Stabilising Mutation Analyser

Group by: Mutant Subsets: Only show mutations present in minimum 2 GPCRs
STATE TARGETS MUTATIONS FREQUENCY SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS
No. Receptor Families
No. Structures
PDBs Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54
I
A
1 1 4
4BWB, 3ZEV, 4BV0, 4BUO
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40
L
A
1 1 4
5KW2, 4PHU, 5TZR, 5TZY
2 1 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51
Y
A
1 1 3
5NDD, 5NJ6, 5NDZ
1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31
D
K
1 1 1
4BVN
4
Intermediate
Inactive
A (Rhodopsin)
Aminergic
Peptide
Nucleotide
Adenosine
Dopamine
Neurotensin
AA1R
AA2AR
NTR1
DRD2
A1
D2
NTS1
A2A
TM6 6x37
L
A
4 3 26
3RFM, 3UZC, 5OLO, 5OM4, 5MZJ, 5N2R, 5MZP, 3REY, 5OLZ, 5IU7, 6CM4, 5N2S, 5IU4, 5OM1, 5NLX, 5OLV, 4GRV, 5IU8, 3UZA, 5IUA, 5IUB, 5OLH, 5OLG, 5NM2, 5NM4, 3PWH
1 1 4
Active
Intermediate
Inactive
A (Rhodopsin)
Sensory
Lipid
Peptide
Neurotensin
Leukotriene
Opsins
OPSD
NTR1
Q9WTK1
OPSD
NTS1
Rhodopsin
BLT1
ECL2
D
S
G
N
C
A
4 3 17
5DGY, 5EN0, 4BEZ, 5T04, 4ZWJ, 6CMO, 5DYS, 4XES, 4XEE, 2J4Y, 2X72, 3C9M, 4GRV, 4A4M, 4BEY, 5X33, 5W0P
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32
R
E
1 1 3
5XRA, 5TGZ, 5XR8
1 3
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49
K
E
1 1 2
5UIW, 4MBS
3 1 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48
T
A
1 1 1
5LWE
2
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
C
A
1 1 3
5NX2, 5VEX, 5VEW
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48
N
Y
1 1 5
5CGD, 6FFI, 6FFH, 4OO9, 5CGC
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38
S
A
1 1 2
4Z9G, 4K5Y
1
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40
M
Y
2 1 5
4ZWJ, 6CMO, 5DGY, 4A4M, 5W0P
1 1
Active
Intermediate
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54
A
L
1 1 8
4BWB, 3ZEV, 4BUO, 5T04, 4BV0, 4GRV, 4XEE, 4XES
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50
D
N
1 1 1
5WF5
Pos Match 1
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60
T
I
1 1 2
5DYS, 5EN0
13
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27
A
L
1 1 18
4GPO, 5A8E, 2YCY, 3ZPQ, 3ZPR, 4BVN, 5F8U, 2Y02, 2VT4, 2Y04, 2Y01, 2YCZ, 2Y03, 2Y00, 2YCW, 4AMJ, 4AMI, 2YCX
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59
R
S
1 1 18
4GPO, 5A8E, 2YCY, 3ZPQ, 3ZPR, 4BVN, 5F8U, 2Y02, 2VT4, 2Y04, 2Y01, 2YCZ, 2Y03, 2Y00, 2YCW, 4AMJ, 4AMI, 2YCX
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54
S
A
1 1 2
5XPR, 5X93
4
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60
C
Y
1 1 2
5UIW, 4MBS
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48
S
A
1 1 2
5VEX, 5VEW
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2
G
M
1 1 5
5CGD, 6FFI, 6FFH, 4OO9, 5CGC
Intermediate
A (Rhodopsin)
Lipid
Peptide
Neurotensin
Free fatty acid
FFAR1
NTR1
NTS1
FFA1
TM3 3x49
G
E
A
2 2 6
5TZY, 5TZR, 4GRV, 4PHU, 4XES, 5KW2
Pos Match 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61
G
N
1 1 2
5UIW, 4MBS
4
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60
L
A
1 1 2
4Z9G, 4K5Y
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47
S
C
1 1 1
5LWE
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63
C
A
1 1 1
5NX2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39
R
A
1 1 2
5EE7, 5YQZ
1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35
E
A
1 1 5
5CGD, 6FFI, 6FFH, 4OO9, 5CGC
Inactive
A (Rhodopsin)
Aminergic
Peptide
Endothelin
Adrenoceptors
ADRB1
EDNRB
β1
ETB
TM7 7x48
F
I
M
A
2 2 20
4GPO, 5A8E, 2YCY, 3ZPQ, 5X93, 3ZPR, 4BVN, 5F8U, 2Y02, 2VT4, 2Y04, 2Y01, 5XPR, 2YCZ, 2Y03, 2Y00, 2YCW, 4AMJ, 4AMI, 2YCX
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55
R
A
1 1 23
3RFM, 3UZC, 5OLO, 5OM4, 5MZJ, 5N2R, 5MZP, 3REY, 5OLZ, 5IU7, 5IU4, 5OM1, 5NLX, 5OLV, 5IU8, 3UZA, 5IUA, 5IUB, 5OLH, 5OLG, 5NM2, 5NM4, 3PWH
1 2
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46
T
A
1 1 4
5XRA, 5U09, 5TGZ, 5XR8
1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67
V
A
1 1 1
5X33
1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36
V
A
1 1 2
4Z9G, 4K5Y
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2Y12
P2RY1
P2Y1
P2Y12
TM7 7x49
D
N
2 1 5
4NTJ, 4PXZ, 4XNV, 4XNW, 4PY0
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50
I
A
1 1 5
5CGD, 6FFI, 6FFH, 4OO9, 5CGC
Pos Match
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38
I
A
1 1 3
5NDD, 5NJ6, 5NDZ
Inactive
A (Rhodopsin)
Aminergic
Nucleotide
Adenosine
Dopamine
AA1R
AA2AR
DRD2
A1
D2
A2A
TM6 6x41
L
V
A
3 2 25
3RFM, 3UZC, 5OLO, 5OM4, 5MZJ, 5N2R, 5MZP, 3REY, 5OLZ, 5IU7, 6CM4, 5N2S, 5IU4, 5OM1, 5NLX, 5OLV, 5IU8, 3UZA, 5IUA, 5IUB, 5OLH, 5OLG, 5NM2, 5NM4, 3PWH
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44
W
A
1 1 2
4Z9G, 4K5Y
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
ECL1
D
L
G
T
Q
F
R
E
A
2 1 2
5EE7, 5NX2
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48
W
K
1 1 1
5VBL
Pos Match 17
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40
V
F
1 1 2
5L7D, 5L7I
1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37
H
A
1 1 3
5NDD, 5NJ6, 5NDZ
1 1 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43
K
A
1 1 2
4Z9G, 4K5Y
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36
F
A
1 1 18
4GPO, 5A8E, 2YCY, 3ZPQ, 3ZPR, 4BVN, 5F8U, 2Y02, 2VT4, 2Y04, 2Y01, 2YCZ, 2Y03, 2Y00, 2YCW, 4AMJ, 4AMI, 2YCX
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42
T
A
1 1 5
5CGD, 6FFI, 6FFH, 4OO9, 5CGC
Intermediate
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM2 2x52
A
L
2 1 28
3RFM, 3UZC, 5OLO, 5OM4, 5MZJ, 5N2R, 5MZP, 3REY, 5OLZ, 5IU7, 2YDV, 5N2S, 5IU4, 5OM1, 5NLX, 5OLV, 5IU8, 3UZA, 5IUA, 4UG2, 5IUB, 5OLH, 4UHR, 2YDO, 5OLG, 5NM2, 5NM4, 3PWH
1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53
Y
A
1 1 2
4Z9G, 4K5Y
Pos Match 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32
M
C
1 1 2
5VEX, 5VEW
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39
F
A
1 1 1
5EE7
Inactive
A (Rhodopsin)
Aminergic
Peptide
Apelin
Dopamine
Adrenoceptors
APJ
ADRB1
DRD2
β1
D2
apelin
TM3 3x40
V
I
V
A
3 3 4
5VBL, 5A8E, 6CM4, 4BVN
2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50
V
A
1 1 1
5LWE
1
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43
V
A
1 1 4
4GRV, 4XES, 4XEE, 5T04
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62
T
A
1 1 4
4UG2, 2YDO, 4UHR, 2YDV
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41
T
A
1 1 1
5LWE
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53
V
E
1 1 3
5NDD, 5NJ6, 5NDZ
5
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29
N
A
1 1 1
5LWE
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33
A
D
1 1 2
5UIW, 4MBS
2 1 5
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53
S
A
1 1 5
5CGD, 6FFI, 6FFH, 4OO9, 5CGC
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42
L
A
1 1 3
5NDD, 5NJ6, 5NDZ
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48
E
F
1 1 1
5EE7
1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36
K
A
1 1 2
5XPR, 5X93
1
Active
Intermediate
Inactive
A (Rhodopsin)
Aminergic
Protein
Dopamine
Chemokine
Adrenoceptors
5-Hydroxytryptamine
5HT2B
5HT1B
CXCR4
ADRB1
DRD3
ADRB2
β1
β2
5-HT2B
D3
5-HT1B
CXCR4
TM3 3x41
L
E
M
W
6 4 20
5A8E, 4NC3, 5V54, 3NYA, 3OE8, 3ODU, 3OE9, 4IB4, 5TVN, 3NY8, 4RWS, 3OE0, 6G79, 4IAQ, 4IAR, 5TUD, 3D4S, 3OE6, 3PBL, 3NY9
1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM5 5x63
L
Y
A
2 1 24
3RFM, 3UZC, 5OLO, 5OM4, 5MZJ, 5N2R, 5MZP, 3REY, 5OLZ, 5IU7, 5N2S, 5IU4, 5OM1, 5NLX, 5OLV, 5IU8, 3UZA, 5IUA, 5IUB, 5OLH, 5OLG, 5NM2, 5NM4, 3PWH
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31
L
F
1 1 1
5NX2
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53
Y
L
1 1 2
5A8E, 4BVN
Pos Match Pos Match 3
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42
P
A
1 1 1
5NX2
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
GLR
CRFR1
CRF1
glucagon
TM2 2x48
S
A
L
A
2 2 3
5EE7, 4Z9G, 4K5Y
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28
E
Q
2 1 5
5W0P, 4ZWJ, 6CMO, 5DGY, 2X72
8
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51
F
A
1 1 2
4Z9G, 4K5Y
1
Intermediate
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
GLP1R
CRFR1
GLP-1
CRF1
ECL2 45x52
F
T
A
2 2 3
4Z9G, 5NX2, 4K5Y
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
TM2 2x56
S
C
A
2 1 3
5EE7, 5VEX, 5VEW
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
TM2 2x59
V
I
F
2 1 3
5EE7, 5VEX, 5VEW
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63
H
C
1 1 2
4QKX, 3PDS
8
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM7 7x41
S
T
A
2 1 24
3RFM, 3UZC, 5OLO, 5OM4, 5MZJ, 5N2R, 5MZP, 3REY, 5OLZ, 5IU7, 5N2S, 5IU4, 5OM1, 5NLX, 5OLV, 5IU8, 3UZA, 5IUA, 5IUB, 5OLH, 5OLG, 5NM2, 5NM4, 3PWH
5
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56
V
A
1 1 1
5NX2
2 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48
I
A
1 1 2
4Z9G, 4K5Y
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
Lysophospholipid (LPA)
CNR1
LPAR1
CB1
LPA1
TM5 5x37
D
E
C
K
2 2 4
5XRA, 4Z36, 5TGZ, 5XR8
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
TM3 3x24
S
G
A
2 1 3
5EE7, 5VEX, 5VEW
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21
K
G
1 1 1
5X33
1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46
G
A
1 1 3
5NDD, 5NJ6, 5NDZ
Intermediate
A (Rhodopsin)
Lipid
Peptide
Proteinase-activated
Free fatty acid
FFAR1
PAR2
PAR2
FFA1
TM3 3x34
F
G
A
2 2 5
5NDD, 4PHU, 5TZR, 5NJ6, 5NDZ
1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47
H
V
1 1 1
5NX2
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45
C
N
1 1 2
6BQG, 6BQH
Pos Match 1
Intermediate
Inactive
A (Rhodopsin)
Aminergic
Lipid
Adrenoceptors
Free fatty acid
FFAR1
ADRB1
β1
FFA1
TM5 5x58
Y
F
A
2 2 22
5A8E, 2YCY, 3ZPR, 4BVN, 5F8U, 2Y01, 5KW2, 5TZR, 2YCZ, 2Y00, 4AMI, 5TZY, 4GPO, 2YCX, 3ZPQ, 2Y02, 2VT4, 2Y04, 2Y03, 2YCW, 4AMJ, 4PHU
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53
M
V
1 1 18
4GPO, 5A8E, 2YCY, 3ZPQ, 3ZPR, 4BVN, 5F8U, 2Y02, 2VT4, 2Y04, 2Y01, 2YCZ, 2Y03, 2Y00, 2YCW, 4AMJ, 4AMI, 2YCX
2
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55
R
Y
1 1 2
5XPR, 5X93
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM3 3x36
T
A
2 1 24
3RFM, 3UZC, 5OLO, 5OM4, 5MZJ, 5N2R, 5MZP, 3REY, 5OLZ, 5IU7, 5N2S, 5IU4, 5OM1, 5NLX, 5OLV, 5IU8, 3UZA, 5IUA, 5IUB, 5OLH, 5OLG, 5NM2, 5NM4, 3PWH
16
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64
M
A
1 1 3
5NDD, 5NJ6, 5NDZ
1 3
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37
Q
A
1 1 4
4UG2, 2YDO, 4UHR, 2YDV
8
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31
C
F
1 1 2
5VEX, 5VEW
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52
G
I
1 1 2
5VEX, 5VEW
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38
M
A
1 1 1
5LWE
1
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59
V
C
1 1 1
4Z36
3
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48
G
A
1 1 1
5EE7
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43
M
L
1 1 3
5NDD, 5NJ6, 5NDZ
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67
H
G
1 1 1
5X33
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
GLR
GLP1R
CRFR1
glucagon
CRF1
GLP-1
TM6 6x30
Y
K
A
3 2 5
5EE7, 4Z9G, 4K5Y, 5VEX, 5VEW
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CCR9
CCR9
CXCR4
TM6 6x36
V
T
P
A
2 1 4
3OE0, 4RWS, 5LWE, 3OE9
2 1 3
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54
M
A
1 1 1
5EE7
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43
K
A
1 1 23
3RFM, 3UZC, 5OLO, 5OM4, 5MZJ, 5N2R, 5MZP, 3REY, 5OLZ, 5IU7, 5IU4, 5OM1, 5NLX, 5OLV, 5IU8, 3UZA, 5IUA, 5IUB, 5OLH, 5OLG, 5NM2, 5NM4, 3PWH
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51
I
C
1 1 2
5VEX, 5VEW
1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39
T
A
1 1 1
5LWE
3
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51
D
C
1 1 1
4RWS
12
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46
L
A
1 1 4
4UG2, 2YDO, 4UHR, 2YDV
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56
D
A
1 1 1
5X93
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39
S
A
1 1 1
5WF6
Pos Match 1
STATE TARGETS MUTATIONS FREQUENCY DATA (MUTANT) SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x48
F
M 1 1 18
4GPO, 5A8E, 2YCY, 3ZPQ, 3ZPR, 4BVN, 5F8U, 2Y02, 2VT4, 2Y04, 2Y01, 2YCZ, 2Y03, 2Y00, 2YCW, 4AMJ, 4AMI, 2YCX
0.05 0.24 -0.67
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27
A
L 1 1 18
4GPO, 5A8E, 2YCY, 3ZPQ, 3ZPR, 4BVN, 5F8U, 2Y02, 2VT4, 2Y04, 2Y01, 2YCZ, 2Y03, 2Y00, 2YCW, 4AMJ, 4AMI, 2YCX
0.11 0.11 0.21 -1.25
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38
I
A 1 1 3
5NDD, 5NJ6, 5NDZ
0.14 0 0.50
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55
R
Y 1 1 2
5XPR, 5X93
0.09 0.53 -0.71
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36
K
A 1 1 2
5XPR, 5X93
0.07 0 0.50 1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM5 5x63
L
Y
A 2 1 24
3RFM, 3UZC, 5OLO, 5OM4, 5MZJ, 5N2R, 5MZP, 3REY, 5OLZ, 5IU7, 5N2S, 5IU4, 5OM1, 5NLX, 5OLV, 5IU8, 3UZA, 5IUA, 5IUB, 5OLH, 5OLG, 5NM2, 5NM4, 3PWH
0.06 0 0.50
Intermediate
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM2 2x52
A
L 2 1 28
3RFM, 3UZC, 5OLO, 5OM4, 5MZJ, 5N2R, 5MZP, 3REY, 5OLZ, 5IU7, 2YDV, 5N2S, 5IU4, 5OM1, 5NLX, 5OLV, 5IU8, 3UZA, 5IUA, 4UG2, 5IUB, 5OLH, 4UHR, 2YDO, 5OLG, 5NM2, 5NM4, 3PWH
0.63 0.21 -1.25 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52
G
I 1 1 2
5VEX, 5VEW
0.07 0.41 -1.12
Intermediate
Inactive
A (Rhodopsin)
Aminergic
Peptide
Nucleotide
Adenosine
Dopamine
Neurotensin
AA1R
AA2AR
NTR1
DRD2
A1
D2
NTS1
A2A
TM6 6x37
L
A 4 3 26
3RFM, 3UZC, 5OLO, 5OM4, 5MZJ, 5N2R, 5MZP, 3REY, 5OLZ, 5IU7, 6CM4, 5N2S, 5IU4, 5OM1, 5NLX, 5OLV, 4GRV, 5IU8, 3UZA, 5IUA, 5IUB, 5OLH, 5OLG, 5NM2, 5NM4, 3PWH
0.04 0 0.50 1 1 4
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48
W
K 1 1 1
5VBL
0.26 2.80 Pos Match (But Not Mutant AA) 17
Inactive
A (Rhodopsin)
Aminergic
Peptide
Apelin
Dopamine
APJ
DRD2
D2
apelin
TM3 3x40
V
I
A 2 2 2
5VBL, 6CM4
0.06 0 0.50 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54
M
A 1 1 1
5EE7
0.27 0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
A 1 1 1
5NX2
0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31
L
F 1 1 1
5NX2
0.4 0.54 -1.71
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37
Q
A 1 1 4
4UG2, 2YDO, 4UHR, 2YDV
0.03 0 0.50 8
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48
G
A 1 1 1
5EE7
0.33 0 0.50
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40
L
A 1 1 4
5KW2, 4PHU, 5TZR, 5TZY
0.06 0 0.50 2 1 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64
M
A 1 1 3
5NDD, 5NJ6, 5NDZ
0.13 0 0.50 1 3
Intermediate
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
GLP1R
CRFR1
GLP-1
CRF1
ECL2 45x52
F
T
A 2 2 3
4Z9G, 5NX2, 4K5Y
0 0.50
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40
V
F 1 1 2
5L7D, 5L7I
0.54 -1.71 1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36
F
A 1 1 18
4GPO, 5A8E, 2YCY, 3ZPQ, 3ZPR, 4BVN, 5F8U, 2Y02, 2VT4, 2Y04, 2Y01, 2YCZ, 2Y03, 2Y00, 2YCW, 4AMJ, 4AMI, 2YCX
0.1 0.11 0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63
C
A 1 1 1
5NX2
0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48
T
A 1 1 1
5LWE
0.03 0 0.50 2
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44
W
A 1 1 2
4Z9G, 4K5Y
0.07 0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46
G
A 1 1 3
5NDD, 5NJ6, 5NDZ
0.11 0 0.50
Active
Intermediate
Inactive
A (Rhodopsin)
Lipid
Peptide
Neurotensin
Leukotriene
NTR1
Q9WTK1
NTS1
BLT1
ECL2
S
G
A 2 2 5
5X33, 4GRV, 4XES, 4XEE, 5T04
0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2Y12
P2RY1
P2Y1
P2Y12
TM7 7x49
D
N 2 1 5
4NTJ, 4PXZ, 4XNV, 4XNW, 4PY0
0.72 0.65 0.85
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59
V
C 1 1 1
4Z36
0.01 0.68 -0.02 3
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM5 5x37
D
C 1 1 1
4Z36
0.68 -0.02 1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67
H
G 1 1 1
5X33
0.2 1.00 1.15
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48
E
F 1 1 1
5EE7
0.13 0.54 -1.71 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29
N
A 1 1 1
5LWE
0.13 0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ICL2
L
F 1 1 1
5NX2
0.54 -1.71
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39
F
A 1 1 1
5EE7
0.07 0 0.50
Active
Intermediate
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54
A
L 1 1 8
4BWB, 3ZEV, 4BUO, 5T04, 4BV0, 4GRV, 4XEE, 4XES
0.37 0.21 -1.25
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33
A
D 1 1 2
5UIW, 4MBS
0.69 0.43 2 1 5
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46
T
A 1 1 4
5XRA, 5U09, 5TGZ, 5XR8
0.01 0 0.50 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
TM2 2x59
V
I
F 2 1 3
5EE7, 5VEX, 5VEW
0.54 -1.71
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
GLR
GLP1R
CRFR1
glucagon
CRF1
GLP-1
TM6 6x30
Y
K
A 3 2 5
5EE7, 4Z9G, 4K5Y, 5VEX, 5VEW
0 0.50
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60
T
I 1 1 2
5DYS, 5EN0
0.04 0.29 0.41 -1.12 13
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67
V
A 1 1 1
5X33
0.08 0 0.50 1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31
D
K 1 1 1
4BVN
0.04 0.11 0.26 2.80 4
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2
G
M 1 1 5
5CGD, 6FFI, 6FFH, 4OO9, 5CGC
0.24 -0.67
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
TM6 6x36
T
P 1 1 3
3OE0, 4RWS, 3OE9
0.0 3.16 0.14 2 1 3
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x56
S
A 1 1 1
5EE7
0.27 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43
K
A 1 1 2
4Z9G, 4K5Y
0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50
I
A 1 1 5
5CGD, 6FFI, 6FFH, 4OO9, 5CGC
0 0.50 Pos & Mutant AA Match
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
ECL1
G
T
E 2 1 2
5EE7, 5NX2
0.40 0.11
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42
L
A 1 1 3
5NDD, 5NJ6, 5NDZ
0.13 0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM3 3x40
I
V 1 1 2
5A8E, 4BVN
0.24 0.61 -0.46 2
Intermediate
A (Rhodopsin)
Lipid
Peptide
Proteinase-activated
Free fatty acid
FFAR1
PAR2
PAR2
FFA1
TM3 3x34
F
G
A 2 2 5
5NDD, 4PHU, 5TZR, 5NJ6, 5NDZ
0.07 0 0.50 1
Active
Inactive
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
N-term
D
N
C 2 1 12
5DGY, 5EN0, 4BEZ, 4ZWJ, 6CMO, 5DYS, 2J4Y, 2X72, 3C9M, 4BEY, 4A4M, 5W0P
0.68 -0.02
Inactive
A (Rhodopsin)
Aminergic
Nucleotide
Adenosine
Dopamine
AA1R
AA2AR
DRD2
A1
D2
A2A
TM6 6x41
L
V
A 3 2 25
3RFM, 3UZC, 5OLO, 5OM4, 5MZJ, 5N2R, 5MZP, 3REY, 5OLZ, 5IU7, 6CM4, 5N2S, 5IU4, 5OM1, 5NLX, 5OLV, 5IU8, 3UZA, 5IUA, 5IUB, 5OLH, 5OLG, 5NM2, 5NM4, 3PWH
0.05 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61
G
N 1 1 2
5UIW, 4MBS
0.03 0.65 0.85 4
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM6 6x36
V
A 1 1 1
5LWE
0.01 0 0.50 2 1 3
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
C 1 1 2
5VEX, 5VEW
0.68 -0.02
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48
N
Y 1 1 5
5CGD, 6FFI, 6FFH, 4OO9, 5CGC
0.05 0.53 -0.71
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM2 2x56
S
C 1 1 2
5VEX, 5VEW
0.68 -0.02
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62
T
A 1 1 4
4UG2, 2YDO, 4UHR, 2YDV
0.13 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31
C
F 1 1 2
5VEX, 5VEW
0.07 0.54 -1.71 1
Active
Intermediate
Inactive
A (Rhodopsin)
Aminergic
Protein
Dopamine
Chemokine
Adrenoceptors
5-Hydroxytryptamine
5HT2B
5HT1B
CXCR4
ADRB1
DRD3
ADRB2
β1
β2
5-HT2B
D3
5-HT1B
CXCR4
TM3 3x41
L
E
M
W 6 4 20
5A8E, 4NC3, 5V54, 3NYA, 3OE8, 3ODU, 3OE9, 4IB4, 5TVN, 3NY8, 4RWS, 3OE0, 6G79, 4IAQ, 4IAR, 5TUD, 3D4S, 3OE6, 3PBL, 3NY9
0.03 0.49 -2.09 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39
S
A 1 1 1
5WF6
0.03 0 0.50 Pos & AA Mutant Match 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51
I
C 1 1 2
5VEX, 5VEW
0.68 -0.02 1
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45
C
N 1 1 2
6BQG, 6BQH
0.67 0.65 0.85 Pos & AA Mutant Match 1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM5 5x58
Y
A 1 1 18
4GPO, 5A8E, 2YCY, 3ZPQ, 3ZPR, 4BVN, 5F8U, 2Y02, 2VT4, 2Y04, 2Y01, 2YCZ, 2Y03, 2Y00, 2YCW, 4AMJ, 4AMI, 2YCX
0.03 0 0.50
Intermediate
A (Rhodopsin)
Lipid
Peptide
Neurotensin
Free fatty acid
FFAR1
NTR1
NTS1
FFA1
TM3 3x49
G
E
A 2 2 6
5TZY, 5TZR, 4GRV, 4PHU, 4XES, 5KW2
0.01 0 0.50 Pos & Mutant AA Match 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32
M
C 1 1 2
5VEX, 5VEW
0.68 -0.02
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM3 3x36
T
A 2 1 24
3RFM, 3UZC, 5OLO, 5OM4, 5MZJ, 5N2R, 5MZP, 3REY, 5OLZ, 5IU7, 5N2S, 5IU4, 5OM1, 5NLX, 5OLV, 5IU8, 3UZA, 5IUA, 5IUB, 5OLH, 5OLG, 5NM2, 5NM4, 3PWH
0.02 0 0.50 16
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51
D
C 1 1 1
4RWS
0.68 -0.02 12
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM5 5x37
E
K 1 1 3
5XRA, 5TGZ, 5XR8
0.11 0.26 2.80 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54
S
A 1 1 2
5XPR, 5X93
0.1 0 0.50 4
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48
I
A 1 1 2
4Z9G, 4K5Y
0 0.50
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40
M
Y 2 1 5
4ZWJ, 6CMO, 5DGY, 4A4M, 5W0P
0.01 0.53 -0.71 1 1
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63
H
C 1 1 2
4QKX, 3PDS
0.0 0.68 -0.02 8
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39
T
A 1 1 1
5LWE
0.08 0 0.50 3
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53
Y
A 1 1 2
4Z9G, 4K5Y
0 0.50 Pos & Mutant AA Match 1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59
R
S 1 1 18
4GPO, 5A8E, 2YCY, 3ZPQ, 3ZPR, 4BVN, 5F8U, 2Y02, 2VT4, 2Y04, 2Y01, 2YCZ, 2Y03, 2Y00, 2YCW, 4AMJ, 4AMI, 2YCX
0.04 0.50 0.46
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38
S
A 1 1 2
4Z9G, 4K5Y
0 0.50 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1
Q
G
A 1 1 1
5NX2
0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37
H
A 1 1 3
5NDD, 5NJ6, 5NDZ
0.05 0 0.50 1 1 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42
P
A 1 1 1
5NX2
0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x48
S
A 1 1 2
4Z9G, 4K5Y
0.2 0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM7 7x41
S
T
A 2 1 24
3RFM, 3UZC, 5OLO, 5OM4, 5MZJ, 5N2R, 5MZP, 3REY, 5OLZ, 5IU7, 5N2S, 5IU4, 5OM1, 5NLX, 5OLV, 5IU8, 3UZA, 5IUA, 5IUB, 5OLH, 5OLG, 5NM2, 5NM4, 3PWH
0.38 0 0.50 5
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55
R
A 1 1 23
3RFM, 3UZC, 5OLO, 5OM4, 5MZJ, 5N2R, 5MZP, 3REY, 5OLZ, 5IU7, 5IU4, 5OM1, 5NLX, 5OLV, 5IU8, 3UZA, 5IUA, 5IUB, 5OLH, 5OLG, 5NM2, 5NM4, 3PWH
0.08 0 0.50 1 2
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53
S
A 1 1 5
5CGD, 6FFI, 6FFH, 4OO9, 5CGC
0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38
M
A 1 1 1
5LWE
0.12 0 0.50 1
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM5 5x58
Y
F 1 1 4
5KW2, 4PHU, 5TZR, 5TZY
0.01 0.54 -1.71
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47
S
C 1 1 1
5LWE
0.02 0.68 -0.02
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54
I
A 1 1 4
4BWB, 3ZEV, 4BV0, 4BUO
0.02 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48
S
A 1 1 2
5VEX, 5VEW
0.07 0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35
E
A 1 1 5
5CGD, 6FFI, 6FFH, 4OO9, 5CGC
0.05 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41
T
A 1 1 1
5LWE
0.07 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39
R
A 1 1 2
5EE7, 5YQZ
0 0.50 1
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28
E
Q 2 1 5
5W0P, 4ZWJ, 6CMO, 5DGY, 2X72
0.01 0.39 0.77 8
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46
L
A 1 1 4
4UG2, 2YDO, 4UHR, 2YDV
0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42
T
A 1 1 5
5CGD, 6FFI, 6FFH, 4OO9, 5CGC
0.05 0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53
M
V 1 1 18
4GPO, 5A8E, 2YCY, 3ZPQ, 3ZPR, 4BVN, 5F8U, 2Y02, 2VT4, 2Y04, 2Y01, 2YCZ, 2Y03, 2Y00, 2YCW, 4AMJ, 4AMI, 2YCX
0.23 0.33 0.61 -0.46 2
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47
H
V 1 1 1
5NX2
0.61 -0.46
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51
Y
A 1 1 3
5NDD, 5NJ6, 5NDZ
0.0 0 0.50 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50
D
N 1 1 1
5WF5
0.03 0.65 0.85 Pos & AA Mutant Match 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43
M
L 1 1 3
5NDD, 5NJ6, 5NDZ
0.73 0.21 -1.25
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53
V
E 1 1 3
5NDD, 5NJ6, 5NDZ
0.01 0.40 0.11 5
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60
L
A 1 1 2
4Z9G, 4K5Y
0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49
K
E 1 1 2
5UIW, 4MBS
0.12 0.40 0.11 3 1 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56
D
A 1 1 1
5X93
0.08 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36
V
A 1 1 2
4Z9G, 4K5Y
0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56
V
A 1 1 1
5NX2
0.07 0 0.50 2 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x48
A
L 1 1 1
5EE7
0.2 0.21 -1.25
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53
Y
L 1 1 2
5A8E, 4BVN
0.03 0.21 -1.25 Pos Match (But Not Mutant AA) Pos & Mutant AA Match 3
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51
F
A 1 1 2
4Z9G, 4K5Y
0 0.50 1
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43
V
A 1 1 4
4GRV, 4XES, 4XEE, 5T04
0.19 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50
V
A 1 1 1
5LWE
0.06 0 0.50 1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21
K
G 1 1 1
5X33
0.67 1.00 1.15 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1
D
R 1 1 1
5NX2
0.21 1.81
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43
K
A 1 1 23
3RFM, 3UZC, 5OLO, 5OM4, 5MZJ, 5N2R, 5MZP, 3REY, 5OLZ, 5IU7, 5IU4, 5OM1, 5NLX, 5OLV, 5IU8, 3UZA, 5IUA, 5IUB, 5OLH, 5OLG, 5NM2, 5NM4, 3PWH
0.13 0 0.50
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM7 7x48
I
A 1 1 2
5XPR, 5X93
0.13 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60
C
Y 1 1 2
5UIW, 4MBS
0.07 0.53 -0.71 1
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32
R
E 1 1 3
5XRA, 5TGZ, 5XR8
0.04 0.40 0.11 1 3
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
TM3 3x24
S
G
A 2 1 3
5EE7, 5VEX, 5VEW
0.07 0 0.50
STATE TARGETS MUTATIONS FREQUENCY DATA (WILD TYPE) SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49 K
E
1 1 2
5UIW, 4MBS
0.13 0.26 2.80 3 1 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL2 45x52 T
A
1 1 1
5NX2
0.2 0.66 0.25
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50 D
N
1 1 1
5WF5
0.92 0.69 0.43 Pos & Wild Type AA Match 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52 G
I
1 1 2
5VEX, 5VEW
0.2 1.00 1.15
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 Q
A
1 1 1
5NX2
0.39 0.77
Inactive
A (Rhodopsin)
Aminergic
Nucleotide
Adenosine
Dopamine
AA1R
DRD2
A1
D2
TM6 6x41 L
A
2 2 2
6CM4, 5N2S
0.19 0.21 -1.25
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40 L
A
1 1 4
5KW2, 4PHU, 5TZR, 5TZY
0.03 0.21 -1.25 2 1 1
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28 E
Q
2 1 5
5W0P, 4ZWJ, 6CMO, 5DGY, 2X72
0.02 0.57 0.40 0.11 8
Intermediate
Inactive
A (Rhodopsin)
Aminergic
Peptide
Nucleotide
Adenosine
Dopamine
Neurotensin
AA1R
AA2AR
NTR1
DRD2
A1
D2
NTS1
A2A
TM6 6x37 L
A
4 3 26
3RFM, 3UZC, 5OLO, 5OM4, 5MZJ, 5N2R, 5MZP, 3REY, 5OLZ, 5IU7, 6CM4, 5N2S, 5IU4, 5OM1, 5NLX, 5OLV, 4GRV, 5IU8, 3UZA, 5IUA, 5IUB, 5OLH, 5OLG, 5NM2, 5NM4, 3PWH
0.38 0.21 -1.25 1 1 4
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46 T
A
1 1 4
5XRA, 5U09, 5TGZ, 5XR8
0.01 0.66 0.25 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51 I
C
1 1 2
5VEX, 5VEW
0.6 0.41 -1.12 1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27 A
L
1 1 18
4GPO, 5A8E, 2YCY, 3ZPQ, 3ZPR, 4BVN, 5F8U, 2Y02, 2VT4, 2Y04, 2Y01, 2YCZ, 2Y03, 2Y00, 2YCW, 4AMJ, 4AMI, 2YCX
0.08 0.11 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39 T
A
1 1 1
5LWE
0.03 0.66 0.25 3
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32 R
E
1 1 3
5XRA, 5TGZ, 5XR8
0.31 0.21 1.81 1 3
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48 N
Y
1 1 5
5CGD, 6FFI, 6FFH, 4OO9, 5CGC
0.41 0.65 0.85
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
TM6 6x30 K
A
2 1 3
5EE7, 5VEX, 5VEW
0.2 0.26 2.80
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39 F
A
1 1 1
5EE7
0.33 0.54 -1.71
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45 C
N
1 1 2
6BQG, 6BQH
0.01 0.68 -0.02 Pos & Wild Type AA Match 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM7 7x48 I
A
1 1 2
5XPR, 5X93
0.15 0.41 -1.12
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50 I
A
1 1 5
5CGD, 6FFI, 6FFH, 4OO9, 5CGC
0.5 0.41 -1.12 Pos & Wild Type AA Match
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53 Y
A
1 1 2
4Z9G, 4K5Y
0.93 0.53 -0.71 Pos & Wild Type AA Match 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54 S
A
1 1 2
5XPR, 5X93
0.05 0.50 0.46 4
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48 E
F
1 1 1
5EE7
0.27 0.40 0.11 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x30 Y
A
1 1 2
4Z9G, 4K5Y
0.73 0.53 -0.71
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM3 3x40 V
A
1 1 1
5VBL
0.24 0.61 -0.46 2
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63 C
A
1 1 1
5NX2
0.07 0.68 -0.02
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39 R
A
1 1 2
5EE7, 5YQZ
1.0 0.21 1.81 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43 M
L
1 1 3
5NDD, 5NJ6, 5NDZ
0.05 0.24 -0.67
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41 T
A
1 1 1
5LWE
0.09 0.66 0.25
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
ECL2 G
E
A
2 1 2
5EE7, 5NX2
1.00 1.15
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59 R
S
1 1 18
4GPO, 5A8E, 2YCY, 3ZPQ, 3ZPR, 4BVN, 5F8U, 2Y02, 2VT4, 2Y04, 2Y01, 2YCZ, 2Y03, 2Y00, 2YCW, 4AMJ, 4AMI, 2YCX
0.24 0.21 1.81
Intermediate
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM2 2x52 A
L
2 1 28
3RFM, 3UZC, 5OLO, 5OM4, 5MZJ, 5N2R, 5MZP, 3REY, 5OLZ, 5IU7, 2YDV, 5N2S, 5IU4, 5OM1, 5NLX, 5OLV, 5IU8, 3UZA, 5IUA, 4UG2, 5IUB, 5OLH, 4UHR, 2YDO, 5OLG, 5NM2, 5NM4, 3PWH
0.06 0 0.50 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56 V
A
1 1 1
5NX2
0.07 0.61 -0.46 2 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51 D
C
1 1 1
4RWS
0.03 0.69 0.43 12
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54 I
A
1 1 4
4BWB, 3ZEV, 4BV0, 4BUO
0.33 0.41 -1.12
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM6 6x36 V
A
1 1 1
5LWE
0.15 0.61 -0.46 2 1 3
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60 L
A
1 1 2
4Z9G, 4K5Y
0.33 0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48 G
A
1 1 1
5EE7
0.13 1.00 1.15
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM3 3x49 G
A
1 1 4
5KW2, 4PHU, 5TZR, 5TZY
0.01 1.00 1.15 Pos & Wild Type AA Match 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
TM6 6x36 T
P
1 1 3
3OE0, 4RWS, 3OE9
0.25 0.66 0.25 2 1 3
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM5 5x37 E
K
1 1 3
5XRA, 5TGZ, 5XR8
0.03 0.40 0.11 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35 E
A
1 1 5
5CGD, 6FFI, 6FFH, 4OO9, 5CGC
0.09 0.40 0.11
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM6 6x41 V
A
1 1 23
3RFM, 3UZC, 5OLO, 5OM4, 5MZJ, 5N2R, 5MZP, 3REY, 5OLZ, 5IU7, 5IU4, 5OM1, 5NLX, 5OLV, 5IU8, 3UZA, 5IUA, 5IUB, 5OLH, 5OLG, 5NM2, 5NM4, 3PWH
0.41 0.61 -0.46
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63 H
C
1 1 2
4QKX, 3PDS
0.03 0.11 0.61 0.11 8
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38 I
A
1 1 3
5NDD, 5NJ6, 5NDZ
0.08 0.41 -1.12
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31 D
K
1 1 1
4BVN
0.1 0.22 0.69 0.43 4
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 T
E
1 1 1
5NX2
0.66 0.25
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37 H
A
1 1 3
5NDD, 5NJ6, 5NDZ
0.03 0.61 0.11 1 1 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36 V
A
1 1 2
4Z9G, 4K5Y
0.07 0.61 -0.46
Active
Inactive
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
N-term N
C
2 1 12
5DGY, 5EN0, 4BEZ, 4ZWJ, 6CMO, 5DYS, 2J4Y, 2X72, 3C9M, 4BEY, 4A4M, 5W0P
0.65 0.85
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60 C
Y
1 1 2
5UIW, 4MBS
0.02 0.68 -0.02 1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
ADRB2
β1
β2
TM3 3x41 E
W
2 1 5
5A8E, 3NY8, 3NY9, 3NYA, 3D4S
0.01 0.33 0.40 0.11 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61 G
N
1 1 2
5UIW, 4MBS
0.02 1.00 1.15 4
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x24 S
A
1 1 2
5VEX, 5VEW
0.27 0.50 0.46
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42 P
A
1 1 1
5NX2
0.93 3.16 0.14
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53 Y
L
1 1 2
5A8E, 4BVN
0.89 1.0 0.53 -0.71 Pos & Wild Type AA Match Pos & Wild Type AA Match 3
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60 T
I
1 1 2
5DYS, 5EN0
0.08 0.43 0.66 0.25 13
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33 A
D
1 1 2
5UIW, 4MBS
0.29 0 0.50 2 1 5
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
TM2 2x56 S
C
A
2 1 3
5EE7, 5VEX, 5VEW
0.47 0.50 0.46
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
C-term S
A
1 1 1
5X33
0.50 0.46
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42 T
A
1 1 5
5CGD, 6FFI, 6FFH, 4OO9, 5CGC
0.09 0.66 0.25
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x48 S
A
1 1 2
4Z9G, 4K5Y
0.07 0.50 0.46
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x48 A
L
1 1 1
5EE7
0.2 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48 I
A
1 1 2
4Z9G, 4K5Y
0.2 0.41 -1.12
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21 K
G
1 1 1
5X33
0.01 0.26 2.80 1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM5 5x63 L
A
1 1 23
3RFM, 3UZC, 5OLO, 5OM4, 5MZJ, 5N2R, 5MZP, 3REY, 5OLZ, 5IU7, 5IU4, 5OM1, 5NLX, 5OLV, 5IU8, 3UZA, 5IUA, 5IUB, 5OLH, 5OLG, 5NM2, 5NM4, 3PWH
0.13 0.21 -1.25
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40 V
F
1 1 2
5L7D, 5L7I
0.09 0.09 0.61 -0.46 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
ECL2 45x52 F
A
1 1 2
4Z9G, 4K5Y
0.13 0.54 -1.71
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67 H
G
1 1 1
5X33
0.1 0.61 0.11
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54 M
A
1 1 1
5EE7
0.07 0.24 -0.67
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31 L
F
1 1 1
5NX2
0.2 0.21 -1.25
Active
Intermediate
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2B
5-HT2B
TM3 3x41 M
W
1 1 4
4NC3, 5TVN, 4IB4, 5TUD
0.04 0.24 -0.67 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55 R
Y
1 1 2
5XPR, 5X93
0.02 0.21 1.81
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50 V
A
1 1 1
5LWE
0.02 0.61 -0.46 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31 C
F
1 1 2
5VEX, 5VEW
0.07 0.68 -0.02 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36 K
A
1 1 2
5XPR, 5X93
0.06 0.26 2.80 1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36 F
A
1 1 18
4GPO, 5A8E, 2YCY, 3ZPQ, 3ZPR, 4BVN, 5F8U, 2Y02, 2VT4, 2Y04, 2Y01, 2YCZ, 2Y03, 2Y00, 2YCW, 4AMJ, 4AMI, 2YCX
0.14 0.44 0.54 -1.71
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53 V
E
1 1 3
5NDD, 5NJ6, 5NDZ
0.07 0.61 -0.46 5
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46 L
A
1 1 4
4UG2, 2YDO, 4UHR, 2YDV
0.9 0.21 -1.25
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37 Q
A
1 1 4
4UG2, 2YDO, 4UHR, 2YDV
0.02 0.39 0.77 8
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2Y12
P2RY1
P2Y1
P2Y12
TM7 7x49 D
N
2 1 5
4NTJ, 4PXZ, 4XNV, 4XNW, 4PY0
0.2 0.69 0.43
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43 V
A
1 1 4
4GRV, 4XES, 4XEE, 5T04
0.1 0.61 -0.46
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42 L
A
1 1 3
5NDD, 5NJ6, 5NDZ
0.24 0.21 -1.25
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62 T
A
1 1 4
4UG2, 2YDO, 4UHR, 2YDV
0.1 0.66 0.25
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59 V
C
1 1 1
4Z36
0.12 0.61 -0.46 3
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56 D
A
1 1 1
5X93
0.01 0.69 0.43
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 D
R
1 1 1
5NX2
0.69 0.43
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45 G
C
A
1 1 3
5NX2, 5VEX, 5VEW
1.0 1.00 1.15
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39 S
A
1 1 1
5WF6
0.72 0.50 0.46 Pos & Wild Type AA Match 1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
A1
TM7 7x41 T
A
1 1 1
5N2S
0.07 0.66 0.25 5
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32 M
C
1 1 2
5VEX, 5VEW
0.13 0.24 -0.67
Active
Intermediate
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54 A
L
1 1 8
4BWB, 3ZEV, 4BUO, 5T04, 4BV0, 4GRV, 4XEE, 4XES
0.04 0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43 K
A
1 1 23
3RFM, 3UZC, 5OLO, 5OM4, 5MZJ, 5N2R, 5MZP, 3REY, 5OLZ, 5IU7, 5IU4, 5OM1, 5NLX, 5OLV, 5IU8, 3UZA, 5IUA, 5IUB, 5OLH, 5OLG, 5NM2, 5NM4, 3PWH
0.16 0.26 2.80
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38 M
A
1 1 1
5LWE
0.04 0.24 -0.67 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48 S
A
1 1 2
5VEX, 5VEW
0.07 0.50 0.46
Inactive
A (Rhodopsin)
Aminergic
Dopamine
Adrenoceptors
ADRB1
DRD2
β1
D2
TM3 3x40 I
V
A
2 2 3
5A8E, 6CM4, 4BVN
0.4 0.41 -1.12 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29 N
A
1 1 1
5LWE
0.04 0.65 0.85
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x59 V
F
1 1 1
5EE7
0.4 0.61 -0.46
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM3 3x36 T
A
2 1 24
3RFM, 3UZC, 5OLO, 5OM4, 5MZJ, 5N2R, 5MZP, 3REY, 5OLZ, 5IU7, 5N2S, 5IU4, 5OM1, 5NLX, 5OLV, 5IU8,