)NS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)00518-8 | ||
CHEMBL87371 | 204628 | 0 | None | -323 | 7 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 437 | 5 | 1 | 4 | 5.2 | O=C(/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1)NS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)00518-8 | ||
44320433 | 167380 | 0 | None | 6 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 521 | 11 | 1 | 5 | 6.3 | O=C(CCc1ccccc1-c1ccccc1CSCCc1ccccc1)NS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)00518-8 | ||
CHEMBL431612 | 167380 | 0 | None | 6 | 4 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 521 | 11 | 1 | 5 | 6.3 | O=C(CCc1ccccc1-c1ccccc1CSCCc1ccccc1)NS(=O)(=O)c1cccs1 | 10.1016/s0960-894x(02)00518-8 | ||
21362851 | 116404 | 0 | None | -151 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 408 | 8 | 1 | 2 | 6.6 | O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1 | 10.1016/s0960-894x(03)00794-7 | ||
CHEMBL338388 | 116404 | 0 | None | -151 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 408 | 8 | 1 | 2 | 6.6 | O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1 | 10.1016/s0960-894x(03)00794-7 | ||
21362849 | 167765 | 0 | None | -10 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 422 | 8 | 1 | 2 | 6.9 | CC(Cc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1)C(=O)O | 10.1016/s0960-894x(03)00794-7 | ||
CHEMBL434247 | 167765 | 0 | None | -10 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 422 | 8 | 1 | 2 | 6.9 | CC(Cc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1)C(=O)O | 10.1016/s0960-894x(03)00794-7 | ||
127026652 | 136957 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 456 | 12 | 2 | 8 | 3.3 | CCOCCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1 | 10.1016/j.bmcl.2015.12.039 | ||
CHEMBL3753898 | 136957 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 456 | 12 | 2 | 8 | 3.3 | CCOCCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1 | 10.1016/j.bmcl.2015.12.039 | ||
22009006 | 141032 | 0 | None | -1698 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 409 | 7 | 1 | 4 | 4.5 | O=C(/C=C/c1ccccc1/C=C/Cc1ccccc1)NS(=O)(=O)c1cccs1 | 10.1016/j.bmcl.2006.08.025 | ||
CHEMBL384878 | 141032 | 0 | None | -1698 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 409 | 7 | 1 | 4 | 4.5 | O=C(/C=C/c1ccccc1/C=C/Cc1ccccc1)NS(=O)(=O)c1cccs1 | 10.1016/j.bmcl.2006.08.025 | ||
9953337 | 141128 | 0 | None | -1698 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 409 | 7 | 1 | 4 | 4.5 | O=C(/C=C/c1ccccc1C/C=C/c1ccccc1)NS(=O)(=O)c1cccs1 | 10.1016/j.bmcl.2006.08.025 | ||
CHEMBL385396 | 141128 | 0 | None | -1698 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 409 | 7 | 1 | 4 | 4.5 | O=C(/C=C/c1ccccc1C/C=C/c1ccccc1)NS(=O)(=O)c1cccs1 | 10.1016/j.bmcl.2006.08.025 | ||
44349551 | 16635 | 0 | None | -1621 | 4 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 415 | 8 | 2 | 4 | 6.2 | O=C(O)CNc1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1 | 10.1016/s0960-894x(03)00794-7 | ||
CHEMBL124675 | 16635 | 0 | None | -1621 | 4 | Human | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 415 | 8 | 2 | 4 | 6.2 | O=C(O)CNc1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1 | 10.1016/s0960-894x(03)00794-7 | ||
44320373 | 204527 | 0 | None | -60 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 376 | 9 | 1 | 2 | 5.8 | O=C(O)CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1 | 10.1016/s0960-894x(02)00518-8 | ||
CHEMBL86799 | 204527 | 0 | None | -60 | 4 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 376 | 9 | 1 | 2 | 5.8 | O=C(O)CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1 | 10.1016/s0960-894x(02)00518-8 | ||
1498200 | 92635 | 8 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 369 | 4 | 1 | 6 | 3.7 | COc1ccc(-c2cc(C(F)(F)F)nn2-c2nc(C(=O)O)cs2)cc1 | 10.1016/j.bmcl.2013.09.032 | ||
CHEMBL2442485 | 92635 | 8 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 369 | 4 | 1 | 6 | 3.7 | COc1ccc(-c2cc(C(F)(F)F)nn2-c2nc(C(=O)O)cs2)cc1 | 10.1016/j.bmcl.2013.09.032 | ||
10413031 | 8862 | 0 | None | -23988 | 3 | Mouse | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 483 | 10 | 3 | 4 | 6.5 | Cc1cc(C)cc([C@@H](CC(C)C)NC(=O)c2cc(Nc3cccc(C#N)c3)ccc2CCC(=O)O)c1 | 10.1016/j.bmc.2010.03.028 | ||
CHEMBL1098047 | 8862 | 0 | None | -23988 | 3 | Mouse | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 483 | 10 | 3 | 4 | 6.5 | Cc1cc(C)cc([C@@H](CC(C)C)NC(=O)c2cc(Nc3cccc(C#N)c3)ccc2CCC(=O)O)c1 | 10.1016/j.bmc.2010.03.028 | ||
66857670 | 136876 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 436 | 9 | 2 | 7 | 3.3 | CC#CCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1 | 10.1016/j.bmcl.2015.12.039 | ||
CHEMBL3753268 | 136876 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 436 | 9 | 2 | 7 | 3.3 | CC#CCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1 | 10.1016/j.bmcl.2015.12.039 | ||
44392527 | 122386 | 0 | None | 97 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 524 | 8 | 1 | 4 | 8.2 | CC(NC(=O)c1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1)c1cccnc1 | 10.1016/j.bmcl.2004.12.005 | ||
CHEMBL360592 | 122386 | 0 | None | 97 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 524 | 8 | 1 | 4 | 8.2 | CC(NC(=O)c1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1)c1cccnc1 | 10.1016/j.bmcl.2004.12.005 | ||
1883 | 3033 | 71 | None | -12 | 24 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1016/j.bmcl.2007.11.020 | ||
1916 | 3033 | 71 | None | -12 | 24 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1016/j.bmcl.2007.11.020 | ||
5280360 | 3033 | 71 | None | -12 | 24 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1016/j.bmcl.2007.11.020 | ||
913 | 3033 | 71 | None | -12 | 24 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1016/j.bmcl.2007.11.020 | ||
CHEMBL548 | 3033 | 71 | None | -12 | 24 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1016/j.bmcl.2007.11.020 | ||
DB00917 | 3033 | 71 | None | -12 | 24 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1016/j.bmcl.2007.11.020 | ||
1883 | 3033 | 71 | None | -12 | 24 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1016/j.bmcl.2007.05.025 | ||
1916 | 3033 | 71 | None | -12 | 24 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1016/j.bmcl.2007.05.025 | ||
5280360 | 3033 | 71 | None | -12 | 24 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1016/j.bmcl.2007.05.025 | ||
913 | 3033 | 71 | None | -12 | 24 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1016/j.bmcl.2007.05.025 | ||
CHEMBL548 | 3033 | 71 | None | -12 | 24 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1016/j.bmcl.2007.05.025 | ||
DB00917 | 3033 | 71 | None | -12 | 24 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10.1016/j.bmcl.2007.05.025 | ||
9953978 | 65987 | 0 | None | 14 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 421 | 6 | 1 | 4 | 6.4 | O=C(O)c1cncc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2004.12.005 | ||
CHEMBL184947 | 65987 | 0 | None | 14 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 421 | 6 | 1 | 4 | 6.4 | O=C(O)c1cncc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | 10.1016/j.bmcl.2004.12.005 | ||
44349531 | 16388 | 0 | None | -8 | 4 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 394 | 7 | 1 | 2 | 6.2 | O=C(O)Cc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1 | 10.1016/s0960-894x(03)00794-7 | ||
CHEMBL123844 | 16388 | 0 | None | -8 | 4 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 394 | 7 | 1 | 2 | 6.2 | O=C(O)Cc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1 | 10.1016/s0960-894x(03)00794-7 | ||
44304334 | 199891 | 0 | None | -47 | 5 | Mouse | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 372 | 13 | 3 | 5 | 3.0 | CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CSCCCCC(=O)O | 10.1016/s0960-894x(01)00365-1 | ||
CHEMBL60555 | 199891 | 0 | None | -47 | 5 | Mouse | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 372 | 13 | 3 | 5 | 3.0 | CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CSCCCCC(=O)O | 10.1016/s0960-894x(01)00365-1 | ||
21362853 | 18346 | 0 | None | -107 | 4 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 408 | 8 | 1 | 2 | 6.6 | O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2COc2ccccc2)c1 | 10.1016/s0960-894x(03)00794-7 | ||
CHEMBL127482 | 18346 | 0 | None | -107 | 4 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 408 | 8 | 1 | 2 | 6.6 | O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2COc2ccccc2)c1 | 10.1016/s0960-894x(03)00794-7 | ||
9954562 | 83722 | 0 | None | -537 | 4 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 433 | 6 | 1 | 4 | 5.0 | O=C(/C=C/c1ccccc1Cc1ccc2ccccc2c1)NS(=O)(=O)c1cccs1 | 10.1016/j.bmcl.2006.08.025 | ||
CHEMBL220802 | 83722 | 0 | None | -537 | 4 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 433 | 6 | 1 | 4 | 5.0 | O=C(/C=C/c1ccccc1Cc1ccc2ccccc2c1)NS(=O)(=O)c1cccs1 | 10.1016/j.bmcl.2006.08.025 | ||
44219292 | 112090 | 30 | None | -3162 | 7 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 431 | 8 | 1 | 4 | 5.5 | O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 | 10.1021/acs.jmedchem.6b00871 | ||
CHEMBL3301604 | 112090 | 30 | None | -3162 | 7 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 431 | 8 | 1 | 4 | 5.5 | O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 | 10.1021/acs.jmedchem.6b00871 | ||
5855 | 1615 | 4 | None | -1071 | 4 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 447 | 7 | 2 | 5 | 4.3 | OC(=O)COc1cccc2c1CC[C@](C2)(O)COC(=O)N(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2005.04.047 | ||
9911469 | 1615 | 4 | None | -1071 | 4 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 447 | 7 | 2 | 5 | 4.3 | OC(=O)COc1cccc2c1CC[C@](C2)(O)COC(=O)N(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2005.04.047 | ||
CHEMBL196779 | 1615 | 4 | None | -1071 | 4 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 447 | 7 | 2 | 5 | 4.3 | OC(=O)COc1cccc2c1CC[C@](C2)(O)COC(=O)N(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2005.04.047 | ||
44304404 | 100115 | 0 | None | -1949 | 4 | Mouse | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 436 | 12 | 3 | 4 | 4.1 | COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C/CCCC(=O)O)c1 | 10.1016/s0960-894x(01)00365-1 | ||
CHEMBL291630 | 100115 | 0 | None | -1949 | 4 | Mouse | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 436 | 12 | 3 | 4 | 4.1 | COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C/CCCC(=O)O)c1 | 10.1016/s0960-894x(01)00365-1 | ||
1884 | 3034 | 46 | None | -169 | 22 | Human | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | None | ||
5280363 | 3034 | 46 | None | -169 | 22 | Human | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | None | ||
912 | 3034 | 46 | None | -169 | 22 | Human | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | None | ||
CHEMBL815 | 3034 | 46 | None | -169 | 22 | Human | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | None | ||
DB12789 | 3034 | 46 | None | -169 | 22 | Human | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | None | ||
1883 | 3033 | 71 | None | -12 | 24 | Human | 7.8 | pKd | = | 7.8 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10634944 | ||
1883 | 3033 | 71 | None | -12 | 24 | Human | 7.8 | pKd | = | 7.8 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 11999132 | ||
1883 | 3033 | 71 | None | -12 | 24 | Human | 7.8 | pKd | = | 7.8 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 16604093 | ||
1916 | 3033 | 71 | None | -12 | 24 | Human | 7.8 | pKd | = | 7.8 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10634944 | ||
1916 | 3033 | 71 | None | -12 | 24 | Human | 7.8 | pKd | = | 7.8 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 11999132 | ||
1916 | 3033 | 71 | None | -12 | 24 | Human | 7.8 | pKd | = | 7.8 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 16604093 | ||
5280360 | 3033 | 71 | None | -12 | 24 | Human | 7.8 | pKd | = | 7.8 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10634944 | ||
5280360 | 3033 | 71 | None | -12 | 24 | Human | 7.8 | pKd | = | 7.8 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 11999132 | ||
5280360 | 3033 | 71 | None | -12 | 24 | Human | 7.8 | pKd | = | 7.8 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 16604093 | ||
913 | 3033 | 71 | None | -12 | 24 | Human | 7.8 | pKd | = | 7.8 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10634944 | ||
913 | 3033 | 71 | None | -12 | 24 | Human | 7.8 | pKd | = | 7.8 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 11999132 | ||
913 | 3033 | 71 | None | -12 | 24 | Human | 7.8 | pKd | = | 7.8 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 16604093 | ||
CHEMBL548 | 3033 | 71 | None | -12 | 24 | Human | 7.8 | pKd | = | 7.8 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10634944 | ||
CHEMBL548 | 3033 | 71 | None | -12 | 24 | Human | 7.8 | pKd | = | 7.8 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 11999132 | ||
CHEMBL548 | 3033 | 71 | None | -12 | 24 | Human | 7.8 | pKd | = | 7.8 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 16604093 | ||
DB00917 | 3033 | 71 | None | -12 | 24 | Human | 7.8 | pKd | = | 7.8 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10634944 | ||
DB00917 | 3033 | 71 | None | -12 | 24 | Human | 7.8 | pKd | = | 7.8 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 11999132 | ||
DB00917 | 3033 | 71 | None | -12 | 24 | Human | 7.8 | pKd | = | 7.8 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 16604093 | ||
1883 | 3033 | 71 | None | -17 | 24 | Rat | 7.5 | pKd | None | 7.5 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 8940129 | ||
1883 | 3033 | 71 | None | -17 | 24 | Rat | 7.5 | pKd | None | 7.5 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 9537820 | ||
1916 | 3033 | 71 | None | -17 | 24 | Rat | 7.5 | pKd | None | 7.5 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 8940129 | ||
1916 | 3033 | 71 | None | -17 | 24 | Rat | 7.5 | pKd | None | 7.5 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 9537820 | ||
5280360 | 3033 | 71 | None | -17 | 24 | Rat | 7.5 | pKd | None | 7.5 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 8940129 | ||
5280360 | 3033 | 71 | None | -17 | 24 | Rat | 7.5 | pKd | None | 7.5 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 9537820 | ||
913 | 3033 | 71 | None | -17 | 24 | Rat | 7.5 | pKd | None | 7.5 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 8940129 | ||
913 | 3033 | 71 | None | -17 | 24 | Rat | 7.5 | pKd | None | 7.5 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 9537820 | ||
CHEMBL548 | 3033 | 71 | None | -17 | 24 | Rat | 7.5 | pKd | None | 7.5 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 8940129 | ||
CHEMBL548 | 3033 | 71 | None | -17 | 24 | Rat | 7.5 | pKd | None | 7.5 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 9537820 | ||
DB00917 | 3033 | 71 | None | -17 | 24 | Rat | 7.5 | pKd | None | 7.5 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 8940129 | ||
DB00917 | 3033 | 71 | None | -17 | 24 | Rat | 7.5 | pKd | None | 7.5 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 9537820 | ||
None | 214666 | 0 | 3H-PGE2 | -6 | 6 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 384 | 9 | 3 | 3 | 4.3 | C1CCC(CC1)C(C=CC2C(CC(C2CC=CCCCC(=O)O)Cl)O)O | None | ||
119304 | 741 | 0 | 3H-PGE2 | -14125 | 9 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 368 | 11 | 3 | 4 | 2.7 | OC(=O)CCCCCCC1C(=O)NC(=O)N1CCC(C1CCCCC1)O | None | ||
1878 | 741 | 0 | 3H-PGE2 | -14125 | 9 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 368 | 11 | 3 | 4 | 2.7 | OC(=O)CCCCCCC1C(=O)NC(=O)N1CCC(C1CCCCC1)O | None | ||
40481312 | 741 | 0 | 3H-PGE2 | -14125 | 9 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 368 | 11 | 3 | 4 | 2.7 | OC(=O)CCCCCCC1C(=O)NC(=O)N1CCC(C1CCCCC1)O | None | ||
CHEMBL575504 | 741 | 0 | 3H-PGE2 | -14125 | 9 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 368 | 11 | 3 | 4 | 2.7 | OC(=O)CCCCCCC1C(=O)NC(=O)N1CCC(C1CCCCC1)O | None | ||
1940 | 1633 | 38 | 3H-PGE2 | -4168 | 10 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 458 | 11 | 4 | 5 | 3.6 | OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O | None | ||
3417 | 1633 | 38 | 3H-PGE2 | -4168 | 10 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 458 | 11 | 4 | 5 | 3.6 | OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O | None | ||
5311100 | 1633 | 38 | 3H-PGE2 | -4168 | 10 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 458 | 11 | 4 | 5 | 3.6 | OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O | None | ||
CHEMBL1201379 | 1633 | 38 | 3H-PGE2 | -4168 | 10 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 458 | 11 | 4 | 5 | 3.6 | OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O | None | ||
DB11519 | 1633 | 38 | 3H-PGE2 | -4168 | 10 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 458 | 11 | 4 | 5 | 3.6 | OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O | None | ||
1817 | 2506 | 60 | 3H-PGE2 | -269 | 12 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 382 | 13 | 2 | 5 | 4.0 | CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C | None | ||
1936 | 2506 | 60 | 3H-PGE2 | -269 | 12 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 382 | 13 | 2 | 5 | 4.0 | CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C | None | ||
5282381 | 2506 | 60 | 3H-PGE2 | -269 | 12 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 382 | 13 | 2 | 5 | 4.0 | CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C | None | ||
CHEMBL606 | 2506 | 60 | 3H-PGE2 | -269 | 12 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 382 | 13 | 2 | 5 | 4.0 | CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C | None | ||
DB00929 | 2506 | 60 | 3H-PGE2 | -269 | 12 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 382 | 13 | 2 | 5 | 4.0 | CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C | None | ||
1980 | 3605 | 0 | 3H-PGE2 | -10000 | 9 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 387 | 10 | 4 | 4 | 3.3 | O=C(Nc1ccccc1)NNC[C@@H]1[C@@H]2CC[C@H]([C@@H]1C/C=C\CCCC(=O)O)O2 | None | ||
1985 | 3605 | 0 | 3H-PGE2 | -10000 | 9 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 387 | 10 | 4 | 4 | 3.3 | O=C(Nc1ccccc1)NNC[C@@H]1[C@@H]2CC[C@H]([C@@H]1C/C=C\CCCC(=O)O)O2 | None | ||
6437074 | 3605 | 0 | 3H-PGE2 | -10000 | 9 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 387 | 10 | 4 | 4 | 3.3 | O=C(Nc1ccccc1)NNC[C@@H]1[C@@H]2CC[C@H]([C@@H]1C/C=C\CCCC(=O)O)O2 | None | ||
1888 | 3837 | 26 | 3H-PGE2 | -707 | 17 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 350 | 12 | 2 | 3 | 4.3 | CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O | None | ||
1974 | 3837 | 26 | 3H-PGE2 | -707 | 17 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 350 | 12 | 2 | 3 | 4.3 | CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O | None | ||
5311493 | 3837 | 26 | 3H-PGE2 | -707 | 17 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 350 | 12 | 2 | 3 | 4.3 | CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O | None | ||
CHEMBL521784 | 3837 | 26 | 3H-PGE2 | -707 | 17 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 350 | 12 | 2 | 3 | 4.3 | CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O | None | ||
5311035 | 97354 | 27 | 3H-PGE2 | -91 | 9 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 408 | 13 | 2 | 5 | 4.3 | CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 | None | ||
CHEMBL271896 | 97354 | 27 | 3H-PGE2 | -91 | 9 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 408 | 13 | 2 | 5 | 4.3 | CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 | None | ||
None | 214667 | 0 | 3H-PGE2 | -10 | 6 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 477 | 11 | 1 | 5 | 5.1 | C1CC(=O)CC1CCC(=CCC(C(=O)O)N2CCOCC2)OCC3=CC=C(C=C3)C4=CC=CC=C4 | None | ||
134689669 | 214279 | 0 | 3H-PGE2 | -15 | 12 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 465 | 12 | 3 | 7 | 1.7 | CS(=O)(=O)NC(=O)CCCC=CCC1C(C(CC1=O)O)C=CC(COC2=CC=CC=C2)O | None | ||
89077401 | 214273 | 0 | 3H-PGE2 | 1 | 12 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 360 | 8 | 3 | 3 | 3.5 | CC#CCC(C)C(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O | None | ||
1913 | 2429 | 0 | 3H-PGE2 | -870 | 15 | Mouse | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 374 | 12 | 2 | 4 | 4.0 | OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O | None | ||
5311223 | 2429 | 0 | 3H-PGE2 | -870 | 15 | Mouse | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 374 | 12 | 2 | 4 | 4.0 | OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O | None | ||
1817 | 2506 | 60 | 3H-PGE2 | -3 | 12 | Mouse | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 382 | 13 | 2 | 5 | 4.0 | CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C | None | ||
1936 | 2506 | 60 | 3H-PGE2 | -3 | 12 | Mouse | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 382 | 13 | 2 | 5 | 4.0 | CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C | None | ||
5282381 | 2506 | 60 | 3H-PGE2 | -3 | 12 | Mouse | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 382 | 13 | 2 | 5 | 4.0 | CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C | None | ||
CHEMBL606 | 2506 | 60 | 3H-PGE2 | -3 | 12 | Mouse | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 382 | 13 | 2 | 5 | 4.0 | CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C | None | ||
DB00929 | 2506 | 60 | 3H-PGE2 | -3 | 12 | Mouse | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 382 | 13 | 2 | 5 | 4.0 | CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C | None | ||
119461 | 317 | 66 | 3H-PGE2 | -3 | 10 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 298 | 3 | 1 | 4 | 3.4 | CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C | None | ||
1896 | 317 | 66 | 3H-PGE2 | -3 | 10 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 298 | 3 | 1 | 4 | 3.4 | CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C | None | ||
CHEMBL1317823 | 317 | 66 | 3H-PGE2 | -3 | 10 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 298 | 3 | 1 | 4 | 3.4 | CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C | None | ||
1884 | 3034 | 46 | 3H-PGE2 | -64 | 22 | Mouse | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | None | ||
5280363 | 3034 | 46 | 3H-PGE2 | -64 | 22 | Mouse | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | None | ||
912 | 3034 | 46 | 3H-PGE2 | -64 | 22 | Mouse | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | None | ||
CHEMBL815 | 3034 | 46 | 3H-PGE2 | -64 | 22 | Mouse | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | None | ||
DB12789 | 3034 | 46 | 3H-PGE2 | -64 | 22 | Mouse | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | None | ||
132748 | 214665 | 0 | 3H-PGE2 | 7 | 6 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 458 | 3 | 2 | 4 | 4.6 | C1C2=CC=CC=C2OC3=C(N1C(=O)NNC(=O)CCC4=CC=NC=C4)C=C(C=C3)Cl.Cl | None | ||
1917 | 914 | 0 | 3H-PGE2 | -22 | 9 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 374 | 6 | 3 | 4 | 2.2 | CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C | None | ||
5311044 | 914 | 0 | 3H-PGE2 | -22 | 9 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 374 | 6 | 3 | 4 | 2.2 | CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C | None | ||
631 | 914 | 0 | 3H-PGE2 | -22 | 9 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 374 | 6 | 3 | 4 | 2.2 | CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C | None | ||
CHEMBL160629 | 914 | 0 | 3H-PGE2 | -22 | 9 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 374 | 6 | 3 | 4 | 2.2 | CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C | None | ||
1551 | 2254 | 0 | 3H-PGE2 | -61 | 7 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 432 | 13 | 3 | 5 | 4.2 | O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O | None | ||
1961 | 2254 | 0 | 3H-PGE2 | -61 | 7 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 432 | 13 | 3 | 5 | 4.2 | O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O | None | ||
5311221 | 2254 | 0 | 3H-PGE2 | -61 | 7 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 432 | 13 | 3 | 5 | 4.2 | O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O | None | ||
CHEMBL1051 | 2254 | 0 | 3H-PGE2 | -61 | 7 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 432 | 13 | 3 | 5 | 4.2 | O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O | None | ||
DB00654 | 2254 | 0 | 3H-PGE2 | -61 | 7 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 432 | 13 | 3 | 5 | 4.2 | O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O | None | ||
1883 | 3033 | 71 | 3H-PGE2 | -11 | 24 | Mouse | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | None | ||
1916 | 3033 | 71 | 3H-PGE2 | -11 | 24 | Mouse | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | None | ||
5280360 | 3033 | 71 | 3H-PGE2 | -11 | 24 | Mouse | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | None | ||
913 | 3033 | 71 | 3H-PGE2 | -11 | 24 | Mouse | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | None | ||
CHEMBL548 | 3033 | 71 | 3H-PGE2 | -11 | 24 | Mouse | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | None | ||
DB00917 | 3033 | 71 | 3H-PGE2 | -11 | 24 | Mouse | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | None | ||
89077401 | 214273 | 0 | 3H-PGE2 | -1 | 12 | Mouse | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 360 | 8 | 3 | 3 | 3.5 | CC#CCC(C)C(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O | None | ||
134689669 | 214279 | 0 | 3H-PGE2 | -7 | 12 | Mouse | 7.7 | pKi | = | 7.7 | Binding | PDSP KiDatabase | 465 | 12 | 3 | 7 | 1.7 | CS(=O)(=O)NC(=O)CCCC=CCC1C(C(CC1=O)O)C=CC(COC2=CC=CC=C2)O | None | ||
133126726 | 214274 | 0 | 3H-PGE2 | 1 | 14 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 350 | 10 | 3 | 3 | 4.1 | CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O | None | ||
24868263 | 214274 | 0 | 3H-PGE2 | 1 | 14 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 350 | 10 | 3 | 3 | 4.1 | CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O | None | ||
138 | 3032 | 84 | 3H-PGE2 | -23 | 18 | Mouse | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | None | ||
1882 | 3032 | 84 | 3H-PGE2 | -23 | 18 | Mouse | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | None | ||
5280723 | 3032 | 84 | 3H-PGE2 | -23 | 18 | Mouse | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | None | ||
CHEMBL495 | 3032 | 84 | 3H-PGE2 | -23 | 18 | Mouse | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | None | ||
DB00770 | 3032 | 84 | 3H-PGE2 | -23 | 18 | Mouse | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | None | ||
656511 | 215988 | 0 | None | -1 | 7 | Human | 8.4 | pKi | = | 8.4 | Binding | Drug Central | 539 | 6 | 3 | 8 | -0.2 | CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](NC(=O)N3CCN(C3=O)S(C)(=O)=O)C3=CC=CC=C3)C(=O)N2[C@H]1C(O)=O | None | ||
133126726 | 214274 | 0 | None | 1 | 14 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 350 | 10 | 3 | 3 | 4.1 | CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O | None | ||
24868263 | 214274 | 0 | None | 1 | 14 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 350 | 10 | 3 | 3 | 4.1 | CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O | None | ||
1913 | 2429 | 0 | 3H-PGE2 | -2884 | 15 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 374 | 12 | 2 | 4 | 4.0 | OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O | None | ||
5311223 | 2429 | 0 | 3H-PGE2 | -2884 | 15 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 374 | 12 | 2 | 4 | 4.0 | OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O | None | ||
1917 | 914 | 0 | None | -22 | 9 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 374 | 6 | 3 | 4 | 2.2 | CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C | None | ||
5311044 | 914 | 0 | None | -22 | 9 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 374 | 6 | 3 | 4 | 2.2 | CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C | None | ||
631 | 914 | 0 | None | -22 | 9 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 374 | 6 | 3 | 4 | 2.2 | CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C | None | ||
CHEMBL160629 | 914 | 0 | None | -22 | 9 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 374 | 6 | 3 | 4 | 2.2 | CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C | None | ||
1884 | 3034 | 46 | None | -64 | 22 | Mouse | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | None | ||
5280363 | 3034 | 46 | None | -64 | 22 | Mouse | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | None | ||
912 | 3034 | 46 | None | -64 | 22 | Mouse | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | None | ||
CHEMBL815 | 3034 | 46 | None | -64 | 22 | Mouse | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | None | ||
DB12789 | 3034 | 46 | None | -64 | 22 | Mouse | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | None | ||
3356 | 2248 | 68 | None | -144 | 8 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 435 | 5 | 1 | 4 | 4.4 | OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F | None | ||
4326 | 2248 | 68 | None | -144 | 8 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 435 | 5 | 1 | 4 | 4.4 | OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F | None | ||
9867642 | 2248 | 68 | None | -144 | 8 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 435 | 5 | 1 | 4 | 4.4 | OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F | None | ||
CHEMBL426559 | 2248 | 68 | None | -144 | 8 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 435 | 5 | 1 | 4 | 4.4 | OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F | None | ||
DB11629 | 2248 | 68 | None | -144 | 8 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 435 | 5 | 1 | 4 | 4.4 | OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F | None | ||
1884 | 3034 | 46 | 3H-PGE2 | -169 | 22 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | None | ||
5280363 | 3034 | 46 | 3H-PGE2 | -169 | 22 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | None | ||
912 | 3034 | 46 | 3H-PGE2 | -169 | 22 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | None | ||
CHEMBL815 | 3034 | 46 | 3H-PGE2 | -169 | 22 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | None | ||
DB12789 | 3034 | 46 | 3H-PGE2 | -169 | 22 | Human | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | None | ||
1881 | 3030 | 0 | 3H-PGE2 | -4897 | 21 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | None | ||
1891 | 3030 | 0 | 3H-PGE2 | -4897 | 21 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | None | ||
448457 | 3030 | 0 | 3H-PGE2 | -4897 | 21 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | None | ||
CHEMBL1235252 | 3030 | 0 | 3H-PGE2 | -4897 | 21 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | None | ||
DB02056 | 3030 | 0 | 3H-PGE2 | -4897 | 21 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | None | ||
1884 | 3034 | 46 | None | -15 | 22 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | None | ||
5280363 | 3034 | 46 | None | -15 | 22 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | None | ||
912 | 3034 | 46 | None | -15 | 22 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | None | ||
CHEMBL815 | 3034 | 46 | None | -15 | 22 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | None | ||
DB12789 | 3034 | 46 | None | -15 | 22 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | None | ||
2720 | 3793 | 55 | None | -6 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 390 | 10 | 3 | 4 | 3.6 | CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O | None | ||
5820 | 3793 | 55 | None | -6 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 390 | 10 | 3 | 4 | 3.6 | CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O | None | ||
6918140 | 3793 | 55 | None | -6 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 390 | 10 | 3 | 4 | 3.6 | CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O | None | ||
CHEMBL1237119 | 3793 | 55 | None | -6 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 390 | 10 | 3 | 4 | 3.6 | CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O | None | ||
DB00374 | 3793 | 55 | None | -6 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 390 | 10 | 3 | 4 | 3.6 | CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O | None | ||
91798918 | 214292 | 0 | None | 1 | 10 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 400 | 10 | 2 | 6 | 2.6 | COC(=O)CCC=C=CCC1C(C(CC1=O)O)C=CC(COC2=CC=CC=C2)O | None | ||
138 | 3032 | 84 | None | -26 | 18 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | None | ||
1882 | 3032 | 84 | None | -26 | 18 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | None | ||
5280723 | 3032 | 84 | None | -26 | 18 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | None | ||
CHEMBL495 | 3032 | 84 | None | -26 | 18 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | None | ||
DB00770 | 3032 | 84 | None | -26 | 18 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | None | ||
134689669 | 214279 | 0 | None | -15 | 12 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 465 | 12 | 3 | 7 | 1.7 | CS(=O)(=O)NC(=O)CCCC=CCC1C(C(CC1=O)O)C=CC(COC2=CC=CC=C2)O | None | ||
134689669 | 214279 | 0 | None | -3 | 12 | Rat | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 465 | 12 | 3 | 7 | 1.7 | CS(=O)(=O)NC(=O)CCCC=CCC1C(C(CC1=O)O)C=CC(COC2=CC=CC=C2)O | None | ||
1883 | 3033 | 71 | None | -17 | 24 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | None | ||
1916 | 3033 | 71 | None | -17 | 24 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | None | ||
5280360 | 3033 | 71 | None | -17 | 24 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | None | ||
913 | 3033 | 71 | None | -17 | 24 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | None | ||
CHEMBL548 | 3033 | 71 | None | -17 | 24 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | None | ||
DB00917 | 3033 | 71 | None | -17 | 24 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | None | ||
138107701 | 186881 | 39 | None | -7 | 15 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 360 | 8 | 3 | 3 | 3.5 | CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O | None | ||
5311181 | 186881 | 39 | None | -7 | 15 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 360 | 8 | 3 | 3 | 3.5 | CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O | None | ||
CHEMBL494 | 186881 | 39 | None | -7 | 15 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 360 | 8 | 3 | 3 | 3.5 | CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O | None | ||
134689669 | 214279 | 0 | None | -7 | 12 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 465 | 12 | 3 | 7 | 1.7 | CS(=O)(=O)NC(=O)CCCC=CCC1C(C(CC1=O)O)C=CC(COC2=CC=CC=C2)O | None | ||
138107701 | 186881 | 39 | None | -7 | 15 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 360 | 8 | 3 | 3 | 3.5 | CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O | None | ||
5311181 | 186881 | 39 | None | -7 | 15 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 360 | 8 | 3 | 3 | 3.5 | CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O | None | ||
CHEMBL494 | 186881 | 39 | None | -7 | 15 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 360 | 8 | 3 | 3 | 3.5 | CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O | None | ||
1883 | 3033 | 71 | None | -12 | 24 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | None | ||
1916 | 3033 | 71 | None | -12 | 24 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | None | ||
5280360 | 3033 | 71 | None | -12 | 24 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | None | ||
913 | 3033 | 71 | None | -12 | 24 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | None | ||
CHEMBL548 | 3033 | 71 | None | -12 | 24 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | None | ||
DB00917 | 3033 | 71 | None | -12 | 24 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | None | ||
138 | 3032 | 84 | None | -23 | 18 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | None | ||
1882 | 3032 | 84 | None | -23 | 18 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | None | ||
5280723 | 3032 | 84 | None | -23 | 18 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | None | ||
CHEMBL495 | 3032 | 84 | None | -23 | 18 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | None | ||
DB00770 | 3032 | 84 | None | -23 | 18 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | None | ||
1883 | 3033 | 71 | None | -11 | 24 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | None | ||
1916 | 3033 | 71 | None | -11 | 24 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | None | ||
5280360 | 3033 | 71 | None | -11 | 24 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | None | ||
913 | 3033 | 71 | None | -11 | 24 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | None | ||
CHEMBL548 | 3033 | 71 | None | -11 | 24 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | None | ||
DB00917 | 3033 | 71 | None | -11 | 24 | Mouse | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | None | ||
67861203 | 214294 | 0 | 3H-PGE2 | -1737 | 8 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 424 | 11 | 4 | 5 | 3.2 | C1C(C(C(C1O)C=CC(COC2=CC(=CC=C2)Cl)O)CC=CCCCC(=O)O)O | None | ||
91798918 | 214292 | 0 | 3H-PGE2 | -12 | 10 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 400 | 10 | 2 | 6 | 2.6 | COC(=O)CCC=C=CCC1C(C(CC1=O)O)C=CC(COC2=CC=CC=C2)O | None | ||
1551 | 2254 | 0 | 3H-PGE2 | -61 | 7 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 432 | 13 | 3 | 5 | 4.2 | O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O | None | ||
1961 | 2254 | 0 | 3H-PGE2 | -61 | 7 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 432 | 13 | 3 | 5 | 4.2 | O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O | None | ||
5311221 | 2254 | 0 | 3H-PGE2 | -61 | 7 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 432 | 13 | 3 | 5 | 4.2 | O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O | None | ||
CHEMBL1051 | 2254 | 0 | 3H-PGE2 | -61 | 7 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 432 | 13 | 3 | 5 | 4.2 | O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O | None | ||
DB00654 | 2254 | 0 | 3H-PGE2 | -61 | 7 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 432 | 13 | 3 | 5 | 4.2 | O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O | None | ||
1883 | 3033 | 71 | 3H-PGE2 | -12 | 24 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | None | ||
1916 | 3033 | 71 | 3H-PGE2 | -12 | 24 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | None | ||
5280360 | 3033 | 71 | 3H-PGE2 | -12 | 24 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | None | ||
913 | 3033 | 71 | 3H-PGE2 | -12 | 24 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | None | ||
CHEMBL548 | 3033 | 71 | 3H-PGE2 | -12 | 24 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | None | ||
DB00917 | 3033 | 71 | 3H-PGE2 | -12 | 24 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | None | ||
1034 | 3036 | 0 | None | -1000 | 3 | Human | 4.8 | pKi | = | 4.8 | Binding | Guide to Pharmacology | 352 | 10 | 3 | 4 | 3.4 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O | 11999132 | ||
1915 | 3036 | 0 | None | -1000 | 3 | Human | 4.8 | pKi | = | 4.8 | Binding | Guide to Pharmacology | 352 | 10 | 3 | 4 | 3.4 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O | 11999132 | ||
5282411 | 3036 | 0 | None | -1000 | 3 | Human | 4.8 | pKi | = | 4.8 | Binding | Guide to Pharmacology | 352 | 10 | 3 | 4 | 3.4 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O | 11999132 | ||
CHEMBL1139 | 3036 | 0 | None | -1000 | 3 | Human | 4.8 | pKi | = | 4.8 | Binding | Guide to Pharmacology | 352 | 10 | 3 | 4 | 3.4 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O | 11999132 | ||
DB01240 | 3036 | 0 | None | -1000 | 3 | Human | 4.8 | pKi | = | 4.8 | Binding | Guide to Pharmacology | 352 | 10 | 3 | 4 | 3.4 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/O2)O | 11999132 | ||
1884 | 3034 | 46 | None | -64 | 22 | Mouse | 5.9 | pKi | = | 5.9 | Binding | Guide to Pharmacology | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 9313928 | ||
5280363 | 3034 | 46 | None | -64 | 22 | Mouse | 5.9 | pKi | = | 5.9 | Binding | Guide to Pharmacology | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 9313928 | ||
912 | 3034 | 46 | None | -64 | 22 | Mouse | 5.9 | pKi | = | 5.9 | Binding | Guide to Pharmacology | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 9313928 | ||
CHEMBL815 | 3034 | 46 | None | -64 | 22 | Mouse | 5.9 | pKi | = | 5.9 | Binding | Guide to Pharmacology | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 9313928 | ||
DB12789 | 3034 | 46 | None | -64 | 22 | Mouse | 5.9 | pKi | = | 5.9 | Binding | Guide to Pharmacology | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 9313928 | ||
2720 | 3793 | 55 | None | -6 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 390 | 10 | 3 | 4 | 3.6 | CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O | 22480736 | ||
5820 | 3793 | 55 | None | -6 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 390 | 10 | 3 | 4 | 3.6 | CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O | 22480736 | ||
6918140 | 3793 | 55 | None | -6 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 390 | 10 | 3 | 4 | 3.6 | CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O | 22480736 | ||
CHEMBL1237119 | 3793 | 55 | None | -6 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 390 | 10 | 3 | 4 | 3.6 | CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O | 22480736 | ||
DB00374 | 3793 | 55 | None | -6 | 6 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 390 | 10 | 3 | 4 | 3.6 | CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O | 22480736 | ||
1914 | 2907 | 0 | None | - | 1 | Mouse | 6.8 | pKi | = | 6.8 | Binding | Guide to Pharmacology | 422 | 11 | 3 | 5 | 3.5 | CCCC[C@@H](C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CC(=O)C1CCC(CC1)C(=O)O)O)C | 10746663 | ||
5311227 | 2907 | 0 | None | - | 1 | Mouse | 6.8 | pKi | = | 6.8 | Binding | Guide to Pharmacology | 422 | 11 | 3 | 5 | 3.5 | CCCC[C@@H](C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CC(=O)C1CCC(CC1)C(=O)O)O)C | 10746663 | ||
138 | 3032 | 84 | None | -158 | 18 | Human | 6.8 | pKi | = | 6.8 | Binding | Guide to Pharmacology | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 11999132 | ||
1882 | 3032 | 84 | None | -158 | 18 | Human | 6.8 | pKi | = | 6.8 | Binding | Guide to Pharmacology | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 11999132 | ||
5280723 | 3032 | 84 | None | -158 | 18 | Human | 6.8 | pKi | = | 6.8 | Binding | Guide to Pharmacology | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 11999132 | ||
CHEMBL495 | 3032 | 84 | None | -158 | 18 | Human | 6.8 | pKi | = | 6.8 | Binding | Guide to Pharmacology | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 11999132 | ||
DB00770 | 3032 | 84 | None | -158 | 18 | Human | 6.8 | pKi | = | 6.8 | Binding | Guide to Pharmacology | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 11999132 | ||
138 | 3032 | 84 | None | -23 | 18 | Mouse | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 9313928 | ||
1882 | 3032 | 84 | None | -23 | 18 | Mouse | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 9313928 | ||
5280723 | 3032 | 84 | None | -23 | 18 | Mouse | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 9313928 | ||
CHEMBL495 | 3032 | 84 | None | -23 | 18 | Mouse | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 9313928 | ||
DB00770 | 3032 | 84 | None | -23 | 18 | Mouse | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 9313928 | ||
1883 | 3033 | 71 | None | -12 | 24 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10634944 | ||
1883 | 3033 | 71 | None | -12 | 24 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 11999132 | ||
1883 | 3033 | 71 | None | -12 | 24 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 16604093 | ||
1916 | 3033 | 71 | None | -12 | 24 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10634944 | ||
1916 | 3033 | 71 | None | -12 | 24 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 11999132 | ||
1916 | 3033 | 71 | None | -12 | 24 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 16604093 | ||
5280360 | 3033 | 71 | None | -12 | 24 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10634944 | ||
5280360 | 3033 | 71 | None | -12 | 24 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 11999132 | ||
5280360 | 3033 | 71 | None | -12 | 24 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 16604093 | ||
913 | 3033 | 71 | None | -12 | 24 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10634944 | ||
913 | 3033 | 71 | None | -12 | 24 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 11999132 | ||
913 | 3033 | 71 | None | -12 | 24 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 16604093 | ||
CHEMBL548 | 3033 | 71 | None | -12 | 24 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10634944 | ||
CHEMBL548 | 3033 | 71 | None | -12 | 24 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 11999132 | ||
CHEMBL548 | 3033 | 71 | None | -12 | 24 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 16604093 | ||
DB00917 | 3033 | 71 | None | -12 | 24 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10634944 | ||
DB00917 | 3033 | 71 | None | -12 | 24 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 11999132 | ||
DB00917 | 3033 | 71 | None | -12 | 24 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 16604093 | ||
1883 | 3033 | 71 | None | -11 | 24 | Mouse | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10746663 | ||
1883 | 3033 | 71 | None | -11 | 24 | Mouse | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 9313928 | ||
1916 | 3033 | 71 | None | -11 | 24 | Mouse | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10746663 | ||
1916 | 3033 | 71 | None | -11 | 24 | Mouse | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 9313928 | ||
5280360 | 3033 | 71 | None | -11 | 24 | Mouse | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10746663 | ||
5280360 | 3033 | 71 | None | -11 | 24 | Mouse | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 9313928 | ||
913 | 3033 | 71 | None | -11 | 24 | Mouse | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10746663 | ||
913 | 3033 | 71 | None | -11 | 24 | Mouse | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 9313928 | ||
CHEMBL548 | 3033 | 71 | None | -11 | 24 | Mouse | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10746663 | ||
CHEMBL548 | 3033 | 71 | None | -11 | 24 | Mouse | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 9313928 | ||
DB00917 | 3033 | 71 | None | -11 | 24 | Mouse | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 10746663 | ||
DB00917 | 3033 | 71 | None | -11 | 24 | Mouse | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 9313928 | ||
1895 | 1976 | 0 | None | -1 | 16 | Rat | 7.9 | pKi | = | 7.9 | Binding | Guide to Pharmacology | 360 | 8 | 3 | 3 | 3.5 | CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C | 9537820 | ||
6435378 | 1976 | 0 | None | -1 | 16 | Rat | 7.9 | pKi | = | 7.9 | Binding | Guide to Pharmacology | 360 | 8 | 3 | 3 | 3.5 | CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C | 9537820 | ||
CHEMBL236025 | 1976 | 0 | None | -1 | 16 | Rat | 7.9 | pKi | = | 7.9 | Binding | Guide to Pharmacology | 360 | 8 | 3 | 3 | 3.5 | CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C | 9537820 | ||
DB01088 | 1976 | 0 | None | -1 | 16 | Rat | 7.9 | pKi | = | 7.9 | Binding | Guide to Pharmacology | 360 | 8 | 3 | 3 | 3.5 | CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C | 9537820 | ||
1924 | 3486 | 33 | None | -1 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | Guide to Pharmacology | 457 | 5 | 2 | 5 | 5.1 | O=C(NNC(=O)N1Cc2ccccc2Oc2c1cc(Cl)cc2)CCSCc1ccco1 | 10634944 | ||
9933831 | 3486 | 33 | None | -1 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | Guide to Pharmacology | 457 | 5 | 2 | 5 | 5.1 | O=C(NNC(=O)N1Cc2ccccc2Oc2c1cc(Cl)cc2)CCSCc1ccco1 | 10634944 | ||
CHEMBL358653 | 3486 | 33 | None | -1 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | Guide to Pharmacology | 457 | 5 | 2 | 5 | 5.1 | O=C(NNC(=O)N1Cc2ccccc2Oc2c1cc(Cl)cc2)CCSCc1ccco1 | 10634944 | ||
1912 | 27 | 0 | None | -2 | 6 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 386 | 11 | 3 | 4 | 3.3 | OC(=O)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O | 11999132 | ||
5283068 | 27 | 0 | None | -2 | 6 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 386 | 11 | 3 | 4 | 3.3 | OC(=O)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O | 11999132 | ||
CHEMBL1879970 | 27 | 0 | None | -2 | 6 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 386 | 11 | 3 | 4 | 3.3 | OC(=O)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O | 11999132 | ||
11306423 | 2489 | 4 | None | 52 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 491 | 6 | 2 | 5 | 6.4 | Clc1ccc(c(c1)c1ccsc1c1cncc(c1)C(C(F)(F)F)(O)O)OCc1ccccc1 | 18287210 | ||
6068 | 2489 | 4 | None | 52 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 491 | 6 | 2 | 5 | 6.4 | Clc1ccc(c(c1)c1ccsc1c1cncc(c1)C(C(F)(F)F)(O)O)OCc1ccccc1 | 18287210 | ||
CHEMBL185346 | 2489 | 4 | None | 52 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 491 | 6 | 2 | 5 | 6.4 | Clc1ccc(c(c1)c1ccsc1c1cncc(c1)C(C(F)(F)F)(O)O)OCc1ccccc1 | 18287210 | ||
1920 | 2892 | 0 | None | 2 | 4 | Human | 9.2 | pKi | = | 9.2 | Binding | Guide to Pharmacology | 439 | 9 | 2 | 3 | 4.8 | OC(=O)CCC/C=C\[C@H]1C2CCC([C@@H]1CNS(=O)(=O)c1ccc(cc1C)Cl)CC2 | 10537280 | ||
9824507 | 2892 | 0 | None | 2 | 4 | Human | 9.2 | pKi | = | 9.2 | Binding | Guide to Pharmacology | 439 | 9 | 2 | 3 | 4.8 | OC(=O)CCC/C=C\[C@H]1C2CCC([C@@H]1CNS(=O)(=O)c1ccc(cc1C)Cl)CC2 | 10537280 | ||
CHEMBL1628612 | 2892 | 0 | None | 2 | 4 | Human | 9.2 | pKi | = | 9.2 | Binding | Guide to Pharmacology | 439 | 9 | 2 | 3 | 4.8 | OC(=O)CCC/C=C\[C@H]1C2CCC([C@@H]1CNS(=O)(=O)c1ccc(cc1C)Cl)CC2 | 10537280 | ||
1551 | 2254 | 0 | None | -61 | 7 | Human | 8.2 | pKi | None | 8.2 | Binding | Drug Central | 432 | 13 | 3 | 5 | 4.2 | O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O | None | ||
1961 | 2254 | 0 | None | -61 | 7 | Human | 8.2 | pKi | None | 8.2 | Binding | Drug Central | 432 | 13 | 3 | 5 | 4.2 | O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O | None | ||
5311221 | 2254 | 0 | None | -61 | 7 | Human | 8.2 | pKi | None | 8.2 | Binding | Drug Central | 432 | 13 | 3 | 5 | 4.2 | O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O | None | ||
CHEMBL1051 | 2254 | 0 | None | -61 | 7 | Human | 8.2 | pKi | None | 8.2 | Binding | Drug Central | 432 | 13 | 3 | 5 | 4.2 | O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O | None | ||
DB00654 | 2254 | 0 | None | -61 | 7 | Human | 8.2 | pKi | None | 8.2 | Binding | Drug Central | 432 | 13 | 3 | 5 | 4.2 | O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O | None | ||
1922 | 3481 | 34 | None | -5 | 3 | Human | 4.5 | pKi | None | 4.5 | Binding | Guide to Pharmacology | 331 | 0 | 2 | 3 | 3.2 | CC(=O)NNC(=O)N1Cc2ccccc2Oc2c1cc(Cl)cc2 | 11999132 | ||
4336830 | 3481 | 34 | None | -5 | 3 | Human | 4.5 | pKi | None | 4.5 | Binding | Guide to Pharmacology | 331 | 0 | 2 | 3 | 3.2 | CC(=O)NNC(=O)N1Cc2ccccc2Oc2c1cc(Cl)cc2 | 11999132 | ||
CHEMBL112816 | 3481 | 34 | None | -5 | 3 | Human | 4.5 | pKi | None | 4.5 | Binding | Guide to Pharmacology | 331 | 0 | 2 | 3 | 3.2 | CC(=O)NNC(=O)N1Cc2ccccc2Oc2c1cc(Cl)cc2 | 11999132 | ||
1888 | 3837 | 26 | None | -707 | 17 | Human | 4.5 | pKi | None | 4.5 | Binding | Guide to Pharmacology | 350 | 12 | 2 | 3 | 4.3 | CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O | 10634944 | ||
1974 | 3837 | 26 | None | -707 | 17 | Human | 4.5 | pKi | None | 4.5 | Binding | Guide to Pharmacology | 350 | 12 | 2 | 3 | 4.3 | CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O | 10634944 | ||
5311493 | 3837 | 26 | None | -707 | 17 | Human | 4.5 | pKi | None | 4.5 | Binding | Guide to Pharmacology | 350 | 12 | 2 | 3 | 4.3 | CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O | 10634944 | ||
CHEMBL521784 | 3837 | 26 | None | -707 | 17 | Human | 4.5 | pKi | None | 4.5 | Binding | Guide to Pharmacology | 350 | 12 | 2 | 3 | 4.3 | CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O | 10634944 | ||
1922 | 3481 | 34 | None | -4 | 3 | Rat | 4.6 | pKi | None | 4.6 | Binding | Guide to Pharmacology | 331 | 0 | 2 | 3 | 3.2 | CC(=O)NNC(=O)N1Cc2ccccc2Oc2c1cc(Cl)cc2 | 9537820 | ||
4336830 | 3481 | 34 | None | -4 | 3 | Rat | 4.6 | pKi | None | 4.6 | Binding | Guide to Pharmacology | 331 | 0 | 2 | 3 | 3.2 | CC(=O)NNC(=O)N1Cc2ccccc2Oc2c1cc(Cl)cc2 | 9537820 | ||
CHEMBL112816 | 3481 | 34 | None | -4 | 3 | Rat | 4.6 | pKi | None | 4.6 | Binding | Guide to Pharmacology | 331 | 0 | 2 | 3 | 3.2 | CC(=O)NNC(=O)N1Cc2ccccc2Oc2c1cc(Cl)cc2 | 9537820 | ||
1881 | 3030 | 0 | None | -4897 | 21 | Human | 4.7 | pKi | None | 4.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 11999132 | ||
1891 | 3030 | 0 | None | -4897 | 21 | Human | 4.7 | pKi | None | 4.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 11999132 | ||
448457 | 3030 | 0 | None | -4897 | 21 | Human | 4.7 | pKi | None | 4.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 11999132 | ||
CHEMBL1235252 | 3030 | 0 | None | -4897 | 21 | Human | 4.7 | pKi | None | 4.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 11999132 | ||
DB02056 | 3030 | 0 | None | -4897 | 21 | Human | 4.7 | pKi | None | 4.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 11999132 | ||
1881 | 3030 | 0 | None | -2884 | 21 | Rat | 5.2 | pKi | None | 5.2 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 9537820 | ||
1891 | 3030 | 0 | None | -2884 | 21 | Rat | 5.2 | pKi | None | 5.2 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 9537820 | ||
448457 | 3030 | 0 | None | -2884 | 21 | Rat | 5.2 | pKi | None | 5.2 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 9537820 | ||
CHEMBL1235252 | 3030 | 0 | None | -2884 | 21 | Rat | 5.2 | pKi | None | 5.2 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 9537820 | ||
DB02056 | 3030 | 0 | None | -2884 | 21 | Rat | 5.2 | pKi | None | 5.2 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 9537820 | ||
1888 | 3837 | 26 | None | -251 | 17 | Rat | 5.2 | pKi | None | 5.2 | Binding | Guide to Pharmacology | 350 | 12 | 2 | 3 | 4.3 | CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O | 9537820 | ||
1974 | 3837 | 26 | None | -251 | 17 | Rat | 5.2 | pKi | None | 5.2 | Binding | Guide to Pharmacology | 350 | 12 | 2 | 3 | 4.3 | CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O | 9537820 | ||
5311493 | 3837 | 26 | None | -251 | 17 | Rat | 5.2 | pKi | None | 5.2 | Binding | Guide to Pharmacology | 350 | 12 | 2 | 3 | 4.3 | CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O | 9537820 | ||
CHEMBL521784 | 3837 | 26 | None | -251 | 17 | Rat | 5.2 | pKi | None | 5.2 | Binding | Guide to Pharmacology | 350 | 12 | 2 | 3 | 4.3 | CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O | 9537820 | ||
119461 | 317 | 66 | None | -3 | 10 | Rat | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 298 | 3 | 1 | 4 | 3.4 | CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C | 9537820 | ||
1896 | 317 | 66 | None | -3 | 10 | Rat | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 298 | 3 | 1 | 4 | 3.4 | CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C | 9537820 | ||
CHEMBL1317823 | 317 | 66 | None | -3 | 10 | Rat | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 298 | 3 | 1 | 4 | 3.4 | CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C | 9537820 | ||
1917 | 914 | 0 | None | -22 | 9 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 374 | 6 | 3 | 4 | 2.2 | CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C | 10634944 | ||
5311044 | 914 | 0 | None | -22 | 9 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 374 | 6 | 3 | 4 | 2.2 | CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C | 10634944 | ||
631 | 914 | 0 | None | -22 | 9 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 374 | 6 | 3 | 4 | 2.2 | CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C | 10634944 | ||
CHEMBL160629 | 914 | 0 | None | -22 | 9 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 374 | 6 | 3 | 4 | 2.2 | CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C | 10634944 | ||
132749 | 3485 | 12 | None | - | 1 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 422 | 3 | 2 | 4 | 4.2 | O=C(NNC(=O)N1Cc2ccccc2Oc2c1cc(Cl)cc2)CCc1ccncc1 | 10634944 | ||
1923 | 3485 | 12 | None | - | 1 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 422 | 3 | 2 | 4 | 4.2 | O=C(NNC(=O)N1Cc2ccccc2Oc2c1cc(Cl)cc2)CCc1ccncc1 | 10634944 | ||
CHEMBL155358 | 3485 | 12 | None | - | 1 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 422 | 3 | 2 | 4 | 4.2 | O=C(NNC(=O)N1Cc2ccccc2Oc2c1cc(Cl)cc2)CCc1ccncc1 | 10634944 | ||
119461 | 317 | 66 | None | -3 | 10 | Human | 6.0 | pKi | None | 6.0 | Binding | Guide to Pharmacology | 298 | 3 | 1 | 4 | 3.4 | CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C | 10634944 | ||
119461 | 317 | 66 | None | -3 | 10 | Human | 6.0 | pKi | None | 6.0 | Binding | Guide to Pharmacology | 298 | 3 | 1 | 4 | 3.4 | CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C | 11999132 | ||
1896 | 317 | 66 | None | -3 | 10 | Human | 6.0 | pKi | None | 6.0 | Binding | Guide to Pharmacology | 298 | 3 | 1 | 4 | 3.4 | CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C | 10634944 | ||
1896 | 317 | 66 | None | -3 | 10 | Human | 6.0 | pKi | None | 6.0 | Binding | Guide to Pharmacology | 298 | 3 | 1 | 4 | 3.4 | CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C | 11999132 | ||
CHEMBL1317823 | 317 | 66 | None | -3 | 10 | Human | 6.0 | pKi | None | 6.0 | Binding | Guide to Pharmacology | 298 | 3 | 1 | 4 | 3.4 | CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C | 10634944 | ||
CHEMBL1317823 | 317 | 66 | None | -3 | 10 | Human | 6.0 | pKi | None | 6.0 | Binding | Guide to Pharmacology | 298 | 3 | 1 | 4 | 3.4 | CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C | 11999132 | ||
1894 | 943 | 35 | None | -257 | 5 | Human | 6.0 | pKi | None | 6 | Binding | Guide to Pharmacology | 424 | 11 | 4 | 5 | 3.2 | OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O | 10634944 | ||
1894 | 943 | 35 | None | -257 | 5 | Human | 6.0 | pKi | None | 6 | Binding | Guide to Pharmacology | 424 | 11 | 4 | 5 | 3.2 | OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O | 11999132 | ||
5311053 | 943 | 35 | None | -257 | 5 | Human | 6.0 | pKi | None | 6 | Binding | Guide to Pharmacology | 424 | 11 | 4 | 5 | 3.2 | OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O | 10634944 | ||
5311053 | 943 | 35 | None | -257 | 5 | Human | 6.0 | pKi | None | 6 | Binding | Guide to Pharmacology | 424 | 11 | 4 | 5 | 3.2 | OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O | 11999132 | ||
CHEMBL37853 | 943 | 35 | None | -257 | 5 | Human | 6.0 | pKi | None | 6 | Binding | Guide to Pharmacology | 424 | 11 | 4 | 5 | 3.2 | OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O | 10634944 | ||
CHEMBL37853 | 943 | 35 | None | -257 | 5 | Human | 6.0 | pKi | None | 6 | Binding | Guide to Pharmacology | 424 | 11 | 4 | 5 | 3.2 | OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O | 11999132 | ||
DB11507 | 943 | 35 | None | -257 | 5 | Human | 6.0 | pKi | None | 6 | Binding | Guide to Pharmacology | 424 | 11 | 4 | 5 | 3.2 | OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O | 10634944 | ||
DB11507 | 943 | 35 | None | -257 | 5 | Human | 6.0 | pKi | None | 6 | Binding | Guide to Pharmacology | 424 | 11 | 4 | 5 | 3.2 | OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O | 11999132 | ||
1884 | 3034 | 46 | None | -169 | 22 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 10634944 | ||
1884 | 3034 | 46 | None | -169 | 22 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 11999132 | ||
5280363 | 3034 | 46 | None | -169 | 22 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 10634944 | ||
5280363 | 3034 | 46 | None | -169 | 22 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 11999132 | ||
912 | 3034 | 46 | None | -169 | 22 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 10634944 | ||
912 | 3034 | 46 | None | -169 | 22 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 11999132 | ||
CHEMBL815 | 3034 | 46 | None | -169 | 22 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 10634944 | ||
CHEMBL815 | 3034 | 46 | None | -169 | 22 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 11999132 | ||
DB12789 | 3034 | 46 | None | -169 | 22 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 10634944 | ||
DB12789 | 3034 | 46 | None | -169 | 22 | Human | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 11999132 | ||
1913 | 2429 | 0 | None | -3548 | 15 | Rat | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 374 | 12 | 2 | 4 | 4.0 | OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O | 9537820 | ||
5311223 | 2429 | 0 | None | -3548 | 15 | Rat | 6.3 | pKi | None | 6.3 | Binding | Guide to Pharmacology | 374 | 12 | 2 | 4 | 4.0 | OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O | 9537820 | ||
1913 | 2429 | 0 | None | -2884 | 15 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 374 | 12 | 2 | 4 | 4.0 | OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O | 10634944 | ||
5311223 | 2429 | 0 | None | -2884 | 15 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 374 | 12 | 2 | 4 | 4.0 | OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O | 10634944 | ||
1884 | 3034 | 46 | None | -15 | 22 | Rat | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 9537820 | ||
5280363 | 3034 | 46 | None | -15 | 22 | Rat | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 9537820 | ||
912 | 3034 | 46 | None | -15 | 22 | Rat | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 9537820 | ||
CHEMBL815 | 3034 | 46 | None | -15 | 22 | Rat | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 9537820 | ||
DB12789 | 3034 | 46 | None | -15 | 22 | Rat | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 354 | 12 | 4 | 4 | 3.0 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O | 9537820 | ||
1918 | 1537 | 0 | None | -16 | 6 | Rat | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 400 | 10 | 2 | 6 | 2.6 | COC(=O)CCC=C=CC[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O | 9537820 | ||
5311225 | 1537 | 0 | None | -16 | 6 | Rat | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 400 | 10 | 2 | 6 | 2.6 | COC(=O)CCC=C=CC[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O | 9537820 | ||
CHEMBL2104194 | 1537 | 0 | None | -16 | 6 | Rat | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 400 | 10 | 2 | 6 | 2.6 | COC(=O)CCC=C=CC[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O | 9537820 | ||
1895 | 1976 | 0 | None | -15 | 16 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 360 | 8 | 3 | 3 | 3.5 | CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C | 10634944 | ||
1895 | 1976 | 0 | None | -15 | 16 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 360 | 8 | 3 | 3 | 3.5 | CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C | 11999132 | ||
6435378 | 1976 | 0 | None | -15 | 16 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 360 | 8 | 3 | 3 | 3.5 | CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C | 10634944 | ||
6435378 | 1976 | 0 | None | -15 | 16 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 360 | 8 | 3 | 3 | 3.5 | CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C | 11999132 | ||
CHEMBL236025 | 1976 | 0 | None | -15 | 16 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 360 | 8 | 3 | 3 | 3.5 | CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C | 10634944 | ||
CHEMBL236025 | 1976 | 0 | None | -15 | 16 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 360 | 8 | 3 | 3 | 3.5 | CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C | 11999132 | ||
DB01088 | 1976 | 0 | None | -15 | 16 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 360 | 8 | 3 | 3 | 3.5 | CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C | 10634944 | ||
DB01088 | 1976 | 0 | None | -15 | 16 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 360 | 8 | 3 | 3 | 3.5 | CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C | 11999132 | ||
1889 | 4080 | 0 | None | -501 | 2 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 384 | 9 | 3 | 3 | 4.3 | OC(=O)CCC/C=C\CC1[C@H](Cl)C[C@H]([C@@H]1/C=C/[C@H](C1CCCCC1)O)O | 11999132 | ||
5311503 | 4080 | 0 | None | -501 | 2 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 384 | 9 | 3 | 3 | 4.3 | OC(=O)CCC/C=C\CC1[C@H](Cl)C[C@H]([C@@H]1/C=C/[C@H](C1CCCCC1)O)O | 11999132 | ||
1913 | 2429 | 0 | None | -870 | 15 | Mouse | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 374 | 12 | 2 | 4 | 4.0 | OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O | 9313928 | ||
5311223 | 2429 | 0 | None | -870 | 15 | Mouse | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 374 | 12 | 2 | 4 | 4.0 | OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O | 9313928 | ||
1919 | 3648 | 0 | None | -323 | 7 | Human | 7.0 | pKi | None | 7.0 | Binding | Guide to Pharmacology | 465 | 12 | 3 | 7 | 1.7 | O=C(NS(=O)(=O)C)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O | 10634944 | ||
1919 | 3648 | 0 | None | -323 | 7 | Human | 7.0 | pKi | None | 7.0 | Binding | Guide to Pharmacology | 465 | 12 | 3 | 7 | 1.7 | O=C(NS(=O)(=O)C)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O | 11999132 | ||
2538 | 3648 | 0 | None | -323 | 7 | Human | 7.0 | pKi | None | 7.0 | Binding | Guide to Pharmacology | 465 | 12 | 3 | 7 | 1.7 | O=C(NS(=O)(=O)C)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O | 10634944 | ||
2538 | 3648 | 0 | None | -323 | 7 | Human | 7.0 | pKi | None | 7.0 | Binding | Guide to Pharmacology | 465 | 12 | 3 | 7 | 1.7 | O=C(NS(=O)(=O)C)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O | 11999132 | ||
5312153 | 3648 | 0 | None | -323 | 7 | Human | 7.0 | pKi | None | 7.0 | Binding | Guide to Pharmacology | 465 | 12 | 3 | 7 | 1.7 | O=C(NS(=O)(=O)C)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O | 10634944 | ||
5312153 | 3648 | 0 | None | -323 | 7 | Human | 7.0 | pKi | None | 7.0 | Binding | Guide to Pharmacology | 465 | 12 | 3 | 7 | 1.7 | O=C(NS(=O)(=O)C)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O | 11999132 | ||
CHEMBL1472830 | 3648 | 0 | None | -323 | 7 | Human | 7.0 | pKi | None | 7.0 | Binding | Guide to Pharmacology | 465 | 12 | 3 | 7 | 1.7 | O=C(NS(=O)(=O)C)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O | 10634944 | ||
CHEMBL1472830 | 3648 | 0 | None | -323 | 7 | Human | 7.0 | pKi | None | 7.0 | Binding | Guide to Pharmacology | 465 | 12 | 3 | 7 | 1.7 | O=C(NS(=O)(=O)C)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O | 11999132 | ||
DB12708 | 3648 | 0 | None | -323 | 7 | Human | 7.0 | pKi | None | 7.0 | Binding | Guide to Pharmacology | 465 | 12 | 3 | 7 | 1.7 | O=C(NS(=O)(=O)C)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O | 10634944 | ||
DB12708 | 3648 | 0 | None | -323 | 7 | Human | 7.0 | pKi | None | 7.0 | Binding | Guide to Pharmacology | 465 | 12 | 3 | 7 | 1.7 | O=C(NS(=O)(=O)C)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O | 11999132 | ||
138 | 3032 | 84 | None | -26 | 18 | Rat | 7.0 | pKi | None | 7 | Binding | Guide to Pharmacology | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 9537820 | ||
1882 | 3032 | 84 | None | -26 | 18 | Rat | 7.0 | pKi | None | 7 | Binding | Guide to Pharmacology | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 9537820 | ||
5280723 | 3032 | 84 | None | -26 | 18 | Rat | 7.0 | pKi | None | 7 | Binding | Guide to Pharmacology | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 9537820 | ||
CHEMBL495 | 3032 | 84 | None | -26 | 18 | Rat | 7.0 | pKi | None | 7 | Binding | Guide to Pharmacology | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 9537820 | ||
DB00770 | 3032 | 84 | None | -26 | 18 | Rat | 7.0 | pKi | None | 7 | Binding | Guide to Pharmacology | 354 | 13 | 3 | 4 | 3.5 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O | 9537820 | ||
1919 | 3648 | 0 | None | -288 | 7 | Rat | 7.0 | pKi | None | 7 | Binding | Guide to Pharmacology | 465 | 12 | 3 | 7 | 1.7 | O=C(NS(=O)(=O)C)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O | 9537820 | ||
2538 | 3648 | 0 | None | -288 | 7 | Rat | 7.0 | pKi | None | 7 | Binding | Guide to Pharmacology | 465 | 12 | 3 | 7 | 1.7 | O=C(NS(=O)(=O)C)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O | 9537820 | ||
5312153 | 3648 | 0 | None | -288 | 7 | Rat | 7.0 | pKi | None | 7 | Binding | Guide to Pharmacology | 465 | 12 | 3 | 7 | 1.7 | O=C(NS(=O)(=O)C)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O | 9537820 | ||
CHEMBL1472830 | 3648 | 0 | None | -288 | 7 | Rat | 7.0 | pKi | None | 7 | Binding | Guide to Pharmacology | 465 | 12 | 3 | 7 | 1.7 | O=C(NS(=O)(=O)C)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O | 9537820 | ||
DB12708 | 3648 | 0 | None | -288 | 7 | Rat | 7.0 | pKi | None | 7 | Binding | Guide to Pharmacology | 465 | 12 | 3 | 7 | 1.7 | O=C(NS(=O)(=O)C)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O | 9537820 | ||
1890 | 4081 | 0 | None | -1 | 2 | Human | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 400 | 9 | 3 | 4 | 3.4 | OC(=O)COC/C=C\C[C@H]1[C@H](Cl)C[C@H]([C@@H]1/C=C/[C@H](C1CCCCC1C)O)O | 11999132 | ||
5311208 | 4081 | 0 | None | -1 | 2 | Human | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 400 | 9 | 3 | 4 | 3.4 | OC(=O)COC/C=C\C[C@H]1[C@H](Cl)C[C@H]([C@@H]1/C=C/[C@H](C1CCCCC1C)O)O | 11999132 | ||
1918 | 1537 | 0 | None | -2 | 6 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 400 | 10 | 2 | 6 | 2.6 | COC(=O)CCC=C=CC[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O | 10634944 | ||
1918 | 1537 | 0 | None | -2 | 6 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 400 | 10 | 2 | 6 | 2.6 | COC(=O)CCC=C=CC[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O | 11999132 | ||
5311225 | 1537 | 0 | None | -2 | 6 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 400 | 10 | 2 | 6 | 2.6 | COC(=O)CCC=C=CC[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O | 10634944 | ||
5311225 | 1537 | 0 | None | -2 | 6 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 400 | 10 | 2 | 6 | 2.6 | COC(=O)CCC=C=CC[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O | 11999132 | ||
CHEMBL2104194 | 1537 | 0 | None | -2 | 6 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 400 | 10 | 2 | 6 | 2.6 | COC(=O)CCC=C=CC[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O | 10634944 | ||
CHEMBL2104194 | 1537 | 0 | None | -2 | 6 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 400 | 10 | 2 | 6 | 2.6 | COC(=O)CCC=C=CC[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O | 11999132 | ||
1912 | 27 | 0 | None | -6 | 6 | Rat | 7.6 | pKi | None | 7.6 | Binding | Guide to Pharmacology | 386 | 11 | 3 | 4 | 3.3 | OC(=O)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O | 9537820 | ||
5283068 | 27 | 0 | None | -6 | 6 | Rat | 7.6 | pKi | None | 7.6 | Binding | Guide to Pharmacology | 386 | 11 | 3 | 4 | 3.3 | OC(=O)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O | 9537820 | ||
CHEMBL1879970 | 27 | 0 | None | -6 | 6 | Rat | 7.6 | pKi | None | 7.6 | Binding | Guide to Pharmacology | 386 | 11 | 3 | 4 | 3.3 | OC(=O)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O | 9537820 | ||
1893 | 783 | 0 | None | -1 | 13 | Human | 7.6 | pKi | None | 7.6 | Binding | Guide to Pharmacology | 350 | 10 | 3 | 3 | 4.1 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O | 10634944 | ||
5311242 | 783 | 0 | None | -1 | 13 | Human | 7.6 | pKi | None | 7.6 | Binding | Guide to Pharmacology | 350 | 10 | 3 | 3 | 4.1 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O | 10634944 | ||
CHEMBL148319 | 783 | 0 | None | -1 | 13 | Human | 7.6 | pKi | None | 7.6 | Binding | Guide to Pharmacology | 350 | 10 | 3 | 3 | 4.1 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O | 10634944 | ||
1895 | 1976 | 0 | None | -1 | 16 | Mouse | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 360 | 8 | 3 | 3 | 3.5 | CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C | 9313928 | ||
6435378 | 1976 | 0 | None | -1 | 16 | Mouse | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 360 | 8 | 3 | 3 | 3.5 | CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C | 9313928 | ||
CHEMBL236025 | 1976 | 0 | None | -1 | 16 | Mouse | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 360 | 8 | 3 | 3 | 3.5 | CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C | 9313928 | ||
DB01088 | 1976 | 0 | None | -1 | 16 | Mouse | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 360 | 8 | 3 | 3 | 3.5 | CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C | 9313928 | ||
1883 | 3033 | 71 | None | -17 | 24 | Rat | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 9537820 | ||
1916 | 3033 | 71 | None | -17 | 24 | Rat | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 9537820 | ||
5280360 | 3033 | 71 | None | -17 | 24 | Rat | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 9537820 | ||
913 | 3033 | 71 | None | -17 | 24 | Rat | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 9537820 | ||
CHEMBL548 | 3033 | 71 | None | -17 | 24 | Rat | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 9537820 | ||
DB00917 | 3033 | 71 | None | -17 | 24 | Rat | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 352 | 12 | 3 | 4 | 3.3 | CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O | 9537820 | ||
1919 | 3648 | 0 | None | -57 | 7 | Mouse | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 465 | 12 | 3 | 7 | 1.7 | O=C(NS(=O)(=O)C)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O | 9313928 | ||
2538 | 3648 | 0 | None | -57 | 7 | Mouse | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 465 | 12 | 3 | 7 | 1.7 | O=C(NS(=O)(=O)C)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O | 9313928 | ||
5312153 | 3648 | 0 | None | -57 | 7 | Mouse | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 465 | 12 | 3 | 7 | 1.7 | O=C(NS(=O)(=O)C)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O | 9313928 | ||
CHEMBL1472830 | 3648 | 0 | None | -57 | 7 | Mouse | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 465 | 12 | 3 | 7 | 1.7 | O=C(NS(=O)(=O)C)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O | 9313928 | ||
DB12708 | 3648 | 0 | None | -57 | 7 | Mouse | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 465 | 12 | 3 | 7 | 1.7 | O=C(NS(=O)(=O)C)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O | 9313928 | ||
1912 | 27 | 0 | None | -3 | 6 | Mouse | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | 386 | 11 | 3 | 4 | 3.3 | OC(=O)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O | 9313928 | ||
5283068 | 27 | 0 | None | -3 | 6 | Mouse | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | 386 | 11 | 3 | 4 | 3.3 | OC(=O)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O | 9313928 | ||
CHEMBL1879970 | 27 | 0 | None | -3 | 6 | Mouse | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | 386 | 11 | 3 | 4 | 3.3 | OC(=O)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O | 9313928 | ||
1921 | 2893 | 0 | None | -31 | 4 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 523 | 10 | 1 | 5 | 5.8 | CC(CN(S(=O)(=O)c1ccco1)c1ccc(cc1OCc1ccc(cc1)/C=C/C(=O)O)C(F)(F)F)C | 10509919 | ||
9936595 | 2893 | 0 | None | -31 | 4 | Human | 8.0 | pKi | None | 8 | Binding | Guide to Pharmacology | 523 | 10 | 1 | 5 | 5.8 | CC(CN(S(=O)(=O)c1ccco1)c1ccc(cc1OCc1ccc(cc1)/C=C/C(=O)O)C(F)(F)F)C | 10509919 | ||
1920 | 2892 | 0 | None | -2 | 4 | Mouse | 8.8 | pKi | None | 8.8 | Binding | Guide to Pharmacology | 439 | 9 | 2 | 3 | 4.8 | OC(=O)CCC/C=C\[C@H]1C2CCC([C@@H]1CNS(=O)(=O)c1ccc(cc1C)Cl)CC2 | 10537280 | ||
9824507 | 2892 | 0 | None | -2 | 4 | Mouse | 8.8 | pKi | None | 8.8 | Binding | Guide to Pharmacology | 439 | 9 | 2 | 3 | 4.8 | OC(=O)CCC/C=C\[C@H]1C2CCC([C@@H]1CNS(=O)(=O)c1ccc(cc1C)Cl)CC2 | 10537280 | ||
CHEMBL1628612 | 2892 | 0 | None | -2 | 4 | Mouse | 8.8 | pKi | None | 8.8 | Binding | Guide to Pharmacology | 439 | 9 | 2 | 3 | 4.8 | OC(=O)CCC/C=C\[C@H]1C2CCC([C@@H]1CNS(=O)(=O)c1ccc(cc1C)Cl)CC2 | 10537280 | ||
1921 | 2893 | 0 | None | 10 | 4 | Mouse | 9.5 | pKi | None | 9.5 | Binding | Guide to Pharmacology | 523 | 10 | 1 | 5 | 5.8 | CC(CN(S(=O)(=O)c1ccco1)c1ccc(cc1OCc1ccc(cc1)/C=C/C(=O)O)C(F)(F)F)C | 10840160 | ||
9936595 | 2893 | 0 | None | 10 | 4 | Mouse | 9.5 | pKi | None | 9.5 | Binding | Guide to Pharmacology | 523 | 10 | 1 | 5 | 5.8 | CC(CN(S(=O)(=O)c1ccco1)c1ccc(cc1OCc1ccc(cc1)/C=C/C(=O)O)C(F)(F)F)C | 10840160 |