Stabilising Mutation Analyser

Group by: Mutant Subsets: Only show mutations present in minimum 2 GPCRs
STATE TARGETS MUTATIONS FREQUENCY SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS
No. Receptor Families
No. Structures
PDBs Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51
D
C
1 1 1
4RWS
12
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55
R
A
1 1 23
3UZC, 5N2R, 5OM4, 5IUB, 3PWH, 5NLX, 5OLV, 5IU4, 3UZA, 5NM4, 5IU8, 5OM1, 5OLH, 5MZP, 5OLG, 5OLZ, 5IU7, 3REY, 5MZJ, 3RFM, 5NM2, 5OLO, 5IUA
1 2
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53
V
E
1 1 3
5NDZ, 5NDD, 5NJ6
5
Active
Intermediate
Inactive
A (Rhodopsin)
Sensory
Peptide
Lipid
Neurotensin
Opsins
Leukotriene
OPSD
NTR1
Q9WTK1
OPSD
NTS1
Rhodopsin
BLT1
ECL2
N
S
G
D
A
C
4 3 17
4XES, 4BEZ, 4GRV, 2X72, 5DYS, 2J4Y, 6CMO, 4A4M, 5X33, 4ZWJ, 5EN0, 3C9M, 5DGY, 4XEE, 5T04, 4BEY, 5W0P
Intermediate
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM2 2x52
A
L
2 1 28
3UZC, 5N2R, 4UG2, 5OM4, 5IUB, 3PWH, 5NLX, 5OLV, 5IU4, 3UZA, 5NM4, 5IU8, 5OM1, 5OLH, 5MZP, 4UHR, 5OLG, 2YDV, 5OLZ, 5N2S, 5IU7, 3REY, 5MZJ, 3RFM, 5NM2, 5OLO, 5IUA, 2YDO
1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31
L
F
1 1 1
5NX2
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38
S
A
1 1 2
4K5Y, 4Z9G
1
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60
T
I
1 1 2
5EN0, 5DYS
13
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50
V
A
1 1 1
5LWE
1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47
S
C
1 1 1
5LWE
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41
T
A
1 1 1
5LWE
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21
K
G
1 1 1
5X33
1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM5 5x63
Y
L
A
2 1 24
3UZC, 5N2R, 5OM4, 5IUB, 3PWH, 5NLX, 5OLV, 5IU4, 3UZA, 5NM4, 5IU8, 5OM1, 5OLH, 5MZP, 5OLG, 5OLZ, 5N2S, 5IU7, 3REY, 5MZJ, 3RFM, 5NM2, 5OLO, 5IUA
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50
D
N
1 1 1
5WF5
Pos Match 1
Intermediate
A (Rhodopsin)
Peptide
Lipid
Proteinase-activated
Free fatty acid
FFAR1
PAR2
FFA1
PAR2
TM3 3x34
F
G
A
2 2 5
5TZR, 5NJ6, 5NDZ, 5NDD, 4PHU
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52
G
I
1 1 2
5VEW, 5VEX
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51
I
C
1 1 2
5VEW, 5VEX
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32
M
C
1 1 2
5VEW, 5VEX
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45
C
N
1 1 2
6BQH, 6BQG
Pos Match 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46
G
A
1 1 3
5NDZ, 5NDD, 5NJ6
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
GLR
GLP1R
CRFR1
glucagon
GLP-1
CRF1
TM6 6x30
Y
K
A
3 2 5
5EE7, 4Z9G, 4K5Y, 5VEW, 5VEX
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53
M
V
1 1 18
3ZPQ, 2YCX, 4AMJ, 4BVN, 5F8U, 2Y02, 2Y04, 3ZPR, 4AMI, 2YCW, 2YCZ, 5A8E, 2YCY, 2Y00, 2Y03, 2VT4, 2Y01, 4GPO
2
Active
Intermediate
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54
A
L
1 1 8
4BV0, 4XES, 4GRV, 4BWB, 4XEE, 3ZEV, 4BUO, 5T04
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42
L
A
1 1 3
5NDZ, 5NDD, 5NJ6
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54
M
A
1 1 1
5EE7
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48
I
A
1 1 2
4K5Y, 4Z9G
Intermediate
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
GLP1R
CRFR1
GLP-1
CRF1
ECL2 45x52
T
F
A
2 2 3
5NX2, 4K5Y, 4Z9G
Intermediate
Inactive
A (Rhodopsin)
Aminergic
Lipid
Adrenoceptors
Free fatty acid
FFAR1
ADRB1
FFA1
β1
TM5 5x58
Y
A
F
2 2 22
5KW2, 5F8U, 2Y02, 2Y04, 5TZY, 3ZPR, 5A8E, 4PHU, 2YCY, 3ZPQ, 2VT4, 2Y01, 5TZR, 2YCX, 4AMJ, 4BVN, 4AMI, 2YCW, 2YCZ, 2Y00, 2Y03, 4GPO
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28
E
Q
2 1 5
5DGY, 4ZWJ, 2X72, 5W0P, 6CMO
8
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46
L
A
1 1 4
2YDV, 4UG2, 2YDO, 4UHR
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55
R
Y
1 1 2
5X93, 5XPR
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48
E
F
1 1 1
5EE7
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48
G
A
1 1 1
5EE7
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61
G
N
1 1 2
4MBS, 5UIW
4
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42
T
A
1 1 5
5CGD, 4OO9, 6FFH, 5CGC, 6FFI
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64
M
A
1 1 3
5NDZ, 5NDD, 5NJ6
1 3
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31
C
F
1 1 2
5VEW, 5VEX
1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53
Y
L
1 1 2
5A8E, 4BVN
Pos Match Pos Match 3
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53
Y
A
1 1 2
4K5Y, 4Z9G
Pos Match 1
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
A
C
1 1 3
5NX2, 5VEW, 5VEX
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39
T
A
1 1 1
5LWE
3
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36
V
A
1 1 2
4K5Y, 4Z9G
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48
S
A
1 1 2
5VEW, 5VEX
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53
S
A
1 1 5
5CGD, 4OO9, 6FFH, 5CGC, 6FFI
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59
V
C
1 1 1
4Z36
3
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56
D
A
1 1 1
5X93
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43
M
L
1 1 3
5NDZ, 5NDD, 5NJ6
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37
H
A
1 1 3
5NDZ, 5NDD, 5NJ6
1 1 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50
I
A
1 1 5
5CGD, 4OO9, 6FFH, 5CGC, 6FFI
Pos Match
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40
M
Y
2 1 5
5DGY, 4ZWJ, 4A4M, 5W0P, 6CMO
1 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38
M
A
1 1 1
5LWE
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
TM2 2x56
S
A
C
2 1 3
5EE7, 5VEW, 5VEX
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Adenosine
Dopamine
AA1R
AA2AR
DRD2
A1
A2A
D2
TM6 6x41
L
V
A
3 2 25
3UZC, 5N2R, 5OM4, 5IUB, 3PWH, 5NLX, 5OLV, 5IU4, 3UZA, 5NM4, 5IU8, 6CM4, 5OM1, 5OLH, 5MZP, 5OLG, 5OLZ, 5N2S, 5IU7, 3REY, 5MZJ, 3RFM, 5NM2, 5OLO, 5IUA
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51
F
A
1 1 2
4K5Y, 4Z9G
1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60
L
A
1 1 2
4K5Y, 4Z9G
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47
H
V
1 1 1
5NX2
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48
W
K
1 1 1
5VBL
Pos Match 17
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48
T
A
1 1 1
5LWE
2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29
N
A
1 1 1
5LWE
Inactive
A (Rhodopsin)
Aminergic
Peptide
Apelin
Adrenoceptors
Dopamine
APJ
ADRB1
DRD2
β1
apelin
D2
TM3 3x40
I
V
A
V
3 3 4
5A8E, 6CM4, 4BVN, 5VBL
2
Active
Intermediate
Inactive
A (Rhodopsin)
Aminergic
Protein
Dopamine
Chemokine
Adrenoceptors
5-Hydroxytryptamine
5HT2B
5HT1B
CXCR4
ADRB1
DRD3
ADRB2
β1
5-HT1B
β2
5-HT2B
CXCR4
D3
TM3 3x41
L
M
E
W
6 4 20
3NY8, 3NYA, 4RWS, 3OE8, 3NY9, 3ODU, 3PBL, 3OE6, 4IAQ, 3OE0, 5A8E, 5TUD, 5V54, 4NC3, 4IAR, 3D4S, 6G79, 5TVN, 3OE9, 4IB4
1
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2Y12
P2RY1
P2Y12
P2Y1
TM7 7x49
D
N
2 1 5
4PXZ, 4XNW, 4XNV, 4PY0, 4NTJ
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60
C
Y
1 1 2
4MBS, 5UIW
1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35
E
A
1 1 5
5CGD, 4OO9, 6FFH, 5CGC, 6FFI
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32
R
E
1 1 3
5TGZ, 5XRA, 5XR8
1 3
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36
K
A
1 1 2
5X93, 5XPR
1
Intermediate
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Peptide
Neurotensin
Adenosine
Dopamine
AA1R
AA2AR
NTR1
DRD2
NTS1
A1
A2A
D2
TM6 6x37
L
A
4 3 26
3UZC, 5N2R, 5OM4, 5IUB, 3PWH, 5NLX, 5OLV, 5IU4, 3UZA, 5NM4, 5IU8, 6CM4, 5OM1, 5OLH, 4GRV, 5MZP, 5OLG, 5OLZ, 5N2S, 5IU7, 3REY, 5MZJ, 3RFM, 5NM2, 5OLO, 5IUA
1 1 4
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49
K
E
1 1 2
4MBS, 5UIW
3 1 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CCR9
CCR9
CXCR4
TM6 6x36
T
V
A
P
2 1 4
3OE9, 3OE0, 5LWE, 4RWS
2 1 3
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
Lysophospholipid (LPA)
CNR1
LPAR1
LPA1
CB1
TM5 5x37
D
E
C
K
2 2 4
5TGZ, 5XRA, 4Z36, 5XR8
1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43
K
A
1 1 23
3UZC, 5N2R, 5OM4, 5IUB, 3PWH, 5NLX, 5OLV, 5IU4, 3UZA, 5NM4, 5IU8, 5OM1, 5OLH, 5MZP, 5OLG, 5OLZ, 5IU7, 3REY, 5MZJ, 3RFM, 5NM2, 5OLO, 5IUA
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46
T
A
1 1 4
5TGZ, 5U09, 5XRA, 5XR8
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
TM2 2x59
I
V
F
2 1 3
5EE7, 5VEW, 5VEX
Intermediate
A (Rhodopsin)
Peptide
Lipid
Neurotensin
Free fatty acid
FFAR1
NTR1
FFA1
NTS1
TM3 3x49
G
E
A
2 2 6
5TZR, 4XES, 4GRV, 5KW2, 4PHU, 5TZY
Pos Match 2
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54
I
A
1 1 4
4BV0, 3ZEV, 4BUO, 4BWB
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33
A
D
1 1 2
4MBS, 5UIW
2 1 5
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62
T
A
1 1 4
2YDV, 4UG2, 2YDO, 4UHR
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42
P
A
1 1 1
5NX2
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM7 7x41
S
T
A
2 1 24
3UZC, 5N2R, 5OM4, 5IUB, 3PWH, 5NLX, 5OLV, 5IU4, 3UZA, 5NM4, 5IU8, 5OM1, 5OLH, 5MZP, 5OLG, 5OLZ, 5N2S, 5IU7, 3REY, 5MZJ, 3RFM, 5NM2, 5OLO, 5IUA
5
Inactive
A (Rhodopsin)
Aminergic
Peptide
Adrenoceptors
Endothelin
ADRB1
EDNRB
β1
ETB
TM7 7x48
F
I
A
M
2 2 20
3ZPQ, 2YCX, 5X93, 4AMJ, 4BVN, 5F8U, 2Y02, 2Y04, 3ZPR, 4AMI, 2YCW, 2YCZ, 5A8E, 5XPR, 2YCY, 2Y00, 2Y03, 2VT4, 2Y01, 4GPO
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48
N
Y
1 1 5
5CGD, 4OO9, 6FFH, 5CGC, 6FFI
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37
Q
A
1 1 4
2YDV, 4UG2, 2YDO, 4UHR
8
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43
K
A
1 1 2
4K5Y, 4Z9G
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2
G
M
1 1 5
5CGD, 4OO9, 6FFH, 5CGC, 6FFI
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51
Y
A
1 1 3
5NDZ, 5NDD, 5NJ6
1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
TM3 3x24
S
G
A
2 1 3
5EE7, 5VEW, 5VEX
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM3 3x36
T
A
2 1 24
3UZC, 5N2R, 5OM4, 5IUB, 3PWH, 5NLX, 5OLV, 5IU4, 3UZA, 5NM4, 5IU8, 5OM1, 5OLH, 5MZP, 5OLG, 5OLZ, 5N2S, 5IU7, 3REY, 5MZJ, 3RFM, 5NM2, 5OLO, 5IUA
16
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
GLR
CRFR1
glucagon
CRF1
TM2 2x48
A
S
A
L
2 2 3
4Z9G, 4K5Y, 5EE7
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36
F
A
1 1 18
3ZPQ, 2YCX, 4AMJ, 4BVN, 5F8U, 2Y02, 2Y04, 3ZPR, 4AMI, 2YCW, 2YCZ, 5A8E, 2YCY, 2Y00, 2Y03, 2VT4, 2Y01, 4GPO
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59
R
S
1 1 18
3ZPQ, 2YCX, 4AMJ, 4BVN, 5F8U, 2Y02, 2Y04, 3ZPR, 4AMI, 2YCW, 2YCZ, 5A8E, 2YCY, 2Y00, 2Y03, 2VT4, 2Y01, 4GPO
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27
A
L
1 1 18
3ZPQ, 2YCX, 4AMJ, 4BVN, 5F8U, 2Y02, 2Y04, 3ZPR, 4AMI, 2YCW, 2YCZ, 5A8E, 2YCY, 2Y00, 2Y03, 2VT4, 2Y01, 4GPO
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43
V
A
1 1 4
4XES, 4GRV, 5T04, 4XEE
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
ECL1
Q
T
G
L
D
A
R
F
E
2 1 2
5NX2, 5EE7
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39
F
A
1 1 1
5EE7
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56
V
A
1 1 1
5NX2
2 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38
I
A
1 1 3
5NDZ, 5NDD, 5NJ6
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67
V
A
1 1 1
5X33
1
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63
H
C
1 1 2
4QKX, 3PDS
8
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67
H
G
1 1 1
5X33
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39
R
A
1 1 2
5YQZ, 5EE7
1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44
W
A
1 1 2
4K5Y, 4Z9G
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54
S
A
1 1 2
5X93, 5XPR
4
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31
D
K
1 1 1
4BVN
4
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40
V
F
1 1 2
5L7I, 5L7D
1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39
S
A
1 1 1
5WF6
Pos Match 1
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40
L
A
1 1 4
5TZR, 5TZY, 5KW2, 4PHU
2 1 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63
C
A
1 1 1
5NX2
STATE TARGETS MUTATIONS FREQUENCY DATA (MUTANT) SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM3 3x36
T
A 2 1 24
3UZC, 5N2R, 5OM4, 5IUB, 3PWH, 5NLX, 5OLV, 5IU4, 3UZA, 5NM4, 5IU8, 5OM1, 5OLH, 5MZP, 5OLG, 5OLZ, 5N2S, 5IU7, 3REY, 5MZJ, 3RFM, 5NM2, 5OLO, 5IUA
0.02 0 0.50 16
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51
D
C 1 1 1
4RWS
0.68 -0.02 12
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM7 7x48
I
A 1 1 2
5X93, 5XPR
0.13 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61
G
N 1 1 2
4MBS, 5UIW
0.03 0.65 0.85 4
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48
W
K 1 1 1
5VBL
0.26 2.80 Pos Match (But Not Mutant AA) 17
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31
D
K 1 1 1
4BVN
0.04 0.11 0.26 2.80 4
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48
T
A 1 1 1
5LWE
0.03 0 0.50 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39
R
A 1 1 2
5YQZ, 5EE7
0 0.50 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56
D
A 1 1 1
5X93
0.08 0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42
L
A 1 1 3
5NDZ, 5NDD, 5NJ6
0.13 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39
T
A 1 1 1
5LWE
0.08 0 0.50 3
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM5 5x37
D
C 1 1 1
4Z36
0.68 -0.02 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31
C
F 1 1 2
5VEW, 5VEX
0.07 0.54 -1.71 1
Active
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM7 7x43
V
A 1 1 4
4XES, 4GRV, 5T04, 4XEE
0.19 0 0.50
Inactive
F (Frizzled)
Protein
Frizzled
SMO
SMO
TM3 3x40
V
F 1 1 2
5L7I, 5L7D
0.54 -1.71 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
A 1 1 1
5NX2
0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2
G
M 1 1 5
5CGD, 4OO9, 6FFH, 5CGC, 6FFI
0.24 -0.67
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM5 5x64
M
A 1 1 3
5NDZ, 5NDD, 5NJ6
0.13 0 0.50 1 3
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46
L
A 1 1 4
2YDV, 4UG2, 2YDO, 4UHR
0 0.50
Active
Inactive
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
N-term
N
D
C 2 1 12
2X72, 4BEZ, 2J4Y, 5DYS, 6CMO, 4A4M, 4ZWJ, 5EN0, 3C9M, 5DGY, 4BEY, 5W0P
0.68 -0.02
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37
H
A 1 1 3
5NDZ, 5NDD, 5NJ6
0.05 0 0.50 1 1 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1
G
Q
A 1 1 1
5NX2
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
TM2 2x59
I
V
F 2 1 3
5EE7, 5VEW, 5VEX
0.54 -1.71
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM3 3x21
K
G 1 1 1
5X33
0.67 1.00 1.15 1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM7 7x41
S
T
A 2 1 24
3UZC, 5N2R, 5OM4, 5IUB, 3PWH, 5NLX, 5OLV, 5IU4, 3UZA, 5NM4, 5IU8, 5OM1, 5OLH, 5MZP, 5OLG, 5OLZ, 5N2S, 5IU7, 3REY, 5MZJ, 3RFM, 5NM2, 5OLO, 5IUA
0.38 0 0.50 5
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54
S
A 1 1 2
5X93, 5XPR
0.1 0 0.50 4
Intermediate
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM2 2x52
A
L 2 1 28
3UZC, 5N2R, 4UG2, 5OM4, 5IUB, 3PWH, 5NLX, 5OLV, 5IU4, 3UZA, 5NM4, 5IU8, 5OM1, 5OLH, 5MZP, 4UHR, 5OLG, 2YDV, 5OLZ, 5N2S, 5IU7, 3REY, 5MZJ, 3RFM, 5NM2, 5OLO, 5IUA, 2YDO
0.63 0.21 -1.25 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50
D
N 1 1 1
5WF5
0.03 0.65 0.85 Pos & AA Mutant Match 1
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60
L
A 1 1 2
4K5Y, 4Z9G
0 0.50
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55
R
Y 1 1 2
5X93, 5XPR
0.09 0.53 -0.71
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x38
I
A 1 1 3
5NDZ, 5NDD, 5NJ6
0.14 0 0.50
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM5 5x37
E
K 1 1 3
5TGZ, 5XRA, 5XR8
0.11 0.26 2.80 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48
N
Y 1 1 5
5CGD, 4OO9, 6FFH, 5CGC, 6FFI
0.05 0.53 -0.71
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52
G
I 1 1 2
5VEW, 5VEX
0.07 0.41 -1.12
Intermediate
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
GLP1R
CRFR1
GLP-1
CRF1
ECL2 45x52
T
F
A 2 2 3
5NX2, 4K5Y, 4Z9G
0 0.50
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67
V
A 1 1 1
5X33
0.08 0 0.50 1
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM5 5x54
I
A 1 1 4
4BV0, 3ZEV, 4BUO, 4BWB
0.02 0 0.50
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40
L
A 1 1 4
5TZR, 5TZY, 5KW2, 4PHU
0.06 0 0.50 2 1 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
TM3 3x24
S
G
A 2 1 3
5EE7, 5VEW, 5VEX
0.07 0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM1 1x48
G
A 1 1 1
5EE7
0.33 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM1 1x60
C
Y 1 1 2
4MBS, 5UIW
0.07 0.53 -0.71 1
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46
G
A 1 1 3
5NDZ, 5NDD, 5NJ6
0.11 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x44
W
A 1 1 2
4K5Y, 4Z9G
0.07 0 0.50
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43
K
A 1 1 23
3UZC, 5N2R, 5OM4, 5IUB, 3PWH, 5NLX, 5OLV, 5IU4, 3UZA, 5NM4, 5IU8, 5OM1, 5OLH, 5MZP, 5OLG, 5OLZ, 5IU7, 3REY, 5MZJ, 3RFM, 5NM2, 5OLO, 5IUA
0.13 0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM5 5x58
Y
A 1 1 18
3ZPQ, 2YCX, 4AMJ, 4BVN, 5F8U, 2Y02, 2Y04, 3ZPR, 4AMI, 2YCW, 2YCZ, 5A8E, 2YCY, 2Y00, 2Y03, 2VT4, 2Y01, 4GPO
0.03 0 0.50
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2Y12
P2RY1
P2Y12
P2Y1
TM7 7x49
D
N 2 1 5
4PXZ, 4XNW, 4XNV, 4PY0, 4NTJ
0.72 0.65 0.85
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41
T
A 1 1 1
5LWE
0.07 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
Glucagon
GLR
GLP1R
CRFR1
glucagon
GLP-1
CRF1
TM6 6x30
Y
K
A 3 2 5
5EE7, 4Z9G, 4K5Y, 5VEW, 5VEX
0 0.50
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32
R
E 1 1 3
5TGZ, 5XRA, 5XR8
0.04 0.40 0.11 1 3
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55
R
A 1 1 23
3UZC, 5N2R, 5OM4, 5IUB, 3PWH, 5NLX, 5OLV, 5IU4, 3UZA, 5NM4, 5IU8, 5OM1, 5OLH, 5MZP, 5OLG, 5OLZ, 5IU7, 3REY, 5MZJ, 3RFM, 5NM2, 5OLO, 5IUA
0.08 0 0.50 1 2
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43
M
L 1 1 3
5NDZ, 5NDD, 5NJ6
0.73 0.21 -1.25
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60
T
I 1 1 2
5EN0, 5DYS
0.04 0.29 0.41 -1.12 13
Active
Inactive
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2C
5-HT2C
TM7 7x45
C
N 1 1 2
6BQH, 6BQG
0.67 0.65 0.85 Pos & AA Mutant Match 1
Intermediate
A (Rhodopsin)
Peptide
Lipid
Neurotensin
Free fatty acid
FFAR1
NTR1
FFA1
NTS1
TM3 3x49
G
E
A 2 2 6
5TZR, 4XES, 4GRV, 5KW2, 4PHU, 5TZY
0.01 0 0.50 Pos & Mutant AA Match 2
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63
C
A 1 1 1
5NX2
0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53
Y
L 1 1 2
5A8E, 4BVN
0.03 0.21 -1.25 Pos Match (But Not Mutant AA) Pos & Mutant AA Match 3
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM2 2x56
S
C 1 1 2
5VEW, 5VEX
0.68 -0.02
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM6 6x59
V
C 1 1 1
4Z36
0.01 0.68 -0.02 3
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37
Q
A 1 1 4
2YDV, 4UG2, 2YDO, 4UHR
0.03 0 0.50 8
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM6 6x40
M
Y 2 1 5
5DGY, 4ZWJ, 4A4M, 5W0P, 6CMO
0.01 0.53 -0.71 1 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50
I
A 1 1 5
5CGD, 4OO9, 6FFH, 5CGC, 6FFI
0 0.50 Pos & Mutant AA Match
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM2 2x48
S
A 1 1 2
4K5Y, 4Z9G
0.2 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x51
F
A 1 1 2
4K5Y, 4Z9G
0 0.50 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39
S
A 1 1 1
5WF6
0.03 0 0.50 Pos & AA Mutant Match 1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM3 3x40
I
V 1 1 2
5A8E, 4BVN
0.24 0.61 -0.46 2
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56
V
A 1 1 1
5NX2
0.07 0 0.50 2 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x51
I
C 1 1 2
5VEW, 5VEX
0.68 -0.02 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62
T
A 1 1 4
2YDV, 4UG2, 2YDO, 4UHR
0.13 0 0.50
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46
T
A 1 1 4
5TGZ, 5U09, 5XRA, 5XR8
0.01 0 0.50 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36
K
A 1 1 2
5X93, 5XPR
0.07 0 0.50 1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67
H
G 1 1 1
5X33
0.2 1.00 1.15
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50
V
A 1 1 1
5LWE
0.06 0 0.50 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42
P
A 1 1 1
5NX2
0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x53
Y
A 1 1 2
4K5Y, 4Z9G
0 0.50 Pos & Mutant AA Match 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29
N
A 1 1 1
5LWE
0.13 0 0.50
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51
Y
A 1 1 3
5NDZ, 5NDD, 5NJ6
0.0 0 0.50 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x56
S
A 1 1 1
5EE7
0.27 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM6 6x36
V
A 1 1 1
5LWE
0.01 0 0.50 2 1 3
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
H8 8x49
K
E 1 1 2
4MBS, 5UIW
0.12 0.40 0.11 3 1 1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM5 5x63
Y
L
A 2 1 24
3UZC, 5N2R, 5OM4, 5IUB, 3PWH, 5NLX, 5OLV, 5IU4, 3UZA, 5NM4, 5IU8, 5OM1, 5OLH, 5MZP, 5OLG, 5OLZ, 5N2S, 5IU7, 3REY, 5MZJ, 3RFM, 5NM2, 5OLO, 5IUA
0.06 0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59
R
S 1 1 18
3ZPQ, 2YCX, 4AMJ, 4BVN, 5F8U, 2Y02, 2Y04, 3ZPR, 4AMI, 2YCW, 2YCZ, 5A8E, 2YCY, 2Y00, 2Y03, 2VT4, 2Y01, 4GPO
0.04 0.50 0.46
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48
I
A 1 1 2
4K5Y, 4Z9G
0 0.50
Active
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB2
β2
TM2 2x63
H
C 1 1 2
4QKX, 3PDS
0.0 0.68 -0.02 8
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Adenosine
Dopamine
AA1R
AA2AR
DRD2
A1
A2A
D2
TM6 6x41
L
V
A 3 2 25
3UZC, 5N2R, 5OM4, 5IUB, 3PWH, 5NLX, 5OLV, 5IU4, 3UZA, 5NM4, 5IU8, 6CM4, 5OM1, 5OLH, 5MZP, 5OLG, 5OLZ, 5N2S, 5IU7, 3REY, 5MZJ, 3RFM, 5NM2, 5OLO, 5IUA
0.05 0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43
K
A 1 1 2
4K5Y, 4Z9G
0 0.50
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36
V
A 1 1 2
4K5Y, 4Z9G
0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x48
F
M 1 1 18
3ZPQ, 2YCX, 4AMJ, 4BVN, 5F8U, 2Y02, 2Y04, 3ZPR, 4AMI, 2YCW, 2YCZ, 5A8E, 2YCY, 2Y00, 2Y03, 2VT4, 2Y01, 4GPO
0.05 0.24 -0.67
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31
L
F 1 1 1
5NX2
0.4 0.54 -1.71
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32
M
C 1 1 2
5VEW, 5VEX
0.68 -0.02
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38
S
A 1 1 2
4K5Y, 4Z9G
0 0.50 1
Active
Intermediate
Inactive
A (Rhodopsin)
Aminergic
Protein
Dopamine
Chemokine
Adrenoceptors
5-Hydroxytryptamine
5HT2B
5HT1B
CXCR4
ADRB1
DRD3
ADRB2
β1
5-HT1B
β2
5-HT2B
CXCR4
D3
TM3 3x41
L
M
E
W 6 4 20
3NY8, 3NYA, 4RWS, 3OE8, 3NY9, 3ODU, 3PBL, 3OE6, 4IAQ, 3OE0, 5A8E, 5TUD, 5V54, 4NC3, 4IAR, 3D4S, 6G79, 5TVN, 3OE9, 4IB4
0.03 0.49 -2.09 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x53
S
A 1 1 5
5CGD, 4OO9, 6FFH, 5CGC, 6FFI
0 0.50
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35
E
A 1 1 5
5CGD, 4OO9, 6FFH, 5CGC, 6FFI
0.05 0 0.50
Inactive
A (Rhodopsin)
Aminergic
Peptide
Apelin
Dopamine
APJ
DRD2
apelin
D2
TM3 3x40
V
I
A 2 2 2
6CM4, 5VBL
0.06 0 0.50 2
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47
S
C 1 1 1
5LWE
0.02 0.68 -0.02
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38
M
A 1 1 1
5LWE
0.12 0 0.50 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1
D
R 1 1 1
5NX2
0.21 1.81
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x45
G
C 1 1 2
5VEW, 5VEX
0.68 -0.02
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM6 6x33
A
D 1 1 2
4MBS, 5UIW
0.69 0.43 2 1 5
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x48
A
L 1 1 1
5EE7
0.2 0.21 -1.25
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42
T
A 1 1 5
5CGD, 4OO9, 6FFH, 5CGC, 6FFI
0.05 0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27
A
L 1 1 18
3ZPQ, 2YCX, 4AMJ, 4BVN, 5F8U, 2Y02, 2Y04, 3ZPR, 4AMI, 2YCW, 2YCZ, 5A8E, 2YCY, 2Y00, 2Y03, 2VT4, 2Y01, 4GPO
0.11 0.11 0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48
S
A 1 1 2
5VEW, 5VEX
0.07 0 0.50
Active
Intermediate
Inactive
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM1 1x54
A
L 1 1 8
4BV0, 4XES, 4GRV, 4BWB, 4XEE, 3ZEV, 4BUO, 5T04
0.37 0.21 -1.25
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM7 7x39
F
A 1 1 1
5EE7
0.07 0 0.50
Active
Intermediate
Inactive
A (Rhodopsin)
Peptide
Lipid
Neurotensin
Leukotriene
NTR1
Q9WTK1
NTS1
BLT1
ECL2
S
G
A 2 2 5
4XES, 4GRV, 5T04, 5X33, 4XEE
0 0.50
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM6 6x48
E
F 1 1 1
5EE7
0.13 0.54 -1.71 1
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28
E
Q 2 1 5
5DGY, 4ZWJ, 2X72, 5W0P, 6CMO
0.01 0.39 0.77 8
Intermediate
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Peptide
Neurotensin
Adenosine
Dopamine
AA1R
AA2AR
NTR1
DRD2
NTS1
A1
A2A
D2
TM6 6x37
L
A 4 3 26
3UZC, 5N2R, 5OM4, 5IUB, 3PWH, 5NLX, 5OLV, 5IU4, 3UZA, 5NM4, 5IU8, 6CM4, 5OM1, 5OLH, 4GRV, 5MZP, 5OLG, 5OLZ, 5N2S, 5IU7, 3REY, 5MZJ, 3RFM, 5NM2, 5OLO, 5IUA
0.04 0 0.50 1 1 4
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ICL2
L
F 1 1 1
5NX2
0.54 -1.71
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM5 5x58
Y
F 1 1 4
5TZR, 5TZY, 5KW2, 4PHU
0.01 0.54 -1.71
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
TM6 6x36
T
P 1 1 3
3OE9, 3OE0, 4RWS
0.0 3.16 0.14 2 1 3
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
ECL1
T
G
E 2 1 2
5NX2, 5EE7
0.40 0.11
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47
H
V 1 1 1
5NX2
0.61 -0.46
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53
V
E 1 1 3
5NDZ, 5NDD, 5NJ6
0.01 0.40 0.11 5
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x36
F
A 1 1 18
3ZPQ, 2YCX, 4AMJ, 4BVN, 5F8U, 2Y02, 2Y04, 3ZPR, 4AMI, 2YCW, 2YCZ, 5A8E, 2YCY, 2Y00, 2Y03, 2VT4, 2Y01, 4GPO
0.1 0.11 0 0.50
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53
M
V 1 1 18
3ZPQ, 2YCX, 4AMJ, 4BVN, 5F8U, 2Y02, 2Y04, 3ZPR, 4AMI, 2YCW, 2YCZ, 5A8E, 2YCY, 2Y00, 2Y03, 2VT4, 2Y01, 4GPO
0.23 0.33 0.61 -0.46 2
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54
M
A 1 1 1
5EE7
0.27 0 0.50
Intermediate
A (Rhodopsin)
Peptide
Lipid
Proteinase-activated
Free fatty acid
FFAR1
PAR2
FFA1
PAR2
TM3 3x34
F
G
A 2 2 5
5TZR, 5NJ6, 5NDZ, 5NDD, 4PHU
0.07 0 0.50 1
STATE TARGETS MUTATIONS FREQUENCY DATA (WILD TYPE) SITES INTERFACES
State Class Ligand Type Receptor Family UniProt Receptor Segment Position (GN) WT Mut No. GPCRS No. Receptor Families No. Structures PDBs Class Sequence Conservation Receptor Family Sequence Conservation Helix Propen- sity Hydroph- obicity Ionic Lock Sodium Ion Binding Site Switch LigandBinding Arrestin G-PROTEIN
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM7 7x38 S
A
1 1 2
4K5Y, 4Z9G
0.13 0.50 0.46 1
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x53 Y
L
1 1 2
5A8E, 4BVN
0.89 1.0 0.53 -0.71 Pos & Wild Type AA Match Pos & Wild Type AA Match 3
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR5
CCR5
TM4 4x61 G
N
1 1 2
4MBS, 5UIW
0.02 1.00 1.15 4
Intermediate
A (Rhodopsin)
Peptide
Neurotensin
NTR1
NTS1
TM3 3x49 E
A
1 1 2
4XES, 4GRV
0.21 0.40 0.11 Pos & Wild Type AA Match 2
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x51 Y
A
1 1 3
5NDZ, 5NDD, 5NJ6
0.66 0.53 -0.71 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x63 C
A
1 1 1
5NX2
0.07 0.68 -0.02
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM2 2x59 I
F
1 1 2
5VEW, 5VEX
0.4 0.41 -1.12
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x39 R
A
1 1 2
5YQZ, 5EE7
1.0 0.21 1.81 1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM6 6x41 V
A
1 1 23
3UZC, 5N2R, 5OM4, 5IUB, 3PWH, 5NLX, 5OLV, 5IU4, 3UZA, 5NM4, 5IU8, 5OM1, 5OLH, 5MZP, 5OLG, 5OLZ, 5IU7, 3REY, 5MZJ, 3RFM, 5NM2, 5OLO, 5IUA
0.41 0.61 -0.46
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL2 45x52 T
A
1 1 1
5NX2
0.2 0.66 0.25
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM2 2x40 L
A
1 1 4
5TZR, 5TZY, 5KW2, 4PHU
0.03 0.21 -1.25 2 1 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM4 4x54 M
A
1 1 1
5EE7
0.07 0.24 -0.67
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM6 6x27 A
L
1 1 18
3ZPQ, 2YCX, 4AMJ, 4BVN, 5F8U, 2Y02, 2Y04, 3ZPR, 4AMI, 2YCW, 2YCZ, 5A8E, 2YCY, 2Y00, 2Y03, 2VT4, 2Y01, 4GPO
0.08 0.11 0 0.50
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 T
E
1 1 1
5NX2
0.66 0.25
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x42 P
A
1 1 1
5NX2
0.93 3.16 0.14
Active
Intermediate
Inactive
A (Rhodopsin)
Aminergic
Protein
Dopamine
Chemokine
5-Hydroxytryptamine
CXCR4
DRD3
5HT1B
5-HT1B
CXCR4
D3
TM3 3x41 L
W
3 3 11
4RWS, 3OE8, 3ODU, 3PBL, 3OE6, 4IAQ, 3OE0, 5V54, 4IAR, 6G79, 3OE9
0.31 0.21 -1.25 1
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM6 6x32 R
E
1 1 3
5TGZ, 5XRA, 5XR8
0.31 0.21 1.81 1 3
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Adenosine
Dopamine
AA1R
DRD2
A1
D2
TM6 6x41 L
A
2 2 2
5N2S, 6CM4
0.19 0.21 -1.25
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x50 D
N
1 1 1
5WF5
0.92 0.69 0.43 Pos & Wild Type AA Match 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM5 5x52 G
I
1 1 2
5VEW, 5VEX
0.2 1.00 1.15
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM6 6x36 V
A
1 1 1
5LWE
0.15 0.61 -0.46 2 1 3
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM1 1x59 R
S
1 1 18
3ZPQ, 2YCX, 4AMJ, 4BVN, 5F8U, 2Y02, 2Y04, 3ZPR, 4AMI, 2YCW, 2YCZ, 5A8E, 2YCY, 2Y00, 2Y03, 2VT4, 2Y01, 4GPO
0.24 0.21 1.81
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x31 D
K
1 1 1
4BVN
0.1 0.22 0.69 0.43 4
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x48 T
A
1 1 1
5LWE
0.05 0.66 0.25 2
Intermediate
A (Rhodopsin)
Nucleotide
P2Y
P2Y12
P2RY1
P2Y12
P2Y1
TM7 7x49 D
N
2 1 5
4PXZ, 4XNW, 4XNV, 4PY0, 4NTJ
0.2 0.69 0.43
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM5 5x67 V
A
1 1 1
5X33
0.02 0.61 -0.46 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 Q
A
1 1 1
5NX2
0.39 0.77
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x53 V
E
1 1 3
5NDZ, 5NDD, 5NJ6
0.07 0.61 -0.46 5
Active
Inactive
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
ECL3 D
C
1 1 8
2X72, 4BEZ, 3C9M, 5EN0, 2J4Y, 5DYS, 4A4M, 4BEY
0.69 0.43
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM6 6x54 S
A
1 1 2
5X93, 5XPR
0.05 0.50 0.46 4
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM1 1x46 G
A
1 1 3
5NDZ, 5NDD, 5NJ6
0.54 1.00 1.15
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM1 1x35 E
A
1 1 5
5CGD, 4OO9, 6FFH, 5CGC, 6FFI
0.09 0.40 0.11
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
C-term S
A
1 1 1
5X33
0.50 0.46
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM2 2x38 M
A
1 1 1
5LWE
0.04 0.24 -0.67 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM7 7x56 V
A
1 1 1
5NX2
0.07 0.61 -0.46 2 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
TM2 2x56 S
A
C
2 1 3
5EE7, 5VEW, 5VEX
0.47 0.50 0.46
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x39 S
A
1 1 1
5WF6
0.72 0.50 0.46 Pos & Wild Type AA Match 1
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM2 2x56 D
A
1 1 1
5X93
0.01 0.69 0.43
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM6 6x48 W
K
1 1 1
5VBL
0.68 0.49 -2.09 Pos & Wild Type AA Match 17
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x31 C
F
1 1 2
5VEW, 5VEX
0.07 0.68 -0.02 1
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x32 M
C
1 1 2
5VEW, 5VEX
0.13 0.24 -0.67
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM6 6x30 Y
A
1 1 2
4K5Y, 4Z9G
0.73 0.53 -0.71
Inactive
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM4 4x48 S
A
1 1 2
5VEW, 5VEX
0.07 0.50 0.46
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x55 R
A
1 1 23
3UZC, 5N2R, 5OM4, 5IUB, 3PWH, 5NLX, 5OLV, 5IU4, 3UZA, 5NM4, 5IU8, 5OM1, 5OLH, 5MZP, 5OLG, 5OLZ, 5IU7, 3REY, 5MZJ, 3RFM, 5NM2, 5OLO, 5IUA
0.05 0.21 1.81 1 2
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM5 5x36 K
A
1 1 2
5X93, 5XPR
0.06 0.26 2.80 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ICL2 L
F
1 1 1
5NX2
0.21 -1.25
Active
Inactive
A (Rhodopsin)
Lipid
Cannabinoid
CNR1
CB1
TM3 3x46 T
A
1 1 4
5TGZ, 5U09, 5XRA, 5XR8
0.01 0.66 0.25 1
Inactive
A (Rhodopsin)
Lipid
Leukotriene
Q9WTK1
BLT1
TM2 2x67 H
G
1 1 1
5X33
0.1 0.61 0.11
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x34 G
A
1 1 3
5NDZ, 5NDD, 5NJ6
0.02 1.00 1.15 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x62 T
A
1 1 4
2YDV, 4UG2, 2YDO, 4UHR
0.1 0.66 0.25
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM4 4x43 K
A
1 1 2
4K5Y, 4Z9G
0.13 0.26 2.80
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM6 6x47 H
V
1 1 1
5NX2
0.73 0.61 0.11
Intermediate
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM2 2x52 A
L
2 1 28
3UZC, 5N2R, 4UG2, 5OM4, 5IUB, 3PWH, 5NLX, 5OLV, 5IU4, 3UZA, 5NM4, 5IU8, 5OM1, 5OLH, 5MZP, 4UHR, 5OLG, 2YDV, 5OLZ, 5N2S, 5IU7, 3REY, 5MZJ, 3RFM, 5NM2, 5OLO, 5IUA, 2YDO
0.06 0 0.50 1
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
TM6 6x36 T
P
1 1 3
3OE9, 3OE0, 4RWS
0.25 0.66 0.25 2 1 3
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM3 3x43 M
L
1 1 3
5NDZ, 5NDD, 5NJ6
0.05 0.24 -0.67
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM5 5x41 T
A
1 1 1
5LWE
0.09 0.66 0.25
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM5 5x48 I
A
1 1 2
4K5Y, 4Z9G
0.2 0.41 -1.12
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM2 2x46 L
A
1 1 4
2YDV, 4UG2, 2YDO, 4UHR
0.9 0.21 -1.25
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM2 2x53 M
V
1 1 18
3ZPQ, 2YCX, 4AMJ, 4BVN, 5F8U, 2Y02, 2Y04, 3ZPR, 4AMI, 2YCW, 2YCZ, 5A8E, 2YCY, 2Y00, 2Y03, 2VT4, 2Y01, 4GPO
0.07 0.33 0.24 -0.67 2
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
Rhodopsin
TM2 2x60 T
I
1 1 2
5EN0, 5DYS
0.08 0.43 0.66 0.25 13
Inactive
A (Rhodopsin)
Lipid
Lysophospholipid (LPA)
LPAR1
LPA1
TM5 5x37 D
C
1 1 1
4Z36
0.01 0.69 0.43 1
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
TM3 3x31 L
F
1 1 1
5NX2
0.2 0.21 -1.25
Intermediate
Inactive
A (Rhodopsin)
Nucleotide
Aminergic
Peptide
Neurotensin
Adenosine
Dopamine
AA1R
AA2AR
NTR1
DRD2
NTS1
A1
A2A
D2
TM6 6x37 L
A
4 3 26
3UZC, 5N2R, 5OM4, 5IUB, 3PWH, 5NLX, 5OLV, 5IU4, 3UZA, 5NM4, 5IU8, 6CM4, 5OM1, 5OLH, 4GRV, 5MZP, 5OLG, 5OLZ, 5N2S, 5IU7, 3REY, 5MZJ, 3RFM, 5NM2, 5OLO, 5IUA
0.38 0.21 -1.25 1 1 4
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM3 3x24 G
A
1 1 1
5EE7
0.4 1.00 1.15
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM7 7x41 S
A
1 1 23
3UZC, 5N2R, 5OM4, 5IUB, 3PWH, 5NLX, 5OLV, 5IU4, 3UZA, 5NM4, 5IU8, 5OM1, 5OLH, 5MZP, 5OLG, 5OLZ, 5IU7, 3REY, 5MZJ, 3RFM, 5NM2, 5OLO, 5IUA
0.16 0.50 0.46 5
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM4 4x43 K
A
1 1 23
3UZC, 5N2R, 5OM4, 5IUB, 3PWH, 5NLX, 5OLV, 5IU4, 3UZA, 5NM4, 5IU8, 5OM1, 5OLH, 5MZP, 5OLG, 5OLZ, 5IU7, 3REY, 5MZJ, 3RFM, 5NM2, 5OLO, 5IUA
0.16 0.26 2.80
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM6 6x42 L
A
1 1 3
5NDZ, 5NDD, 5NJ6
0.24 0.21 -1.25
Intermediate
B1 (Secretin)
Peptide
Glucagon
GLP1R
GLP-1
ECL1 D
R
1 1 1
5NX2
0.69 0.43
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
ICL1 12x50 V
A
1 1 1
5LWE
0.02 0.61 -0.46 1
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
ICL2 G
M
1 1 5
5CGD, 4OO9, 6FFH, 5CGC, 6FFI
1.00 1.15
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
glucagon
TM2 2x48 A
L
1 1 1
5EE7
0.2 0 0.50
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM3 3x47 S
C
1 1 1
5LWE
0.56 0.50 0.46
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
ECL2 45x52 F
A
1 1 2
4K5Y, 4Z9G
0.13 0.54 -1.71
Active
Intermediate
A (Rhodopsin)
Aminergic
5-Hydroxytryptamine
5HT2B
5-HT2B
TM3 3x41 M
W
1 1 4
5TVN, 5TUD, 4NC3, 4IB4
0.04 0.24 -0.67 1
Intermediate
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM3 3x37 Q
A
1 1 4
2YDV, 4UG2, 2YDO, 4UHR
0.02 0.39 0.77 8
Intermediate
A (Rhodopsin)
Lipid
Free fatty acid
FFAR1
FFA1
TM3 3x34 F
A
1 1 2
5TZR, 4PHU
0.11 0.54 -1.71 1
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
AA2AR
A1
A2A
TM3 3x36 T
A
2 1 24
3UZC, 5N2R, 5OM4, 5IUB, 3PWH, 5NLX, 5OLV, 5IU4, 3UZA, 5NM4, 5IU8, 5OM1, 5OLH, 5MZP, 5OLG, 5OLZ, 5N2S, 5IU7, 3REY, 5MZJ, 3RFM, 5NM2, 5OLO, 5IUA
0.05 0.66 0.25 16
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM5 5x42 T
A
1 1 5
5CGD, 4OO9, 6FFH, 5CGC, 6FFI
0.09 0.66 0.25
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x48 N
Y
1 1 5
5CGD, 4OO9, 6FFH, 5CGC, 6FFI
0.41 0.65 0.85
Inactive
C (Glutamate)
Amino acid
Metabotropic glutamate
GRM5
mGlu5
TM3 3x50 I
A
1 1 5
5CGD, 4OO9, 6FFH, 5CGC, 6FFI
0.5 0.41 -1.12 Pos & Wild Type AA Match
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM7 7x48 I
A
1 1 2
5X93, 5XPR
0.15 0.41 -1.12
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
Dopamine
ADRB1
DRD2
β1
D2
TM3 3x40 I
A
V
2 2 3
5A8E, 6CM4, 4BVN
0.4 0.41 -1.12 2
Inactive
A (Rhodopsin)
Aminergic
Adrenoceptors
ADRB1
β1
TM7 7x48 F
M
1 1 18
3ZPQ, 2YCX, 4AMJ, 4BVN, 5F8U, 2Y02, 2Y04, 3ZPR, 4AMI, 2YCW, 2YCZ, 5A8E, 2YCY, 2Y00, 2Y03, 2VT4, 2Y01, 4GPO
0.06 0.33 0.54 -1.71
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x36 V
A
1 1 2
4K5Y, 4Z9G
0.07 0.61 -0.46
Inactive
A (Rhodopsin)
Protein
Chemokine
CXCR4
CXCR4
ECL2 45x51 D
C
1 1 1
4RWS
0.03 0.69 0.43 12
Active
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
TM3 3x28 E
Q
2 1 5
5DGY, 4ZWJ, 2X72, 5W0P, 6CMO
0.02 0.57 0.40 0.11 8
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x29 N
A
1 1 1
5LWE
0.04 0.65 0.85
Inactive
B1 (Secretin)
Peptide
Corticotropin-releasing factor
CRFR1
CRF1
TM1 1x60 L
A
1 1 2
4K5Y, 4Z9G
0.33 0.21 -1.25
Intermediate
A (Rhodopsin)
Peptide
Proteinase-activated
PAR2
PAR2
TM2 2x37 H
A
1 1 3
5NDZ, 5NDD, 5NJ6
0.03 0.61 0.11 1 1 1
Inactive
A (Rhodopsin)
Peptide
Apelin
APJ
apelin
TM3 3x40 V
A
1 1 1
5VBL
0.24 0.61 -0.46 2
Active
Inactive
A (Rhodopsin)
Sensory
Opsins
OPSD
OPSD
Rhodopsin
N-term N
C
2 1 12
2X72, 4BEZ, 2J4Y, 5DYS, 6CMO, 4A4M, 4ZWJ, 5EN0, 3C9M, 5DGY, 4BEY, 5W0P
0.65 0.85
Inactive
A (Rhodopsin)
Peptide
Endothelin
EDNRB
ETB
TM1 1x55 R
Y
1 1 2
5X93, 5XPR
0.02 0.21 1.81
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA2AR
A2A
TM5 5x63 L
A
1 1 23
3UZC, 5N2R, 5OM4, 5IUB, 3PWH, 5NLX, 5OLV, 5IU4, 3UZA, 5NM4, 5IU8, 5OM1, 5OLH, 5MZP, 5OLG, 5OLZ, 5IU7, 3REY, 5MZJ, 3RFM, 5NM2, 5OLO, 5IUA
0.13 0.21 -1.25
Intermediate
Inactive
B1 (Secretin)
Peptide
Glucagon
GLR
GLP1R
glucagon
GLP-1
ECL2 G
A
E
2 1 2
5NX2, 5EE7
1.00 1.15
Inactive
A (Rhodopsin)
Nucleotide
Adenosine
AA1R
A1
TM7 7x41 T
A
1 1 1
5N2S
0.07 0.66 0.25 5
Inactive
A (Rhodopsin)
Protein
Chemokine
CCR9
CCR9
TM7 7x39 T
A
1 1 1
5LWE
0.03 0.66 0.25 3
Inactive
B1 (Secretin)
Peptide