Structure information

NOP receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

4EA3

SPECIES

Homo sapiens

RESOLUTION

3.010

PREFERRED CHAIN

A

REFERENCE

10.1038/NATURE11085

PUBLICATION DATE

April 25, 2012

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
compound 24 [PMID: 16451050] Q107 2.60x60 TM2 Van der Waals
compound 24 [PMID: 16451050] Q107 2.60x60 TM2 polar (hydrogen bond)
compound 24 [PMID: 16451050] D110 2.63x63 TM2 Van der Waals
compound 24 [PMID: 16451050] I127 3.29x29 TM3 hydrophobic
compound 24 [PMID: 16451050] I127 3.29x29 TM3 Van der Waals
compound 24 [PMID: 16451050] D130 3.32x32 TM3 polar (charge-assisted hydrogen bond)
compound 24 [PMID: 16451050] Y131 3.33x33 TM3 Van der Waals
compound 24 [PMID: 16451050] Y131 3.33x33 TM3 hydrophobic
compound 24 [PMID: 16451050] M134 3.36x36 TM3 Van der Waals
compound 24 [PMID: 16451050] M134 3.36x36 TM3 hydrophobic
compound 24 [PMID: 16451050] F135 3.37x37 TM3 Van der Waals
compound 24 [PMID: 16451050] F135 3.37x37 TM3 hydrophobic
compound 24 [PMID: 16451050] C200 45.50x50 ECL2 Van der Waals
compound 24 [PMID: 16451050] L201 45.51x51 ECL2 hydrophobic
compound 24 [PMID: 16451050] L201 45.51x51 ECL2 Van der Waals
compound 24 [PMID: 16451050] V202 45.52x52 ECL2 Van der Waals
compound 24 [PMID: 16451050] I219 5.42x43 TM5 hydrophobic
compound 24 [PMID: 16451050] S223 5.46x461 TM5 Van der Waals
compound 24 [PMID: 16451050] W276 6.48x48 TM6 hydrophobic
compound 24 [PMID: 16451050] W276 6.48x48 TM6 Van der Waals
compound 24 [PMID: 16451050] Q280 6.52x52 TM6 Van der Waals
compound 24 [PMID: 16451050] V283 6.55x55 TM6 Van der Waals
compound 24 [PMID: 16451050] V283 6.55x55 TM6 hydrophobic
compound 24 [PMID: 16451050] T305 7.39x38 TM7 Van der Waals
compound 24 [PMID: 16451050] Y309 7.43x42 TM7 Van der Waals

Ligands

compound 24 [PMID: 16451050]

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Residue Diagrams

C N G L L G G V C V A L Y L G V I T V K 1 F N L A L A D T L V L L T L P F Q G T D 2 A T L T F T S T F M N Y Y D I A I V T K 3 A Q A V N V A I W A L A S V V G V P V A 4 Y C V S I V L V P V I F S F L F I C I A F 5 L V V V A V F V G C W T P V Q V F V L A 6 I P N L C S N V Y G L A T C F R L I A 7
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ICL1 T K M K ICL1ECL1 F W P F ECL1ICL2 P I R A L D V R ICL2ECL2 S A Q V E D E E I E C L V E I P T ECL2ICL3 R L L S G ICL3ECL3 V Q P S ECL3N-term M E P L F P A P F W E V I Y G S H L Q G N L S L L S P N H S L L P P H L L L N A S H G A F L P N-termC-term A S A L R R D V Q V S D R V R S I A K D V A L A C K T S E T V P R P A C-term L G L K V T I V G L Y L A V C V G G L L G N C L V M Y V I L R H T A T N I Y I F N L A L A D T L V L L T L P F Q G T D I L L G G N A L C K T V I A I D Y Y N M F T S T F T L T A M S V D R Y V A I C H T S S K A Q A V N V A I W A L A S V V G V P V A I M G P Q D Y W G P V F A I C I F L F S F I V P V L V I S V C Y S L M I R R L R G V S R E K D R N L R R I T R L V L V V V A V F V G C W T P V Q V F V L A Q G L G S E T A V A I L R F C T A L G Y V N S C L N P I L Y A F L D E N F R K F K A C F C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
NOP receptor
TM2
2x60 2.60x60 Q107
2x63 2.63x63 D110
TM3
3x29 3.29x29 I127
3x32 3.32x32 D130
3x33 3.33x33 Y131
3x36 3.36x36 M134
3x37 3.37x37 F135
ECL2
45x50 45.50x50 C200
45x51 45.51x51 L201
45x52 45.52x52 V202
TM5
5x43 5.42x43 I219
5x461 5.46x461 S223
TM6
6x48 6.48x48 W276
6x52 6.52x52 Q280
6x55 6.55x55 V283
TM7
7x38 7.39x38 T305
7x42 7.43x42 Y309